RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies
Solomon, Benjamin J., Tan, Lavinia, Lin, Jessica J., Wong, Stephen Q., Hollizeck, Sebastian, Ebata, Kevin, Tuch, Brian B., Yoda, Satoshi, Gainor, Justin F., Sequist, Lecia V., Oxnard, Geoffrey R., Gautschi, Oliver, Drilon, Alexander, Subbiah, Vivek, Khoo, Christine, Zhu, Edward Y., Nguyen, Michele, Henry, Dahlia, Condroski, Kevin R., Kolakowski, Gabrielle R., Gomez, Eliana, Ballard, Joshua, Metcalf, Andrew T., Blake, James F., Dawson, Sarah-Jane, Blosser, Wayne, Stancato, Louis F., Brandhuber, Barbara J., Andrews, Steve, Robinson, Bruce G., Rothenberg, S. Michael
Published in Journal of thoracic oncology (01.04.2020)
Published in Journal of thoracic oncology (01.04.2020)
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Journal Article
Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease
Jiang, Yutong, Andrews, Steven W., Condroski, Kevin R., Buckman, Brad, Serebryany, Vlad, Wenglowsky, Steve, Kennedy, April L., Madduru, Machender R., Wang, Bin, Lyon, Michael, Doherty, George A., Woodard, Benjamin T., Lemieux, Christine, Do, Mary Geck, Zhang, Hailong, Ballard, Joshua, Vigers, Guy, Brandhuber, Barbra J., Stengel, Peter, Josey, John A., Beigelman, Leonid, Blatt, Lawrence, Seiwert, Scott D.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)
Seiwert, Scott D, Andrews, Steven W, Jiang, Yutong, Serebryany, Vladimir, Tan, Hua, Kossen, Karl, Rajagopalan, P T Ravi, Misialek, Shawn, Stevens, Sarah K, Stoycheva, Antitsa, Hong, Jin, Lim, Sharlene R, Qin, Xiaoli, Rieger, Robert, Condroski, Kevin R, Zhang, Hailong, Do, Mary Geck, Lemieux, Christine, Hingorani, Gary P, Hartley, Dylan P, Josey, John A, Pan, Lin, Beigelman, Leonid, Blatt, Lawrence M
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
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Journal Article
Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator
Hinklin, Ronald J., Baer, Brian R., Boyd, Steven A., Chicarelli, Mark D., Condroski, Kevin R., DeWolf, Walter E., Fischer, John, Frank, Michele, Hingorani, Gary P., Lee, Patrice A., Neitzel, Nickolas A., Pratt, Scott A., Singh, Ajay, Sullivan, Francis X., Turner, Timothy, Voegtli, Walter C., Wallace, Eli M., Williams, Lance, Aicher, Thomas D.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
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Journal Article
Collaborative virtual screening to elaborate an imidazo[1,2-]pyridine hit series for visceral leishmaniasis
Akao, Yuichiro, Canan, Stacie, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Itono, Sachiko, Kaki, Rina, Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Nakai, Hiromi, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shimada, Mitsuyuki, Shum, David, Watanabe, Nao-aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin
Published in MedChemComm (01.04.2021)
Published in MedChemComm (01.04.2021)
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Journal Article
Identification of a New Class of Glucokinase Activators through Structure-Based Design
Hinklin, Ronald J, Boyd, Steven A, Chicarelli, Mark J, Condroski, Kevin R, DeWolf, Walter E, Lee, Patrice A, Lee, Waiman, Singh, Ajay, Thomas, Laurie, Voegtli, Walter C, Williams, Lance, Aicher, Thomas D
Published in Journal of medicinal chemistry (10.10.2013)
Published in Journal of medicinal chemistry (10.10.2013)
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Journal Article
Discovery of 2‑Pyridylureas as Glucokinase Activators
Hinklin, Ronald J, Aicher, Thomas D, Anderson, Deborah A, Baer, Brian R, Boyd, Steven A, Condroski, Kevin R, DeWolf, Walter E, Kraser, Christopher F, McVean, Maralee, Rhodes, Susan P, Sturgis, Hillary L, Voegtli, Walter C, Williams, Lance, Houze, Jonathan B
Published in Journal of medicinal chemistry (09.10.2014)
Published in Journal of medicinal chemistry (09.10.2014)
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Journal Article
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394
Dransfield, Paul J, Pattaropong, Vatee, Lai, Sujen, Fu, Zice, Kohn, Todd J, Du, Xiaohui, Cheng, Alan, Xiong, Yumei, Komorowski, Renee, Jin, Lixia, Conn, Marion, Tien, Eric, DeWolf, Walter E, Hinklin, Ronald J, Aicher, Thomas D, Kraser, Christopher F, Boyd, Steven A, Voegtli, Walter C, Condroski, Kevin R, Veniant-Ellison, Murielle, Medina, Julio C, Houze, Jonathan, Coward, Peter
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
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Journal Article
Transition States of Epoxidations: Diradical Character, Spiro Geometries, Transition State Flexibility, and the Origins of Stereoselectivity
Houk, K. N, Liu, Jian, DeMello, Nicholas C, Condroski, Kevin R
Published in Journal of the American Chemical Society (22.10.1997)
Published in Journal of the American Chemical Society (22.10.1997)
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Journal Article
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators
Du, Xiaohui, Hinklin, Ronald J, Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J, Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M, Anderson, Deborah A, Baer, Brian R, Bencsik, Josef R, Boyd, Steven A, Chicarelli, Mark Joseph, Mohr, Peter J, Wang, Bin, Condroski, Kevin R, DeWolf, Walter E, Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D, Medina, Julio C, Coward, Peter, Houze, Jonathan B
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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Journal Article
Radical and Concerted Mechanisms in Oxidations of Amines, Sulfides, and Alkenes by Peroxynitrite, Peroxynitrous Acid, and the Peroxynitrite−CO2 Adduct: Density Functional Theory Transition Structures and Energetics
Houk, K. N, Condroski, Kevin R, Pryor, William A
Published in Journal of the American Chemical Society (25.12.1996)
Published in Journal of the American Chemical Society (25.12.1996)
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Journal Article
Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization
Sanders, William J, Nienaber, Vicki L, Lerner, Claude G, McCall, J. Owen, Merrick, Sean M, Swanson, Susan J, Harlan, John E, Stoll, Vincent S, Stamper, Geoffrey F, Betz, Stephen F, Condroski, Kevin R, Meadows, Robert P, Severin, Jean M, Walter, Karl A, Magdalinos, Peter, Jakob, Clarissa G, Wagner, Rolf, Beutel, Bruce A
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
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Journal Article
Synthesis of (.+-.)-7,8-Epoxy-4-basmen-6-one by a Transannular Cyclization Strategy
Myers, Andrew G, Condroski, Kevin R
Published in Journal of the American Chemical Society (01.03.1995)
Published in Journal of the American Chemical Society (01.03.1995)
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Journal Article
Protein Degradation via CRL4(CRBN) Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1
Hansen, Joshua D., Condroski, Kevin, Correa, Matthew, Muller, George, Man, Hon-Wah, Ruchelman, Alexander, Zhang, Weihong, Vocanson, Fan, Crea, Tim, Liu, Wei, Lu, Gang, Baculi, Frans, LeBrun, Laurie, Mahmoudi, Afshin, Carmel, Gilles, Hickman, Matt, Lu, Chin-Chun
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001
Nagy, Mark A, Hilgraf, Robert, Mortensen, Deborah S, Elsner, Jan, Norris, Stephen, Tikhe, Jayashree, Yoon, Won, Paisner, David, Delgado, Mercedes, Erdman, Paul, Haelewyn, Jason, Khambatta, Godrej, Xu, Li, Romanow, William J, Condroski, Kevin, Bahmanyar, Sogole, McCarrick, Meg, Benish, Brent, Blease, Kate, LeBrun, Laurie, Moghaddam, Mehran F, Apuy, Julius, Canan, Stacie S, Bennett, Brydon L, Satoh, Yoshitaka
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Journal Article
Collaborative Virtual Screening Identifies a 2‑Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection
Tawaraishi, Taisuke, Ochida, Atsuko, Akao, Yuichiro, Itono, Sachiko, Kamaura, Masahiro, Akther, Thamina, Shimada, Mitsuyuki, Canan, Stacie, Chowdhury, Sanjoy, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Francisco, Amanda, Ghosh, Sunil, Kaki, Rina, Kelly, John M., Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shum, David, Watanabe, Nao-aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin
Published in Journal of medicinal chemistry (26.01.2023)
Published in Journal of medicinal chemistry (26.01.2023)
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Journal Article
Abstract 1464: Pre-clinical characterization of potent and selective next-generation RET inhibitors
Kolakowski, Gabrielle R., Anderson, Erin D., Ballard, Joshua A., Brandhuber, Barbara J., Condroski, Kevin R., Gomez, Eliana B., Irvin, Thomas C., Kumar, Manoj, Patel, Nisha A., Watson, Faith D., Andrews, Steven W.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy
Riggs, Jennifer R, Elsner, Jan, Cashion, Dan, Robinson, Dale, Tehrani, Lida, Nagy, Mark, Fultz, Kimberly E, Krishna Narla, Rama, Peng, Xiaohui, Tran, Tam, Kulkarni, Ashutosh, Bahmanyar, Sogole, Condroski, Kevin, Pagarigan, Barbra, Fenalti, Gustavo, LeBrun, Laurie, Leftheris, Katerina, Zhu, Dan, Boylan, John F
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Stereoselectivities of Nucleophilic Additions to Cycloheptanones. Experimental and Theoretical Studies and General Purpose Force Field for the Prediction of Nucleophilic Addition Stereoselectivities
Ando, Kaori, Condroski, Kevin R, Houk, K. N, Wu, Yun-Dong, Ly, Sylvie Kim, Overman, L. E
Published in Journal of organic chemistry (15.05.1998)
Published in Journal of organic chemistry (15.05.1998)
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Journal Article
Abstract P141: Preclinical characterization of LOX-24350, a highly potent and isoform-selective FGFR3 inhibitor
Ballard, Joshua A., Kercher, Timothy, Abraham, David, Brecht, Ryan, Brooks, Nathan A., Buckles, Thomas, Bume, Desta, Busha, David, Cedervall, Ernst Peder, Condroski, Kevin, Ebata, Kevin, Gharbi, Severine Isabelle, Hazlitt, Robert, Morales, Tony, Patel, Nisha, Podoll, Jessica, Urkalan, Kaveri, Villalain, Sandra Gomez, Walls, Shane, Watson, Faith, Yang, Peiyi, Brandhuber, Barbara J., Andrews, Steven W.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article