GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain
De Alba, Jorge, Clayton, Nick M., Collins, Sue D., Colthup, Philip, Chessell, Iain, Knowles, Richard G.
Published in Pain (Amsterdam) (2006)
Published in Pain (Amsterdam) (2006)
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Discovery of 2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a Selective CB2 Receptor Agonist for the Treatment of Inflammatory Pain
Giblin, Gerard M. P, O'Shaughnessy, Celestine T, Naylor, Alan, Mitchell, William L, Eatherton, Andrew J, Slingsby, Brian P, Rawlings, D. Anthony, Goldsmith, Paul, Brown, Andrew J, Haslam, Carl P, Clayton, Nick M, Wilson, Alex W, Chessell, Iain P, Wittington, Andrew R, Green, Richard
Published in Journal of medicinal chemistry (31.05.2007)
Published in Journal of medicinal chemistry (31.05.2007)
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Discovery of 1-[4-(3-Chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a Brain Penetrant 5-Azaindole CB2 Agonist for the Treatment of Chronic Pain
Giblin, Gerard M. P, Billinton, Andrew, Briggs, Michael, Brown, Andrew J, Chessell, Iain P, Clayton, Nick M, Eatherton, Andrew J, Goldsmith, Paul, Haslam, Carl, Johnson, Matthew R, Mitchell, William L, Naylor, Alan, Perboni, Alcide, Slingsby, Brian P, Wilson, Alex W
Published in Journal of medicinal chemistry (08.10.2009)
Published in Journal of medicinal chemistry (08.10.2009)
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Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat
ELMES, Steven J. R, WINYARD, Lisa A, MEDHURST, Stephen J, CLAYTON, Nick M, WILSON, Alex W, KENDALL, David A, CHAPMAN, Victoria
Published in Pain (Amsterdam) (05.12.2005)
Published in Pain (Amsterdam) (05.12.2005)
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Activation of the α7 -Nicotinic Acetylcholine Receptor Reverses Complete Freund Adjuvant–Induced Mechanical Hyperalgesia in the Rat Via a Central Site of Action
Medhurst, Stephen J, Hatcher, Jon P, Hille, Christopher J, Bingham, Sharon, Clayton, Nick M, Billinton, Andy, Chessell, Iain P
Published in The journal of pain (01.07.2008)
Published in The journal of pain (01.07.2008)
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Effect of SB-750364, a specific TRPV1 receptor antagonist, on injury-induced ectopic discharge in the lingual nerve
Biggs, James E., Yates, Julian M., Loescher, Alison R., Clayton, Nick M., Robinson, Peter P., Boissonade, Fiona M.
Published in Neuroscience letters (26.09.2008)
Published in Neuroscience letters (26.09.2008)
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Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain
Myatt, James W., Healy, Mark P., Bravi, Gianpaolo S., Billinton, Andrew, Johnson, Christopher N., Matthews, Kim L., Jandu, Karamjit S., Meng, Wenjing, Hersey, Anne, Livermore, David G., Douault, Clement B., Witherington, Jason, Bit, Rino A., Rowedder, James E., Brown, Jason D., Clayton, Nick M.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Pyridine-3-carboxamides as novel CB(2) agonists for analgesia
Mitchell, William L, Giblin, Gerard M P, Naylor, Alan, Eatherton, Andrew J, Slingsby, Brian P, Rawlings, Anthony D, Jandu, Karamjit S, Haslam, Carl P, Brown, Andrew J, Goldsmith, Paul, Clayton, Nick M, Wilson, Alex W, Chessell, Iain P, Green, Richard H, Whittington, Andrew R, Wall, Ian D
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
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Journal Article
Pyridine-3-carboxamides as novel CB2 agonists for analgesia
MITCHELL, William L, GIBLIN, Gerard M. P, CLAYTON, Nick M, WILSON, Alex W, CHESSELL, Iain P, GREEN, Richard H, WHITTINGTON, Andrew R, WALL, Ian D, NAYLOR, Alan, EATHERTON, Andrew J, SLINGSBY, Brian P, RAWLINGS, Anthony D, JANDU, Karamjit S, HASLAM, Carl P, BROWN, Andrew J, GOLDSMITH, Paul
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors
Swarbrick, Martin E., Beswick, Paul J., Gleave, Robert J., Green, Richard H., Bingham, Sharon, Bountra, Chas, Carter, Malcolm C., Chambers, Laura J., Chessell, Iain P., Clayton, Nick M., Collins, Sue D., Corfield, John A., Hartley, C. David, Kleanthous, Savvas, Lambeth, Paul F., Lucas, Fiona S., Mathews, Neil, Naylor, Alan, Page, Lee W., Payne, Jeremy J., Pegg, Neil A., Price, Helen S., Skidmore, John, Stevens, Alexander J., Stocker, Richard, Stratton, Sharon C., Stuart, Alastair J., Wiseman, Joanne O.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
P2X(3) expression is not altered by lingual nerve injury
Biggs, James E, Yates, Julian M, Loescher, Alison R, Clayton, Nick M, Robinson, Peter P, Boissonade, Fiona M
Published in Neuroscience letters (15.08.2008)
Published in Neuroscience letters (15.08.2008)
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Journal Article
P2X3 expression is not altered by lingual nerve injury
BIGGS, James E, YATES, Julian M, LOESCHER, Alison R, CLAYTON, Nick M, ROBINSON, Peter P, BOISSONADE, Fiona M
Published in Neuroscience letters (15.08.2008)
Published in Neuroscience letters (15.08.2008)
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The Cyclooxygenase-2 Inhibitor GW406381X [2-(4-Ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] Is Effective in Animal Models of Neuropathic Pain and Central Sensitization
Bingham, Sharon, Beswick, Paul J, Bountra, Chas, Brown, Terry, Campbell, Ian B, Chessell, Iain P, Clayton, Nick, Collins, Sue D, Davey, Philip T, Goodland, Helen, Gray, Norman, Haslam, Claudine, Hatcher, Jonathan P, Hunter, A Jacqueline, Lucas, Fiona, Murkitt, Graham, Naylor, Alan, Pickup, Elizabeth, Sargent, Becky, Summerfield, Scott G, Stevens, Alexander, Stratton, Sharon C, Wiseman, Joanne
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
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Journal Article
Vanilloid receptor 1 (TRPV1) expression in lingual nerve neuromas from patients with or without symptoms of burning pain
Biggs, James E, Yates, Julian M, Loescher, Alison R, Clayton, Nick M, Boissonade, Fiona M, Robinson, Peter P
Published in Brain research (05.01.2007)
Published in Brain research (05.01.2007)
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The effects of ibuprofen and the neurokinin-1 receptor antagonist GR205171A on Fos expression in the ferret trigeminal nucleus following tooth pulp stimulation
Worsley, Matthew A, Clayton, Nick M, Bountra, Chas, Boissonade, Fiona M
Published in European journal of pain (01.04.2008)
Published in European journal of pain (01.04.2008)
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Journal Article
The effect of inflammation on Fos expression in the ferret trigeminal nucleus
Worsley, Matthew A., Davies, Shelley L., Clayton, Nick M., Bountra, Chas, Loescher, Alison R., Robinson, Peter P., Boissonade, Fiona M.
Published in European journal of oral sciences (01.02.2007)
Published in European journal of oral sciences (01.02.2007)
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nNOS expression following inferior alveolar nerve injury in the ferret
Davies, Shelley L., Loescher, Alison R., Clayton, Nick M., Bountra, Chas, Robinson, Peter P., Boissonade, Fiona M.
Published in Brain research (19.11.2004)
Published in Brain research (19.11.2004)
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