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Differential effect of simvastatin on activation of Rac1 vs. activation of the heat shock protein 27-mediated pathway upon oxidative stress, in human smooth muscle cells
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Novel non-systemic inhibitor of ileal apical Na +-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys
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Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1
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Inhibitors of prenylation of Ras and other G-proteins and their application as therapeutics
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Synthesis and biological evaluation of lipophilic Ca1a2L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1
EL OUALID, Farid, BAKTAWAR, Jayand, LEROY, Ingrid M, VAN DEN ELST, Hans, COHEN, Louis H, VAN DER MAREL, Gijs A, OVERKLEEFT, Herman S, OVERHAND, Mark
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Design and synthesis of a protein:Farnesyltransferase inhibitor based on sugar amino acids
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Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types
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Published in Biochimica et biophysica acta (21.04.1997)
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Design, Synthesis, and Evaluation of Su- gar Amino Acid Based Inhibitors of Pro- tein Prenyl Transferases PFT and PGGT-1
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Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase and squalene synthase
Cohen, Louis H., Van Vliet, Arlène, Roodenburg, Loes, Jansen, Lucres M.C., Griffigen, Marieke
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Different effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors of sterol synthesis in various human cell types
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Different effects of the hypolipidemic drugs pravastatin and lovastatin on the cholesterol biosynthesis of the human ocular lens in organ culture and on the cholesterol content of the rat lens in vivo
de Vries, Alfons C.J., Cohen, Louis H.
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Published in Journal of combinatorial chemistry (01.09.2005)
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Differential effect of simvastatin on activation of Rac(1) vs. activation of the heat shock protein 27-mediated pathway upon oxidative stress, in human smooth muscle cells
Nègre-Aminou, Pascale, van Leeuwen, Rick E W, van Thiel, G Christa F, van den IJssel, Paul, de Jong, Wilfried W, Quinlan, Roy A, Cohen, Louis H
Published in Biochemical pharmacology (15.11.2002)
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Synthesis and biological evaluation of lipophilic Ca 1a 2L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1
El Oualid, Farid, Baktawar, Jayand, Leroy, Ingrid M., van den Elst, Hans, Cohen, Louis H., van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark
Published in Bioorganic & medicinal chemistry (2005)
Published in Bioorganic & medicinal chemistry (2005)
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Synthesis and biological evaluation of lipophilic Ca(1)a(2)L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1
El Oualid, Farid, Baktawar, Jayand, Leroy, Ingrid M, van den Elst, Hans, Cohen, Louis H, van der Marel, Gijs A, Overkleeft, Herman S, Overhand, Mark
Published in Bioorganic & medicinal chemistry (01.03.2005)
Published in Bioorganic & medicinal chemistry (01.03.2005)
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Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells11Abbreviations: SMC, smooth muscle cells; S, simvastatin; ERK1/2, extracellular-regulated kinase 1/2; SAPK, stress-activated protein kinase; PDGF, platelet-derived growth factor; PMA, phorbol myristil acetate; POD, peroxydase; MAPK, mitogen-activated protein kinase; TBS, Tris-buffered saline; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; Mev, mevalonic acid lac
Nègre-Aminou, Pascale, van Erck, Monique, van Leeuwen, Rick E.W., Collard, John G., Cohen, Louis H.
Published in Biochemical pharmacology (01.04.2001)
Published in Biochemical pharmacology (01.04.2001)
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