RNAi modulation of placental sFLT1 for the treatment of preeclampsia
Turanov, Anton A, Lo, Agnes, Hassler, Matthew R, Makris, Angela, Ashar-Patel, Ami, Alterman, Julia F, Coles, Andrew H, Haraszti, Reka A, Roux, Loic, Godinho, Bruno M D C, Echeverria, Dimas, Pears, Suzanne, Iliopoulos, Jim, Shanmugalingam, Renuka, Ogle, Robert, Zsengeller, Zsuzsanna K, Hennessy, Annemarie, Karumanchi, S Ananth, Moore, Melissa J, Khvorova, Anastasia
Published in Nature biotechnology (01.12.2018)
Published in Nature biotechnology (01.12.2018)
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Journal Article
Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing
Didiot, Marie-Cécile, Hall, Lauren M, Coles, Andrew H, Haraszti, Reka A, Godinho, Bruno MDC, Chase, Kathryn, Sapp, Ellen, Ly, Socheata, Alterman, Julia F, Hassler, Matthew R, Echeverria, Dimas, Raj, Lakshmi, Morrissey, David V, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in Molecular therapy (01.10.2016)
Published in Molecular therapy (01.10.2016)
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Journal Article
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
Alterman, Julia F., Godinho, Bruno M. D. C., Hassler, Matthew R., Ferguson, Chantal M., Echeverria, Dimas, Sapp, Ellen, Haraszti, Reka A., Coles, Andrew H., Conroy, Faith, Miller, Rachael, Roux, Loic, Yan, Paul, Knox, Emily G., Turanov, Anton A., King, Robert M., Gernoux, Gwladys, Mueller, Christian, Gray-Edwards, Heather L., Moser, Richard P., Bishop, Nina C., Jaber, Samer M., Gounis, Matthew J., Sena-Esteves, Miguel, Pai, Athma A., DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in Nature biotechnology (01.08.2019)
Published in Nature biotechnology (01.08.2019)
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Journal Article
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
Osborn, Maire F, Coles, Andrew H, Biscans, Annabelle, Haraszti, Reka A, Roux, Loic, Davis, Sarah, Ly, Socheata, Echeverria, Dimas, Hassler, Matthew R, Godinho, Bruno M D C, Nikan, Mehran, Khvorova, Anastasia
Published in Nucleic acids research (20.02.2019)
Published in Nucleic acids research (20.02.2019)
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Journal Article
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
Hassler, Matthew R, Turanov, Anton A, Alterman, Julia F, Haraszti, Reka A, Coles, Andrew H, Osborn, Maire F, Echeverria, Dimas, Nikan, Mehran, Salomon, William E, Roux, Loïc, Godinho, Bruno M D C, Davis, Sarah M, Morrissey, David V, Zamore, Phillip D, Karumanchi, S Ananth, Moore, Melissa J, Aronin, Neil, Khvorova, Anastasia
Published in Nucleic acids research (16.03.2018)
Published in Nucleic acids research (16.03.2018)
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Journal Article
5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo
Haraszti, Reka A, Roux, Loic, Coles, Andrew H, Turanov, Anton A, Alterman, Julia F, Echeverria, Dimas, Godinho, Bruno M D C, Aronin, Neil, Khvorova, Anastasia
Published in Nucleic acids research (27.07.2017)
Published in Nucleic acids research (27.07.2017)
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Journal Article
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier
Godinho, Bruno M.D.C., Henninger, Nils, Bouley, James, Alterman, Julia F., Haraszti, Reka A., Gilbert, James W., Sapp, Ellen, Coles, Andrew H., Biscans, Annabelle, Nikan, Mehran, Echeverria, Dimas, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in Molecular therapy (07.11.2018)
Published in Molecular therapy (07.11.2018)
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Journal Article
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O‑Phosphocholine‑N‑docosahexaenoyl‑l‑serine siRNA Conjugate in Mouse Brain
Nikan, Mehran, Osborn, Maire F, Coles, Andrew H, Biscans, Annabelle, Godinho, Bruno M.D.C, Haraszti, Reka A, Sapp, Ellen, Echeverria, Dimas, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in Bioconjugate chemistry (21.06.2017)
Published in Bioconjugate chemistry (21.06.2017)
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Journal Article
Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs
Osborn, Maire F, Alterman, Julia F, Nikan, Mehran, Cao, Hong, Didiot, Marie C, Hassler, Matthew R, Coles, Andrew H, Khvorova, Anastasia
Published in Nucleic acids research (15.10.2015)
Published in Nucleic acids research (15.10.2015)
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Journal Article
Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain
Alterman, Julia F, Hall, Lauren M, Coles, Andrew H, Hassler, Matthew R, Didiot, Marie-Cecile, Chase, Kathryn, Abraham, Jasmin, Sottosanti, Emily, Johnson, Emily, Sapp, Ellen, Osborn, Maire F, Difiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in Molecular therapy. Nucleic acids (01.12.2015)
Published in Molecular therapy. Nucleic acids (01.12.2015)
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Journal Article
Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin
Didiot, Marie-Cécile, Ferguson, Chantal M., Ly, Socheata, Coles, Andrew H., Smith, Abigail O., Bicknell, Alicia A., Hall, Lauren M., Sapp, Ellen, Echeverria, Dimas, Pai, Athma A., DiFiglia, Marian, Moore, Melissa J., Hayward, Lawrence J., Aronin, Neil, Khvorova, Anastasia
Published in Cell reports (Cambridge) (04.09.2018)
Published in Cell reports (Cambridge) (04.09.2018)
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Journal Article
Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition
Haraszti, Reka Agnes, Miller, Rachael, Dubuke, Michelle L, Rockwell, Hannah E, Coles, Andrew H, Sapp, Ellen, Didiot, Marie-Cecile, Echeverria, Dimas, Stoppato, Matteo, Sere, Yves Y, Leszyk, John, Alterman, Julia F, Godinho, Bruno M D C, Hassler, Matthew R, McDaniel, Justice, Narain, Niven R, Wollacott, Rachel, Wang, Yang, Shaffer, Scott A, Kiebish, Michael A, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Published in iScience (28.06.2019)
Published in iScience (28.06.2019)
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Journal Article
Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs
Osborn, Maire F, Coles, Andrew H, Golebiowski, Diane, Echeverria, Dimas, Moazami, Michael P, Watts, Jonathan K, Sena-Esteves, Miguel, Khvorova, Anastasia
Published in Molecular cancer therapeutics (01.06.2018)
Published in Molecular cancer therapeutics (01.06.2018)
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Journal Article
Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain
Nikan, Mehran, Osborn, Maire F, Coles, Andrew H, Godinho, Bruno MDC, Hall, Lauren M, Haraszti, Reka A, Hassler, Matthew R, Echeverria, Dimas, Aronin, Neil, Khvorova, Anastasia
Published in Molecular therapy. Nucleic acids (2016)
Published in Molecular therapy. Nucleic acids (2016)
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Journal Article
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs
Godinho, Bruno M.D.C., Knox, Emily G., Hildebrand, Samuel, Gilbert, James W., Echeverria, Dimas, Kennedy, Zachary, Haraszti, Reka A., Ferguson, Chantal M., Coles, Andrew H., Biscans, Annabelle, Caiazzi, Jillian, Alterman, Julia F., Hassler, Matthew R., Khvorova, Anastasia
Published in Molecular therapy. Nucleic acids (13.09.2022)
Published in Molecular therapy. Nucleic acids (13.09.2022)
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Journal Article
Long-Term Survival for Patients With Acute Decompensated Heart Failure According to Ejection Fraction Findings
Coles, Andrew H., PhD, Fisher, Kimberly, MD, Darling, Chad, MD, Yarzebski, Jorge, MD, MPH, McManus, David D., MD, Gore, Joel M., MD, Lessard, Darleen, MS, Goldberg, Robert J., PhD
Published in The American journal of cardiology (15.09.2014)
Published in The American journal of cardiology (15.09.2014)
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Journal Article
Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay
Godinho, Bruno M.D.C., Gilbert, James W., Haraszti, Reka A., Coles, Andrew H., Biscans, Annabelle, Roux, Loic, Nikan, Mehran, Echeverria, Dimas, Hassler, Matthew, Khvorova, Anastasia
Published in Nucleic acid therapeutics (01.12.2017)
Published in Nucleic acid therapeutics (01.12.2017)
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Journal Article