Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors
Meng, Zhaoyang, Ciavarri, Jeffrey P., McRiner, Andrew, Zhao, Yinyan, Zhao, Lianyun, Reddy, Panduranga Adulla, Zhang, Xingmin, Fischmann, Thierry O., Whitehurst, Charles, Arshad Siddiqui, M.
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
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A Second-Generation Total Synthesis of (+)-Phorboxazole A
Smith, Amos B, Razler, Thomas M, Ciavarri, Jeffrey P, Hirose, Tomoyasu, Ishikawa, Tomoyasu, Meis, Regina M
Published in Journal of organic chemistry (15.02.2008)
Published in Journal of organic chemistry (15.02.2008)
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Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route
Vyskocil, Stepan, Cardin, David, Ciavarri, Jeffrey, Conlon, Joe, Cullis, Courtney, England, Dylan, Gershman, Rachel, Gigstad, Kenneth, Gipson, Krista, Gould, Alexandra, Greenspan, Paul, Griffin, Robert, Gulavita, Nanda, Harrison, Sean, Hu, Zhigen, Hu, Yongbo, Hata, Akito, Huang, Jian, Huang, Shih-Chung, Janowick, Dave, Jones, Matthew, Kolev, Vihren, Langston, Steven P, Lee, Hong Myung, Li, Gang, Lok, David, Ma, Liting, Mai, Doanh, Malley, Jenna, Matsuda, Atsushi, Mizutani, Hirotake, Mizutani, Miho, Molchanova, Nina, Nunes, Elise, Pusalkar, Sandeep, Renou, Christelle, Rowland, Scott, Sato, Yosuke, Shaw, Michael, Shen, Luhua, Shi, Zhan, Skene, Robert, Soucy, Francois, Stroud, Steve, Xu, He, Xu, Tianlin, Abu-Yousif, Adnan O, Zhang, Ji
Published in Journal of medicinal chemistry (27.05.2021)
Published in Journal of medicinal chemistry (27.05.2021)
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Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome
Xie, Stanley C., Metcalfe, Riley D., Mizutani, Hirotake, Puhalovich, Tanya, Hanssen, Eric, Morton, Craig J., Du, Yawei, Dogovski, Con, Huang, Shih-Chung, Ciavarri, Jeffrey, Hales, Paul, Griffin, Robert J., Cohen, Lawrence H., Chuang, Bei-Ching, Wittlin, Sergio, Deni, Ioanna, Yeo, Tomas, Ward, Kurt E., Barry, Daniel C., Liu, Boyin, Gillett, David L., Crespo-Fernandez, Benigno F., Ottilie, Sabine, Mittal, Nimisha, Churchyard, Alisje, Ferguson, Daniel, Aguiar, Anna Caroline C., Guido, Rafael V. C., Baum, Jake, Hanson, Kirsten K., Winzeler, Elizabeth A., Gamo, Francisco-Javier, Fidock, David A., Baud, Delphine, Parker, Michael W., Brand, Stephen, Dick, Lawrence R., Griffin, Michael D. W., Gould, Alexandra E., Tilley, Leann
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.2021)
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A novel copper (i) mediated, symmetrical coupling procedure for alkyl, aryl, benzyl, and thiophenyl dihalides
Johnson, David K., Ciavarri, Jeffrey P, Ishmael, Faoud T, Schillinger, Kurl J., van Geel, Thomas A.P., Stratton, Stephen M.
Published in Tetrahedron letters (20.11.1995)
Published in Tetrahedron letters (20.11.1995)
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Abstract 3719: TAK-243, a small molecule inhibitor of the ubiquitin activating enzyme (UAE), disrupts DNA damage repair and sensitizes tumor cells and xenografts to ionizing radiation
Milhollen, Michael A., Shi, Judy Qiuju, Traore, Tary, Huck, Jessica, Sappal, Darshan, Iwai, Kenichi, Ohashi, Akihiro, Rabino, Claudia, Duffy, Jennifer A., Lightcap, Eric, Ishii, Yuko, Ciavarri, Jeffrey, Bence, Neil, Berger, Allison J., Hyer, Marc L.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Preclinical Combination Of The Oral Investigational Agents ACY-1215, a Selective HDAC6 Inhibitor, and Ixazomib, a Proteasome Inhibitor, Demonstrates Combination Benefit In Multiple Myeloma Cell Lines and Xenograft Models
Berger, Allison J, Bannerman, Bret, Quayle, Steven N, Yu, Jie, Garcia, Khristofer, Ciavarri, Jeffrey, Tamang, David, Yang, Min, Jones, Simon S
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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STING 조절제 화합물, 및 제조 및 사용 방법
CULLIS COURTNEY, GOULD ALEXANDRA E, MIZUTANI HIROTAKE, HU YONGBO, ENGLAND DYLAN BRADLEY, VYSKOCIL STEPAN, CIAVARRI JEFFREY, GREENSPAN PAUL, LANGSTON STEVEN, LI GANG, OKANIWA MASANORI
Year of Publication 20.08.2020
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Year of Publication 20.08.2020
Patent
Abstract C99: Beyond bortezomib: Development of Millennium's next-generation proteasome inhibitors
Tsu, Christopher A., Blank, Jonathan, Garcia, Khristofer, Liu, Jane, Bruzzese, Frank, Lee, Edmund, Kao, Yueying, Bannerman, Bret, Fitzgerald, Michael, Fleming, Paul, Ciavarri, Jeffrey, Hales, Paul, Yu, Jie, Yang, Yu, Berger, Allison, Sintchak, Michael, Kupperman, Erik, Manfredi, Mark, Dick, Lawrence
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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HETEROARYLS AND USES THEREOF
D'AMORE NATALIE, STROUD STEPHEN G, HU YONGBO, REZAEI MANSOUREH, SOUCY FRANCOIS, BHARATHAN INDU T, XU HE, CHOUITAR JOUHARA, CIAVARRI JEFFREY P, FLEMING PAUL E, YE YINGCHUN, CULLIS COURTNEY A, GIPSON KRISTA E, XU TIANLIN, GIGSTAD KENNETH M, BLACKBURN CHRIS, GIRARD MARIO, LEE JANICE, SINTCHAK MICHAEL D, WONG TZU TSHIN, VOS TRICIA J, LI GANG
Year of Publication 24.10.2016
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Year of Publication 24.10.2016
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Development of Immunoproteasome-Specific Inhibitors as Novel Anti-Cancer Drugs
Kuhn, Deborah J., Voorhees, Peter M., Chen, Qing, Strader, John S., Bruzzese, Frank, Ciavarri, Jeffrey P., Hu, Zhigen, Orlowski, Robert Z.
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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PYRAZOLOPYRIMIDINYL INHIBITORS OF UBIQUITIN-ACTIVATING ENZYME
GIRARD MARIO, BHARATHAN INDU T, GAULIN JEFFREY L, SOUCY FRANCOIS R, CIAVARRI JEFFREY P, WONG TZU TSHIN, FLEMING PAUL E, YE YINGCHUN, LANGSTON STEVEN P, AFROZE ROUSHAN
Year of Publication 21.10.2014
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Year of Publication 21.10.2014
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ARYL ALKYNAMIDE DERIVATIVES
CIAVARRI, Jeffrey, NEGORO, Kenji, KITAMURA, Kai, SEO, Ryushi, KAKEFUDA, Kenichi, KAMIKAWA, Akio, MAEDA, Junko, YAMASHITA, Yumi, HAMAGUCHI, Wataru, KURIWAKI, Ikumi
Year of Publication 15.08.2024
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Year of Publication 15.08.2024
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Aryl alkynamide derivatives
Yamashita, Yumi, Kamikawa, Akio, Kuriwaki, Ikumi, Maeda, Junko, Hamaguchi, Wataru, Kitamura, Kai, Seo, Ryushi, Kakefuda, Kenichi, Negoro, Kenji, Ciavarri, Jeffrey
Year of Publication 27.02.2024
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Year of Publication 27.02.2024
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ARYL ALKYNAMIDE DERIVATIVES
Yamashita, Yumi, Kamikawa, Akio, Kuriwaki, Ikumi, Maeda, Junko, Hamaguchi, Wataru, Kitamura, Kai, Seo, Ryushi, Kakefuda, Kenichi, Negoro, Kenji, Ciavarri, Jeffrey
Year of Publication 18.01.2024
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Year of Publication 18.01.2024
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Sting modulator compounds, and methods of making and using
Cullis, Courtney, Greenspan, Paul, Okaniwa, Masanori, England, Dylan Bradley, Langston, Steven, Li, Gang, Hu, Yongbo, Vyskocil, Stepan, Ciavarri, Jeffrey, Gould, Alexandra E, Mizutani, Hirotake
Year of Publication 06.08.2024
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Year of Publication 06.08.2024
Patent