Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents
Antonow, Dyeison, Kaliszczak, Maciej, Kang, Gyoung-Dong, Coffils, Marissa, Tiberghien, Arnaud C, Cooper, Nectaroula, Barata, Teresa, Heidelberger, Sibylle, James, Colin H, Zloh, Mire, Jenkins, Terence C, Reszka, Anthony P, Neidle, Stephen, Guichard, Sylvie M, Jodrell, Duncan I, Hartley, John A, Howard, Philip W, Thurston, David E
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
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Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1- c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate
Howard, Philip W., Chen, Zhizhi, Gregson, Stephen J., Masterson, Luke A., Tiberghien, Arnaud C., Cooper, Nectaroula, Fang, Min, Coffils, Marissa J., Klee, Sarah, Hartley, John A., Thurston, David E.
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
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SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity
HARTLEY, John A, HAMAGUCHI, Anzu, PEPPER, Christopher, THET THET LIN, FEGAN, Christopher, THURSTON, David E, HOWARD, Philip W, COFFILS, Marissa, MARTIN, Christopher R. H, SUGGITT, Marie, ZHIZHI CHEN, GREGSON, Stephen J, MASTERSON, Luke A, TIBERGHIEN, Arnaud C, HARTLEY, Janet M
Published in Cancer research (Chicago, Ill.) (01.09.2010)
Published in Cancer research (Chicago, Ill.) (01.09.2010)
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SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer pro-drug that cross-links DNA and exerts highly potent antitumor activity
Hartley, John A., Hamaguchi, Anzu, Coffils, Marissa, Martin, Christopher R.H., Suggitt, Marie, Chen, Zhizhi, Gregson, Stephen J., Masterson, Luke A., Tiberghien, Arnaud C., Hartley, Janet M., Pepper, Christopher, Lin, Thet Thet, Fegan, Christopher, Thurston, David E., Howard, Philip W.
Published in Cancer research (Chicago, Ill.) (26.07.2010)
Published in Cancer research (Chicago, Ill.) (26.07.2010)
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Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization
Wells, Geoffrey, Suggitt, Marie, Coffils, Marissa, Baig, Mirza A.H., Howard, Philip W., Loadman, Paul M., Hartley, John A., Jenkins, Terence C., Thurston, David E.
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
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