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Bhattacharyya, Anuradha, Trotta, Christopher R., Narasimhan, Jana, Wiedinger, Kari J., Li, Wencheng, Effenberger, Kerstin A., Woll, Matthew G., Jani, Minakshi B., Risher, Nicole, Yeh, Shirley, Cheng, Yaofeng, Sydorenko, Nadiya, Moon, Young-Choon, Karp, Gary M., Weetall, Marla, Dakka, Amal, Gabbeta, Vijayalakshmi, Naryshkin, Nikolai A., Graci, Jason D., Tripodi, Thomas, Southwell, Amber, Hayden, Michael, Colacino, Joseph M., Peltz, Stuart W.
Published in Nature communications (15.12.2021)
Published in Nature communications (15.12.2021)
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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines
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Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent
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The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential
Friesen, Westley J, Johnson, Briana, Sierra, Jairo, Zhuo, Jin, Vazirani, Priya, Xue, Xiaojiao, Tomizawa, Yuki, Baiazitov, Ramil, Morrill, Christie, Ren, Hongyu, Babu, Suresh, Moon, Young-Choon, Branstrom, Art, Mollin, Anna, Hedrick, Jean, Sheedy, Josephine, Elfring, Gary, Weetall, Marla, Colacino, Joseph M, Welch, Ellen M, Peltz, Stuart W
Published in PloS one (25.10.2018)
Published in PloS one (25.10.2018)
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Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform
Cao, Liangxian, Weetall, Marla, Bombard, Jenelle, Qi, Hongyan, Arasu, Tamil, Lennox, William, Hedrick, Jean, Sheedy, Josephine, Risher, Nicole, Brooks, Peter C, Trifillis, Panayiota, Trotta, Christopher, Moon, Young-Choon, Babiak, John, Almstead, Neil G, Colacino, Joseph M, Davis, Thomas W, Peltz, Stuart W
Published in PloS one (16.12.2016)
Published in PloS one (16.12.2016)
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Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
Branstrom, Arthur, Cao, Liangxian, Furia, Bansri, Trotta, Christopher, Santaguida, Marianne, Graci, Jason D, Colacino, Joseph M, Ray, Balmiki, Li, Wencheng, Sheedy, Josephine, Mollin, Anna, Yeh, Shirley, Kong, Ronald, Sheridan, Richard, Baird, John D, O'Keefe, Kylie, Spiegel, Robert, Goodwin, Elizabeth, Keating, Suzanne, Weetall, Marla
Published in Frontiers in oncology (09.02.2022)
Published in Frontiers in oncology (09.02.2022)
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Structure–Activity Relationship (SAR) Optimization of 6‑(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting Hepatitis C (HCV) NS4B
Zhang, Nanjing, Zhang, Xiaoyan, Zhu, Jin, Turpoff, Anthony, Chen, Guangming, Morrill, Christie, Huang, Song, Lennox, William, Kakarla, Ramesh, Liu, Ronggang, Li, Chunshi, Ren, Hongyu, Almstead, Neil, Venkatraman, Srikanth, Njoroge, F. George, Gu, Zhengxian, Clausen, Valerie, Graci, Jason, Jung, Stephen P., Zheng, Yingcong, Colacino, Joseph M., Lahser, Fred, Sheedy, Josephine, Mollin, Anna, Weetall, Marla, Nomeir, Amin, Karp, Gary M.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Identification of benzazole compounds that induce HIV-1 transcription
Graci, Jason D, Michaels, Daniel, Chen, Guangming, Schiralli Lester, Gillian M, Nodder, Sarah, Weetall, Marla, Karp, Gary M, Gu, Zhengxian, Colacino, Joseph M, Henderson, Andrew J
Published in PloS one (28.06.2017)
Published in PloS one (28.06.2017)
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In vitro cytochrome P450‐ and transporter‐mediated drug interaction potential of 6β‐hydroxy‐21‐desacetyl deflazacort—A major human metabolite of deflazacort
Ma, Jiyuan, Beers, Brian, Manohar, Ravi, Roe, Stephen, Colacino, Joseph M., Kong, Ronald
Published in Pharmacology research & perspectives (01.04.2021)
Published in Pharmacology research & perspectives (01.04.2021)
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In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren
Kong, Ronald, Ma, Jiyuan, Hwang, Seongwoo, Moon, Young‐Choon, Welch, Ellen M., Weetall, Marla, Colacino, Joseph M., Almstead, Neil, Babiak, John, Goodwin, Elizabeth
Published in Pharmacology research & perspectives (01.04.2020)
Published in Pharmacology research & perspectives (01.04.2020)
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Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein
Gu, Zhengxian, Graci, Jason D, Lahser, Frederick C, Breslin, Jamie J, Jung, Stephen P, Crona, James H, McMonagle, Patricia, Xia, Ellen, Liu, Shaotang, Karp, Gary, Zhu, Jin, Huang, Song, Nomeir, Amin, Weetall, Marla, Almstead, Neil G, Peltz, Stuart W, Tong, Xiao, Ralston, Robert, Colacino, Joseph M
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
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Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA Polymerase
Wang, Q May, Hockman, Michelle A, Staschke, Kirk, Johnson, Robert B, Case, Katharine A, Lu, Jirong, Parsons, Steve, Zhang, Faming, Rathnachalam, Radhakrishnan, Kirkegaard, Karla, Colacino, Joseph M
Published in Journal of Virology (01.04.2002)
Published in Journal of Virology (01.04.2002)
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SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
Naryshkin, Nikolai A., Weetall, Marla, Dakka, Amal, Narasimhan, Jana, Zhao, Xin, Feng, Zhihua, Ling, Karen K. Y., Karp, Gary M., Qi, Hongyan, Woll, Matthew G., Chen, Guangming, Zhang, Nanjing, Gabbeta, Vijayalakshmi, Vazirani, Priya, Bhattacharyya, Anuradha, Furia, Bansri, Risher, Nicole, Sheedy, Josephine, Kong, Ronald, Ma, Jiyuan, Turpoff, Anthony, Lee, Chang-Sun, Zhang, Xiaoyan, Moon, Young-Choon, Trifillis, Panayiota, Welch, Ellen M., Colacino, Joseph M., Babiak, John, Almstead, Neil G., Peltz, Stuart W., Eng, Loren A., Chen, Karen S., Mull, Jesse L., Lynes, Maureen S., Rubin, Lee L., Fontoura, Paulo, Santarelli, Luca, Haehnke, Daniel, McCarthy, Kathleen D., Schmucki, Roland, Ebeling, Martin, Sivaramakrishnan, Manaswini, Ko, Chien-Ping, Paushkin, Sergey V., Ratni, Hasane, Gerlach, Irene, Ghosh, Anirvan, Metzger, Friedrich
Published in Science (American Association for the Advancement of Science) (08.08.2014)
Published in Science (American Association for the Advancement of Science) (08.08.2014)
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Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
Cao, Liangxian, Weetall, Marla, Trotta, Christopher, Cintron, Katherine, Ma, Jiyuan, Kim, Min Jung, Furia, Bansri, Romfo, Charles, Graci, Jason D, Li, Wencheng, Du, Joshua, Sheedy, Josephine, Hedrick, Jean, Risher, Nicole, Yeh, Shirley, Qi, Hongyan, Arasu, Tamil, Hwang, Seongwoo, Lennox, William, Kong, Ronald, Petruska, Janet, Moon, Young-Choon, Babiak, John, Davis, Thomas W, Jacobson, Allan, Almstead, Neil G, Branstrom, Art, Colacino, Joseph M, Peltz, Stuart W
Published in Molecular cancer therapeutics (01.01.2019)
Published in Molecular cancer therapeutics (01.01.2019)
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PTC124 targets genetic disorders caused by nonsense mutations
Chen, Guangming, Jacobson, Allan, Spatrick, Phyllis, Peltz, Stuart W, Conn, M. Morgan, Friesen, Westley J, Almstead, Neil G, Hedrick, Jean, Campbell, Jeffrey A, Mollin, Anna, Kawana, Masataka, Wilde, Richard G, Yeh, Shirley, Sweeney, H. Lee, Trotta, Christopher R, Khan, Atiyya, Welch, Ellen M, Barton, Elisabeth R, Hirawat, Samit, Turpoff, Anthony A, Weetall, Marla, Ren, Hongyu, Risher, Nicole, Tomizawa, Yuki, Northcutt, Valerie J, Miller, Langdon L, He, Feng, Jones, Stephen, Colacino, Joseph M, Feng, Huisheng, Branstrom, Arthur A, Corson, Donald, Zhuo, Jin, Ju, William D, Patel, Meenal, Moon, Young-Choon, Hwang, Seongwoo, Paushkin, Sergey, Babiak, John, Trifillis, Panayiota, Karp, Gary, Takasugi, James
Published in Nature (03.05.2007)
Published in Nature (03.05.2007)
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The nucleoside analog clitocine is a potent and efficacious readthrough agent
Friesen, Westley J, Trotta, Christopher R, Tomizawa, Yuki, Zhuo, Jin, Johnson, Briana, Sierra, Jairo, Roy, Bijoyita, Weetall, Marla, Hedrick, Jean, Sheedy, Josephine, Takasugi, James, Moon, Young-Choon, Babu, Suresh, Baiazitov, Ramil, Leszyk, John D, Davis, Thomas W, Colacino, Joseph M, Peltz, Stuart W, Welch, Ellen M
Published in RNA (Cambridge) (01.04.2017)
Published in RNA (Cambridge) (01.04.2017)
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PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally
Graci, Jason D, Jung, Stephen P, Pichardo, John, Lahser, Frederick, Tong, Xiao, Gu, Zhengxian, Colacino, Joseph M
Published in Antimicrobial agents and chemotherapy (01.12.2016)
Published in Antimicrobial agents and chemotherapy (01.12.2016)
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High-throughput Screening Uncovers a Compound That Activates Latent HIV-1 and Acts Cooperatively with a Histone Deacetylase (HDAC) Inhibitor
Micheva-Viteva, Sofiya, Kobayashi, Yoshifumi, Edelstein, Leonard C., Pacchia, Annmarie L., Lee, Hui-Ling Rose, Graci, Jason D., Breslin, Jamie, Phelan, Bradley D., Miller, Leia K., Colacino, Joseph M., Gu, Zhengxian, Ron, Yacov, Peltz, Stuart W., Dougherty, Joseph P.
Published in The Journal of biological chemistry (17.06.2011)
Published in The Journal of biological chemistry (17.06.2011)
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Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase
Johnson, Allison A., Ray, Adrian S., Hanes, Jeremiah, Suo, Zucai, Colacino, Joseph M., Anderson, Karen S., Johnson, Kenneth A.
Published in The Journal of biological chemistry (02.11.2001)
Published in The Journal of biological chemistry (02.11.2001)
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