The use of spirocyclic scaffolds in drug discovery
Zheng, Yajun, Tice, Colin M., Singh, Suresh B.
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
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Journal Article
Conformational control in structure-based drug design
Zheng, Yajun, Tice, Colin M., Singh, Suresh B.
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
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Journal Article
PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication
Emert-Sedlak, Lori A., Tice, Colin M., Shi, Haibin, Alvarado, John J., Shu, Sherry T., Reitz, Allen B., Smithgall, Thomas E.
Published in Cell chemical biology (18.04.2024)
Published in Cell chemical biology (18.04.2024)
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Journal Article
The Medicinal Chemistry of Liver X Receptor (LXR) Modulators
Tice, Colin M, Noto, Paul B, Fan, Kristi Yi, Zhuang, Linghang, Lala, Deepak S, Singh, Suresh B
Published in Journal of medicinal chemistry (11.09.2014)
Published in Journal of medicinal chemistry (11.09.2014)
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Journal Article
Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor
Emert-Sedlak, Lori A, Shi, Haibin, Tice, Colin M, Chen, Li, Alvarado, John J, Shu, Sherry T, Du, Shoucheng, Thomas, Catherine E, Wrobel, Jay E, Reitz, Allen B, Smithgall, Thomas E
Published in Viruses (01.09.2022)
Published in Viruses (01.09.2022)
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Journal Article
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist
Zheng, Yajun, Zhuang, Linghang, Fan, Kristi Yi, Tice, Colin M, Zhao, Wei, Dong, Chengguo, Lotesta, Stephen D, Leftheris, Katerina, Lindblom, Peter R, Liu, Zhijie, Shimada, Jun, Noto, Paul B, Meng, Shi, Hardy, Andrew, Howard, Lamont, Krosky, Paula, Guo, Joan, Lipinski, Kerri, Kandpal, Geeta, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak, Van Orden, Rebecca, Zhou, Jing, Chen, Guozhou, Wu, Zhongren, McKeever, Brian M, McGeehan, Gerard M, Gregg, Richard E, Claremon, David A, Singh, Suresh B
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Journal Article
Tight-Binding Hydroxypyrazole HIV‑1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC‑I Downregulation
Shi, Haibin, Tice, Colin M, Emert-Sedlak, Lori, Chen, Li, Li, Wing Fai, Carlsen, Marianne, Wrobel, Jay E, Reitz, Allen B, Smithgall, Thomas E
Published in ACS infectious diseases (14.02.2020)
Published in ACS infectious diseases (14.02.2020)
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Journal Article
Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor
Zhuang, Linghang, Tice, Colin M., Xu, Zhenrong, Zhao, Wei, Cacatian, Salvacion, Ye, Yuan-Jie, Singh, Suresh B., Lindblom, Peter, McKeever, Brian M., Krosky, Paula M., Zhao, Yi, Lala, Deepak, Kruk, Barbara A., Meng, Shi, Howard, Lamont, Johnson, Judith A., Bukhtiyarov, Yuri, Panemangalore, Reshma, Guo, Joan, Guo, Rong, Himmelsbach, Frank, Hamilton, Bradford, Schuler-Metz, Annette, Schauerte, Heike, Gregg, Richard, McGeehan, Gerard M., Leftheris, Katerina, Claremon, David A.
Published in Bioorganic & medicinal chemistry (15.07.2017)
Published in Bioorganic & medicinal chemistry (15.07.2017)
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Journal Article
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core
Tice, Colin M., Noto, Paul B., Fan, Kristi Yi, Zhao, Wei, Lotesta, Stephen D., Dong, Chengguo, Marcus, Andrew P., Zheng, Ya-Jun, Chen, Guozhou, Wu, Zhongren, Van Orden, Rebecca, Zhou, Jing, Bukhtiyarov, Yuri, Zhao, Yi, Lipinski, Kerri, Howard, Lamont, Guo, Joan, Kandpal, Geeta, Meng, Shi, Hardy, Andrew, Krosky, Paula, Gregg, Richard E., Leftheris, Katerina, McKeever, Brian M., Singh, Suresh B., Lala, Deepak, McGeehan, Gerard M., Zhuang, Linghang, Claremon, David A.
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
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Journal Article
Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
Xu, Zhenrong, Tice, Colin M, Zhao, Wei, Cacatian, Salvacion, Ye, Yuan-Jie, Singh, Suresh B, Lindblom, Peter, McKeever, Brian M, Krosky, Paula M, Kruk, Barbara A, Berbaum, Jennifer, Harrison, Richard K, Johnson, Judith A, Bukhtiyarov, Yuri, Panemangalore, Reshma, Scott, Boyd B, Zhao, Yi, Bruno, Joseph G, Togias, Jennifer, Guo, Joan, Guo, Rong, Carroll, Patrick J, McGeehan, Gerard M, Zhuang, Linghang, He, Wei, Claremon, David A
Published in Journal of medicinal chemistry (08.09.2011)
Published in Journal of medicinal chemistry (08.09.2011)
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Journal Article
Optimization of orally bioavailable alkyl amine renin inhibitors
Xu, Zhenrong, Cacatian, Salvacion, Yuan, Jing, Simpson, Robert D., Jia, Lanqi, Zhao, Wei, Tice, Colin M., Flaherty, Patrick T., Guo, Joan, Ishchenko, Alexey, Singh, Suresh B., Wu, Zhongren, McKeever, Brian M., Scott, Boyd B., Bukhtiyarov, Yuri, Berbaum, Jennifer, Mason, Jennifer, Panemangalore, Reshma, Cappiello, Maria Grazia, Bentley, Ross, Doe, Christopher P., Harrison, Richard K., McGeehan, Gerard M., Dillard, Lawrence W., Baldwin, John J., Claremon, David A.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility
Jia, Lanqi, Simpson, Robert D, Yuan, Jing, Xu, Zhenrong, Zhao, Wei, Cacatian, Salvacion, Tice, Colin M, Guo, Joan, Ishchenko, Alexey, Singh, Suresh B, Wu, Zhongren, McKeever, Brian M, Bukhtiyarov, Yuri, Johnson, Judith A, Doe, Christopher P, Harrison, Richard K, McGeehan, Gerard M, Dillard, Lawrence W, Baldwin, John J, Claremon, David A
Published in ACS medicinal chemistry letters (13.10.2011)
Published in ACS medicinal chemistry letters (13.10.2011)
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Journal Article
Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design
Tice, Colin M., Zhao, Wei, Xu, Zhenrong, Cacatian, Salvacion T., Simpson, Robert D., Ye, Yuan-Jie, Singh, Suresh B., McKeever, Brian M., Lindblom, Peter, Guo, Joan, Krosky, Paula M., Kruk, Barbara A., Berbaum, Jennifer, Harrison, Richard K., Johnson, Judith J., Bukhtiyarov, Yuri, Panemangalore, Reshma, Scott, Boyd B., Zhao, Yi, Bruno, Joseph G., Zhuang, Linghang, McGeehan, Gerard M., He, Wei, Claremon, David A.
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket
Yuan, Jing, Simpson, Robert D., Zhao, Wei, Tice, Colin M., Xu, Zhenrong, Cacatian, Salvacion, Jia, Lanqi, Flaherty, Patrick T., Guo, Joan, Ishchenko, Alexey, Wu, Zhongren, McKeever, Brian M., Scott, Boyd B., Bukhtiyarov, Yuri, Berbaum, Jennifer, Panemangalore, Reshma, Bentley, Ross, Doe, Christopher P., Harrison, Richard K., McGeehan, Gerard M., Singh, Suresh B., Dillard, Lawrence W., Baldwin, John J., Claremon, David A.
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
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Journal Article
Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1
Tice, Colin M., Zhao, Wei, Krosky, Paula M., Kruk, Barbara A., Berbaum, Jennifer, Johnson, Judith A., Bukhtiyarov, Yuri, Panemangalore, Reshma, Scott, Boyd B., Zhao, Yi, Bruno, Joseph G., Howard, Lamont, Togias, Jennifer, Ye, Yuan-Jie, Singh, Suresh B., McKeever, Brian M., Lindblom, Peter R., Guo, Joan, Guo, Rong, Nar, Herbert, Schuler-Metz, Annette, Gregg, Richard E., Leftheris, Katerina, Harrison, Richard K., McGeehan, Gerard M., Zhuang, Linghang, Claremon, David A.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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