Development of a Scalable Chiral Synthesis of MK-3281, an Inhibitor of the Hepatitis C Virus NS5B Polymerase
Colarusso, Stefania, Conte, Immacolata, Di Filippo, Marcello, Ercolani, Caterina, Mackay, Angela C., Palumbi, Maria Cecilia, Ferreira, Maria del Rosario Rico, Stansfield, Ian, Zaramella, Simone, Narjes, Frank, Habermann, Joerg
Published in Synlett (01.07.2011)
Published in Synlett (01.07.2011)
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Journal Article
Optimization of Thienopyrrole‐Based Finger‐Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase
Martin Hernando, Jose Ignacio, Ontoria, Jesus Maria, Malancona, Savina, Attenni, Barbara, Fiore, Fabrizio, Bonelli, Fabio, Koch, Uwe, Di Marco, Stefania, Colarusso, Stefania, Ponzi, Simona, Gennari, Nadia, Vignetti, Sue Ellen, del Rosario Rico Ferreira, Maria, Habermann, Jörg, Rowley, Michael, Narjes, Frank
Published in ChemMedChem (05.10.2009)
Published in ChemMedChem (05.10.2009)
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Journal Article
Front Cover: Katritzky Salts for the Synthesis of Unnatural Amino Acids and Late‐Stage Functionalization of Peptides (Eur. J. Org. Chem. 12/2023)
Yousif, Ali Munaim, Colarusso, Stefania, Bianchi, Elisabetta
Published in European journal of organic chemistry (21.03.2023)
Published in European journal of organic chemistry (21.03.2023)
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Journal Article
Inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
Attenni, Barbara, Avolio, Salvatore, Colarusso, Stefania, Malancona, Savina, Harper, Steven, Altamura, Sergio, Koch, Uwe, Narjes, Frank
Published in ARKIVOC (19.03.2006)
Published in ARKIVOC (19.03.2006)
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Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction
Colarusso, Stefania, De Simone, Daniele, Frattarelli, Tommaso, Andreini, Matteo, Cerretani, Mauro, Missineo, Antonino, Moretti, Daniele, Tambone, Sara, Kempf, Georg, Augustin, Martin, Steinbacher, Stefan, Munoz-Sanjuan, Ignacio, Park, Larry, Summa, Vincenzo, Tomei, Licia, Bresciani, Alberto, Dominguez, Celia, Toledo-Sherman, Leticia, Bianchi, Elisabetta
Published in Bioorganic & medicinal chemistry (01.11.2020)
Published in Bioorganic & medicinal chemistry (01.11.2020)
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Journal Article
SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease
Colarusso, Stefania, Ferrigno, Federica, Ponzi, Simona, Pavone, Francesca, Conte, Immacolata, Abate, Luigi, Beghetto, Elisa, Missineo, Antonino, Amaudrut, Jerome, Bresciani, Alberto, Paonessa, Giacomo, Tomei, Licia, Montalbetti, Christian, Bianchi, Elisabetta, Toniatti, Carlo, Ontoria, Jesus M.
Published in Bioorganic & medicinal chemistry (01.03.2022)
Published in Bioorganic & medicinal chemistry (01.03.2022)
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Journal Article
Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor
Morissette, Pierre, Li, Nianyu, Ballard, Jeanine E, Vavrek, Marissa, Adams, Gregory L, Regan, Chris, Regan, Hillary, Lee, K J, Wang, Weixun, Burton, Aimee, Chen, Feifei, Gerenser, Pamela, Li, Yuxing, Kraus, Richard L, Tellers, David, Palani, Anand, Zhu, Yuping, Sun, Chengzao, Bianchi, Elisabetta, Colarusso, Stefania, De Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo’ Maria, Amin, Rupesh P
Published in Toxicological sciences (24.01.2022)
Published in Toxicological sciences (24.01.2022)
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Journal Article
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain
Adams, Gregory L, Pall, Parul S, Grauer, Steven M, Zhou, Xiaoping, Ballard, Jeanine E, Vavrek, Marissa, Kraus, Richard L, Morissette, Pierre, Li, Nianyu, Colarusso, Stefania, Bianchi, Elisabetta, Palani, Anandan, Klein, Rebecca, John, Christopher T, Wang, Deping, Tudor, Matthew, Nolting, Andrew F, Biba, Mirlinda, Nowak, Timothy, Makarov, Alexey A, Reibarkh, Mikhail, Buevich, Alexei V, Zhong, Wendy, Regalado, Erik L, Wang, Xiao, Gao, Qi, Shahripour, Aurash, Zhu, Yuping, de Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo’ Maria, Magotti, Paola, Iaccarino, Roberto, Li, Yuxing, Solly, Kelli, Lee, Keun-Joong, Wang, Weixun, Chen, Feifei, Zeng, Haoyu, Wang, Jixin, Regan, Hilary, Amin, Rupesh P, Regan, Christopher P, Burgey, Christopher S, Henze, Darrell A, Sun, Chengzao, Tellers, David M
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Journal Article
Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction
Ontoria, Jesus M, Biancofiore, Ilaria, Fezzardi, Paola, Ferrigno, Federica, Torrente, Esther, Colarusso, Stefania, Bianchi, Elisabetta, Andreini, Matteo, Patsilinakos, Alexandros, Kempf, Georg, Augustin, Martin, Steinbacher, Stefan, Summa, Vincenzo, Pacifici, Robert, Muñoz-Sanjuan, Ignacio, Park, Larry, Bresciani, Alberto, Dominguez, Celia, Sherman, Leticia Toledo, Harper, Steven
Published in ACS medicinal chemistry letters (14.05.2020)
Published in ACS medicinal chemistry letters (14.05.2020)
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Journal Article
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na v 1.7 for the Treatment of Pain
Adams, Gregory L, Pall, Parul S, Grauer, Steven M, Zhou, Xiaoping, Ballard, Jeanine E, Vavrek, Marissa, Kraus, Richard L, Morissette, Pierre, Li, Nianyu, Colarusso, Stefania, Bianchi, Elisabetta, Palani, Anandan, Klein, Rebecca, John, Christopher T, Wang, Deping, Tudor, Matthew, Nolting, Andrew F, Biba, Mirlinda, Nowak, Timothy, Makarov, Alexey A, Reibarkh, Mikhail, Buevich, Alexei V, Zhong, Wendy, Regalado, Erik L, Wang, Xiao, Gao, Qi, Shahripour, Aurash, Zhu, Yuping, de Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo' Maria, Magotti, Paola, Iaccarino, Roberto, Li, Yuxing, Solly, Kelli, Lee, Keun-Joong, Wang, Weixun, Chen, Feifei, Zeng, Haoyu, Wang, Jixin, Regan, Hilary, Amin, Rupesh P, Regan, Christopher P, Burgey, Christopher S, Henze, Darrell A, Sun, Chengzao, Tellers, David M
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Journal Article
Discovery of (7 R )-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase
Narjes, Frank, Crescenzi, Benedetta, Ferrara, Marco, Habermann, Jörg, Colarusso, Stefania, del Rosario Rico Ferreira, Maria, Stansfield, Ian, Mackay, Angela Claire, Conte, Immacolata, Ercolani, Caterina, Zaramella, Simone, Palumbi, Maria-Cecilia, Meuleman, Philip, Leroux-Roels, Geert, Giuliano, Claudio, Fiore, Fabrizio, Di Marco, Stefania, Baiocco, Paola, Koch, Uwe, Migliaccio, Giovanni, Altamura, Sergio, Laufer, Ralph, De Francesco, Raffaele, Rowley, Michael
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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Journal Article
Inhibition of the Hepatitis C Virus NS3/4A Protease
Di Marco, Stefania, Rizzi, Menico, Volpari, Cinzia, Walsh, Martin A., Narjes, Frank, Colarusso, Stefania, De Francesco, Raffaele, Matassa, Victor G., Sollazzo, Maurizio
Published in The Journal of biological chemistry (10.03.2000)
Published in The Journal of biological chemistry (10.03.2000)
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Journal Article
Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase
Narjes, Frank, Crescenzi, Benedetta, Ferrara, Marco, Habermann, Jörg, Colarusso, Stefania, del Rosario Rico Ferreira, Maria, Stansfield, Ian, Mackay, Angela Claire, Conte, Immacolata, Ercolani, Caterina, Zaramella, Simone, Palumbi, Maria-Cecilia, Meuleman, Philip, Leroux-Roels, Geert, Giuliano, Claudio, Fiore, Fabrizio, Di Marco, Stefania, Baiocco, Paola, Koch, Uwe, Migliaccio, Giovanni, Altamura, Sergio, Laufer, Ralph, De Francesco, Raffaele, Rowley, Michael
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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Journal Article
2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as Inhibitors of the Hepatitis C Virus NS5B Polymerase: Discovery, SAR, Modeling, and Mutagenesis
Koch, Uwe, Attenni, Barbara, Malancona, Savina, Colarusso, Stefania, Conte, Immacolata, Di Filippo, Marcello, Harper, Steven, Pacini, Barbara, Giomini, Claudia, Thomas, Steven, Incitti, Ilario, Tomei, Licia, De Francesco, Raffaele, Altamura, Sergio, Matassa, Victor G, Narjes, Frank
Published in Journal of medicinal chemistry (09.03.2006)
Published in Journal of medicinal chemistry (09.03.2006)
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Journal Article
Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid
STANSFIELD, Ian, AVOLIO, Salvatore, COLARUSSO, Stefania, GENNARI, Nadia, NARJES, Frank, PACINI, Barbara, PONZI, Simona, HARPER, Steven
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
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Journal Article
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease
Narjes, Frank, Koehler, Konrad F, Koch, Uwe, Gerlach, Benjamin, Colarusso, Stefania, Steinkühler, Christian, Brunetti, Mirko, Altamura, Sergio, De Francesco, Raffaele, Matassa, Victor G
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
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Journal Article
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease
NARJES, Frank, KOEHLER, Konrad F, KOCH, Uwe, GERLACH, Benjamin, COLARUSSO, Stefania, STEINKÜHLER, Christian, BRUNETTI, Mirko, ALTAMURA, Sergio, DE FRANCESCO, Raffaele, MATASSA, Victor G
Published in Bioorganic & medicinal chemistry letters (01.02.2002)
Published in Bioorganic & medicinal chemistry letters (01.02.2002)
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Journal Article
Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes
Di Marco, S, Rizzi, M, Volpari, C, Walsh, M A, Narjes, F, Colarusso, S, De Francesco, R, Matassa, V G, Sollazzo, M
Published in The Journal of biological chemistry (10.03.2000)
Published in The Journal of biological chemistry (10.03.2000)
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Journal Article