Loading…
MicroRNA-339-5p Down-regulates Protein Expression of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (BACE1) in Human Primary Brain Cultures and Is Reduced in Brain Tissue Specimens of Alzheimer Disease Subjects
Long, Justin M., Ray, Balmiki, Lahiri, Debomoy K.
Published in The Journal of biological chemistry (21.02.2014)
Published in The Journal of biological chemistry (21.02.2014)
Get full text
Journal Article
Loading…
Safety, Tolerability, and Pharmacokinetics of the β‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitor Verubecestat (MK‐8931) in Healthy Elderly Male and Female Subjects
Forman, Mark, Palcza, John, Tseng, Jack, Stone, Julie A., Walker, Brittany, Swearingen, Dennis, Troyer, Matthew D., Dockendorf, Marissa F.
Published in Clinical and translational science (01.09.2019)
Published in Clinical and translational science (01.09.2019)
Get full text
Journal Article
Loading…
Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence
Kimura, Ayano, Hata, Saori, Suzuki, Toshiharu
Published in The Journal of biological chemistry (11.11.2016)
Published in The Journal of biological chemistry (11.11.2016)
Get full text
Journal Article
Loading…
A Bilingual Nanobiosensor for Cross‐Category Integrated Decoding of the Beta‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1–Aβ Oligomer Signaling Pathway
Cheng, Tao, Lu, Peifen, Dong, Yixi, Yu, Jiabao, Wang, Gang, Jiao, Jianwei, Miao, Peng, Jiao, Jin
Published in Small structures (01.11.2024)
Published in Small structures (01.11.2024)
Get full text
Journal Article
Loading…
Sevoflurane anesthesia reduces the expression of inflammatory response genes and β-site amyloid precursor protein-cleaving enzyme in hippocampi of diabetic mice
Han, Yu Xiang, Liang, Rui, Yi, Xian Ping, Zhang, Xue Xia, Zhou, Shao Peng
Published in Neuroreport (07.02.2024)
Published in Neuroreport (07.02.2024)
Get more information
Journal Article
Loading…
Stable cerebrospinal fluid neurogranin and β-site amyloid precursor protein cleaving enzyme 1 levels differentiate predementia Alzheimer’s disease patients
Kirsebom, Bjørn Eivind, Richter, Grit, Nordengen, Kaja, Aarsland, Dag, Bråthen, Geir, Tijms, Betty M, Visser, Pieter Jelle, Nilsson, Johanna, Selnes, Per, Kramberger, Milica G, Winblad, Bengt, Waterloo, Knut, Gísladóttir, Berglind, Blennow, Kaj, Fladby, Tormod
Published in Brain communications (2022)
Published in Brain communications (2022)
Get full text
Journal Article
Loading…
Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors
Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
Get full text
Journal Article
Loading…
Fibronectin fragments and the cleaving enzyme ADAM-8 in the degenerative human intervertebral disc
Ruel, Nancy, Markova, Dessislava Z, Adams, Sherrill L, Scanzello, Carla, Cs-Szabo, Gabriella, Gerard, David, Shi, Peng, Anderson, D Greg, Zack, Marc, An, Howard S, Chen, Di, Zhang, Yejia
Published in Spine (Philadelphia, Pa. 1976) (15.07.2014)
Published in Spine (Philadelphia, Pa. 1976) (15.07.2014)
Get more information
Journal Article
Loading…
β-Site amyloid precursor protein–cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau
Tsolakidou, Amalia, Alexopoulos, Panagiotis, Guo, Liang-Hao, Grimmer, Timo, Westerteicher, Christine, Kratzer, Martina, Jiang, Meizi, Bujo, Hideaki, Roselli, Francesco, Leante, Maria Rosaria, Livrea, Paolo, Kurz, Alexander, Perneczky, Robert
Published in Alzheimer's & dementia (01.07.2013)
Published in Alzheimer's & dementia (01.07.2013)
Get full text
Journal Article
Loading…
Loading…
Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice
Ilievski, Vladimir, Zuchowska, Paulina K., Green, Stefan J., Toth, Peter T., Ragozzino, Michael E., Le, Khuong, Aljewari, Haider W., O’Brien-Simpson, Neil M., Reynolds, Eric C., Watanabe, Keiko
Published in PloS one (03.10.2018)
Published in PloS one (03.10.2018)
Get full text
Journal Article
Loading…
Stable cerebrospinal fluid neurogranin and β-site amyloid precursor protein cleaving enzyme 1 levels differentiate predementia Alzheimer's disease patients
Kirsebom, Bjørn-Eivind, Richter, Grit, Nordengen, Kaja, Aarsland, Dag, Bråthen, Geir, Tijms, Betty M, Visser, Pieter Jelle, Nilsson, Johanna, Selnes, Per, Kramberger, Milica G, Winblad, Bengt, Waterloo, Knut, Gísladóttir, Berglind, Blennow, Kaj, Fladby, Tormod
Published in Brain communications (2022)
Get full text
Published in Brain communications (2022)
Journal Article
Loading…
β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage
Portelius, Erik, Dean, Robert A, Andreasson, Ulf, Mattsson, Niklas, Westerlund, Anni, Olsson, Maria, Demattos, Ronald Bradley, Racke, Margaret M, Zetterberg, Henrik, May, Patrick C, Blennow, Kaj
Published in Alzheimer's research & therapy (01.01.2014)
Published in Alzheimer's research & therapy (01.01.2014)
Get full text
Journal Article
Loading…
Current state of Alzheimer’s fluid biomarkers
Molinuevo, José Luis, Ayton, Scott, Batrla, Richard, Bednar, Martin M., Bittner, Tobias, Cummings, Jeffrey, Fagan, Anne M., Hampel, Harald, Mielke, Michelle M., Mikulskis, Alvydas, O’Bryant, Sid, Scheltens, Philip, Sevigny, Jeffrey, Shaw, Leslie M., Soares, Holly D., Tong, Gary, Trojanowski, John Q., Zetterberg, Henrik, Blennow, Kaj
Published in Acta neuropathologica (01.12.2018)
Published in Acta neuropathologica (01.12.2018)
Get full text
Journal Article
Loading…
Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
Readhead, Ben, Haure-Mirande, Jean-Vianney, Funk, Cory C., Richards, Matthew A., Shannon, Paul, Haroutunian, Vahram, Sano, Mary, Liang, Winnie S., Beckmann, Noam D., Price, Nathan D., Reiman, Eric M., Schadt, Eric E., Ehrlich, Michelle E., Gandy, Sam, Dudley, Joel T.
Published in Neuron (Cambridge, Mass.) (11.07.2018)
Published in Neuron (Cambridge, Mass.) (11.07.2018)
Get full text
Journal Article
Loading…
site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces A[beta]5-X peptides through alternative amyloid precursor protein cleavage
Portelius, Erik, Dean, Robert A, Andreasson, Ulf, Mattsson, Niklas, Westerlund, Anni, Olsson, Maria, Demattos, Ronald Bradley, Racke, Margaret M, Zetterberg, Henrik, May, Patrick C, Blennow, Kaj
Published in Alzheimer's research & therapy (17.11.2014)
Published in Alzheimer's research & therapy (17.11.2014)
Get full text
Journal Article
Loading…
Alterations in the Expression of Amyloid Precursor Protein Cleaving Enzymes mRNA in Alzheimer Peripheral Blood
Wongchitrat, Prapimpun, Pakpian, Nattaporn, Kitidee, Kuntida, Phopin, Kamonrat, Dharmasaroja, Pornpatr A, Govitrapong, Piyarat
Published in Current Alzheimer research (01.01.2019)
Published in Current Alzheimer research (01.01.2019)
Get more information
Journal Article
Loading…
AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease
Cebers, Gvido, Alexander, Robert C, Haeberlein, Samantha Budd, Han, David, Goldwater, Ronald, Ereshefsky, Larry, Olsson, Tina, Ye, Naidong, Rosen, Laura, Russell, Muir, Maltby, Justine, Eketjäll, Susanna, Kugler, Alan R
Published in Journal of Alzheimer's disease (01.01.2017)
Published in Journal of Alzheimer's disease (01.01.2017)
Get more information
Journal Article
Loading…
Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics
Ramamurthy, Easwaran, Welch, Gwyneth, Cheng, Jemmie, Yuan, Yixin, Gunsalus, Laura, Bennett, David A., Tsai, Li-Huei, Pfenning, Andreas R.
Published in Frontiers in molecular neuroscience (06.01.2023)
Published in Frontiers in molecular neuroscience (06.01.2023)
Get full text
Journal Article
Loading…
Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells
Lee, Han-Kyu, Velazquez Sanchez, Clara, Chen, Mei, Morin, Peter J., Wells, John M., Hanlon, Eugene B., Xia, Weiming
Published in PloS one (29.09.2016)
Published in PloS one (29.09.2016)
Get full text
Journal Article