Discovery of 2‑[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro‑1H‑isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP‑1 Inhibitor for Cancer Therapy
Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Journal Article
PARP inhibitors in cancer therapy: an update
Papeo, Gianluca, Casale, Elena, Montagnoli, Alessia, Cirla, Alessandra
Published in Expert opinion on therapeutic patents (01.04.2013)
Published in Expert opinion on therapeutic patents (01.04.2013)
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Journal Article
Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding
Menichincheri, Maria, Albanese, Clara, Alli, Cristina, Ballinari, Dario, Bargiotti, Alberto, Caldarelli, Marina, Ciavolella, Antonella, Cirla, Alessandra, Colombo, Maristella, Colotta, Francesco, Croci, Valter, D’Alessio, Roberto, D’Anello, Matteo, Ermoli, Antonella, Fiorentini, Francesco, Forte, Barbara, Galvani, Arturo, Giordano, Patrizia, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Moll, Jürgen K, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Vianello, Paola, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes
Published in Journal of medicinal chemistry (28.10.2010)
Published in Journal of medicinal chemistry (28.10.2010)
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Journal Article
Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships
Vanotti, Ermes, Amici, Raffaella, Bargiotti, Alberto, Berthelsen, Jens, Bosotti, Roberta, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, D’Alessio, Roberto, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Menichincheri, Maria, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Pillan, Antonio, Roletto, Fulvia, Scolaro, Alessandra, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Journal Article
First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery
Menichincheri, Maria, Bargiotti, Alberto, Berthelsen, Jens, Bertrand, Jay A, Bossi, Roberto, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, Croci, Valter, D’Alessio, Roberto, Fasolini, Marina, Fiorentini, Francesco, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pezzetta, Daniele, Pillan, Antonio, Poggesi, Italo, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Alkylsulfanyl-1,2,4-triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure–Activity Relationships
Polucci, Paolo, Magnaghi, Paola, Angiolini, Mauro, Asa, Daniela, Avanzi, Nilla, Badari, Alessandra, Bertrand, Jay, Casale, Elena, Cauteruccio, Silvia, Cirla, Alessandra, Cozzi, Liviana, Galvani, Arturo, Jackson, Peter K, Liu, Yichin, Magnuson, Steven, Malgesini, Beatrice, Nuvoloni, Stefano, Orrenius, Christian, Sirtori, Federico Riccardi, Riceputi, Laura, Rizzi, Simona, Trucchi, Beatrice, O’Brien, Tom, Isacchi, Antonella, Donati, Daniele, D’Alessio, Roberto
Published in Journal of medicinal chemistry (24.01.2013)
Published in Journal of medicinal chemistry (24.01.2013)
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Journal Article
Discovery of Stereospecific PARP‑1 Inhibitor Isoindolinone NMS-P515
Papeo, Gianluca, Orsini, Paolo, Avanzi, Nilla R, Borghi, Daniela, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Desperati, Viviana, Donati, Daniele, Felder, Eduard R, Galvani, Arturo, Guanci, Marco, Isacchi, Antonella, Posteri, Helena, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Montagnoli, Alessia
Published in ACS medicinal chemistry letters (11.04.2019)
Published in ACS medicinal chemistry letters (11.04.2019)
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Journal Article
Abstract 4785: NMS-E668, a highly potent orally available RET inhibitor with selectivity towards VEGFR2 and demonstrated antitumor efficacy in multiple RET-driven cancer models
Ardini, Elena, Banfi, Patrizia, Avanzi, Nilla, Ciomei, Marina, Polucci, Paolo, Cirla, Alessandra, D'Anello, Matteo, Borgia, Andrea Lombardi, Motto, Ilaria, Cristiani, Cinzia, Ballinari, Dario, Felder, Eduard, Donati, Daniele, Galvani, Arturo, Isacchi, Antonella, Menichincheri, Maria
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Discovery of 2‑(Cyclohexylmethylamino)pyrimidines as a New Class of Reversible Valosine Containing Protein Inhibitors
Cervi, Giovanni, Magnaghi, Paola, Asa, Daniela, Avanzi, Nilla, Badari, Alessandra, Borghi, Daniela, Caruso, Michele, Cirla, Alessandra, Cozzi, Liviana, Felder, Eduard, Galvani, Arturo, Gasparri, Fabio, Lomolino, Antonio, Magnuson, Steven, Malgesini, Beatrice, Motto, Ilaria, Pasi, Maurizio, Rizzi, Simona, Salom, Barbara, Sorrentino, Graziella, Troiani, Sonia, Valsasina, Barbara, O’Brien, Thomas, Isacchi, Antonella, Donati, Daniele, D’Alessio, Roberto
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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Journal Article
Abstract 2082: NMS-E668, a potent and selective RET kinase inhibitor characterized by specificity towards VEGFR2 and high antitumor efficacy against RET-driven models
Ardini, Elena, Banfi, Patrizia, Avanzi, Nilla, Ciomei, Marina, Polucci, Paolo, Cirla, Alessandra, Ermoli, Antonella, Motto, Ilaria, Casale, Elena, Canevari, Giulia, Cristiani, Cinzia, Troiani, Sonia, Sirtori, Federico Riccardi, Amboldi, Nadia, Ballinari, Dario, Caprera, Francesco, Felder, Eduard, Galvani, Arturo, Donati, Daniele, Isacchi, Antonella, Menichincheri, Maria
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors
Brasca, Maria Gabriella, Nesi, Marcella, Avanzi, Nilla, Ballinari, Dario, Bandiera, Tiziano, Bertrand, Jay, Bindi, Simona, Canevari, Giulia, Carenzi, Davide, Casero, Daniele, Ceriani, Lucio, Ciomei, Marina, Cirla, Alessandra, Colombo, Maristella, Cribioli, Sabrina, Cristiani, Cinzia, Della Vedova, Franco, Fachin, Gabriele, Fasolini, Marina, Felder, Eduard R., Galvani, Arturo, Isacchi, Antonella, Mirizzi, Danilo, Motto, Ilaria, Panzeri, Achille, Pesenti, Enrico, Vianello, Paola, Gnocchi, Paola, Donati, Daniele
Published in Bioorganic & medicinal chemistry (01.09.2014)
Published in Bioorganic & medicinal chemistry (01.09.2014)
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Journal Article
Abstract 2851: Preclinical characterization of NMS-P648, a novel and potent PARP-1/-3 inhibitor
Montagnoli, Alessia, Papeo, Gianluca, Rainoldi, Sonia, Cirla, Alessandra, Ciavolella, Antonella, Albanese, Clara, Modugno, Michele, Bosotti, Roberta, Somaschini, Alessio, Carapezza, Giovanni, Lupi, Rosita, Ballinari, Dario, Ciomei, Marina, Pesenti, Enrico, Donati, Daniele, Isacchi, Antonella, Galvani, Arturo
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1 H -isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy
Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Journal Article
Abstract 1775: Characterization of new highly selective and potent PARP-1 inhibitors
Montagnoli, Alessia, Papeo, Gianluca, Rainoldi, Sonia, Ciavolella, Antonella, Sola, Francesco, Lupi, Rosita, Ciomei, Marina, Cirla, Alessandra, Scolaro, Alessandra, Posteri, Helena, Donati, Daniele, Felder, Eduard, Isacchi, Antonella, Pesenti, Enrico, Galvani, Arturo
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS
SCOLARO ALESSANDRA, ZUCCOTTO FABIO, CIRLA ALESSANDRA, D'ANELLO MATTEO, PAPEO GIANLUCA MARIANO ENRICO
Year of Publication 06.08.2014
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Year of Publication 06.08.2014
Patent
First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery
Menichincheri, Maria, Bargiotti, Alberto, Berthelsen, Jens, Bertrand, Jay A, Bossi, Roberto, Ciavolella, Antonella, Cirla, Alessandra, Cristiani, Cinzia, Croci, Valter, D’Alessio, Roberto, Fasolini, Marina, Fiorentini, Francesco, Forte, Barbara, Isacchi, Antonella, Martina, Katia, Molinari, Antonio, Montagnoli, Alessia, Orsini, Paolo, Orzi, Fabrizio, Pesenti, Enrico, Pezzetta, Daniele, Pillan, Antonio, Poggesi, Italo, Roletto, Fulvia, Scolaro, Alessandra, Tatò, Marco, Tibolla, Marcellino, Valsasina, Barbara, Varasi, Mario, Volpi, Daniele, Santocanale, Corrado, Vanotti, Ermes
Published in Journal of medicinal chemistry (26.02.2009)
Published in Journal of medicinal chemistry (26.02.2009)
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Journal Article
3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS
PAPEO, Gianluca Mariano Enrico, CIRLA, Alessandra, D'ANELLO, Matteo, SCOLARO, Alessandra, ZUCCOTTO, Fabio
Year of Publication 31.01.2018
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Year of Publication 31.01.2018
Patent