Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality
Beauparlant, David, Rusert, Peter, Magnus, Carsten, Kadelka, Claus, Weber, Jacqueline, Uhr, Therese, Zagordi, Osvaldo, Oberle, Corinna, Duenas-Decamp, Maria J, Clapham, Paul R, Metzner, Karin J, Günthard, Huldrych F, Trkola, Alexandra
Published in PLoS pathogens (06.03.2017)
Published in PLoS pathogens (06.03.2017)
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Macrophages in Vaginal but Not Intestinal Mucosa Are Monocyte-Like and Permissive to Human Immunodeficiency Virus Type 1 Infection
RUIZHONG SHEN, RICHTER, Holly E, SMITH, Phillip D, CLEMENTS, Ronald H, NOVAK, Lea, HUFF, Kayci, BIMCZOK, Diane, SANKARAN-WALTERS, Sumathi, DANDEKAR, Satya, CLAPHAM, Paul R, SMYTHIES, Lesley E
Published in Journal of Virology (01.04.2009)
Published in Journal of Virology (01.04.2009)
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Gag Regulates Association of Human Immunodeficiency Virus Type 1 Envelope with Detergent-Resistant Membranes
BHATTACHARYA, Jayanta, REPIK, Alexander, CLAPHAM, Paul R
Published in Journal of Virology (01.06.2006)
Published in Journal of Virology (01.06.2006)
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A Conserved Determinant in the V1 Loop of HIV-1 Modulates the V3 Loop To Prime Low CD4 Use and Macrophage Infection
Musich, Thomas, Peters, Paul J, Duenas-Decamp, Maria José, Gonzalez-Perez, Maria Paz, Robinson, James, Zolla-Pazner, Susan, Ball, Jonathan K, Luzuriaga, Katherine, Clapham, Paul R
Published in Journal of Virology (01.03.2011)
Published in Journal of Virology (01.03.2011)
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Natural Resistance of Human Immunodeficiency Virus Type 1 to the CD4bs Antibody b12 Conferred by a Glycan and an Arginine Residue Close to the CD4 Binding Loop
DUENAS-DECAMP, Maria José, PETERS, Paul, BURTON, Dennis, CLAPHAM, Paul R
Published in Journal of Virology (01.06.2008)
Published in Journal of Virology (01.06.2008)
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Biological Analysis of Human Immunodeficiency Virus Type 1 R5 Envelopes Amplified from Brain and Lymph Node Tissues of AIDS Patients with Neuropathology Reveals Two Distinct Tropism Phenotypes and Identifies Envelopes in the Brain That Confer an Enhanced Tropism and Fusigenicity for Macrophages
PETERS, Paul J, BHATTACHARYA, Jayanta, HIBBITTS, Samantha, DITTMAR, Matthias T, SIMMONS, Graham, BELL, Jeanne, SIMMONDS, Peter, CLAPHAM, Paul R
Published in Journal of Virology (01.07.2004)
Published in Journal of Virology (01.07.2004)
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Intercompartmental Recombination of HIV-1 Contributes to env Intrahost Diversity and Modulates Viral Tropism and Sensitivity to Entry Inhibitors
BROWN, Richard J. P, PETERS, Paul J, SHARP, Paul M, CLAPHAM, Paul R, BALL, Jonathan K, CARON, Catherine, PAZ GONZALEZ-PEREZ, Maria, STONES, Leanne, ANKGHUAMBOM, Chiambah, PONDEI, Kemebradikumo, PATRICK MCCLURE, C, ALEMNJI, George, TAYLOR, Stephen
Published in Journal of Virology (01.06.2011)
Published in Journal of Virology (01.06.2011)
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Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages
Shen, Ruizhong, Meng, Gang, Ochsenbauer, Christina, Clapham, Paul R, Grams, Jayleen, Novak, Lea, Kappes, John C, Smythies, Lesley E, Smith, Phillip D
Published in PLoS pathogens (01.05.2011)
Published in PLoS pathogens (01.05.2011)
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Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue
Gonzalez-Perez, Maria Paz, O'Connell, Olivia, Lin, Rongheng, Sullivan, W Matthew, Bell, Jeanne, Simmonds, Peter, Clapham, Paul R
Published in Retrovirology (15.03.2012)
Published in Retrovirology (15.03.2012)
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Non-Macrophage-Tropic Human Immunodeficiency Virus Type 1 R5 Envelopes Predominate in Blood, Lymph Nodes, and Semen: Implications for Transmission and Pathogenesis
PETERS, Paul J, MATTHEW SULLIVAN, W, CLAPHAM, Paul R, DUENAS-DECAMP, Maria J, BHATTACHARYA, Jayanta, ANKGHUAMBOM, Chiambah, BROWN, Richard, LUZURIAGA, Katherine, BELL, Jeanne, SIMMONDS, Peter, BALL, Jonathan
Published in Journal of Virology (01.07.2006)
Published in Journal of Virology (01.07.2006)
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Genotypic and functional properties of early infant HIV-1 envelopes
Kishko, Michael, Somasundaran, Mohan, Brewster, Frank, Sullivan, John L, Clapham, Paul R, Luzuriaga, Katherine
Published in Retrovirology (15.08.2011)
Published in Retrovirology (15.08.2011)
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Efficiency of Bridging-Sheet Recruitment Explains HIV-1 R5 Envelope Glycoprotein Sensitivity to Soluble CD4 and Macrophage Tropism
O'Connell, Olivia, Repik, Alexander, Reeves, Jacqueline D, Gonzalez-Perez, Maria Paz, Quitadamo, Briana, Anton, Elizabeth D, Duenas-Decamp, Maria, Peters, Paul, Lin, Rongheng, Zolla-Pazner, Susan, Corti, Davide, Wallace, Aaron, Wang, Shixia, Kong, Xiang-Peng, Lu, Shan, Clapham, Paul R
Published in Journal of Virology (01.01.2013)
Published in Journal of Virology (01.01.2013)
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Human Immunodeficiency Virus Type 1 Envelope Glycoproteins That Lack Cytoplasmic Domain Cysteines: Impact on Association with Membrane Lipid Rafts and Incorporation onto Budding Virus Particles
BHATTACHARYA, Jayanta, PETERS, Paul J, CLAPHAM, Paul R
Published in Journal of Virology (01.05.2004)
Published in Journal of Virology (01.05.2004)
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Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist
Simmons, Graham, Clapham, Paul R., Picard, Laurent, Offord, Robin E., Rosenkilde, Mette M., Schwartz, Thue W., Buser, Raphaële, Timothy N. C. Wells, Amanda E. I. Proudfoot
Published in Science (American Association for the Advancement of Science) (11.04.1997)
Published in Science (American Association for the Advancement of Science) (11.04.1997)
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