Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent
Li, Qun, Woods, Keith W., Claiborne, Akiyo, Gwaltney, II, Stephen L., Barr, Kenneth J., Liu, Gang, Gehrke, Laura, Credo, R.Bruce, Hui, Yu Hua, Lee, Jang, Warner, Robert B., Kovar, Peter, Nukkala, Michael A., Zielinski, Nicolette A., Tahir, Stephen K., Fitzgerald, Michael, Kim, Ki H., Marsh, Kennan, Frost, David, Ng, Shi-Chung, Rosenberg, Saul, Sham, Hing L.
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Get full text
Journal Article
New Antimitotic Agents with Activity in Multi-Drug-Resistant Cell Lines and in Vivo Efficacy in Murine Tumor Models
Szczepankiewicz, Bruce G, Liu, Gang, Jae, Hwan-Soo, Tasker, Andrew S, Gunawardana, Indrani W, von Geldern, Thomas W, Gwaltney, Stephen L, Wu-Wong, J. Ruth, Gehrke, Laura, Chiou, William J, Credo, R. Bruce, Alder, Jeffery D, Nukkala, Michael A, Zielinski, Nicolette A, Jarvis, Ken, Mollison, Karl W, Frost, David J, Bauch, Joy L, Hui, Yu Hua, Claiborne, Akiyo K, Li, Qun, Rosenberg, Saul H
Published in Journal of medicinal chemistry (06.12.2001)
Published in Journal of medicinal chemistry (06.12.2001)
Get full text
Journal Article
Biological Activity of A-289099: An Orally Active Tubulin-binding Indolyloxazoline Derivative
Tahir, Stephen K, Nukkala, Michael A, Zielinski Mozny, Nicolette A, Credo, R Bruce, Warner, Robert B, Li, Qun, Woods, Keith W, Claiborne, Akiyo, Gwaltney, 2nd, Stephen L, Frost, David J, Sham, Hing L, Rosenberg, Saul H, Ng, Shi-Chung
Published in Molecular cancer therapeutics (01.03.2003)
Get full text
Published in Molecular cancer therapeutics (01.03.2003)
Journal Article
Synthesis and Structure−Activity Relationships of 2-Pyridones: A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents
Li, Qun, Chu, Daniel T. W, Claiborne, Akiyo, Cooper, Curt S, Lee, Cheuk M, Raye, Kathleen, Berst, Kristine B, Donner, Pamela, Wang, Weibo, Hasvold, Lisa, Fung, Anthony, Ma, Zhenkun, Tufano, Michael, Flamm, Robert, Shen, Linus L, Baranowski, John, Nilius, Angela, Alder, Jeff, Meulbroek, Jonathan, Marsh, Kennan, Crowell, DeAnne, Hui, Yuhua, Seif, Louis, Melcher, Laura M, Henry, Rodger, Spanton, Steven, Faghih, Ramin, Klein, Larry L, Tanaka, S. Ken, Plattner, Jacob J
Published in Journal of medicinal chemistry (02.08.1996)
Published in Journal of medicinal chemistry (02.08.1996)
Get full text
Journal Article
Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents
Chu, Daniel T. W, Fernandes, Prabhavathi B, Claiborne, Akiyo K, Pihuleac, Eva, Nordeen, Carl W, Maleczka, Robert E, Pernet, Andre G
Published in Journal of medicinal chemistry (01.11.1985)
Published in Journal of medicinal chemistry (01.11.1985)
Get full text
Journal Article
Practical synthesis of 2-pyridone core: Ethyl 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizinone-3-carboxylate
Li, Q, Sowin, T, Claiborne, A, Lijewski, L, Zhang, XL, Raye, K, Mazdiyasni, H, Arnold, W, Melcher, LM, Wang, WB, Hasvold, L, Fung, A, Chu, DTW, Plattner, JJ
Published in Heterocycles (01.06.1999)
Published in Heterocycles (01.06.1999)
Get more information
Journal Article
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors
Woods, Keith W., Fischer, John P., Claiborne, Akiyo, Li, Tongmei, Thomas, Sheela A., Zhu, Gui-Dong, Diebold, Robert B., Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Han, Edward K., Guan, Ran, Magnone, Shayna R., Johnson, Eric F., Bouska, Jennifer J., Olson, Amanda M., Jong, Ron de, Oltersdorf, Tilman, Luo, Yan, Rosenberg, Saul H., Giranda, Vincent L., Li, Qun
Published in Bioorganic & medicinal chemistry (15.10.2006)
Published in Bioorganic & medicinal chemistry (15.10.2006)
Get full text
Journal Article
Discovery of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors
Tong, Yunsong, Claiborne, Akiyo, Stewart, Kent D., Park, Chang, Kovar, Peter, Chen, Zehan, Credo, Robert B., Gu, Wen-Zhen, Gwaltney, Stephen L., Judge, Russell A., Zhang, Haiying, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-horng
Published in Bioorganic & medicinal chemistry (01.04.2007)
Published in Bioorganic & medicinal chemistry (01.04.2007)
Get full text
Journal Article
Isoquinoline–pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity
Zhu, Gui-Dong, Gong, Jianchun, Claiborne, Akiyo, Woods, Keith W., Gandhi, Viraj B., Thomas, Sheela, Luo, Yan, Liu, Xuesong, Shi, Yan, Guan, Ran, Magnone, Shayna R., Klinghofer, Vered, Johnson, Eric F., Bouska, Jennifer, Shoemaker, Alexander, Oleksijew, Anatol, Stoll, Vincent S., Jong, Ron De, Oltersdorf, Tilman, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L.
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Get full text
Journal Article
An alternative synthesis of temafloxacin, a potent antibacterial agent
Chu, Daniel T. W, Lico, Isabella M, Claiborne, Akiyo K, Faubl, Hermann
Published in Canadian journal of chemistry (01.05.1992)
Published in Canadian journal of chemistry (01.05.1992)
Get full text
Journal Article
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors
Li, Qun, Woods, Keith W., Wang, Weibo, Lin, Nan-Horng, Claiborne, Akiyo, Gu, Wen-zhen, Cohen, Jerry, Stoll, Vincent S., Hutchins, Charles, Frost, David, Rosenberg, Saul H., Sham, Hing L.
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Get full text
Journal Article
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors
QUN LI, CLAIBORNE, Akiyo, FROST, David, ROSENBERG, Saul H, SHAM, Hing L, TONGMEI LI, HASVOLD, Lisa, STOLL, Vincent S, MUCHMORE, Steven, JAKOB, Clarissa G, GU, Wendy, COHEN, Jerry, HUTCHINS, Charles
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Get full text
Journal Article
1,4-Dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies
Tong, Yunsong, Claiborne, Akiyo, Pyzytulinska, Magdalena, Tao, Zhi-Fu, Stewart, Kent D., Kovar, Peter, Chen, Zehan, Credo, Robert B., Guan, Ran, Merta, Philip J., Zhang, Haiying, Bouska, Jennifer, Everitt, Elizabeth A., Murry, Bernard P., Hickman, Dean, Stratton, Tim J., Wu, Jian, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-horng
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Get full text
Journal Article
Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability
Tong, Yunsong, Przytulinska, Magdalena, Tao, Zhi-Fu, Bouska, Jennifer, Stewart, Kent D., Park, Chang, Li, Gaoquan, Claiborne, Akiyo, Kovar, Peter, Chen, Zehan, Merta, Philip J., Bui, Mai-Ha, Olson, Amanda, Osterling, Donald, Zhang, Haiying, Sham, Hing L., Rosenberg, Saul H., Sowin, Thomas J., Lin, Nan-horng
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Get full text
Journal Article
L,4 -dihydroindeno[1,2 -c ]pyrazoles as potent checkpoint kinase 1 inhibitors : Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies
YUNSONG TONG, CLAIBORNE, Akiyo, HAIYING ZHANG, BOUSKA, Jennifer, EVERITT, Elizabeth A, MURRY, Bernard P, HICKMAN, Dean, STRATTON, Tim J, JIAN WU, ROSENBERG, Saul H, SHAM, Hing L, SOWIN, Thomas J, PYZYTULINSKA, Magdalena, LIN, Nan-Horng, TAO, Zhi-Fu, STEWART, Kent D, KOVAR, Peter, ZEHAN CHEN, CREDO, Robert B, RAN GUAN, MERTA, Philip J
Published in Bioorganic & medicinal chemistry letters (2007)
Get full text
Published in Bioorganic & medicinal chemistry letters (2007)
Journal Article
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors
QUN LI, WANG, Gary T, HUTCHINS, Charles, FROST, David, ROSENBERG, Saul H, SHAM, Hing L, TONGMEI LI, GWALTNEY, Stephen L, WOODS, Keith W, CLAIBORNE, Akiyo, XILU WANG, WENDY GU, COHEN, Jerry, STOLL, Vincent S
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Get full text
Journal Article
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents
Li, Qun, Wang, Weibo, Berst, Kristine B., Claiborne, Akiyo, Hasvold, Lisa, Raye, Kathleen, Tufano, Michael, Nilius, Angela, Shen, Linus L., Flamm, Robert, Alder, Jeff, Marsh, Kennan, Crowell, DeAnne, Chu, Daniel T.W., Plattner, Jacob J.
Published in Bioorganic & medicinal chemistry letters (04.08.1998)
Published in Bioorganic & medicinal chemistry letters (04.08.1998)
Get full text
Journal Article
A practical stereoselective synthesis of ( 2S, 4S)-4- tert-butoxycarbonylamino-2-methylpyrrolidine
Li, Qun, Chu, Daniel T.W., Raye, Kathleen, Claiborne, Akiyo, Seif, Louis, Macri, Bryan, Plattner, Jacob J.
Published in Tetrahedron letters (13.11.1995)
Published in Tetrahedron letters (13.11.1995)
Get full text
Journal Article