Rapid Turnover of Hepatitis B Virus Covalently Closed Circular DNA Indicated by Monitoring Emergence and Reversion of Signature‐Mutation in Treated Chronic Hepatitis B Patients
Huang, Qi, Zhou, Bin, Cai, Dawei, Zong, Yuhua, Wu, Yaobo, Liu, Shi, Mercier, Alexandre, Guo, Haitao, Hou, Jinlin, Colonno, Richard, Sun, Jian
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Published in Hepatology (Baltimore, Md.) (01.01.2021)
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Long‐term monitoring shows hepatitis B virus resistance to entecavir in nucleoside‐naïve patients is rare through 5 years of therapy
Tenney, Daniel J., Rose, Ronald E., Baldick, Carl J., Pokornowski, Kevin A., Eggers, Betsy J., Fang, Jie, Wichroski, Michael J., Xu, Dong, Yang, Joanna, Wilber, Richard B., Colonno, Richard J.
Published in Hepatology (Baltimore, Md.) (01.05.2009)
Published in Hepatology (Baltimore, Md.) (01.05.2009)
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Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731
Huang, Qi, Cai, Dawei, Yan, Ran, Li, Lichun, Zong, Yuhua, Guo, Lida, Mercier, Alexandre, Zhou, Yi, Tang, Ariel, Henne, Kirk, Colonno, Richard
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Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)
MCPHEE, Fiona, SHEAFFER, Amy K, CHAOQUN CHEN, LEE, Min S, MOSURE, Kathy, SUN, Li-Qiang, SINZ, Michael, MEANWELL, Nicholas A, COLONNO, Richard J, KNIPE, Jay, SCOLA, Paul, FRIBORG, Jacques, HERNANDEZ, Dennis, FALK, Paul, GUANGZHI ZHAI, LEVINE, Steven, CHANIEWSKI, Susan, FEI YU, BARRY, Diana
Published in Antimicrobial Agents and Chemotherapy (01.10.2012)
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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
Meanwell, Nicholas A, Gao, Min, Nettles, Richard E, Belema, Makonen, Snyder, Lawrence B, Nguyen, Van N, Fridell, Robert A, Serrano-Wu, Michael H, Langley, David R, Sun, Jin-Hua, O’Boyle II, Donald R, Lemm, Julie A, Wang, Chunfu, Knipe, Jay O, Chien, Caly, Colonno, Richard J, Grasela, Dennis M, Hamann, Lawrence G
Published in Nature (London) (06.05.2010)
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Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir
Wang, Tao, Ueda, Yasu, Zhang, Zhongxing, Yin, Zhiwei, Matiskella, John, Pearce, Bradley C, Yang, Zheng, Zheng, Ming, Parker, Dawn D, Yamanaka, Gregory A, Gong, Yi-Fei, Ho, Hsu-Tso, Colonno, Richard J, Langley, David R, Lin, Pin-Fang, Meanwell, Nicholas A, Kadow, John F
Published in Journal of medicinal chemistry (26.07.2018)
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A Comparison of Entecavir and Lamivudine for HBeAg-Positive Chronic Hepatitis B
Chang, Ting-Tsung, Gish, Robert G, de Man, Robert, Gadano, Adrian, Sollano, José, Chao, You-Chen, Lok, Anna S, Han, Kwang-Hyub, Goodman, Zachary, Zhu, Jin, Cross, Anne, DeHertogh, Deborah, Wilber, Richard, Colonno, Richard, Apelian, David
Published in The New England journal of medicine (09.03.2006)
Published in The New England journal of medicine (09.03.2006)
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Entecavir resistance is rare in nucleoside naïve patients with hepatitis B
Colonno, Richard J., Rose, Ronald, Baldick, Carl J., Levine, Steven, Pokornowski, Kevin, Yu, Cheng F., Walsh, Ann, Fang, Jie, Hsu, Mayla, Mazzucco, Charles, Eggers, Betsy, Zhang, Sharon, Plym, Mary, Klesczewski, Kenneth, Tenney, Daniel J.
Published in Hepatology (Baltimore, Md.) (01.12.2006)
Published in Hepatology (Baltimore, Md.) (01.12.2006)
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Two-Year Assessment of Entecavir Resistance in Lamivudine-Refractory Hepatitis B Virus Patients Reveals Different Clinical Outcomes Depending on the Resistance Substitutions Present
TENNEY, Daniel J, ROSE, Ronald E, EGGERS, Betsy, HSU, Mayla, MARY JANE PLYM, POUNDSTONE, Patricia, YANG, Joanna, COLONNO, Richard J, BALDICK, Carl J, LEVINE, Steven M, POKORNOWSKI, Kevin A, WALSH, Ann W, JIE FANG, YU, Cheng-Fang, SHARON ZHANG, MAZZUCCO, Charles E
Published in Antimicrobial Agents and Chemotherapy (01.03.2007)
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Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B
Sherman, Morris, Yurdaydin, Cihan, Sollano, Jose, Silva, Marcelo, Liaw, Yun-Fan, Cianciara, Janusz, Boron-Kaczmarska, Anna, Martin, Paul, Goodman, Zachary, Colonno, Richard, Cross, Anne, Denisky, Gail, Kreter, Bruce, Hindes, Robert
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2006)
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2006)
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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Scola, Paul M., Wang, Alan Xiangdong, Good, Andrew C., Sun, Li-Qiang, Combrink, Keith D., Campbell, Jeffrey A., Chen, Jie, Tu, Yong, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley, Zheng, Barbara, Hewawasam, Piyasena, Ding, Min, Thuring, Jan, Li, Jianqing, Hernandez, Dennis, Yu, Fei, Falk, Paul, Zhai, Guangzhi, Sheaffer, Amy K., Chen, Chaoqun, Lee, Min S., Barry, Diana, Knipe, Jay O., Li, Wenying, Han, Yong-Hae, Jenkins, Susan, Gesenberg, Christoph, Gao, Qi, Sinz, Michael W., Santone, Kenneth S., Zvyaga, Tatyana, Rajamani, Ramkumar, Klei, Herbert E., Colonno, Richard J., Grasela, Dennis M., Hughes, Eric, Chien, Caly, Adams, Stephen, Levesque, Paul C., Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir
Walsh, Ann W, Langley, David R, Colonno, Richard J, Tenney, Daniel J
Published in PloS one (12.02.2010)
Published in PloS one (12.02.2010)
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Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion
Moore, John P, Klasse, Per Johan, Schader, Susan M, Marx, Preston A, Dufour, Jason, Colonno, Richard J, Ketas, Thomas J, Hu, Qinxue, Lu, Min, Shattock, Robin J, Springer, Martin S, Veazey, Ronald S
Published in Nature (03.11.2005)
Published in Nature (03.11.2005)
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Inhibition of Hepatitis B Virus Polymerase by Entecavir
LANGLEY, David R, WALSH, Ann W, BALDICK, Carl J, EGGERS, Betsy J, ROSE, Ronald E, LEVINE, Steven M, JAYNE KAPUR, A, COLONNO, Richard J, TENNEY, Daniel J
Published in Journal of Virology (01.04.2007)
Published in Journal of Virology (01.04.2007)
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Identification of Hepatitis C Virus NS5A Inhibitors
LEMM, Julie A, O'BOYLE, Donald, ROMINE, Jeffrey L, MEANWELL, Nicholas A, MIN GAO, MENGPING LIU, NOWER, Peter T, COLONNO, Richard, DESHPANDE, Milind S, SNYDER, Lawrence B, MARTIN, Scott W, LAURENT, Denis R. St, SERRANO-WU, Michael H
Published in Journal of Virology (01.01.2010)
Published in Journal of Virology (01.01.2010)
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Discovery of ravidasvir (PPI-668) as a potent pan-genotypic HCV NS5A inhibitor
Zhong, Min, Peng, Eric, Huang, Ningwu, Huang, Qi, Huq, Anja, Lau, Meiyen, Colonno, Richard, Li, Leping
Published in Bioorganic & medicinal chemistry letters (15.09.2016)
Published in Bioorganic & medicinal chemistry letters (15.09.2016)
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A dose-ranging study of the efficacy and tolerability of entecavir in Lamivudine-refractory chronic hepatitis B patients
Chang, Ting-Tsung, Gish, Robert G, Hadziyannis, Stephanos J, Cianciara, Janusz, Rizzetto, Mario, Schiff, Eugene R, Pastore, Giuseppe, Bacon, Bruce R, Poynard, Thierry, Joshi, Shobha, Klesczewski, Kenneth S, Thiry, Alexandra, Rose, Ronald E, Colonno, Richard J, Hindes, Robert G
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2005)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2005)
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Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase
LEMM, Julie A, MENGPING LIU, KNIPE, Jay O, COLONNO, Richard, MEANWELL, Nicholas A, KADOW, John F, SANTONE, Kenneth S, ROBERTS, Susan B, MIN GAO, GENTLES, Robert G, MIN DING, VOSS, Stacey, PELOSI, Lenore A, WANG, Ying-Kai, RIGAT, Karen L, MOSURE, Kathleen W, BENDER, John A
Published in Antimicrobial agents and chemotherapy (01.06.2014)
Published in Antimicrobial agents and chemotherapy (01.06.2014)
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Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 12. Structure–Activity Relationships Associated with 4‑Fluoro-6-azaindole Derivatives Leading to the Identification of 1‑(4-Benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl‑1H‑pyrrolo[2,3‑c]pyridin-3-yl)ethane-1,2-dione (BMS-585248)
Regueiro-Ren, Alicia, Xue, Qiufen M, Swidorski, Jacob J, Gong, Yi-Fei, Mathew, Marina, Parker, Dawn D, Yang, Zheng, Eggers, Betsy, D’Arienzo, Celia, Sun, Yongnian, Malinowski, Jacek, Gao, Qi, Wu, Dedong, Langley, David R, Colonno, Richard J, Chien, Caly, Grasela, Dennis M, Zheng, Ming, Lin, Pin-Fang, Meanwell, Nicholas A, Kadow, John F
Published in Journal of medicinal chemistry (28.02.2013)
Published in Journal of medicinal chemistry (28.02.2013)
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Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 5. An Evolution from Indole to Azaindoles Leading to the Discovery of 1-(4-Benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a Drug Candidate That Demonstrates Antiviral Activity in HIV-1-Infected Subjects
Wang, Tao, Yin, Zhiwei, Zhang, Zhongxing, Bender, John A, Yang, Zhong, Johnson, Graham, Yang, Zheng, Zadjura, Lisa M, D’Arienzo, Celia J, DiGiugno Parker, Dawn, Gesenberg, Christophe, Yamanaka, Gregory A, Gong, Yi-Fei, Ho, Hsu-Tso, Fang, Hua, Zhou, Nannan, McAuliffe, Brian V, Eggers, Betsy J, Fan, Li, Nowicka-Sans, Beata, Dicker, Ira B, Gao, Qi, Colonno, Richard J, Lin, Pin-Fang, Meanwell, Nicholas A, Kadow, John F
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
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