Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D)
Wang, Jocelyn, Nakafuku, Kohki M., Ziff, Jeannie, Gelin, Christine F., Gholami, Hadi, Thompson, Aaron A., Karpowich, Nathan K., Limon, Luis, Coate, Heather R., Damm-Ganamet, Kelly L., Shih, Amy Y., Grant, Joanna C., Côte, Marjorie, Mak, Puiying A., Pascual, Heather A., Rives, Marie-Laure, Edwards, James P., Venable, Jennifer D., Venkatesan, Hariharan, Shi, Zhicai, Allen, Samantha J., Sharma, Sujata, Kung, Pei-Pei, Shireman, Brock T.
Published in Bioorganic & medicinal chemistry letters (15.11.2023)
Published in Bioorganic & medicinal chemistry letters (15.11.2023)
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Identification of small-molecule protein-protein interaction inhibitors for NKG2D
Thompson, Aaron A, Harbut, Michael B, Kung, Pei-Pei, Karpowich, Nathan K, Branson, Jeffrey D, Grant, Joanna C, Hagan, Deborah, Pascual, Heather A, Bai, Guoyun, Zavareh, Reza Beheshti, Coate, Heather R, Collins, Bernard C, Côte, Marjorie, Gelin, Christine F, Damm-Ganamet, Kelly L, Gholami, Hadi, Huff, Adam R, Limon, Luis, Lumb, Kevin J, Mak, Puiying A, Nakafuku, Kohki M, Price, Edmund V, Shih, Amy Y, Tootoonchi, Mandana, Vellore, Nadeem A, Wang, Jocelyn, Wei, Na, Ziff, Jeannie, Berger, Scott B, Edwards, James P, Gardet, Agnès, Sun, Siquan, Towne, Jennifer E, Venable, Jennifer D, Shi, Zhicai, Venkatesan, Hariharan, Rives, Marie-Laure, Sharma, Sujata, Shireman, Brock T, Allen, Samantha J
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2023)
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Novel 2-phenylquinolin-7-yl-derived imidazo[1,5- a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors
Mulvihill, Mark J., Ji, Qun-Sheng, Coate, Heather R., Cooke, Andrew, Dong, Hanqing, Feng, Lixin, Foreman, Kenneth, Rosenfeld-Franklin, Maryland, Honda, Ayako, Mak, Gilda, Mulvihill, Kristen M., Nigro, Anthony I., O’Connor, Matthew, Pirrit, Caroline, Steinig, Arno G., Siu, Kam, Stolz, Kathryn M., Sun, Yingchuan, Tavares, Paula A.R., Yao, Yan, Gibson, Neil W.
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung
Stebbins, Karin J, Broadhead, Alex R, Baccei, Christopher S, Scott, Jill M, Truong, Yen P, Coate, Heather, Stock, Nicholas S, Santini, Angelina M, Fagan, Patrick, Prodanovich, Patricia, Bain, Gretchen, Stearns, Brian A, King, Christopher D, Hutchinson, John H, Prasit, Peppi, Evans, Jilly F, Lorrain, Daniel S
Published in The Journal of pharmacology and experimental therapeutics (01.03.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2010)
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Pharmacology of JNJ-28583113: A novel TRPM2 antagonist
Fourgeaud, Lawrence, Dvorak, Curt, Faouzi, Malika, Starkus, John, Sahdeo, Sunil, Wang, Qi, Lord, Brian, Coate, Heather, Taylor, Natalie, He, Yingbo, Qin, Ning, Wickenden, Alan, Carruthers, Nicholas, Lovenberg, Timothy W., Penner, Reinhold, Bhattacharya, Anindya
Published in European journal of pharmacology (15.06.2019)
Published in European journal of pharmacology (15.06.2019)
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Discovery of a Series of Substituted 1H‑((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators
Gelin, Christine F., Stenne, Brice, Coate, Heather, Hiscox, Afton, Soyode-Johnson, Akinola, Wall, Jessica L., Lord, Brian, Schoellerman, Jeffrey, Coe, Kevin J., Wang, Kai, Alcázar, Jesus, Chrovian, Christa C., Dvorak, Curt A., Carruthers, Nicholas I., Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A.
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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Discovery of a Series of Substituted 1 H -((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators
Gelin, Christine F, Stenne, Brice, Coate, Heather, Hiscox, Afton, Soyode-Johnson, Akinola, Wall, Jessica L, Lord, Brian, Schoellerman, Jeffrey, Coe, Kevin J, Wang, Kai, Alcázar, Jesus, Chrovian, Christa C, Dvorak, Curt A, Carruthers, Nicholas I, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine
Liu, Changlu, Bonaventure, Pascal, Lee, Grace, Nepomuceno, Diane, Kuei, Chester, Wu, Jiejun, Li, Qingqin, Joseph, Victory, Sutton, Steven W, Eckert, William, Yao, Xiang, Yieh, Lynn, Dvorak, Curt, Carruthers, Nicholas, Coate, Heather, Yun, Sujin, Dugovic, Christine, Harrington, Anthony, Lovenberg, Timothy W
Published in Molecular pharmacology (01.11.2015)
Published in Molecular pharmacology (01.11.2015)
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Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin‑1 Antagonists: Discovery of JNJ-54717793
Préville, Cathy, Bonaventure, Pascal, Koudriakova, Tatiana, Lord, Brian, Nepomuceno, Diane, Rizzolio, Michele, Mani, Neelakandha, Coe, Kevin J, Ndifor, Anthony, Dugovic, Christine, Dvorak, Curt A, Coate, Heather, Pippel, Daniel J, Fitzgerald, Anne, Allison, Brett, Lovenberg, Timothy W, Carruthers, Nicholas I, Shireman, Brock T
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor
Dvorak, Curt A, Coate, Heather, Nepomuceno, Diane, Wennerholm, Michelle, Kuei, Chester, Lord, Brian, Woody, David, Bonaventure, Pascal, Liu, Changlu, Lovenberg, Timothy, Carruthers, Nicholas I
Published in ACS medicinal chemistry letters (10.09.2015)
Published in ACS medicinal chemistry letters (10.09.2015)
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P2X7 P2X7 MODULATORS
DENG XIAOHU, SAVALL BRAD M, ALCAZAR VACA MANUEL JESUS, ANDRES GIL JOSE IGNACIO, STENNE BRICE M, GELIN CHRISTINE F, DVORAK CURT A, SWANSON DEVIN M, COATE HEATHER R, SOYODE JOHNSON AKINOLA, DE ANGELIS MERI, ALLISON BRETT D, LETAVIC MICHAEL A, CHROVIAN CHRISTA C, LIANG JIMMY T, MANI NEELAKANDHA S, RECH JASON C, WALL JESSICA L
Year of Publication 13.04.2023
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Year of Publication 13.04.2023
Patent
P2X7 P2X7 MODULATORS
DENG XIAOHU, SAVALL BRAD M, ALCAZAR VACA MANUEL JESUS, ANDRES GIL JOSE IGNACIO, STENNE BRICE M, GELIN CHRISTINE F, DVORAK CURT A, SWANSON DEVIN M, COATE HEATHER R, DE ANGELIS MERI, SOYODEJOHNSON AKINOLA, ALLISON BRETT D, LETAVIC MICHAEL A, CHROVIAN CHRISTA C, LIANG JIMMY T, MANI NEELAKANDHA S, RECH JASON C, WALL JESSICA L
Year of Publication 07.04.2022
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Year of Publication 07.04.2022
Patent
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis
STEARNS, Brian A, BACCEI, Christopher, LEE, Catherine, LORRAIN, Daniel S, PRASIT, Peppi, PRODANOVICH, Pat, SANTINI, Angelina, SCOTT, Jill M, STOCK, Nicholas S, TRUONG, Yen P, BAIN, Gretchen, BROADHEAD, Alex, CLARK, Ryan C, COATE, Heather, EVANS, Jilly F, FAGAN, Patrick, HUTCHINSON, John H, KING, Christopher
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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One-Pot Friedlander Quinoline Synthesis: Scope and Limitations
Li, An-Hu, Beard, David J., Coate, Heather, Honda, Ayako, Kadalbajoo, Mridula, Kleinberg, Andrew, Laufer, Radoslaw, Mulvihill, Kristen M., Nigro, Anthony, Rastogi, Pawan, Sherman, Dan, Siu, Kam W., Steinig, Arno G., Wang, Ti, Werner, Doug, Crew, Andrew P., Mulvihill, Mark J.
Published in Synthesis (Stuttgart) (01.05.2010)
Published in Synthesis (Stuttgart) (01.05.2010)
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5-(2′-Pyridyl)-2-aminothiazoles: Alkyl amino sulfonamides and sulfamides as potent NPY₅ antagonists
Packiarajan, Mathivanan, Coate, Heather, Desai, Mahesh, Jimenez, Hermogenes N, Reinhard, Emily J, Jubian, Vrej J, Marzabadi, Mohammad R, Chandrasena, Gamini, Wolinski, Toni C, Walker, Mary W, Andersen, Kim
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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5-(2'-Pyridyl)-2-aminothiazoles: Alkyl amino sulfonamides and sulfamides as potent NPY sub(5 antagonists)
Packiarajan, Mathivanan, Coate, Heather, Desai, Mahesh, Jimenez, Hermogenes N, Reinhard, Emily J, Jubian, Vrej J, Marzabadi, Mohammad R, Chandrasena, Gamini, Wolinski, Toni C, Walker, Mary W, Andersen, Kim
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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