Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
Park, Jang-June, Thi, Emily P., Carpio, Victor H., Bi, Yingzhi, Cole, Andrew G., Dorsey, Bruce D., Fan, Kristi, Harasym, Troy, Iott, Christina L., Kadhim, Salam, Kim, Jin Hyang, Lee, Amy C. H., Nguyen, Duyan, Paratala, Bhavna S., Qiu, Ruiqing, White, Andre, Lakshminarasimhan, Damodharan, Leo, Christopher, Suto, Robert K., Rijnbrand, Rene, Tang, Sunny, Sofia, Michael J., Moore, Chris B.
Published in Nature communications (22.02.2021)
Published in Nature communications (22.02.2021)
Get full text
Journal Article
Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161
Lam, Angela M, Dugyala, Ravi R, Sheraz, Muhammed, Liu, Fei, Thi, Emily P, Graves, Ingrid E, Cuconati, Andrea, Steuer, Holly Micolochick, Ardzinski, Andrzej, Overholt, Nathan, Mason, Jeremy D, Gotchev, Dimitar, Cole, Andrew G, Harasym, Troy O, Sofia, Michael J
Published in Viruses (21.02.2024)
Published in Viruses (21.02.2024)
Get full text
Journal Article
Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836
Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Ardzinski, Andrzej, Stever, Kim, Dorsey, Bruce D., Mesaros, Eugen F., Thi, Emily P., Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lee, Amy C. H., Olland, Andrea, Suto, Robert K., Sofia, Michael J.
Published in Journal of medicinal chemistry (26.09.2024)
Published in Journal of medicinal chemistry (26.09.2024)
Get full text
Journal Article
Structure-Activity Relationships and Discovery of ( S )-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6 H -pyrido[1,2- h ][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer
Gotchev, Dimitar, Dorsey, Bruce D, Nguyen, Duyan, Kakarla, Ramesh, Dugan, Benjamin, Chen, Shuai, Gao, Min, Bailey, Laurèn, Liu, Fei, Harasym, Troy, Chiu, Tim, Tang, Sunny, Lee, Amy C-H, Cole, Andrew G, Sofia, Michael J
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
Get full text
Journal Article
Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries
Stroke, Ilana L., Cole, Andrew G., Simhadri, Srilatha, Brescia, Marc-Raleigh, Desai, Madhuri, Zhang, Joan J., Merritt, J. Robert, Appell, Kenneth C., Henderson, Ian, Webb, Maria L.
Published in Biochemical and biophysical research communications (13.10.2006)
Published in Biochemical and biophysical research communications (13.10.2006)
Get full text
Journal Article
Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 M pro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants
Wang, Xu, Gotchev, Dimitar, Fan, Kristi Yi, Vega, Marvin M, Mani, Nagraj, McGovern-Gooch, Kayleigh, Cuconati, Andrea, Tercero, Breanna, Wang, Xiaohe, Carpino, Philip, Maskos, Klaus, Centrella, Paolo A, Schmitt, Andreas, Preuss, Franziska, Prasad, Archna, Chen, Chia-Yi, Clark, Matthew A, Guilinger, John P, Johnstone, Shawn, von König, Konstanze, Keefe, Anthony D, Liu, Jenny, Turcotte, Stéphane, Zhang, Ying, Konz Makino, Debora L, Lam, Angela M, Cole, Andrew G, Sofia, Michael J
Published in Journal of medicinal chemistry (25.10.2024)
Published in Journal of medicinal chemistry (25.10.2024)
Get full text
Journal Article
Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA
Liu, Fei, Lee, Amy C. H, Guo, Fang, Kondratowicz, Andrew S, Micolochick Steuer, Holly M, Miller, Angela, Bailey, Lauren D, Wang, Xiaohe, Chen, Shuai, Kultgen, Steven G, Cuconati, Andrea, Cole, Andrew G, Gotchev, Dimitar, Dorsey, Bruce D, Rijnbrand, Rene, Lam, Angela M, Sofia, Michael J, Gao, Min
Published in Journal of virology (25.08.2021)
Published in Journal of virology (25.08.2021)
Get full text
Journal Article
Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506
Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Quintero, Jorge G., Yi Fan, Kristi, Ardzinski, Andrzej, Stever, Kim, Dorsey, Bruce D., Phelps, Janet R., Lee, Amy C.H., Thi, Emily P., Chiu, Tim, Tang, Sunny, Horanyi, Peter S., Mayclin, Stephen J., Harasym, Troy O., Sofia, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.10.2023)
Published in Bioorganic & medicinal chemistry letters (01.10.2023)
Get full text
Journal Article
Preclinical and clinical antiviral characterization of AB-836, a potent capsid assembly modulator against hepatitis B virus
Lam, Angela M., Mani, Nagraj, Ardzinski, Andrzej, Stever, Kim, Cuconati, Andrea, Micolochick Steuer, Holly, Thi, Emily P., Graves, Ingrid E., Espiritu, Christine L., Mesaros, Eugen, Kultgen, Steven G., Fan, Kristi, Cole, Andrew G., Harasym, Troy O., Rijnbrand, Rene, Brown, Joanne, Eley, Timothy, Varughese, Tilly, Gane, Edward, Picchio, Gaston, Sims, Karen D., Sofia, Michael J.
Published in Antiviral research (01.11.2024)
Published in Antiviral research (01.11.2024)
Get full text
Journal Article
Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation
Mani, Nagraj, Cole, Andrew G, Phelps, Janet R, Ardzinski, Andrzej, Cobarrubias, Kyle D, Cuconati, Andrea, Dorsey, Bruce D, Evangelista, Ellen, Fan, Kristi, Guo, Fang, Guo, Haitao, Guo, Ju-Tao, Harasym, Troy O, Kadhim, Salam, Kultgen, Steven G, Lee, Amy C H, Li, Alice H L, Long, Quanxin, Majeski, Sara A, Mao, Richeng, McClintock, Kevin D, Reid, Stephen P, Rijnbrand, Rene, Snead, Nicholas M, Micolochick Steuer, Holly M, Stever, Kim, Tang, Sunny, Wang, Xiaohe, Zhao, Qiong, Sofia, Michael J
Published in Antimicrobial agents and chemotherapy (01.06.2018)
Published in Antimicrobial agents and chemotherapy (01.06.2018)
Get full text
Journal Article
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein
Mani, Nagraj, Cole, Andrew G., Phelps, Janet R., Ardzinski, Andrzej, Burns, Robbin, Chiu, Tim, Cuconati, Andrea, Dorsey, Bruce D., Evangelista, Ellen, Fan, Kristi, Guo, Fang, Harasym, Troy O., Kadhim, Salam, Kowalski, Roseann, Kultgen, Steven G., Lee, Amy C.H., Li, Alice H., Majeski, Sara A., Miller, Angela, Pasetka, Chris, Reid, Stephen P., Rijnbrand, Rene, Micolochick Steuer, Holly M., Stever, Kim, Tang, Sunny, Teng, Xiaowei, Wang, Xiaohe, Sofia, Michael J.
Published in Antiviral research (01.01.2022)
Published in Antiviral research (01.01.2022)
Get full text
Journal Article
Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators
Mesaros, Eugen F., Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Dugan, Benjamin J., Ardzinski, Andrzej, Stever, Kim, Steuer, Holly M. Micolochick, Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lam, Angela M., Thi, Emily P., Dorsey, Bruce D., Sofia, Michael J.
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
Get full text
Journal Article
The identification of highly efficacious functionalised tetrahydrocyclopenta[]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly
Cole, Andrew G, Kultgen, Steven G, Mani, Nagraj, Ardzinski, Andrzej, Fan, Kristi Yi, Thi, Emily P, Dorsey, Bruce D, Stever, Kim, Chiu, Tim, Tang, Sunny, Daly, Owen, Phelps, Janet R, Harasym, Troy, Olland, Andrea, Suto, Robert K, Sofia, Michael J
Published in MedChemComm (23.03.2022)
Published in MedChemComm (23.03.2022)
Get full text
Journal Article
Synthesis and SAR studies of novel benzodiazepinedione-based inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB)
Letourneau, Jeffrey J., Stroke, Ilana L., Hilbert, David W., Cole, Andrew G., Sturzenbecker, Laurie J., Marinelli, Brett A., Quintero, Jorge G., Sabalski, Joan, Li, Yanfang, Ma, Linh, Pechik, Igor, Stein, Philip D., Webb, Maria L.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Get full text
Journal Article
Discovery of C‑Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV‑2
Mesaros, Eugen F., Dugan, Benjamin J., Gao, Min, Sheraz, Muhammad, McGovern-Gooch, Kayleigh, Xu, Fran, Fan, Kristi Yi, Nguyen, Duyan, Kultgen, Steven G., Lindstrom, Aaron, Stever, Kim, Tercero, Breanna, Binder, Randall J., Liu, Fei, Micolochick Steuer, Holly M., Mani, Nagraj, Harasym, Troy O., Thi, Emily P., Cuconati, Andrea, Dorsey, Bruce D., Cole, Andrew G., Lam, Angela M., Sofia, Michael J.
Published in ACS infectious diseases (10.05.2024)
Published in ACS infectious diseases (10.05.2024)
Get full text
Journal Article
Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3
Nedjai, Belinda, Li, Hubert, Stroke, Ilana L, Wise, Emma L, Webb, Maria L, Merritt, J Robert, Henderson, Ian, Klon, Anthony E, Cole, Andrew G, Horuk, Richard, Vaidehi, Nagarajan, Pease, James E
Published in British journal of pharmacology (01.06.2012)
Published in British journal of pharmacology (01.06.2012)
Get full text
Journal Article
Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors
Koltun, Dmitry O, Parkhill, Eric Q, Vasilevich, Natalya I, Glushkov, Andrei I, Zilbershtein, Timur M, Ivanov, Alexei V, Cole, Andrew G, Henderson, Ian, Zautke, Nathan A, Brunn, Sandra A, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W, Zablocki, Jeff
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Get full text
Journal Article
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury
Krenitsky, Véronique Plantevin, Delgado, Mercedes, Nadolny, Lisa, Sahasrabudhe, Kiran, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Kois, Adam, Hughes, Kevin, Wright, Jonathan, Nowakowski, Jacek, Sudbeck, Elise, Ghosh, Sutapa, Bahmanyar, Sogole, Chamberlain, Philip, Muir, Jeff, Cathers, Brian E., Giegel, David, Xu, Li, Celeridad, Maria, Moghaddam, Mehran, Khatsenko, Oleg, Omholt, Paul, Katz, Jason, Pai, Sema, Fan, Rachel, Tang, Yang, Shirley, Michael A., Benish, Brent, Blease, Kate, Raymon, Heather, Bhagwat, Shripad, Henderson, Ian, Cole, Andrew G., Bennett, Brydon, Satoh, Yoshitaka
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Get full text
Journal Article