Search Results - "COGHLAN, MICHAEL, J" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets

Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets

by Sloop, Kyle W, Willard, Francis S, Brenner, Martin B, Ficorilli, James, Valasek, Kathleen, Showalter, Aaron D, Farb, Thomas B, Cao, Julia X C, Cox, Amy L, Michael, M Dodson, Gutierrez Sanfeliciano, Sonia Maria, Tebbe, Mark J, Coghlan, Michael J
Published in Diabetes (New York, N.Y.) (01.12.2010)

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Glucocorticoid Receptor Modulators Informed by Crystallography Lead to a New Rationale for Receptor Selectivity, Function, and Implications for Structure-Based Design

Glucocorticoid Receptor Modulators Informed by Crystallography Lead to a New Rationale for Receptor Selectivity, Function, and Implications for Structure-Based Design

by Carson, Matthew W, Luz, John G, Suen, Chen, Montrose, Chahrzad, Zink, Richard, Ruan, Xiaoping, Cheng, Christine, Cole, Harlan, Adrian, Mary D, Kohlman, Dan T, Mabry, Thomas, Snyder, Nancy, Condon, Brad, Maletic, Milan, Clawson, David, Pustilnik, Anna, Coghlan, Michael J
Published in Journal of medicinal chemistry (13.02.2014)

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Recent Developments in the Biology and Medicinal Chemistry of Potassium Channel Modulators: Update from a Decade of Progress

Recent Developments in the Biology and Medicinal Chemistry of Potassium Channel Modulators: Update from a Decade of Progress

by Coghlan, Michael J, Carroll, William A, Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (24.05.2001)

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Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

by Kym, Philip R, Kort, Michael E, Coghlan, Michael J, Moore, Jimmie L, Tang, Rui, Ratajczyk, James D, Larson, Daniel P, Elmore, Steven W, Pratt, John K, Stashko, Michael A, Falls, H. Douglass, Lin, Chun W, Nakane, Masake, Miller, Loan, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Nguyen, Phong, Lane, Benjamin C
Published in Journal of medicinal chemistry (13.03.2003)

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Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators

Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators

by Buckner, Steven A, Milicic, Ivan, Daza, Anthony V, Coghlan, Michael J, Gopalakrishnan, Murali
Published in British journal of pharmacology (01.02.2002)

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Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener

Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener

by Altenbach, Robert J, Brune, Michael E, Buckner, Steven A, Coghlan, Michael J, Daza, Anthony V, Fabiyi, Adebola, Gopalakrishnan, Murali, Henry, Rodger F, Khilevich, Albert, Kort, Michael E, Milicic, Ivan, Scott, Victoria E, Smith, Jamie C, Whiteaker, Kristi L, Carroll, William A
Published in Journal of medicinal chemistry (16.11.2006)

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Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

by Elmore, Steven W, Pratt, John K, Coghlan, Michael J, Mao, Yue, Green, Brian E, Anderson, David D, Stashko, Michael A, Lin, Chun W, Falls, Douglas, Nakane, Masaki, Miller, Loan, Tyree, Curtis M, Miner, Jeffrey N, Lane, Ben
Published in Bioorganic & medicinal chemistry letters (05.04.2004)

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Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site

Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site

by Luz, John G, Carson, Matthew W, Condon, Bradley, Clawson, David, Pustilnik, Anna, Kohlman, Daniel T, Barr, Robert J, Bean, James S, Dill, M. Joelle, Sindelar, Dana K, Maletic, Milan, Coghlan, Michael J
Published in Journal of medicinal chemistry (27.08.2015)

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Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo

Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo

by Durham, Timothy B., Toth, James L., Klimkowski, Valentine J., Cao, Julia X.C., Siesky, Angela M., Alexander-Chacko, Jesline, Wu, Ginger Y., Dixon, Jeffrey T., McGee, James E., Wang, Yong, Guo, Sherry Y., Cavitt, Rachel Nicole, Schindler, John, Thibodeaux, Stefan J., Calvert, Nathan A., Coghlan, Michael J., Sindelar, Dana K., Christe, Michael, Kiselyov, Vladislav V., Michael, M. Dodson, Sloop, Kyle W.
Published in The Journal of biological chemistry (14.08.2015)

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Validation of FLIPR membrane potential dye for high throughput screening of potassium channel modulators

Validation of FLIPR membrane potential dye for high throughput screening of potassium channel modulators

by Whiteaker, K L, Gopalakrishnan, S M, Groebe, D, Shieh, C C, Warrior, U, Burns, D J, Coghlan, M J, Scott, V E, Gopalakrishnan, M
Published in Journal of biomolecular screening (01.10.2001)

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(âˆ’)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. II. In Vivo Characterization

(â)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. II. In Vivo Characterization

by Brune, Michael E, Fey, Thomas A, Brioni, Jorge D, Sullivan, James P, Williams, Michael, Carroll, William A, Coghlan, Michael J, Gopalakrishnan, Murali
Published in The Journal of pharmacology and experimental therapeutics (01.10.2002)

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An Intra/Intermolecular Suzuki Sequence to Benzopyridyloxepines Containing Geometrically Pure Exocyclic Tetrasubstituted Alkenes

An Intra/Intermolecular Suzuki Sequence to Benzopyridyloxepines Containing Geometrically Pure Exocyclic Tetrasubstituted Alkenes

by Carson, Matthew W, Giese, Matthew W, Coghlan, Michael J
Published in Organic letters (03.07.2008)

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(âˆ’)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. I. In Vitro Characterization

(â)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. I. In Vitro Characterization

by Gopalakrishnan, Murali, Buckner, Steven A, Whiteaker, Kristi L, Shieh, Char-Chang, Molinari, Eduardo J, Milicic, Ivan, Daza, Anthony V, Davis-Taber, Rachel, Scott, Victoria E, Sellers, Donna, Chess-Williams, Russ, Chapple, Christopher R, Liu, Yi, Liu, Dong, Brioni, Jorge D, Sullivan, James P, Williams, Michael, Carroll, William A, Coghlan, Michael J
Published in The Journal of pharmacology and experimental therapeutics (01.10.2002)

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[125I]A-312110, a Novel High-Affinity 1,4-Dihydropyridine ATP-sensitive K+ Channel Opener: Characterization and Pharmacology of Binding

[125I]A-312110, a Novel High-Affinity 1,4-Dihydropyridine ATP-sensitive K+ Channel Opener: Characterization and Pharmacology of Binding

by Davis-Taber, Rachel, Molinari, Eduardo J, Altenbach, Robert J, Whiteaker, Kristi L, Shieh, Char-Chang, Rotert, Gary, Buckner, Steven A, Malysz, John, Milicic, Ivan, McDermott, Jeffrey S, Gintant, Gary A, Coghlan, Michael J, Carroll, William A, Scott, Victoria E, Gopalakrishnan, Murali
Published in Molecular pharmacology (01.07.2003)

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The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: Synthesis and structure-activity relationships of 2-amino-4-azaindoles

The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: Synthesis and structure-activity relationships of 2-amino-4-azaindoles

by TURNER, Sean C, CARROLL, William A, SULLIVAN, James P, WHITE, Tammie K, GOPALAKRISHNAN, Murali, COGHLAN, Michael J, SHIEH, Char-Chang, ZHANG, Xu-Feng, PARIHAR, Ashutosh S, BUCKNER, Steven A, MILICIC, Ivan
Published in Bioorganic & medicinal chemistry letters (16.06.2003)

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A Novel Antiinflammatory Maintains Glucocorticoid Efficacy with Reduced Side Effects

A Novel Antiinflammatory Maintains Glucocorticoid Efficacy with Reduced Side Effects

by Coghlan, Michael J, Jacobson, Peer B, Lane, Ben, Nakane, Masaki, Lin, Chun Wei, Elmore, Steven W, Kym, Philip R, Luly, Jay R, Carter, George W, Turner, Russell, Tyree, Curtis M, Hu, Junlian, Elgort, Marc, Rosen, Jon, Miner, Jeffrey N
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2003)

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Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation

Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation

by PARIHAR, Ashutosh S, COGHLAN, Michael J, GOPALAKRISHNAN, Murali, SHIEH, Char-Chang
Published in European journal of pharmacology (27.06.2003)

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Cyclocarbopalladation of Alkynes: A Stereoselective Method for Preparing Dibenzoxapine Containing Tetrasubstituted Exocyclic Alkenes

Cyclocarbopalladation of Alkynes: A Stereoselective Method for Preparing Dibenzoxapine Containing Tetrasubstituted Exocyclic Alkenes

by Yu, Hannah, Richey, Rachel N, Carson, Matthew W, Coghlan, Michael J
Published in Organic letters (13.04.2006)

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Effects of ATP-sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction

Effects of ATP-sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction

by Fey, Thomas A., Gopalakrishnan, Murali, Strake, James G., King, Linda L., Brioni, Jorge D., Sullivan, James P., Coghlan, Michael J., Brune, Michael E.
Published in Neurourology and urodynamics (2003)

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Nonsteroidal Selective Glucocorticoid Modulators: the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

by Elmore, Steven W, Coghlan, Michael J, Anderson, David D, Pratt, John K, Green, Brian E, Wang, Alan X, Stashko, Michael A, Lin, Chun W, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Lane, Benjamin C
Published in Journal of medicinal chemistry (06.12.2001)

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