Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate
Andexer, Jennifer N, Kendrew, Steven G, Nur-e-Alam, Mohammad, Lazos, Orestis, Foster, Teresa A, Zimmermann, Anna-Sophie, Warneck, Tony D, Suthar, Dipen, Coates, Nigel J, Koehn, Frank E, Skotnicki, Jerauld S, Carter, Guy T, Gregory, Matthew A, Martin, Christine J, Moss, Steven J, Leadlay, Peter F, Wilkinson, Barrie
Published in Proceedings of the National Academy of Sciences - PNAS (22.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (22.03.2011)
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Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family
GREGORY, Matthew A, BOBARDT, Michael, NUR-E-ALAM, Mohammad, PAESHUYSE, Jan, PIRAEE, Mahmood, SUTHAR, Dipen, WARNECK, Tony, ZHANG, Ming-Qiang, WILKINSON, Barrie, OBEID, Susan, CHATTERJI, Udayan, COATES, Nigel J, FOSTER, Teresa, GALLAY, Philippe, LEYSSEN, Pieter, MOSS, Steven J, NEYTS, Johan
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
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Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors
Zhang, Ming-Qiang, Gaisser, Sabine, Nur-E-Alam, Mohammad, Sheehan, Lesley S, Vousden, William A, Gaitatzis, Nikolaos, Peck, Gerrard, Coates, Nigel J, Moss, Steven J, Radzom, Markus, Foster, Teresa A, Sheridan, Rose M, Gregory, Matthew A, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence, Boyd, Susan M, Wilkinson, Barrie, Martin, Christine J
Published in Journal of medicinal chemistry (25.09.2008)
Published in Journal of medicinal chemistry (25.09.2008)
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Journal Article
Structure guided design of improved anti-proliferative rapalogs through biosynthetic medicinal chemistry
Gregory, Matthew A, Kaja, Andrew L, Kendrew, Steven G, Coates, Nigel J, Warneck, Tony, Nur-e-Alam, Mohammad, Lill, Rachel E, Sheehan, Lesley S, Chudley, Lindsey, Moss, Steven J, Sheridan, Rose M, Quimpere, Miguel, Zhang, Ming-Qiang, Martin, Christine J, Wilkinson, Barrie
Published in Chemical science (Cambridge) (01.01.2013)
Published in Chemical science (Cambridge) (01.01.2013)
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SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp: I. Fermentation, Isolation and Properties
STEFANSKA, ANNA L, COATES, NIGEL J., MENSAH, LUCY M., POPE, ANDREW J., READY, SARAH J., WARR, STEPHEN. R.
Published in Journal of antibiotics (01.04.2000)
Published in Journal of antibiotics (01.04.2000)
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Recombinant strains for the enhanced production of bioengineered rapalogs
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Published in Metabolic engineering (01.01.2013)
Published in Metabolic engineering (01.01.2013)
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Diversity oriented biosynthesis via accelerated evolution of modular gene clusters
Wlodek, Aleksandra, Kendrew, Steve G., Coates, Nigel J., Hold, Adam, Pogwizd, Joanna, Rudder, Steven, Sheehan, Lesley S., Higginbotham, Sarah J., Stanley-Smith, Anna E., Warneck, Tony, Nur-E-Alam, Mohammad, Radzom, Markus, Martin, Christine J., Overvoorde, Lois, Samborskyy, Markiyan, Alt, Silke, Heine, Daniel, Carter, Guy T., Graziani, Edmund I., Koehn, Frank E., McDonald, Leonard, Alanine, Alexander, Rodríguez Sarmiento, Rosa María, Chao, Suzan Keen, Ratni, Hasane, Steward, Lucinda, Norville, Isobel H., Sarkar-Tyson, Mitali, Moss, Steven J., Leadlay, Peter F., Wilkinson, Barrie, Gregory, Matthew A.
Published in Nature communications (31.10.2017)
Published in Nature communications (31.10.2017)
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SB-204900, a Novel Oxirane Carboxamide from Clausena lansium
Milner, Peter H, Coates, Nigel J, Gilpin, Martin L, Spear, Simon R, Eggleston, Drake S
Published in Journal of natural products (Washington, D.C.) (01.04.1996)
Published in Journal of natural products (Washington, D.C.) (01.04.1996)
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Novel FK506 and FK520 analogues via mutasynthesis: mutasynthon scope and product characteristics
Moss, Steven J., Stanley-Smith, Anna E., Schell, Ursula, Coates, Nigel J., Foster, Teresa A., Gaisser, Sabine, Gregory, Matthew A., Martin, Christine J., Nur-e-Alam, Mohammad, Piraee, Mahmood, Radzom, Markus, Suthar, Dipen, Thexton, David G., Warneck, Tony D., Zhang, Ming-Qiang, Wilkinson, Barrie
Published in MedChemComm (01.02.2013)
Published in MedChemComm (01.02.2013)
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MM 55266 AND MM 55268, GLYCOPEPTIDE ANTIBIOTICS PRODUCED BY A NEW STRAIN OF Amycolatopsis: ISOLATION, PURIFICATION AND STRUCTURE DETERMINATION
BOX, STEPHEN J., COATES, NIGEL J., DAVIS, CHRIS J., GILPIN, MARTIN L., HOUGE-FRYDRYCH, CATHERINE S. V., MILNER, PETER H.
Published in Journal of antibiotics (01.08.1991)
Published in Journal of antibiotics (01.08.1991)
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Novel FK506 and FK520 analogues via mutasynthesis: mutasynthon scope and product characteristicsElectronic supplementary information (ESI) available: Materials and methods for generating strains and experimental data for compounds assayed, materials and methods for in vitro and in vivo assays. See DOI: 10.1039/c2md20266b
Moss, Steven J, Stanley-Smith, Anna E, Schell, Ursula, Coates, Nigel J, Foster, Teresa A, Gaisser, Sabine, Gregory, Matthew A, Martin, Christine J, Nur-e-Alam, Mohammad, Piraee, Mahmood, Radzom, Markus, Suthar, Dipen, Thexton, David G, Warneck, Tony D, Zhang, Ming-Qiang, Wilkinson, Barrie
Year of Publication 30.01.2013
Year of Publication 30.01.2013
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Journal Article
Compounds and compositions for the treatment of bacterial infections in animals
CURTIS; LAWRENCE M, DAVIS; CHRISTOPHER J, SYKES; RACHEL, COATES; NIGEL J
Year of Publication 09.03.1993
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Year of Publication 09.03.1993
Patent
COMPOUNDS
COATES, NIGEL J, SYKES, RACHEL, DAVIS, CHRISTOPHER J, CURTIS, LAWRENCE M
Year of Publication 23.06.1990
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Year of Publication 23.06.1990
Patent
PRODUCTS
COATES, NIGEL J, ELSON, ANNA L, ATHALYE, MEDHA, CURTIS, LAWRENCE M, MOORES, LINDA V
Year of Publication 07.06.1990
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Year of Publication 07.06.1990
Patent