Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis
Ma, Zhuo, King, Kayla, Alqahtani, Maha, Worden, Madeline, Muthuraman, Parthasarathy, Cioffi, Christopher L, Bakshi, Chandra Shekhar, Malik, Meenakshi
Published in PloS one (24.10.2019)
Published in PloS one (24.10.2019)
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The novel visual cycle inhibitor (±)-RPE65-61 protects retinal photoreceptors from light-induced degeneration
Wang, Yuhong, Ma, Xiang, Muthuraman, Parthasarathy, Raja, Arun, Jayaraman, Aravindan, Petrukhin, Konstantin, Cioffi, Christopher L, Ma, Jian-Xing, Moiseyev, Gennadiy
Published in PloS one (13.10.2022)
Published in PloS one (13.10.2022)
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Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals
Bafna, Khushboo, Cioffi, Christopher L., Krug, Robert M., Montelione, Gaetano T.
Published in Frontiers in chemistry (06.10.2022)
Published in Frontiers in chemistry (06.10.2022)
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Journal Article
Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities
Cioffi, Christopher L, Muthuraman, Parthasarathy, Raja, Arun, Varadi, Andras, Racz, Boglarka, Petrukhin, Konstantin
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4‑Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities
Cioffi, Christopher L, Raja, Arun, Muthuraman, Parthasarathy, Jayaraman, Aravindan, Jayakumar, Srinivasan, Varadi, Andras, Racz, Boglarka, Petrukhin, Konstantin
Published in Journal of medicinal chemistry (08.07.2021)
Published in Journal of medicinal chemistry (08.07.2021)
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Journal Article
A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle
Racz, Boglarka, Varadi, Andras, Kong, Jian, Allikmets, Rando, Pearson, Paul G., Johnson, Graham, Cioffi, Christopher L., Petrukhin, Konstantin
Published in The Journal of biological chemistry (20.07.2018)
Published in The Journal of biological chemistry (20.07.2018)
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Journal Article
The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites
Chater, Ryan Cantwell, Quinn, Ada S, Wilson, Katie, Frangos, Zachary J, Sutton, Patrick, Jayakumar, Srinivasan, Cioffi, Christopher L, O'Mara, Megan L, Vandenberg, Robert J
Published in Journal of neurochemistry (01.09.2024)
Published in Journal of neurochemistry (01.09.2024)
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Identification and characterisation of lipids that are positive allosteric modulators of glycine receptors
Gallagher, Casey I., Chang Lin, Yie, Kumar, Arvind, Ha, Damian, Cioffi, Christopher L., Chakrapani, Sudha, O'Mara, Megan L., Vandenberg, Robert J.
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Journal Article
A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration
Shin, Younghwa, Moiseyev, Gennadiy, Petrukhin, Konstantin, Cioffi, Christopher L., Muthuraman, Parthasarathy, Takahashi, Yusuke, Ma, Jian-xing
Published in Biochimica et biophysica acta (01.07.2018)
Published in Biochimica et biophysica acta (01.07.2018)
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Journal Article
Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis
Cioffi, Christopher L, Racz, Boglarka, Varadi, Andras, Freeman, Emily E, Conlon, Michael P, Chen, Ping, Zhu, Lei, Kitchen, Douglas B, Barnes, Keith D, Martin, William H, Pearson, Paul G, Johnson, Graham, Blaner, William S, Petrukhin, Konstantin
Published in Journal of medicinal chemistry (13.06.2019)
Published in Journal of medicinal chemistry (13.06.2019)
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Journal Article
Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2
Gallagher, Casey I., Frangos, Zachary J., Sheipouri, Diba, Shimmon, Susan, Duman, Meryem-Nur, Jayakumar, Srinivasan, Cioffi, Christopher L., Rawling, Tristan, Vandenberg, Robert J.
Published in ACS chemical neuroscience (02.08.2023)
Published in ACS chemical neuroscience (02.08.2023)
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Journal Article
Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2
Mostyn, Shannon N, Sarker, Subhodeep, Muthuraman, Parthasarathy, Raja, Arun, Shimmon, Susan, Rawling, Tristan, Cioffi, Christopher L, Vandenberg, Robert J
Published in ACS chemical neuroscience (06.05.2020)
Published in ACS chemical neuroscience (06.05.2020)
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Journal Article
Synthesis of 2-Aminobenzoxazoles Using Tetramethyl Orthocarbonate or 1,1-Dichlorodiphenoxymethane
Cioffi, Christopher L, Lansing, John J, Yüksel, Hamza
Published in Journal of organic chemistry (19.11.2010)
Published in Journal of organic chemistry (19.11.2010)
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Journal Article
Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease
Cioffi, Christopher L, Dobri, Nicoleta, Freeman, Emily E, Conlon, Michael P, Chen, Ping, Stafford, Douglas G, Schwarz, Daniel M. C, Golden, Kathy C, Zhu, Lei, Kitchen, Douglas B, Barnes, Keith D, Racz, Boglarka, Qin, Qiong, Michelotti, Enrique, Cywin, Charles L, Martin, William H, Pearson, Paul G, Johnson, Graham, Petrukhin, Konstantin
Published in Journal of medicinal chemistry (25.09.2014)
Published in Journal of medicinal chemistry (25.09.2014)
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Journal Article
Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease
Cioffi, Christopher L, Racz, Boglarka, Freeman, Emily E, Conlon, Michael P, Chen, Ping, Stafford, Douglas G, Schwarz, Daniel M. C, Zhu, Lei, Kitchen, Douglas B, Barnes, Keith D, Dobri, Nicoleta, Michelotti, Enrique, Cywin, Charles L, Martin, William H, Pearson, Paul G, Johnson, Graham, Petrukhin, Konstantin
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
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