Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir
Belema, Makonen, Nguyen, Van N., Bachand, Carol, Deon, Dan H., Goodrich, Jason T., James, Clint A., Lavoie, Rico, Lopez, Omar D., Martel, Alain, Romine, Jeffrey L., Ruediger, Edward H., Snyder, Lawrence B., Laurent, Denis R. St, Yang, Fukang, Zhu, Juliang, Wong, Henry S., Langley, David R., Adams, Stephen P., Cantor, Glenn H., Chimalakonda, Anjaneya, Fura, Aberra, Johnson, Benjamin M., Knipe, Jay O., Parker, Dawn D., Santone, Kenneth S., Fridell, Robert A., Lemm, Julie A., O’Boyle, Donald R., Colonno, Richard J., Gao, Min, Meanwell, Nicholas A., Hamann, Lawrence G.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Combined Directed ortho and Remote Metalation−Suzuki Cross-Coupling Strategies. Efficient Synthesis of Heteroaryl-Fused Benzopyranones from Biaryl O-Carbamates
James, Clint A, Coelho, Antonio Luiz, Gevaert, Matt, Forgione, Pat, Snieckus, Victor
Published in Journal of organic chemistry (05.06.2009)
Published in Journal of organic chemistry (05.06.2009)
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Journal Article
Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors
James, Clint A., DeRoy, Patrick, Duplessis, Martin, Edwards, Paul J., Halmos, Teddy, Minville, Joannie, Morency, Louis, Morin, Sébastien, Simoneau, Bruno, Tremblay, Martin, Bethell, Richard, Cordingley, Michael, Duan, Jianmin, Lamorte, Louie, Pelletier, Alex, Rajotte, Daniel, Salois, Patrick, Tremblay, Sonia, Sturino, Claudio F.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Journal Article
Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors
Tremblay, Martin, Bethell, Richard C., Cordingley, Michael G., DeRoy, Patrick, Duan, Jianmin, Duplessis, Martin, Edwards, Paul J., Faucher, Anne-Marie, Halmos, Ted, James, Clint A., Kuhn, Cyrille, Lacoste, Jean-Éric, Lamorte, Louie, LaPlante, Steven R., Malenfant, Éric, Minville, Joannie, Morency, Louis, Morin, Sébastien, Rajotte, Daniel, Salois, Patrick, Simoneau, Bruno, Tremblay, Sonia, Sturino, Claudio F.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Journal Article
Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: In vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors
Sturino, Claudio F., Bousquet, Yves, James, Clint A., DeRoy, Patrick, Duplessis, Martin, Edwards, Paul J., Halmos, Ted, Minville, Joannie, Morency, Louis, Morin, Sébastien, Thavonekham, Bounkham, Tremblay, Martin, Duan, Jianmin, Ribadeneira, Maria, Garneau, Michel, Pelletier, Alex, Tremblay, Sonia, Lamorte, Louie, Bethell, Richard, Cordingley, Michael G., Rajotte, Daniel, Simoneau, Bruno
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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Journal Article
2-Arylaminothiazoles as high-affinity corticotropin-Releasing factor 1 receptor (CRF 1R) antagonists: synthesis, binding studies and behavioral efficacy
Dubowchik, Gene M., Michne, Jodi A., Zuev, Dmitry, Schwartz, Wendy, Scola, Paul M., James, Clint A., Ruediger, Edward H., Pin, Sokhom S., Burris, Kevin D., Balanda, Lynn A., Gao, Qi, Wu, Dedong, Fung, Lawrence, Fiedler, Tracey, Browman, Kaitlin E., Taber, Matthew T., Zhang, Jie
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Journal Article
General synthesis of tetrasubstituted alkenyl-1,3,4-oxadiazoles
James, Clint A., Poirier, Brigitte, Grisé, Christiane, Martel, Alain, Ruediger, Edward H.
Published in Tetrahedron letters (23.01.2006)
Published in Tetrahedron letters (23.01.2006)
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Journal Article
inibidores do vírus da hepatite c
Makonen Belema, Carol Bachand, Jeffrey Lee Romine, Denis R. St Laurent, David R. Langley, Fukang Yang, Daniel H. Deon, Van N. Nguyen, Lawrence G. Hamann, Clint A. James, Nicholas A. Meanwell, Omar D. Lopez, Edward H. Ruediger, Jason Goodrich, Rico Lavoie, Alain Martel, Andrew C. Good, Lawrence B. Snyder, Gan Wang
Year of Publication 24.09.2019
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Year of Publication 24.09.2019
Patent
derivados de bifenil restritos estruturalmente para uso como inibidores do vírus da hepatite c
Makonen Belema, Carol Bachand, Jeffrey Lee Romine, David R. Langley, Fukang Yang, Daniel H. Deon, Van N. Nguyen, Lawrence G. Hamann, Clint A. James, Nicholas A. Meanwell, Omar D. Lopez, Edward H. Ruediger, Jason Goodrich, Rico Lavoie, Alain Martel, ANDREW C. GOOD, Lawrence B. Snyder, Denis R. St. Laurent, Gan Wang
Year of Publication 24.09.2019
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Year of Publication 24.09.2019
Patent
Tricyclic alkene derivatives as HIV attachment inhibitors
Ruediger Edward H, Yin Zhiwei, Deon Daniel H, Meanwell Nicholas A, Zhang Zhongxing, Kadow John F, James Clint A, Wang Tao
Year of Publication 23.05.2017
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Year of Publication 23.05.2017
Patent
HEPATITIS C VIRUS INHIBITORS
Goodrich, Jason, Good, Andrew C, James, Clint A, Lavoie, Rico, Hamann, Lawrence G, Deon, Daniel H, Langley, David R, Wang, Gan, Meanwell, Nicholas A, Nguyen, Van N, Yang, Fukang, Ruediger, Edward H, Belema, Makonen, Lopez, Omar D, Bachand, Carol, St. Laurent, Denis R, Romine, Jeffrey Lee, Snyder, Lawrence B, Martel, Alain
Year of Publication 19.04.2019
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Year of Publication 19.04.2019
Patent
Piperidine amide derivatives as HIV attachment inhibitors
Ruediger Edward H, Carini David J, Deon Daniel H, Meanwell Nicholas A, Zhang Zhongxing, Kadow John F, James Clint A, Wang Tao, Johnson Barry L
Year of Publication 29.11.2016
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Year of Publication 29.11.2016
Patent