Inhibition of mutation and combating the evolution of antibiotic resistance
Cirz, Ryan T, Chin, Jodie K, Andes, David R, de Crécy-Lagard, Valérie, Craig, William A, Romesberg, Floyd E
Published in PLoS biology (01.06.2005)
Published in PLoS biology (01.06.2005)
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Journal Article
Small-molecule sensitization of RecBCD helicase–nuclease to a Chi hotspot-activated state
Karabulut, Ahmet C, Cirz, Ryan T, Taylor, Andrew F, Smith, Gerald R
Published in Nucleic acids research (20.08.2020)
Published in Nucleic acids research (20.08.2020)
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Journal Article
Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa
Krause, Kevin M, Haglund, Cat M, Hebner, Christy, Serio, Alisa W, Lee, Grace, Nieto, Vincent, Cohen, Frederick, Kane, Timothy R, Machajewski, Timothy D, Hildebrandt, Darrin, Pillar, Chris, Thwaites, Mary, Hall, Danielle, Miesel, Lynn, Hackel, Meredith, Burek, Amanda, Andrews, Logan D, Armstrong, Eliana, Swem, Lee, Jubb, Adrian, Cirz, Ryan T
Published in Antimicrobial agents and chemotherapy (01.11.2019)
Published in Antimicrobial agents and chemotherapy (01.11.2019)
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Journal Article
Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase
Andrews, Logan D, Kane, Timothy R, Dozzo, Paola, Haglund, Cat M, Hilderbrandt, Darin J, Linsell, Martin S, Machajewski, Timothy, McEnroe, Glen, Serio, Alisa W, Wlasichuk, Kenneth B, Neau, David B, Pakhomova, Svetlana, Waldrop, Grover L, Sharp, Marc, Pogliano, Joe, Cirz, Ryan T, Cohen, Frederick
Published in Journal of medicinal chemistry (22.08.2019)
Published in Journal of medicinal chemistry (22.08.2019)
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Journal Article
Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety
Cohen, Frederick, Aggen, James B., Andrews, Logan D., Assar, Zahra, Boggs, Jen, Choi, Taylor, Dozzo, Paola, Easterday, Ashton N., Haglund, Cat M., Hildebrandt, Darin J., Holt, Melissa C., Joly, Kristin, Jubb, Adrian, Kamal, Zeeshan, Kane, Timothy R., Konradi, Andrei W., Krause, Kevin M., Linsell, Martin S., Machajewski, Timothy D., Miroshnikova, Olga, Moser, Heinz E., Nieto, Vincent, Phan, Thu, Plato, Craig, Serio, Alisa W., Seroogy, Julie, Shakhmin, Anton, Stein, Adam J., Sun, Alex D., Sviridov, Serguei, Wang, Zhan, Wlasichuk, Kenneth, Yang, Wen, Zhou, Xiaoming, Zhu, Hai, Cirz, Ryan T.
Published in ChemMedChem (20.08.2019)
Published in ChemMedChem (20.08.2019)
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Journal Article
Controlling Mutation: Intervening in Evolution as a Therapeutic Strategy
Cirz, Ryan T., Romesberg, Floyd E.
Published in Critical reviews in biochemistry and molecular biology (01.09.2007)
Published in Critical reviews in biochemistry and molecular biology (01.09.2007)
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Journal Article
Exploring the active site of the Streptococcus pneumoniae topoisomerase IV–DNA cleavage complex with novel 7,8-bridged fluoroquinolones
Laponogov, Ivan, Pan, Xiao-Su, Veselkov, Dennis A., Cirz, Ryan T., Wagman, Allan, Moser, Heinz E., Fisher, L. Mark, Sanderson, Mark R.
Published in Open biology (01.09.2016)
Published in Open biology (01.09.2016)
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Journal Article
Structural and Initial Biological Analysis of Synthetic Arylomycin A2
Roberts, Tucker C, Smith, Peter A, Cirz, Ryan T, Romesberg, Floyd E
Published in Journal of the American Chemical Society (26.12.2007)
Published in Journal of the American Chemical Society (26.12.2007)
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Journal Article
Unraveling the Gentamicin Drug Product Complexity Reveals Variation in Microbiological Activities and Nephrotoxicity
Bulman, Zackery P, Cirz, Ryan, Hildebrandt, Darin, Kane, Tim, Rosario, Zuelay, Wlasichuk, Ken, Park, Minjong, Andrews, Logan D
Published in Antimicrobial agents and chemotherapy (20.08.2020)
Published in Antimicrobial agents and chemotherapy (20.08.2020)
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Journal Article
Structural and initial biological analysis of synthetic arylomycin A(2)
Roberts, Tucker C., Smith, Peter A., Cirz, Ryan T., Romesberg, Floyd E.
Published in Journal of the American Chemical Society (26.12.2007)
Published in Journal of the American Chemical Society (26.12.2007)
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Journal Article
Interaction of Drug- and Granulocyte-Mediated Killing of Pseudomonas aeruginosa in a Murine Pneumonia Model
Drusano, George Louis, Liu, Weiguo, Fikes, Steven, Cirz, Ryan, Robbins, Nichole, Kurhanewicz, Stephanie, Rodriquez, Jaime, Brown, David, Baluya, Dodge, Louie, Arnold
Published in The Journal of infectious diseases (15.10.2014)
Published in The Journal of infectious diseases (15.10.2014)
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Journal Article
Structural and Initial Biological Analysis of Synthetic Arylomycin A 2
Roberts, Tucker C., Smith, Peter A., Cirz, Ryan T., Romesberg, Floyd E.
Published in Journal of the American Chemical Society (26.12.2007)
Published in Journal of the American Chemical Society (26.12.2007)
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Journal Article
Natural History of Francisella tularensis in Aerosol-Challenged BALB/c Mice
Heine, Henry S, Chuvala, Lara, Riggins, Renaldo, Cirz, Ryan, Cass, Robert, Louie, Arnold, Drusano, G L
Published in Antimicrobial agents and chemotherapy (01.03.2016)
Published in Antimicrobial agents and chemotherapy (01.03.2016)
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Journal Article
Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones
Wagman, Allan S., Cirz, Ryan, McEnroe, Glenn, Aggen, James, Linsell, Martin S., Goldblum, Adam A., Lopez, Sara, Gomez, Marcela, Miller, George, Simons, Lloyd J., Belliotti, Thomas R., Harris, Christina R., Poel, Toni‐Jo, Melnick, Michael J., Gaston, Ricky D., Moser, Heinz E.
Published in ChemMedChem (20.10.2017)
Published in ChemMedChem (20.10.2017)
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