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Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization
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Published in The Journal of biological chemistry (13.05.2011)
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Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics
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Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase
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Published in Biochemical journal (15.03.2013)
Published in Biochemical journal (15.03.2013)
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Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics
Lalaoui, Najoua, Hänggi, Kay, Brumatti, Gabriela, Chau, Diep, Nguyen, Nhu-Y.N., Vasilikos, Lazaros, Spilgies, Lisanne M., Heckmann, Denise A., Ma, Chunyan, Ghisi, Margherita, Salmon, Jessica M., Matthews, Geoffrey M., de Valle, Elisha, Moujalled, Donia M., Menon, Manoj B., Spall, Sukhdeep Kaur, Glaser, Stefan P., Richmond, Jennifer, Lock, Richard B., Condon, Stephen M., Gugasyan, Raffi, Gaestel, Matthias, Guthridge, Mark, Johnstone, Ricky W., Munoz, Lenka, Wei, Andrew, Ekert, Paul G., Vaux, David L., Wong, W. Wei-Lynn, Silke, John
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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
Brumatti, Gabriela, Ma, Chunyan, Lalaoui, Najoua, Nguyen, Nhu-Y, Navarro, Mario, Tanzer, Maria C, Richmond, Jennifer, Ghisi, Margherita, Salmon, Jessica M, Silke, Natasha, Pomilio, Giovanna, Glaser, Stefan P, de Valle, Elisha, Gugasyan, Raffi, Gurthridge, Mark A, Condon, Stephen M, Johnstone, Ricky W, Lock, Richard, Salvesen, Guy, Wei, Andrew, Vaux, David L, Ekert, Paul G, Silke, John
Published in Science translational medicine (18.05.2016)
Published in Science translational medicine (18.05.2016)
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Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies
Condon, Stephen M, Mitsuuchi, Yasuhiro, Deng, Yijun, LaPorte, Matthew G, Rippin, Susan R, Haimowitz, Thomas, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Benetatos, Christopher A, Yu, Guangyao, Kapoor, Gurpreet Singh, Neiman, Eric, Seipel, Martin E, Burns, Jennifer M, Graham, Martin A, McKinlay, Mark A, Li, Xiaochun, Wang, Jiawei, Shi, Yigong, Feltham, Rebecca, Bettjeman, Bodhi, Cumming, Mathew H, Vince, James E, Khan, Nufail, Silke, John, Day, Catherine L, Chunduru, Srinivas K
Published in Journal of medicinal chemistry (08.05.2014)
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TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα
Vince, James E, Chau, Diep, Callus, Bernard, Wong, W. Wei-Lynn, Hawkins, Christine J, Schneider, Pascal, McKinlay, Mark, Benetatos, Christopher A, Condon, Stephen M, Chunduru, Srinivas K, Yeoh, George, Brink, Robert, Vaux, David L, Silke, John
Published in The Journal of cell biology (14.07.2008)
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Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways
Tanzer, Maria C, Khan, Nufail, Rickard, James A, Etemadi, Nima, Lalaoui, Najoua, Spall, Sukhdeep Kaur, Hildebrand, Joanne M, Segal, David, Miasari, Maria, Chau, Diep, Wong, WendyWei-Lynn, McKinlay, Mark, Chunduru, Srinivas K, Benetatos, Christopher A, Condon, Stephen M, Vince, James E, Herold, Marco J, Silke, John
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Process Development of the Soft Histone Deacetylate Enzyme Inhibitor SHP-141: Acylation of Methyl Paraben and Suberyl Hydroxamic Acid Formation
Deng, Yijun, Ng DiMarco, Christina, Vakhilt, Tanya, Jonas, Marco, White, Jaclyn, Arefyev, Dennis, Tokala, Ramachandar, Akhtar, Parveen, Zhu, Lei, Sun, Xufeng, Haimowitz, Thomas, Condon, Stephen M
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Published in Organic process research & development (21.10.2016)
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A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin: Construction of the C(21−42) Perimeters
Smith, Amos B, Condon, Stephen M, McCauley, John A, Leazer, Johnnie L, Leahy, James W, Maleczka, Robert E
Published in Journal of the American Chemical Society (05.02.1997)
Published in Journal of the American Chemical Society (05.02.1997)
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A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin: Assembly of the Common C(1−20) Perimeter and Final Elaboration
Smith, Amos B, Condon, Stephen M, McCauley, John A, Leazer, Johnnie L, Leahy, James W, Maleczka, Robert E
Published in Journal of the American Chemical Society (05.02.1997)
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Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate
Deng, Yijun, Xie, Qiuzhe, LaPorte, Matthew G, Chasnoff, Anna T. A, Mortensen, Mark A, Patra, Debasis, Putrelo, Seth A, Antonovich, Robert S, Cao, Hong, Yan, Jun, Cooper, Arthur J, Rippin, Susan R, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Haimowitz, Thomas, Condon, Stephen M
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Published in Organic process research & development (19.02.2016)
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Total Synthesis of Rapamycin and Demethoxyrapamycin
Smith, Amos B, Condon, Stephen M, McCauley, John A, Leazer, Johnnie L, Leahy, James W, Maleczka, Robert E
Published in Journal of the American Chemical Society (01.05.1995)
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The discovery and structure–activity relationships of pyrano[3,4- b]indole-based inhibitors of hepatitis C virus NS5B polymerase
Jackson, Randy W., LaPorte, Matthew G., Herbertz, Torsten, Draper, Tandy L., Gaboury, Janet A., Rippin, Susan R., Patel, Ravi, Chunduru, Srinivas K., Benetatos, Christopher A., Young, Dorothy C., Burns, Christopher J., Condon, Stephen M.
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Electrophilic Oxidation and [1,2]-Rearrangement of the Biindole Core of Birinapant
Deng, Yijun, Haimowitz, Thomas, LaPorte, Matthew G, Rippin, Susan R, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Condon, Stephen M
Published in ACS medicinal chemistry letters (10.03.2016)
Published in ACS medicinal chemistry letters (10.03.2016)
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The discovery and structure–activity relationships of pyrano[3,4- b]indole based inhibitors of hepatitis C virus NS5B polymerase
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Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4
Blackburn, Christopher, Guan, Bing, Brown, James, Cullis, Courtney, Condon, Stephen M., Jenkins, Tracy J., Peluso, Stephane, Ye, Yingchun, Gimeno, Ruth E., Punreddy, Sandhya, Sun, Ying, Wu, Hui, Hubbard, Brian, Kaushik, Virendar, Tummino, Peter, Sanchetti, Praveen, Yu Sun, Dong, Daniels, Tom, Tozzo, Effie, Balani, Suresh K., Raman, Prakash
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models
Benetatos, Christopher A, Mitsuuchi, Yasuhiro, Burns, Jennifer M, Neiman, Eric M, Condon, Stephen M, Yu, Guangyao, Seipel, Martin E, Kapoor, Gurpreet S, Laporte, Matthew G, Rippin, Susan R, Deng, Yijun, Hendi, Mukta S, Tirunahari, Pavan K, Lee, Yu-Hua, Haimowitz, Thomas, Alexander, Matthew D, Graham, Martin A, Weng, David, Shi, Yigong, McKinlay, Mark A, Chunduru, Srinivas K
Published in Molecular cancer therapeutics (01.04.2014)
Published in Molecular cancer therapeutics (01.04.2014)
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