The Structure of the Staphylococcus aureus Sortase-Substrate Complex Reveals How the Universally Conserved LPXTG Sorting Signal Is Recognized
Suree, Nuttee, Liew, Chu Kong, Villareal, Valerie A., Thieu, William, Fadeev, Evgeny A., Clemens, Jeremy J., Jung, Michael E., Clubb, Robert T.
Published in The Journal of biological chemistry (04.09.2009)
Published in The Journal of biological chemistry (04.09.2009)
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Journal Article
Sphingosine 1-Phosphate Analogs as Receptor Antagonists
Davis, Michael D., Clemens, Jeremy J., Macdonald, Timothy L., Lynch, Kevin R.
Published in The Journal of biological chemistry (18.03.2005)
Published in The Journal of biological chemistry (18.03.2005)
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Journal Article
When structure–affinity relationships meet structure–kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists
Vilums, Maris, Zweemer, Annelien J.M., Barmare, Farhana, van der Gracht, Anouk M.F., Bleeker, Dave C.T., Yu, Zhiyi, de Vries, Henk, Gross, Raymond, Clemens, Jeremy, Krenitsky, Paul, Brussee, Johannes, Stamos, Dean, Saunders, John, Heitman, Laura H., IJzerman, Adriaan P.
Published in European journal of medicinal chemistry (26.03.2015)
Published in European journal of medicinal chemistry (26.03.2015)
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Journal Article
Staphylococcus aureus Sortase A transpeptidase. Calcium promotes sorting signal binding by altering the mobility and structure of an active site loop
Naik, Mandar T, Suree, Nuttee, Ilangovan, Udayar, Liew, Chu Kong, Thieu, William, Campbell, Dean O, Clemens, Jeremy J, Jung, Michael E, Clubb, Robert T
Published in The Journal of biological chemistry (20.01.2006)
Published in The Journal of biological chemistry (20.01.2006)
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Journal Article
Sphingosine-1-Phosphate Prevents Tumor Necrosis Factor-α–Mediated Monocyte Adhesion to Aortic Endothelium in Mice
Bolick, David T, Srinivasan, Suseela, Kim, Kyu W, Hatley, Melissa E, Clemens, Jeremy J, Whetzel, Angela, Ferger, Nicole, Macdonald, Timothy L, Davis, Michael D, Tsao, Philip S, Lynch, Kevin R, Hedrick, Catherine C
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2005)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2005)
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Journal Article
Strategies for the modulation of phase II metabolism in a series of PKC epsilon inhibitors
Clemens, Jeremy J., Coon, Timothy, Busch, Brett B., Asgian, Juliana L., Hudson, Sarah, Termin, Andreas, Flores, Tina B., Tran, Dao, Chiang, Peggy, Sperry, Sam, Gross, Ray, Abt, Jeffrey, Heim, Roger, Lechner, Sandra, Twin, Heather, Studley, John, Brenchley, Guy, Collier, Philip N., Pierard, Francoise, Miller, Andrew, Mak, Chau, Dvornikovs, Vadims, Jimenez, Juan-Miguel, Stamos, Dean
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
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Journal Article
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720 : Discovery of potent S1P1 receptor agonists
CLEMENS, Jeremy J, DAVIS, Michael D, LYNCH, Kevin R, MACDONALD, Timothy L
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Journal Article
Diastereoselective One-Pot Knoevenagel Condensation/Corey–Chaykovsky Cyclopropanation
Clemens, Jeremy J, Asgian, Juliana L, Busch, Brett B, Coon, Timothy, Ernst, Justin, Kaljevic, Leonard, Krenitsky, Paul J, Neubert, Timothy D, Schweiger, Edwin J, Termin, Andreas, Stamos, Dean
Published in Journal of organic chemistry (18.01.2013)
Published in Journal of organic chemistry (18.01.2013)
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Journal Article
Synthesis of (2 R,3 S) 3-amino-4-mercapto-2-butanol, a threonine analogue for covalent inhibition of sortases
Jung, Michael E., Clemens, Jeremy J., Suree, Nuttee, Liew, Chu Kong, Pilpa, Rosemarie, Campbell, Dean O., Clubb, Robert T.
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
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Journal Article
Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors
Foss, Frank W., Clemens, Jeremy J., Davis, Michael D., Snyder, Ashley H., Zigler, Molly A., Lynch, Kevin R., Macdonald, Timothy L.
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
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Journal Article
Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists
CLEMENS, Jeremy J, DAVIS, Michael D, LYNCH, Kevin R, MACDONALD, Timothy L
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
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Journal Article
Characterization of the Human and Mouse Sphingosine 1-Phosphate Receptor, S1P5 (Edg-8): Structure−Activity Relationship of Sphingosine1-Phosphate Receptors
Im, Dong-Soon, Clemens, Jeremy, Macdonald, Timothy L, Lynch, Kevin R
Published in Biochemistry (Easton) (20.11.2001)
Published in Biochemistry (Easton) (20.11.2001)
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Journal Article
Staphylococcus aureus Sortase A Transpeptidase
Naik, Mandar T., Suree, Nuttee, Ilangovan, Udayar, Liew, Chu Kong, Thieu, William, Campbell, Dean O., Clemens, Jeremy J., Jung, Michael E., Clubb, Robert T.
Published in The Journal of biological chemistry (20.01.2006)
Published in The Journal of biological chemistry (20.01.2006)
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Journal Article
Structure–Kinetic RelationshipsAn Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists
Vilums, Maris, Zweemer, Annelien J. M, Yu, Zhiyi, de Vries, Henk, Hillger, Julia M, Wapenaar, Hannah, Bollen, Ilse A. E, Barmare, Farhana, Gross, Raymond, Clemens, Jeremy, Krenitsky, Paul, Brussee, Johannes, Stamos, Dean, Saunders, John, Heitman, Laura H, IJzerman, Adriaan P
Published in Journal of medicinal chemistry (10.10.2013)
Published in Journal of medicinal chemistry (10.10.2013)
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Journal Article
Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors
Neubert, Timothy, Numa, Mehdi, Ernst, Justin, Clemens, Jeremy, Krenitsky, Paul, Liu, Michael, Fleck, Beth, Woody, Lisa, Zuccola, Harmon, Stamos, Dean
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
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Journal Article
낭성 섬유증 막관통 전도도 조절제로서 사용하기 위한 1,3,4-옥사디아졸 고리를 함유하는 거대환
HADIDA RUAH SARA SABINA, BECHARA WILLIAM SCHULZ, COON TIMOTHY, RAMTOHUL YEEMAN K, ZHOU JINGLAN, BOOKSER BRETT C, VALDEZ LINO, GROOTENHUIS PETER DIEDERIK JAN, LATERREUR JULIE, PARASELLI PRASUNA, BAEK MINSON, STURINO CLAUDIO, CLEVELAND THOMAS, GALLANT MICHEL, REDDY THUMKUNTA JAGADEESWAR, MILLER MARK THOMAS, CLEMENS JEREMY J
Year of Publication 23.08.2023
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Year of Publication 23.08.2023
Patent
낭성 섬유증 막관통 전도도 조절자의 조절제
HADIDA RUAH SARA SABINA, ZHOU JINGLAN, VALDEZ LINO, PIERRE FABRICE, MCCARTNEY JASON, ABRAHAM SUNNY, DWIGHT TIMOTHY A, TRAN JOE A, CHAU JACLYN, CLEVELAND THOMAS, ABELA ALEXANDER RUSSELL, DINH ANDREW, FANNING LEV TYLER DEWEY, MILLER MARK THOMAS, SILINA ALINA, ARUMUGAM VIJAYALAKSMI, GROOTENHUIS PETER, ANDERSON COREY DON, CLEMENS JEREMY, COON TIMOTHY RICHARD, FRIEMAN BRYAN A, KRENITSKY PAUL, ISHIHARA YOSHIHIRO
Year of Publication 10.07.2023
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Year of Publication 10.07.2023
Patent
낭포성 섬유증 막횡단 전도도 조절자의 조정제
HADIDA RUAH SARA SABINA, BECHARA WILLIAM SCHULZ, RAMTOHUL YEEMAN K, ZHOU JINGLAN, BOOKSER BRETT C, VALDEZ LINO, LATERREUR JULIE, MELILLO VITO, PARASELLI PRASUNA, BAEK MINSON, STURINO CLAUDIO, CLEVELAND THOMAS, GALLANT MICHEL, REDDY THUMKUNTA JAGADEESWAR, COON TIMOTHY R, MILLER MARK THOMAS, GROOTENHUIS PETER, CLEMENS JEREMY J
Year of Publication 15.05.2023
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Year of Publication 15.05.2023
Patent