Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
Takahashi, Nobuaki, Chen, Hsing-Yu, Harris, Isaac S., Stover, Daniel G., Selfors, Laura M., Bronson, Roderick T., Deraedt, Thomas, Cichowski, Karen, Welm, Alana L., Mori, Yasuo, Mills, Gordon B., Brugge, Joan S.
Published in Cancer cell (11.06.2018)
Published in Cancer cell (11.06.2018)
Get full text
Journal Article
Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy
Montero, Joan, Sarosiek, Kristopher A., DeAngelo, Joseph D., Maertens, Ophélia, Ryan, Jeremy, Ercan, Dalia, Piao, Huiying, Horowitz, Neil S., Berkowitz, Ross S., Matulonis, Ursula, Jänne, Pasi A., Amrein, Philip C., Cichowski, Karen, Drapkin, Ronny, Letai, Anthony
Published in Cell (26.02.2015)
Published in Cell (26.02.2015)
Get full text
Journal Article
mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors
Malone, Clare F, Emerson, Chloe, Ingraham, Rachel, Barbosa, William, Guerra, Stephanie, Yoon, Haejin, Liu, Lin L, Michor, Franziska, Haigis, Marcia, Macleod, Kay F, Maertens, Ophélia, Cichowski, Karen
Published in Cancer discovery (01.12.2017)
Published in Cancer discovery (01.12.2017)
Get full text
Journal Article
The RasGAP Gene, RASAL2, Is a Tumor and Metastasis Suppressor
McLaughlin, Sara Koenig, Olsen, Sarah Naomi, Dake, Benjamin, De Raedt, Thomas, Lim, Elgene, Bronson, Roderick Terry, Beroukhim, Rameen, Polyak, Kornelia, Brown, Myles, Kuperwasser, Charlotte, Cichowski, Karen
Published in Cancer cell (09.09.2013)
Published in Cancer cell (09.09.2013)
Get full text
Journal Article
Elucidating distinct roles for NF1 in melanomagenesis
Maertens, Ophélia, Johnson, Bryan, Hollstein, Pablo, Frederick, Dennie T, Cooper, Zachary A, Messiaen, Ludwine, Bronson, Roderick T, McMahon, Martin, Granter, Scott, Flaherty, Keith, Wargo, Jennifer A, Marais, Richard, Cichowski, Karen
Published in Cancer discovery (01.03.2013)
Published in Cancer discovery (01.03.2013)
Get full text
Journal Article
Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer
Nardi, Francesca, Perurena, Naiara, Schade, Amy E, Li, Ze-Hua, Ngo, Kenneth, Ivanova, Elena V, Saldanha, Aisha, Li, Chendi, Gokhale, Prafulla C, Hata, Aaron N, Barbie, David A, Paweletz, Cloud P, Jänne, Pasi A, Cichowski, Karen
Published in The Journal of clinical investigation (15.08.2023)
Published in The Journal of clinical investigation (15.08.2023)
Get full text
Journal Article
Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors
Beert, Eline, Brems, Hilde, Daniëls, Bruno, De Wever, Ivo, Van Calenbergh, Frank, Schoenaers, Joseph, Debiec-Rychter, Maria, Gevaert, Olivier, De Raedt, Thomas, Van Den Bruel, Annick, de Ravel, Thomy, Cichowski, Karen, Kluwe, Lan, Mautner, Victor, Sciot, Raf, Legius, Eric
Published in Genes chromosomes & cancer (01.12.2011)
Published in Genes chromosomes & cancer (01.12.2011)
Get full text
Journal Article
Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors
De Raedt, Thomas, Walton, Zandra, Yecies, Jessica L., Li, Danan, Chen, Yimei, Malone, Clare F., Maertens, Ophélia, Jeong, Seung Min, Bronson, Roderick T., Lebleu, Valerie, Kalluri, Raghu, Normant, Emmanuel, Haigis, Marcia C., Manning, Brendan D., Wong, Kwok-Kin, Macleod, Kay F., Cichowski, Karen
Published in Cancer cell (13.09.2011)
Published in Cancer cell (13.09.2011)
Get full text
Journal Article
Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence
Singleton, Katherine R., Crawford, Lorin, Tsui, Elizabeth, Manchester, Haley E., Maertens, Ophelia, Liu, Xiaojing, Liberti, Maria V., Magpusao, Anniefer N., Stein, Elizabeth M., Tingley, Jennifer P., Frederick, Dennie T., Boland, Genevieve M., Flaherty, Keith T., McCall, Shannon J., Krepler, Clemens, Sproesser, Katrin, Herlyn, Meenhard, Adams, Drew J., Locasale, Jason W., Cichowski, Karen, Mukherjee, Sayan, Wood, Kris C.
Published in Cell reports (Cambridge) (05.12.2017)
Published in Cell reports (Cambridge) (05.12.2017)
Get full text
Journal Article
Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023)
De Raedt, Thomas, Chawla, Sant, Van Tine, Brian A., O’Sullivan, Geraldine, Chen, Alice, Cichowski, Karen, Widemann, Brigitte C., Wolters, Pamela L., Basu, Mitali, Perentesis, John, Maertens, Ophélia, Reinke, Denise, Okuno, Scott H., Lu, Yao, Kim, AeRang, Chugh, Rashmi
Published in Complexity (New York, N.Y.) (2020)
Published in Complexity (New York, N.Y.) (2020)
Get full text
Journal Article
ErbB-3 Mediates Phosphoinositide 3-Kinase Activity in Gefitinib-Sensitive Non-Small Cell Lung Cancer Cell Lines
Engelman, Jeffrey A., Jänne, Pasi A., Mermel, Craig, Pearlberg, Joseph, Mukohara, Toru, Fleet, Christina, Cichowski, Karen, Johnson, Bruce E., Cantley, Lewis C.
Published in Proceedings of the National Academy of Sciences - PNAS (08.03.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (08.03.2005)
Get full text
Journal Article
Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016)
Hirbe, Angela C., Kim, AeRang, Turpin, Brian, Dombi, Eva, Jayaprakash, Nalini, Helman, Lee J., Onwudiwe, Ndidi, Cichowski, Karen, Perentesis, John, Milhem, Mohammed, Chugh, Rashmi, Cote, Gregory M., Meyer, Christian F., Okuno, Scott H., Reinke, Denise, Lu, Yao, Widemann, Brigitte C., Pressey, Joseph G.
Published in Complexity (New York, N.Y.) (2019)
Published in Complexity (New York, N.Y.) (2019)
Get full text
Journal Article
Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity
Zhang, Yang, Guillermier, Christelle, De Raedt, Thomas, Cox, Andrew G., Maertens, Ophelia, Yimlamai, Dean, Lun, Mingyue, Whitney, Adam, Maas, Richard L., Goessling, Wolfram, Cichowski, Karen, Steinhauser, Matthew L.
Published in iScience (21.08.2020)
Published in iScience (21.08.2020)
Get full text
Journal Article
Mouse Models of Tumor Development in Neurofibromatosis Type 1
Cichowski, Karen, Shih, T. Shane, Schmitt, Earlene, Santiago, Sabrina, Reilly, Karlyne, McLaughlin, Margaret E., Bronson, Roderick T., Jacks, Tyler
Published in Science (American Association for the Advancement of Science) (10.12.1999)
Published in Science (American Association for the Advancement of Science) (10.12.1999)
Get full text
Journal Article