Prion Strain Mutation and Selection
Collinge, John
Published in Science (American Association for the Advancement of Science) (28.05.2010)
Published in Science (American Association for the Advancement of Science) (28.05.2010)
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Journal Article
Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis
Smethurst, Phillip, Risse, Emmanuel, Tyzack, Giulia E, Mitchell, Jamie S, Taha, Doaa M, Chen, Yun-Ru, Newcombe, Jia, Collinge, John, Sidle, Katie, Patani, Rickie
Published in Brain (London, England : 1878) (01.02.2020)
Published in Brain (London, England : 1878) (01.02.2020)
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Journal Article
2.7 Å cryo-EM structure of ex vivo RML prion fibrils
Manka, Szymon W, Zhang, Wenjuan, Wenborn, Adam, Betts, Jemma, Joiner, Susan, Saibil, Helen R, Collinge, John, Wadsworth, Jonathan D F
Published in Nature communications (13.07.2022)
Published in Nature communications (13.07.2022)
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Sleep symptomatology in the National prion monitoring cohort
Marie-Claire, Porter, Harpreet, Hyare, Peter, Rudge, John, Collinge, Simon, Mead
Published in Journal of neurology, neurosurgery and psychiatry (28.11.2023)
Published in Journal of neurology, neurosurgery and psychiatry (28.11.2023)
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Journal Article
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases
SANDBERG, Malin K, AL-DOUJAILY, Huda, SHARPS, Bernadette, CLARKE, Anthony R, COLLINGE, John
Published in Nature (London) (24.02.2011)
Published in Nature (London) (24.02.2011)
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Journal Article
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins
Corbett, Grant T., Wang, Zemin, Hong, Wei, Colom-Cadena, Marti, Rose, Jamie, Liao, Meichen, Asfaw, Adhana, Hall, Tia C., Ding, Lai, DeSousa, Alexandra, Frosch, Matthew P., Collinge, John, Harris, David A., Perkinton, Michael S., Spires-Jones, Tara L., Young-Pearse, Tracy L., Billinton, Andrew, Walsh, Dominic M.
Published in Acta neuropathologica (01.03.2020)
Published in Acta neuropathologica (01.03.2020)
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Journal Article
Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay
Edgeworth, Julie Ann, PhD, Farmer, Michael, BSc, Sicilia, Anita, MSc, Tavares, Paul, MSc, Beck, Jonathan, BSc, Campbell, Tracy, BSc, Lowe, Jessica, BSc, Mead, Simon, PhD, Rudge, Peter, FRCP, Collinge, John, Prof, Jackson, Graham S, Dr
Published in The Lancet (British edition) (05.02.2011)
Published in The Lancet (British edition) (05.02.2011)
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Journal Article
Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial
Collinge, John, MD, Gorham, Michele, RN, Hudson, Fleur, BA, Kennedy, Angus, MD, Keogh, Geraldine, Pal, Suvankar, MRCP, Rossor, Martin, MD, Rudge, Peter, FRCP, Siddique, Durre, PhD, Spyer, Moira, PhD, Thomas, Dafydd, MD, Walker, Sarah, PhD, Webb, Tom, BSc, Wroe, Steve, MD, Darbyshire, Janet, FRCP
Published in Lancet neurology (01.04.2009)
Published in Lancet neurology (01.04.2009)
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Journal Article
Bank vole prion protein extends the use of RT-QuIC assays to detect prions in a range of inherited prion diseases
Mok, Tze How, Nihat, Akin, Luk, Connie, Sequeira, Danielle, Batchelor, Mark, Mead, Simon, Collinge, John, Jackson, Graham S
Published in Scientific reports (04.03.2021)
Published in Scientific reports (04.03.2021)
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Journal Article
A naturally occurring variant of the human prion protein completely prevents prion disease
Asante, Emmanuel A, Smidak, Michelle, Grimshaw, Andrew, Houghton, Richard, Tomlinson, Andrew, Jeelani, Asif, Jakubcova, Tatiana, Hamdan, Shyma, Richard-Londt, Angela, Linehan, Jacqueline M, Brandner, Sebastian, Alpers, Michael, Whitfield, Jerome, Mead, Simon, Wadsworth, Jonathan D F, Collinge, John
Published in Nature (London) (25.06.2015)
Published in Nature (London) (25.06.2015)
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Journal Article
Large C9orf72 Hexanucleotide Repeat Expansions Are Seen in Multiple Neurodegenerative Syndromes and Are More Frequent Than Expected in the UK Population
Beck, Jon, Poulter, Mark, Hensman, Davina, Rohrer, Jonathan D., Mahoney, Colin J., Adamson, Gary, Campbell, Tracy, Uphill, James, Borg, Aaron, Fratta, Pietro, Orrell, Richard W., Malaspina, Andrea, Rowe, James, Brown, Jeremy, Hodges, John, Sidle, Katie, Polke, James M., Houlden, Henry, Schott, Jonathan M., Fox, Nick C., Rossor, Martin N., Tabrizi, Sarah J., Isaacs, Adrian M., Hardy, John, Warren, Jason D., Collinge, John, Mead, Simon
Published in American journal of human genetics (07.03.2013)
Published in American journal of human genetics (07.03.2013)
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Journal Article
Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked
Sandberg, Malin K, Al-Doujaily, Huda, Sharps, Bernadette, De Oliveira, Michael Wiggins, Schmidt, Christian, Richard-Londt, Angela, Lyall, Sarah, Linehan, Jacqueline M, Brandner, Sebastian, Wadsworth, Jonathan D F, Clarke, Anthony R, Collinge, John
Published in Nature communications (09.07.2014)
Published in Nature communications (09.07.2014)
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Journal Article
Prion protein gene mutation detection using long-read Nanopore sequencing
Kroll, François, Dimitriadis, Athanasios, Campbell, Tracy, Darwent, Lee, Collinge, John, Mead, Simon, Vire, Emmanuelle
Published in Scientific reports (18.05.2022)
Published in Scientific reports (18.05.2022)
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Journal Article
Novel inherited prion disease due to E146G mutation has distinctive clinicopathological and CSF biomarker features
Thomas, Coysh, Zane, Jaunmuktane, Nour, Majbour, Marcelo Barria, Matus, Leah, Holm-Mercer, Laszlo, Hosszu, Sebastian, Brandner, Colin, Smith, John, Collinge, Simon, Mead
Published in Journal of neurology, neurosurgery and psychiatry (23.11.2023)
Published in Journal of neurology, neurosurgery and psychiatry (23.11.2023)
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Journal Article
A high-content neuron imaging assay demonstrates inhibition of prion disease-associated neurotoxicity by an anti-prion protein antibody
Reilly, Madeleine, Benilova, Iryna, Khalili-Shirazi, Azadeh, Schmidt, Christian, Ahmed, Parvin, Yip, Daniel, Jat, Parmjit S, Collinge, John
Published in Scientific reports (09.06.2022)
Published in Scientific reports (09.06.2022)
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Journal Article
Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro
Terry, Cassandra, Harniman, Robert L, Sells, Jessica, Wenborn, Adam, Joiner, Susan, Saibil, Helen R, Miles, Mervyn J, Collinge, John, Wadsworth, Jonathan D F
Published in Scientific reports (23.01.2019)
Published in Scientific reports (23.01.2019)
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Two mouse models of Alzheimer’s disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein
Purro, Silvia A., Farmer, Michael, Noble, Elizabeth, Sarell, Claire J., Powell, Megan, Yip, Daniel, Giggins, Lauren, Zakka, Leila, Thomas, David X., Farrow, Mark, Nicoll, Andrew J., Walsh, Dominic, Collinge, John
Published in PloS one (17.11.2023)
Published in PloS one (17.11.2023)
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Journal Article
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease
White, Melanie D, Farmer, Michael, Mirabile, Ilaria, Brandner, Sebastian, Collinge, John, Mallucci, Giovanna R
Published in Proceedings of the National Academy of Sciences - PNAS (22.07.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (22.07.2008)
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