Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Krönke, Jan, Udeshi, Namrata D., Narla, Anupama, Grauman, Peter, Hurst, Slater N., McConkey, Marie, Svinkina, Tanya, Heckl, Dirk, Comer, Eamon, Li, Xiaoyu, Ciarlo, Christie, Hartman, Emily, Munshi, Nikhil, Schenone, Monica, Schreiber, Stuart L., Carr, Steven A., Ebert, Benjamin L
Published in Science (American Association for the Advancement of Science) (17.01.2014)
Published in Science (American Association for the Advancement of Science) (17.01.2014)
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Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines
Sharma, Manmohan, Malhotra, Nipun, Yogavel, Manickam, Harlos, Karl, Melillo, Bruno, Comer, Eamon, Gonse, Arthur, Parvez, Suhel, Mitasev, Branko, Fang, Francis G, Schreiber, Stuart L, Sharma, Amit
Published in Nature communications (12.01.2021)
Published in Nature communications (12.01.2021)
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Harnessing the necessary nitrogen atom in chemical biology and drug discovery
Pennington, Lewis D., Collier, Philip N., Comer, Eamon
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
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Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase
Radke, Joshua B, Melillo, Bruno, Mittal, Payal, Sharma, Manmohan, Sharma, Amit, Fu, Yong, Uddin, Taher, Gonse, Arthur, Comer, Eamon, Schreiber, Stuart L, Gupta, Anil K, Chatterjee, Arnab K, Sibley, L David
Published in Nature communications (24.01.2022)
Published in Nature communications (24.01.2022)
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An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors
Marcaurelle, Lisa A, Comer, Eamon, Dandapani, Sivaraman, Duvall, Jeremy R, Gerard, Baudouin, Kesavan, Sarathy, Lee, Maurice D, Liu, Haibo, Lowe, Jason T, Marie, Jean-Charles, Mulrooney, Carol A, Pandya, Bhaumik A, Rowley, Ann, Ryba, Troy D, Suh, Byung-Chul, Wei, Jingqiang, Young, Damian W, Akella, Lakshmi B, Ross, Nathan T, Zhang, Yan-Ling, Fass, Daniel M, Reis, Surya A, Zhao, Wen-Ning, Haggarty, Stephen J, Palmer, Michelle, Foley, Michael A
Published in Journal of the American Chemical Society (01.12.2010)
Published in Journal of the American Chemical Society (01.12.2010)
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Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity
Nühs, Andrea, De Rycker, Manu, Manthri, Sujatha, Comer, Eamon, Scherer, Christina A, Schreiber, Stuart L, Ioset, Jean-Robert, Gray, David W
Published in PLoS neglected tropical diseases (01.09.2015)
Published in PLoS neglected tropical diseases (01.09.2015)
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Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression
Nagiec, Marek M, Skepner, Adam P, Negri, Joseph, Eichhorn, Michelle, Kuperwasser, Nicolas, Comer, Eamon, Muncipinto, Giovanni, Subramanian, Aravind, Clish, Clary, Musunuru, Kiran, Duvall, Jeremy R, Foley, Michael, Perez, Jose R, Palmer, Michelle A J
Published in PloS one (26.03.2015)
Published in PloS one (26.03.2015)
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Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles
Comer, Eamon, Liu, Haibo, Joliton, Adrien, Clabaut, Alexandre, Johnson, Christopher, Akella, Lakshmi B., Marcaurelle, Lisa A., Schreiber, Stuart L.
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
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Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp3)–H Arylation
Maetani, Micah, Zoller, Jochen, Melillo, Bruno, Verho, Oscar, Kato, Nobutaka, Pu, Jun, Comer, Eamon, Schreiber, Stuart L
Published in Journal of the American Chemical Society (16.08.2017)
Published in Journal of the American Chemical Society (16.08.2017)
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The bromoquinone annulation reaction: a formal total synthesis of EO9
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Web Resource
Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development
Sharma, Manmohan, Mutharasappan, Nachiappan, Manickam, Yogavel, Harlos, Karl, Melillo, Bruno, Comer, Eamon, Tabassum, Heena, Parvez, Suhel, Schreiber, Stuart L, Sharma, Amit
Published in Structure (London) (07.07.2022)
Published in Structure (London) (07.07.2022)
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Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
Kato, Nobutaka, Comer, Eamon, Sakata-Kato, Tomoyo, Sharma, Arvind, Sharma, Manmohan, Maetani, Micah, Bastien, Jessica, Brancucci, Nicolas M, Bittker, Joshua A, Corey, Victoria, Clarke, David, Derbyshire, Emily R, Dornan, Gillian L, Duffy, Sandra, Eckley, Sean, Itoe, Maurice A, Koolen, Karin M J, Lewis, Timothy A, Lui, Ping S, Lukens, Amanda K, Lund, Emily, March, Sandra, Meibalan, Elamaran, Meier, Bennett C, McPhail, Jacob A, Mitasev, Branko, Moss, Eli L, Sayes, Morgane, Van Gessel, Yvonne, Wawer, Mathias J, Yoshinaga, Takashi, Zeeman, Anne-Marie, Avery, Vicky M, Bhatia, Sangeeta N, Burke, John E, Catteruccia, Flaminia, Clardy, Jon C, Clemons, Paul A, Dechering, Koen J, Duvall, Jeremy R, Foley, Michael A, Gusovsky, Fabian, Kocken, Clemens H M, Marti, Matthias, Morningstar, Marshall L, Munoz, Benito, Neafsey, Daniel E, Sharma, Amit, Winzeler, Elizabeth A, Wirth, Dyann F, Scherer, Christina A, Schreiber, Stuart L
Published in Nature (London) (20.10.2016)
Published in Nature (London) (20.10.2016)
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High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission
Plouffe, David M., Wree, Melanie, Du, Alan Y., Meister, Stephan, Li, Fengwu, Patra, Kailash, Lubar, Aristea, Okitsu, Shinji L., Flannery, Erika L., Kato, Nobutaka, Tanaseichuk, Olga, Comer, Eamon, Zhou, Bin, Kuhen, Kelli, Zhou, Yingyao, Leroy, Didier, Schreiber, Stuart L., Scherer, Christina A., Vinetz, Joseph, Winzeler, Elizabeth A.
Published in Cell host & microbe (13.01.2016)
Published in Cell host & microbe (13.01.2016)
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Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase
Vinayak, Sumiti, Jumani, Rajiv S, Miller, Peter, Hasan, Muhammad M, McLeod, Briana I, Tandel, Jayesh, Stebbins, Erin E, Teixeira, Jose E, Borrel, Julien, Gonse, Arthur, Zhang, Mingliang, Yu, Xianshui, Wernimont, Amy, Walpole, Chris, Eckley, Sean, Love, Melissa S, McNamara, Case W, Sharma, Manmohan, Sharma, Amit, Scherer, Christina A, Kato, Nobutaka, Schreiber, Stuart L, Melillo, Bruno, Striepen, Boris, Huston, Christopher D, Comer, Eamon
Published in Science translational medicine (30.09.2020)
Published in Science translational medicine (30.09.2020)
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TYK2 분해제 및 이의 용도
ZHU XIAO, COMER EAMON, YATES CHRISTOPHER MICHAEL, PENNINGTON LEWIS DALE, MARX ISAAC, FORD MELISSA
Year of Publication 16.07.2024
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Year of Publication 16.07.2024
Patent
Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures
Mortison, Jonathan D., Schenone, Monica, Myers, Jacob A., Zhang, Ziyang, Chen, Linfeng, Ciarlo, Christie, Comer, Eamon, Natchiar, S. Kundhavai, Carr, Steven A., Klaholz, Bruno P., Myers, Andrew G.
Published in Cell chemical biology (20.12.2018)
Published in Cell chemical biology (20.12.2018)
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Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t‑RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure
Ence, Chloe C., Uddin, Taher, Borrel, Julien, Mittal, Payal, Xie, Han, Zoller, Jochen, Sharma, Amit, Comer, Eamon, Schreiber, Stuart L., Melillo, Bruno, Sibley, L. David, Chatterjee, Arnab K.
Published in ACS infectious diseases (14.05.2024)
Published in ACS infectious diseases (14.05.2024)
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