Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma
Apollonio, Benedetta, Spada, Filomena, Petrov, Nedyalko, Cozzetto, Domenico, Papazoglou, Despoina, Jarvis, Peter, Kannambath, Shichina, Terranova-Barberio, Manuela, Amini, Rose-Marie, Enblad, Gunilla, Graham, Charlotte, Benjamin, Reuben, Phillips, Elisabeth, Ellis, Richard, Nuamah, Rosamond, Saqi, Mansoor, Calado, Dinis P, Rosenquist, Richard, Sutton, Lesley A, Salisbury, Jon, Zacharioudakis, Georgios, Vardi, Anna, Hagner, Patrick R, Gandhi, Anita K, Bacac, Marina, Claus, Christina, Umana, Pablo, Jarrett, Ruth F, Klein, Christian, Deutsch, Alexander, Ramsay, Alan G
Published in The Journal of clinical investigation (03.07.2023)
Published in The Journal of clinical investigation (03.07.2023)
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Journal Article
CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies
Al Sayed, Mohamad F., Ruckstuhl, Carla A., Hilmenyuk, Tamara, Claus, Christina, Bourquin, Jean-Pierre, Bornhauser, Beat C., Radpour, Ramin, Riether, Carsten, Ochsenbein, Adrian F.
Published in Blood (20.07.2017)
Published in Blood (20.07.2017)
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Journal Article
Abstract 6135: Tumor-bearing non-human primates: An unrivaled model for translational cancer immunology research
Ceppi, Maurizio, Hettich, Michael, Teichgräber, Volker, Driessen, Wouter, Tuerck, Dietrich, Marrer-Berger, Estelle, Evers, Stefan, Crameri, Flavio, Gomes, Bruno, Bachl, Jürgen, Klein, Christian, Claus, Christina, Amann, Maria, Krieter, Oliver, Dugan, Greg, Caudell, David, Grayson, Jason, Kiran, Sai Kumar Solingapuram, Cline, Mark
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
A model‐based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno‐oncology
Sánchez, Javier, Claus, Christina, Albrecht, Rosmarie, Gaillard, Brenda C., Marinho, Joana, McIntyre, Christine, Tanos, Tamara, Boehnke, Axel, Friberg, Lena E., Jönsson, Siv, Frances, Nicolas
Published in CPT: pharmacometrics and systems pharmacology (01.11.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.11.2023)
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Journal Article
Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer
Trüb, Marta, Uhlenbrock, Franziska, Claus, Christina, Herzig, Petra, Thelen, Martin, Karanikas, Vaios, Bacac, Marina, Amann, Maria, Albrecht, Rosemarie, Ferrara-Koller, Claudia, Thommen, Daniela, Rothschield, Sacha, Savic Prince, Spasenija, Mertz, Kirsten D, Cathomas, Gieri, Rosenberg, Robert, Heinzelmann-Schwarz, Viola, Wiese, Mark, Lardinois, Didier, Umana, Pablo, Klein, Christian, Laubli, Heinz, Kashyap, Abhishek S, Zippelius, Alfred
Published in Journal for immunotherapy of cancer (01.07.2020)
Published in Journal for immunotherapy of cancer (01.07.2020)
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Journal Article
P1211: TUMOR‐ACTIVATED LYMPH NODE FIBROBLASTS SUPPRESS T CELL FUNCTION IN DIFFUSE LARGE B CELL LYMPHOMA
Apollonio, Benedetta, Spada, Filomena, Petrov, Nedyalko, Cozzetto, Domenico, Jarvis, Peter, Papazoglou, Despoina, Kannambath, Shichina, Terranova‐Barberio, Manuela, Amini, Rose‐Marie, Enblad, Gunilla, Graham, Charlotte, Benjamin, Reuben, Phillips, Elizabeth H., Ellis, Richard, Nuamah, Rosamond, Saqi, Mansoor, Calado, Dinis, Rosenquist, Richard, Ann Sutton, Lesley, Salisbury, Jon, Zacharioudakis, Georgios, Vardi, Anna, Hagner, Patrick, Gandhi, Anita, Bacac, Marina, Claus, Christina, Umana, Pablo, Jarrett, Ruth, Klein, Christian, Deutsch, Alexander, Ramsay, Alan
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Journal Article
370 Pharmacodynamic assessment of a novel FAP-targeted 4–1BB agonist, administered as single agent and in combination with atezolizumab to patients with advanced solid tumors
Moreno, Victor, Hernandez, Tatiana, Melero, Ignacio, Sanmamed, Miguel, Spanggaard, Iben, Rohrberg, Kristoffer Staal, Tabernero, Josep, Azaro, Analia, Garcia, Maria Martinez, Rodriguez-Vida, Alejo, Claus, Christina, Heil, Florian, Krieter, Oliver, Grimm, Oliver, Canamero, Marta, Duarte, Jose, Nica, Alexandra-Cristina, Davydov, Iakov, Hettich, Michael, Ooi, Chia-Huey, Heichinger, Christian, Guarin, Ernesto, Helbaj, Radoiane, Tanos, Tamara, Nueesch, Eveline, Ceppi, Maurizio, Moreno, Irene, Calvo, Emiliano
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Destruction of lymphoid organ architecture and hepatitis caused by CD4+ T cells
Matter, Matthias S, Hilmenyuk, Tamara, Claus, Christina, Marone, Romina, Schürch, Christian, Tinguely, Marianne, Terracciano, Luigi, Luther, Sanjiv A, Ochsenbein, Adrian F
Published in PloS one (23.09.2011)
Published in PloS one (23.09.2011)
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Journal Article
Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy
Claus, Christina, Ferrara, Claudia, Xu, Wei, Sam, Johannes, Lang, Sabine, Uhlenbrock, Franziska, Albrecht, Rosmarie, Herter, Sylvia, Schlenker, Ramona, Hüsser, Tamara, Diggelmann, Sarah, Challier, John, Mössner, Ekkehard, Hosse, Ralf J, Hofer, Thomas, Brünker, Peter, Joseph, Catherine, Benz, Jörg, Ringler, Philippe, Stahlberg, Henning, Lauer, Matthias, Perro, Mario, Chen, Stanford, Küttel, Christine, Bhavani Mohan, Preethi L, Nicolini, Valeria, Birk, Martina Carola, Ongaro, Amandine, Prince, Christophe, Gianotti, Reto, Dugan, Gregory, Whitlow, Christopher T, Solingapuram Sai, Kiran Kumar, Caudell, David L, Burgos-Rodriguez, Armando G, Cline, J Mark, Hettich, Michael, Ceppi, Maurizio, Giusti, Anna Maria, Crameri, Flavio, Driessen, Wouter, Morcos, Peter N, Freimoser-Grundschober, Anne, Levitsky, Victor, Amann, Maria, Grau-Richards, Sandra, von Hirschheydt, Thomas, Tournaviti, Stella, Mølhøj, Michael, Fauti, Tanja, Heinzelmann-Schwarz, Viola, Teichgräber, Volker, Colombetti, Sara, Bacac, Marina, Zippelius, Alfred, Klein, Christian, Umaña, Pablo
Published in Science translational medicine (12.06.2019)
Published in Science translational medicine (12.06.2019)
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Journal Article
Augmenting Efficacy of T-Cell Bispecific Antibodies in AML through a Tumor Stroma-Targeted 4-1BB Agonist
Hänel, Gerulf, Neumann, Anne-Sophie, Pulko, Vesna, Claus, Christina, Leutbecher, Alexandra, Marcinek, Anetta, Zieger, Nora, Buecklein, Veit L, Umana, Pablo, Klein, Christian, Subklewe, Marion
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
RG6076 (CD19-4-1BBL): CD19-Targeted 4-1BB Ligand Combination with Glofitamab As an Off-the-Shelf, Enhanced T-Cell Redirection Therapy for B-Cell Malignancies
Herter, Sylvia, Sam, Johannes, Ferrara Koller, Claudia, Diggelmann, Sarah, Bommer, Esther, Schönle, Anne, Claus, Christina, Bacac, Marina, Klein, Christian, Umana, Pablo
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
CD19-CD28: an affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy
Sam, Johannes, Hofer, Thomas, Kuettel, Christine, Claus, Christina, Thom, Jenny, Herter, Sylvia, Georges, Guy, Korfi, Koorosh, Lechmann, Martin, Eigenmann, Miro Julian, Marbach, Daniel, Jamois, Candice, Lechner, Katharina, Krishnan, Sreenath M., Gaillard, Brenda, Marinho, Joana, Kronenberg, Sven, Kunz, Leo, Wilson, Sabine, Briner, Stefanie, Gebhardt, Samuel, Varol, Ahmet, Appelt, Birte, Nicolini, Valeria, Speziale, Dario, Bez, Miriam, Bommer, Esther, Eckmann, Jan, Hage, Carina, Limani, Florian, Jenni, Silvia, Schoenle, Anne, Le Clech, Marine, Vallier, Jean-Baptiste Pierre, Colombetti, Sara, Bacac, Marina, Gasser, Stephan, Klein, Christian, Umaña, Pablo
Published in Blood (23.05.2024)
Published in Blood (23.05.2024)
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Journal Article
RG6333 (CD19-CD28), a CD19-Targeted Affinity-Optimized CD28 Bispecific Antibody, Enhances and Prolongs the Anti-Tumor Activity of Glofitamab (CD20-TCB) in Preclinical Models
Sam, Johannes, Hofer, Thomas, Kuettel, Christine, Claus, Christina, Herter, Sylvia, Georges, Guy, Thom, Jenny Tosca, Kunz, Leo, Gebhardt, Samuel, Limani, Florian, Briner, Stefanie, Jenni, Silvia, Schönle, Anne, Le Clech, Marine, Varol, Ahmet, Bommer, Esther, Appelt, Birte, Colombetti, Sara, Gasser, Stephan, Bacac, Marina, Klein, Christian, Umana, Pablo
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
새로운 4-1BBL 삼량체-함유 항원 결합 분자
FERRARA KOLLER CLAUDIA, KLEIN CHRISTIAN, UMANA PABLO, CLAUS CHRISTINA
Year of Publication 02.08.2022
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Year of Publication 02.08.2022
Patent
Abstract LB-389: Combination of TYRP1-TCB, a novel T cell bispecific antibody for the treatment of melanoma, with immunomodulatory agents
Nicolini, Valeria G., Waldhauer, Inja, Freimoser-Grundschober, Anne, Richard, Marine, Fahrni, Linda, Bommer, Esther, Claus, Christina, Sam, Johannes, Colombetti, Sara, Sutmuller, Roger, Levesque, Mitchell P., Irmisch, Anja, Bleul, Conrad, Campbell, Neil, Bacac, Marina, Moessner, Ekkehard, Klein, Christian, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 957: Design of CD19-4-1BBL, a novel CD19-targeted 4-1BB ligand for combination therapy with CD20 T-cell bispecific antibodies and CD20 antibodies
Xu, Wei, Sam, Johannes, Perro, Mario, Challier, John, Claus, Christina, Chen, Stanford, Koller, Claudia Ferrara, Mølhøj, Michael, Tournaviti, Stella, Bacac, Marina, Moore, Tom, Klein, Christian, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 5621: FAP-4-1BBL: A novel versatile tumor-stroma targeted 4-1BB agonist for combination immunotherapy with checkpoint inhibitors, T-cell bispecific antibodies, and ADCC-mediating antibodies
Sam, Johannes, Claus, Christina, Ferrara, Claudia, Lang, Sabine, Nicolini, Valeria, Colombetti, Sara, Teichgräber, Volker, Evers, Stefan, Bacac, Marina, Umana, Pablo, Klein, Christian
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 1129: Monitoring intratumoral CD8 T cell infiltrates in human stem cell engrafted mice during single agent and combination immunotherapy with T cell bispecific antibodies using the human PET-tracer 89Zr-Df-IAB22M2C
Griessinger, Christoph M., Mascioni, Alessandro, Jia, Fang, Torgov, Michael, Nayak, Tapan, Mohan, Preethi Latha Bhavani, Nicolini, Valeria G., Sam, Johannes, Claus, Christina, Ferrara-Koller, Claudia, Bacac, Marina, Umana, Pablo, Wilson, Ian, Klein, Christian, Tessier, Jean J.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article