Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension
Asaki, Tetsuo, Kuwano, Keiichi, Morrison, Keith, Gatfield, John, Hamamoto, Taisuke, Clozel, Martine
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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The Discovery of N‑[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]‑N′‑propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Antagonist
Bolli, Martin H, Boss, Christoph, Binkert, Christoph, Buchmann, Stephan, Bur, Daniel, Hess, Patrick, Iglarz, Marc, Meyer, Solange, Rein, Josiane, Rey, Markus, Treiber, Alexander, Clozel, Martine, Fischli, Walter, Weller, Thomas
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist
Iglarz, Marc, Binkert, Christoph, Morrison, Keith, Fischli, Walter, Gatfield, John, Treiber, Alexander, Weller, Thomas, Bolli, Martin H, Boss, Christoph, Buchmann, Stephan, Capeleto, Bruno, Hess, Patrick, Qiu, Changbin, Clozel, Martine
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2008)
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The Cardiovascular Physiology and Pharmacology of Endothelin-1
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The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation
Piali, Luca, Froidevaux, Sylvie, Hess, Patrick, Nayler, Oliver, Bolli, Martin H, Schlosser, Eva, Kohl, Christopher, Steiner, Beat, Clozel, Martine
Published in The Journal of pharmacology and experimental therapeutics (01.05.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2011)
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Promotion of sleep by targeting the orexin system in rats, dogs and humans
Jenck, François, Brisbare-Roch, Catherine, Dingemanse, Jasper, Koberstein, Ralf, Hoever, Petra, Aissaoui, Hamed, Flores, Susan, Mueller, Celia, Nayler, Oliver, van Gerven, Joop, de Haas, Sanne L, Hess, Patrick, Qiu, Changbin, Buchmann, Stephan, Scherz, Michael, Weller, Thomas, Fischli, Walter, Clozel, Martine
Published in Nature medicine (01.02.2007)
Published in Nature medicine (01.02.2007)
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CRISPR‐Cas9‐modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine‐containing compounds but potentiates artemisinin‐based combination therapy partner drugs
Ng, Caroline L., Siciliano, Giulia, Lee, Marcus C. S., de Almeida, Mariana J., Corey, Victoria C., Bopp, Selina E., Bertuccini, Lucia, Wittlin, Sergio, Kasdin, Rachel G., Le Bihan, Amélie, Clozel, Martine, Winzeler, Elizabeth A., Alano, Pietro, Fidock, David A.
Published in Molecular microbiology (01.08.2016)
Published in Molecular microbiology (01.08.2016)
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Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery
Morrison, Keith, Studer, Rolf, Ernst, Roland, Haag, Franck, Kauser, Katalin, Clozel, Martine
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)
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Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension
Iglarz, Marc, Bossu, Alexandre, Wanner, Daniel, Bortolamiol, Céline, Rey, Markus, Hess, Patrick, Clozel, Martine
Published in Life sciences (1973) (24.11.2014)
Published in Life sciences (1973) (24.11.2014)
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Development of macitentan for the treatment of pulmonary arterial hypertension
Selej, Mona, Romero, Alain J., Channick, Richard N., Clozel, Martine
Published in Annals of the New York Academy of Sciences (01.11.2015)
Published in Annals of the New York Academy of Sciences (01.11.2015)
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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling
Le Bihan, Amélie, de Kanter, Ruben, Angulo-Barturen, Iñigo, Binkert, Christoph, Boss, Christoph, Brun, Reto, Brunner, Ralf, Buchmann, Stephan, Burrows, Jeremy, Dechering, Koen J, Delves, Michael, Ewerling, Sonja, Ferrer, Santiago, Fischli, Christoph, Gamo-Benito, Francisco Javier, Gnädig, Nina F, Heidmann, Bibia, Jiménez-Díaz, María Belén, Leroy, Didier, Martínez, Maria Santos, Meyer, Solange, Moehrle, Joerg J, Ng, Caroline L, Noviyanti, Rintis, Ruecker, Andrea, Sanz, Laura María, Sauerwein, Robert W, Scheurer, Christian, Schleiferboeck, Sarah, Sinden, Robert, Snyder, Christopher, Straimer, Judith, Wirjanata, Grennady, Marfurt, Jutta, Price, Ric N, Weller, Thomas, Fischli, Walter, Fidock, David A, Clozel, Martine, Wittlin, Sergio
Published in PLoS medicine (04.10.2016)
Published in PLoS medicine (04.10.2016)
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Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator
Rey, Markus, Hess, Patrick, Clozel, Martine, Delahaye, Stéphane, Gatfield, John, Nayler, Oliver, Steiner, Beat
Published in PloS one (12.09.2013)
Published in PloS one (12.09.2013)
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Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes
You, Sylvaine, Piali, Luca, Kuhn, Chantal, Steiner, Beat, Sauvaget, Virginia, Valette, Fabrice, Clozel, Martine, Bach, Jean-François, Chatenoud, Lucienne
Published in PloS one (24.10.2013)
Published in PloS one (24.10.2013)
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Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension
Iglarz, Marc, Landskroner, Kyle, Bauer, Yasmina, Vercauteren, Magali, Rey, Markus, Renault, Berengère, Studer, Rolf, Vezzali, Enrico, Freti, Diego, Hadana, Hakim, Schläpfer, Manuela, Cattaneo, Christophe, Bortolamiol, Céline, Weber, Edgar, Whitby, Brian R, Delahaye, Stéphane, Wanner, Daniel, Steiner, Pauline, Nayler, Oliver, Hess, Patrick, Clozel, Martine
Published in Journal of cardiovascular pharmacology (01.11.2015)
Published in Journal of cardiovascular pharmacology (01.11.2015)
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Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat
Treiber, Alexander, Schneiter, Ralph, Delahaye, Stephane, Clozel, Martine
Published in The Journal of pharmacology and experimental therapeutics (01.03.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2004)
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