Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection
de Wit, Emmie, Feldmann, Friederike, Cronin, Jacqueline, Jordan, Robert, Okumura, Atsushi, Thomas, Tina, Scott, Dana, Cihlar, Tomas, Feldmann, Heinz
Published in Proceedings of the National Academy of Sciences - PNAS (24.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (24.03.2020)
Get full text
Journal Article
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
Sheahan, Timothy P., Sims, Amy C., Leist, Sarah R., Schäfer, Alexandra, Won, John, Brown, Ariane J., Montgomery, Stephanie A., Hogg, Alison, Babusis, Darius, Clarke, Michael O., Spahn, Jamie E., Bauer, Laura, Sellers, Scott, Porter, Danielle, Feng, Joy Y., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.
Published in Nature Communications (10.01.2020)
Published in Nature Communications (10.01.2020)
Get full text
Journal Article
Web Resource
A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19
Xie, Xuping, Muruato, Antonio E., Zhang, Xianwen, Lokugamage, Kumari G., Fontes-Garfias, Camila R., Zou, Jing, Liu, Jianying, Ren, Ping, Balakrishnan, Mini, Cihlar, Tomas, Tseng, Chien-Te K., Makino, Shinji, Menachery, Vineet D., Bilello, John P., Shi, Pei-Yong
Published in Nature communications (15.10.2020)
Published in Nature communications (15.10.2020)
Get full text
Journal Article
Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets
Cox, Robert M., Wolf, Josef D., Lieber, Carolin M., Sourimant, Julien, Lin, Michelle J., Babusis, Darius, DuPont, Venice, Chan, Julie, Barrett, Kim T., Lye, Diane, Kalla, Rao, Chun, Kwon, Mackman, Richard L., Ye, Chengjin, Cihlar, Tomas, Martinez-Sobrido, Luis, Greninger, Alexander L., Bilello, John P., Plemper, Richard K.
Published in Nature communications (05.11.2021)
Published in Nature communications (05.11.2021)
Get full text
Journal Article
Toll-Like Receptor 7 Agonist GS-9620 Induces HIV Expression and HIV-Specific Immunity in Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy
Tsai, Angela, Irrinki, Alivelu, Kaur, Jasmine, Cihlar, Tomas, Kukolj, George, Sloan, Derek D, Murry, Jeffrey P
Published in Journal of virology (15.04.2017)
Published in Journal of virology (15.04.2017)
Get full text
Journal Article
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Sheahan, Timothy P, Sims, Amy C, Graham, Rachel L, Menachery, Vineet D, Gralinski, Lisa E, Case, James B, Leist, Sarah R, Pyrc, Krzysztof, Feng, Joy Y, Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O, Mackman, Richard L, Spahn, Jamie E, Palmiotti, Christopher A, Siegel, Dustin, Ray, Adrian S, Cihlar, Tomas, Jordan, Robert, Denison, Mark R, Baric, Ralph S
Published in Science translational medicine (28.06.2017)
Published in Science translational medicine (28.06.2017)
Get more information
Journal Article
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R
Published in mBio (06.03.2018)
Published in mBio (06.03.2018)
Get full text
Journal Article
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.
Published in Scientific reports (06.03.2017)
Published in Scientific reports (06.03.2017)
Get full text
Journal Article
Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid
Peng, Ke, Muranyi, Walter, Glass, Bärbel, Laketa, Vibor, Yant, Stephen R, Tsai, Luong, Cihlar, Tomas, Müller, Barbara, Kräusslich, Hans-Georg
Published in eLife (17.12.2014)
Published in eLife (17.12.2014)
Get full text
Journal Article
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L
Published in Journal of Medicinal Chemistry (09.03.2017)
Published in Journal of Medicinal Chemistry (09.03.2017)
Get full text
Journal Article
Web Resource
Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat
Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P., Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S.
Published in Kidney international (01.08.2014)
Published in Kidney international (01.08.2014)
Get full text
Journal Article
TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy
Lim, So-Yon, Osuna, Christa E, Hraber, Peter T, Hesselgesser, Joe, Gerold, Jeffrey M, Barnes, Tiffany L, Sanisetty, Srisowmya, Seaman, Michael S, Lewis, Mark G, Geleziunas, Romas, Miller, Michael D, Cihlar, Tomas, Lee, William A, Hill, Alison L, Whitney, James B
Published in Science translational medicine (02.05.2018)
Published in Science translational medicine (02.05.2018)
Get more information
Journal Article
Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing
Wei, Datsen George, Chiang, Vicki, Fyne, Elizabeth, Balakrishnan, Mini, Barnes, Tiffany, Graupe, Michael, Hesselgesser, Joseph, Irrinki, Alivelu, Murry, Jeffrey P, Stepan, George, Stray, Kirsten M, Tsai, Angela, Yu, Helen, Spindler, Jonathan, Kearney, Mary, Spina, Celsa A, McMahon, Deborah, Lalezari, Jacob, Sloan, Derek, Mellors, John, Geleziunas, Romas, Cihlar, Tomas
Published in PLoS pathogens (01.04.2014)
Published in PLoS pathogens (01.04.2014)
Get full text
Journal Article
PREVAIL IV: A Randomized, Double-Blind, 2-Phase, Phase 2 Trial of Remdesivir vs Placebo for Reduction of Ebola Virus RNA in the Semen of Male Survivors
Higgs, Elizabeth S, Gayedyu-Dennis, Dehkontee, Fischer II, William A, Nason, Martha, Reilly, Cavan, Beavogui, Abdoul Habib, Aboulhab, Jamila, Nordwall, Jacqueline, Lobbo, Princess, Wachekwa, Ian, Cao, Huyen, Cihlar, Tomas, Hensley, Lisa, Lane, H Clifford
Published in Clinical infectious diseases (16.11.2021)
Published in Clinical infectious diseases (16.11.2021)
Get full text
Journal Article
Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice
Martinez, David R., Schäfer, Alexandra, Leist, Sarah R., Li, Dapeng, Gully, Kendra, Yount, Boyd, Feng, Joy Y., Bunyan, Elaine, Porter, Danielle P., Cihlar, Tomas, Montgomery, Stephanie A., Haynes, Barton F., Baric, Ralph S., Nussenzweig, Michel C., Sheahan, Timothy P.
Published in Cell reports (Cambridge) (27.07.2021)
Published in Cell reports (Cambridge) (27.07.2021)
Get full text
Journal Article
Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells
Balakrishnan, Mini, Yant, Stephen R, Tsai, Luong, O'Sullivan, Christopher, Bam, Rujuta A, Tsai, Angela, Niedziela-Majka, Anita, Stray, Kirsten M, Sakowicz, Roman, Cihlar, Tomas
Published in PloS one (09.09.2013)
Published in PloS one (09.09.2013)
Get full text
Journal Article
Author Correction: A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19
Xie, Xuping, Muruato, Antonio E., Zhang, Xianwen, Lokugamage, Kumari G., Fontes-Garfias, Camila R., Zou, Jing, Liu, Jianying, Ren, Ping, Balakrishnan, Mini, Cihlar, Tomas, Tseng, Chien-Te K., Makino, Shinji, Menachery, Vineet D., Bilello, John P., Shi, Pei-Yong
Published in Nature communications (21.06.2021)
Published in Nature communications (21.06.2021)
Get full text
Journal Article
Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells
Sloan, Derek D, Lam, Chia-Ying Kao, Irrinki, Alivelu, Liu, Liqin, Tsai, Angela, Pace, Craig S, Kaur, Jasmine, Murry, Jeffrey P, Balakrishnan, Mini, Moore, Paul A, Johnson, Syd, Nordstrom, Jeffrey L, Cihlar, Tomas, Koenig, Scott
Published in PLoS pathogens (01.11.2015)
Published in PLoS pathogens (01.11.2015)
Get full text
Journal Article
Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy
Burdette, Dara L, Lazerwith, Scott, Yang, Jenny, Chan, Henry L Y, Delaney Iv, William E, Fletcher, Simon P, Cihlar, Tomas, Feierbach, Becket
Published in PloS one (01.04.2022)
Published in PloS one (01.04.2022)
Get full text
Journal Article