High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates
Clement, Helen A., Boghi, Michele, McDonald, Rory M., Bernier, Louise, Coe, Jotham W., Farrell, William, Helal, Christopher J., Reese, Matthew R., Sach, Neal W., Lee, Jack C., Hall, Dennis G.
Published in Angewandte Chemie International Edition (16.12.2019)
Published in Angewandte Chemie International Edition (16.12.2019)
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Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors
Casimiro-Garcia, Agustin, Trujillo, John I, Vajdos, Felix, Juba, Brian, Banker, Mary Ellen, Aulabaugh, Ann, Balbo, Paul, Bauman, Jonathan, Chrencik, Jill, Coe, Jotham W, Czerwinski, Robert, Dowty, Martin, Knafels, John D, Kwon, Soojin, Leung, Louis, Liang, Sidney, Robinson, Ralph P, Telliez, Jean-Baptiste, Unwalla, Ray, Yang, Xin, Thorarensen, Atli
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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Design considerations for chiral frustrated Lewis pairs: B/N FLPs derived from 3,5-bicyclic aryl piperidines
Lam, Jolie, Sampaolesi, Susanna, LaFortune, James H W, Coe, Jotham W, Stephan, Douglas W
Published in Dalton transactions : an international journal of inorganic chemistry (2019)
Published in Dalton transactions : an international journal of inorganic chemistry (2019)
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Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice
Pryde, David C, Jones, Lyn H, Gervais, David P, Stead, David R, Blakemore, David C, Selby, Matthew D, Brown, Alan D, Coe, Jotham W, Badland, Matthew, Beal, David M, Glen, Rebecca, Wharton, Yvonne, Miller, Gavin J, White, Phil, Zhang, Ningli, Benoit, Michelle, Robertson, Karen, Merson, James R, Davis, Heather L, McCluskie, Michael J
Published in PloS one (01.10.2013)
Published in PloS one (01.10.2013)
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Access to Highly Substituted 7‑Azaindoles from 2‑Fluoropyridines via 7‑Azaindoline Intermediates
Nuhant, Philippe, Allais, Christophe, Chen, Ming Z, Coe, Jotham W, Dermenci, Alpay, Fadeyi, Olugbeminiyi O, Flick, Andrew C, Mousseau, James J
Published in Organic letters (04.09.2015)
Published in Organic letters (04.09.2015)
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Journal Article
High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates
Clement, Helen A., Boghi, Michele, McDonald, Rory M., Bernier, Louise, Coe, Jotham W., Farrell, William, Helal, Christopher J., Reese, Matthew R., Sach, Neal W., Lee, Jack C., Hall, Dennis G.
Published in Angewandte Chemie (16.12.2019)
Published in Angewandte Chemie (16.12.2019)
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Journal Article
Structural and Rate Studies of the Formation of Substituted Benzynes
Riggs, Jason C, Ramirez, Antonio, Cremeens, Matthew E, Bashore, Crystal G, Candler, John, Wirtz, Michael C, Coe, Jotham W, Collum, David B
Published in Journal of the American Chemical Society (19.03.2008)
Published in Journal of the American Chemical Society (19.03.2008)
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Journal Article
Formation of 3-Halobenzyne: Solvent Effects and Cycloaddition Adducts
Coe, Jotham W, Wirtz, Michael C, Bashore, Crystal G, Candler, John
Published in Organic letters (13.05.2004)
Published in Organic letters (13.05.2004)
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Journal Article
Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation
Rollema, Hans, Coe, Jotham W., Chambers, Leslie K., Hurst, Raymond S., Stahl, Stephen M., Williams, Kathryn E.
Published in Trends in pharmacological sciences (Regular ed.) (01.07.2007)
Published in Trends in pharmacological sciences (Regular ed.) (01.07.2007)
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Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Jones, Peter, Storer, R. Ian, Sabnis, Yogesh A, Wakenhut, Florian M, Whitlock, Gavin A, England, Katherine S, Mukaiyama, Takasuke, Dehnhardt, Christoph M, Coe, Jotham W, Kortum, Steve W, Chrencik, Jill E, Brown, David G, Jones, Rhys M, Murphy, John R, Yeoh, Thean, Morgan, Paul, Kilty, Iain
Published in Journal of medicinal chemistry (26.01.2017)
Published in Journal of medicinal chemistry (26.01.2017)
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Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening
Magnus, Philip, Ghavimi, Bahman, Coe, Jotham W.
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
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Journal Article
Development of a Scalable Synthesis for an Inhaled pan-JAK Inhibitor
Gontcharov, Alexander, Magano, Javier, Samp, Lacey, Houck, Tim L, Rose, Peter R, Rane, Anil, Coe, Jotham W, Kortum, Steven W, Chung, SeungWon, Jones, Peter, Pattavina, David
Published in Organic process research & development (20.09.2019)
Published in Organic process research & development (20.09.2019)
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Journal Article
Partial Agonists of the α3β4 Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats
CHATTERJEE, Susmita, STEENSLAND, Pia, SIMMS, Jeffrey A, HOLGATE, Joan, COE, Jotham W, HURST, Raymond S, SHAFFER, Christopher L, LOWE, John, ROLLEMA, Hans, BARTLETT, Selena E
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2011)
Published in Neuropsychopharmacology (New York, N.Y.) (01.02.2011)
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Journal Article
Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect
Rollema, Hans, Guanowsky, Victor, Mineur, Yann S., Shrikhande, Alka, Coe, Jotham W., Seymour, Patricia A., Picciotto, Marina R.
Published in European journal of pharmacology (01.03.2009)
Published in European journal of pharmacology (01.03.2009)
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Journal Article
Metabolism and disposition of varenicline, a selective α4β2 acetylcholine receptor partial agonist, in vivo and in vitro
OBACH, R. Scott, REED-HAGEN, Anne E, KRUEGER, Suzanne S, OBACH, Beth J, O'CONNELL, Thomas N, ZANDI, Kathleen S, MILLER, Sandra, COE, Jotham W
Published in Drug metabolism and disposition (2006)
Published in Drug metabolism and disposition (2006)
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Journal Article
Kiloscale Buchwald–Hartwig Amination: Optimized Coupling of Base-Sensitive 6‑Bromoisoquinoline-1-carbonitrile with (S)‑3-Amino-2-methylpropan-1-ol
Sperry, Jeffrey B, Price Wiglesworth, Kristin E, Edmonds, Ian, Fiore, Phillip, Boyles, David C, Damon, David B, Dorow, Roberta L, Piatnitski Chekler, Eugene L, Langille, Jonathan, Coe, Jotham W
Published in Organic process research & development (19.12.2014)
Published in Organic process research & development (19.12.2014)
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Journal Article
Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights
Coe, Jotham W, Bianco, Krista E, Boscoe, Brian P, Brooks, Paige R, Cox, Eric D, Vetelino, Michael G
Published in Journal of organic chemistry (26.12.2003)
Published in Journal of organic chemistry (26.12.2003)
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Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel alpha 7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models
O'Donnell, Christopher J., Rogers, Bruce N., Bronk, Brian S., Bryce, Dianne K., Coe, Jotham W., Cook, Karen K., Duplantier, Allen J., Evrard, Edelweiss, Hajos, Mihaly, Hoffmann, William E., Hurst, Raymond S., Maklad, Noha, Mather, Robert J., McLean, Stafford, Nedza, Frank M., O'Neill, Brian T., Peng, Langu, Qian, Weimin, Rottas, Melinda M., Sands, Steven B., Schmidt, Anne W., Shrikhande, Alka V., Spracklin, Douglas K., Wong, Diane F., Zhang, Andy, Zhang, Lei
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Journal Article
α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties
Mineur, Yann S, Einstein, Emily B, Seymour, Patricia A, Coe, Jotham W, O'neill, Brian T, Rollema, Hans, Picciotto, Marina R
Published in Behavioural pharmacology (01.08.2011)
Published in Behavioural pharmacology (01.08.2011)
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