The Shikimate Pathway and Its Branches in Apicomplexan Parasites
Roberts, Craig W., Roberts, Fiona, Lyons, Russell E., Kirisits, Michael J., Mui, Ernest J, Finnerty, John, Johnson, Jennifer J., Ferguson, David J. P., Coggins, John R., Krell, Tino, Coombs, Graham H., Milhous, Wilbur K., Kyle, Dennis E., Tzipori, Saul, Barnwell, John, Dame, John B., Jane, Carlton, McLeod, Rima
Published in The Journal of infectious diseases (15.02.2002)
Published in The Journal of infectious diseases (15.02.2002)
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Conference Proceeding
Evidence for the shikimate pathway in apicomplexan parasites
McLeod, Rima, Roberts, Fiona, Roberts, Craig W, Johnson, Jennifer J, Kyle, Dennis E, Krell, Tino, Coggins, John R, Coombs, Graham H, Milhous, Wilbur K, Tzipori, Saul, Ferguson, David J. P, Chakrabarti, Debopam
Published in Nature (London) (25.06.1998)
Published in Nature (London) (25.06.1998)
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The Structure and Mechanism of the Type II Dehydroquinase from Streptomyces coelicolor
Roszak, Aleksander W., Robinson, David A., Krell, Tino, Hunter, Iain S., Fredrickson, Martyn, Abell, Chris, Coggins, John R., Lapthorn, Adrian J.
Published in Structure (London) (01.04.2002)
Published in Structure (London) (01.04.2002)
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The Structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of Substrate Binding Sites and Mode of AMP Inhibition
Lohkamp, Bernhard, McDermott, Gerry, Campbell, Samantha A., Coggins, John R., Lapthorn, Adrian J.
Published in Journal of molecular biology (06.02.2004)
Published in Journal of molecular biology (06.02.2004)
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Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase
Prazeres, Verónica F. V., Sánchez-Sixto, Cristina, Castedo, Luis, Lamb, Heather, Hawkins, Alastair R., Riboldi-Tunnicliffe, Alan, Coggins, John R., Lapthorn, Adrian J., González-Bello, Concepción
Published in ChemMedChem (12.02.2007)
Published in ChemMedChem (12.02.2007)
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Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities
Michel, Gurvan, Roszak, Aleksander W, Sauvé, Véronique, Maclean, John, Matte, Allan, Coggins, John R, Cygler, Miroslaw, Lapthorn, Adrian J
Published in The Journal of biological chemistry (23.05.2003)
Published in The Journal of biological chemistry (23.05.2003)
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Crystal Structures of Helicobacter pylori Type II Dehydroquinase Inhibitor Complexes: New Directions for Inhibitor Design
ROBINSON, David A., STEWART, Kirsty A., PRICE, Nicholas C., CHALK, Peter A., COGGINS, John R., LAPTHORN, Adrian J.
Published in Journal of medicinal chemistry (23.02.2006)
Published in Journal of medicinal chemistry (23.02.2006)
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Identification of 4-Amino-4-deoxychorismate Synthase as the Molecular Target for the Antimicrobial Action of (6S)-6-Fluoroshikimate
Bulloch, Esther M. M, Jones, Michelle A, Parker, Emily J, Osborne, Andrew P, Stephens, Elaine, Davies, Gareth M, Coggins, John R, Abell, Chris
Published in Journal of the American Chemical Society (18.08.2004)
Published in Journal of the American Chemical Society (18.08.2004)
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Biochemical and X‐ray crystallographic studies on shikimate kinase: The important structural role of the P‐loop lysine
Krell, Tino, Maclean, John, Boam, Deborah J., Cooper, Alan, Resmini, Marina, Brocklehurst, Keith, Kelly, Sharon M., Price, Nicholas C., Lapthorn, Adrian J., Coggins, John R.
Published in Protein science (01.06.2001)
Published in Protein science (01.06.2001)
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(1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases
Frederickson, M, Roszak, AW, Coggins, Lapthorn, AJ, Abell, C
Published in Organic & biomolecular chemistry (07.06.2004)
Published in Organic & biomolecular chemistry (07.06.2004)
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Parallel Solid-Phase Synthesis and Evaluation of Inhibitors of Streptomyces coelicolor Type II Dehydroquinase
GONZáLEZ-BELLO, Concepción, LENCE, Emilio, TOSCANO, Miguel D., CASTEDO, Luis, COGGINS, John R., ABELL, Chris
Published in Journal of medicinal chemistry (18.12.2003)
Published in Journal of medicinal chemistry (18.12.2003)
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A catalase from Streptomyces coelicolor A3(2)
Walker, G. E, Dunbar, Bryan, Hunter, Iain S, Nimmo, Hugh G, Coggins, John R
Published in Microbiology (Society for General Microbiology) (01.06.1995)
Published in Microbiology (Society for General Microbiology) (01.06.1995)
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Rational design of new bifunctional inhibitors of type II dehydroquinase
Toscano, MD, Stewart, KA, Coggins, Lapthorn, AJ, Abell, C
Published in Organic & biomolecular chemistry (07.09.2005)
Published in Organic & biomolecular chemistry (07.09.2005)
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Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase
Toscano, MD, Frederickson, M, Evans, DP, Coggins, Abell, C, Gonzalez-Bello, C
Published in Organic & biomolecular chemistry (21.06.2003)
Published in Organic & biomolecular chemistry (21.06.2003)
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Journal Article
Crystal Structures of Helicobacter p ylori Type II Dehydroquinase Inhibitor Complexes: New Directions for Inhibitor Design
Robinson, David A, Stewart, Kirsty A, Price, Nicholas C, Chalk, Peter A, Coggins, John R, Lapthorn, Adrian J
Published in Journal of medicinal chemistry (23.02.2006)
Published in Journal of medicinal chemistry (23.02.2006)
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Selective Inhibition of Type II Dehydroquinases
Frederickson, Martyn, Parker, Emily J, Hawkins, Alastair R, Coggins, John R, Abell, Chris
Published in Journal of organic chemistry (16.04.1999)
Published in Journal of organic chemistry (16.04.1999)
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Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions
Evans, Lewis D.B, Roszak, Aleksander W, Noble, Lorna J, Robinson, David A, Chalk, Peter A, Matthews, Jennifer L, Coggins, John R, Price, Nicholas C, Lapthorn, Adrian J
Published in FEBS letters (23.10.2002)
Published in FEBS letters (23.10.2002)
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Parallel Solid-Phase Synthesis and Evaluation of Inhibitors of Streptomyces c oelicolor Type II Dehydroquinase
González-Bello, Concepción, Lence, Emilio, Toscano, Miguel D, Castedo, Luis, Coggins, John R, Abell, Chris
Published in Journal of medicinal chemistry (18.12.2003)
Published in Journal of medicinal chemistry (18.12.2003)
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