Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
Yu, Yi, Leete, Thomas C., Born, David A., Young, Lauren, Barrera, Luis A., Lee, Seung-Joo, Rees, Holly A., Ciaramella, Giuseppe, Gaudelli, Nicole M.
Published in Nature communications (28.04.2020)
Published in Nature communications (28.04.2020)
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Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
Bahl, Kapil, Senn, Joe J., Yuzhakov, Olga, Bulychev, Alex, Brito, Luis A., Hassett, Kimberly J., Laska, Michael E., Smith, Mike, Almarsson, Örn, Thompson, James, Ribeiro, Amilcar (Mick), Watson, Mike, Zaks, Tal, Ciaramella, Giuseppe
Published in Molecular therapy (07.06.2017)
Published in Molecular therapy (07.06.2017)
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Directed evolution of adenine base editors with increased activity and therapeutic application
Gaudelli, Nicole M., Lam, Dieter K., Rees, Holly A., Solá-Esteves, Noris M., Barrera, Luis A., Born, David A., Edwards, Aaron, Gehrke, Jason M., Lee, Seung-Joo, Liquori, Alexander J., Murray, Ryan, Packer, Michael S., Rinaldi, Conrad, Slaymaker, Ian M., Yen, Jonathan, Young, Lauren E., Ciaramella, Giuseppe
Published in Nature biotechnology (01.07.2020)
Published in Nature biotechnology (01.07.2020)
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mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials
Feldman, Robert A., Fuhr, Rainard, Smolenov, Igor, (Mick) Ribeiro, Amilcar, Panther, Lori, Watson, Mike, Senn, Joseph J., Smith, Mike, Almarsson, Ӧrn, Pujar, Hari S., Laska, Michael E., Thompson, James, Zaks, Tal, Ciaramella, Giuseppe
Published in Vaccine (31.05.2019)
Published in Vaccine (31.05.2019)
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Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques
Liang, Frank, Lindgren, Gustaf, Lin, Ang, Thompson, Elizabeth A., Ols, Sebastian, Röhss, Josefine, John, Shinu, Hassett, Kimberly, Yuzhakov, Olga, Bahl, Kapil, Brito, Luis A., Salter, Hugh, Ciaramella, Giuseppe, Loré, Karin
Published in Molecular therapy (06.12.2017)
Published in Molecular therapy (06.12.2017)
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Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
Hassett, Kimberly J., Benenato, Kerry E., Jacquinet, Eric, Lee, Aisha, Woods, Angela, Yuzhakov, Olga, Himansu, Sunny, Deterling, Jessica, Geilich, Benjamin M., Ketova, Tatiana, Mihai, Cosmin, Lynn, Andy, McFadyen, Iain, Moore, Melissa J., Senn, Joseph J., Stanton, Matthew G., Almarsson, Örn, Ciaramella, Giuseppe, Brito, Luis A.
Published in Molecular therapy. Nucleic acids (15.04.2019)
Published in Molecular therapy. Nucleic acids (15.04.2019)
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A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques
Zhang, Peng, Narayanan, Elisabeth, Liu, Qingbo, Tsybovsky, Yaroslav, Boswell, Kristin, Ding, Shilei, Hu, Zonghui, Follmann, Dean, Lin, Yin, Miao, Huiyi, Schmeisser, Hana, Rogers, Denise, Falcone, Samantha, Elbashir, Sayda M., Presnyak, Vladimir, Bahl, Kapil, Prabhakaran, Madhu, Chen, Xuejun, Sarfo, Edward K., Ambrozak, David R., Gautam, Rajeev, Martin, Malcom A., Swerczek, Joanna, Herbert, Richard, Weiss, Deborah, Misamore, Johnathan, Ciaramella, Giuseppe, Himansu, Sunny, Stewart-Jones, Guillaume, McDermott, Adrian, Koup, Richard A., Mascola, John R., Finzi, Andrés, Carfi, Andrea, Fauci, Anthony S., Lusso, Paolo
Published in Nature medicine (01.12.2021)
Published in Nature medicine (01.12.2021)
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Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection
Espeseth, Amy S., Cejas, Pedro J., Citron, Michael P., Wang, Dai, DiStefano, Daniel J., Callahan, Cheryl, Donnell, Gregory O’, Galli, Jennifer D., Swoyer, Ryan, Touch, Sinoeun, Wen, Zhiyun, Antonello, Joseph, Zhang, Lan, Flynn, Jessica A., Cox, Kara S., Freed, Daniel C., Vora, Kalpit A., Bahl, Kapil, Latham, Andrew H., Smith, Jeffrey S., Gindy, Marian E., Ciaramella, Giuseppe, Hazuda, Daria, Shaw, Christine A., Bett, Andrew J.
Published in npj vaccines (14.02.2020)
Published in npj vaccines (14.02.2020)
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A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice
Roth, Claude, Cantaert, Tineke, Colas, Chloé, Prot, Matthieu, Casadémont, Isabelle, Levillayer, Laurine, Thalmensi, Jessie, Langlade-Demoyen, Pierre, Gerke, Christiane, Bahl, Kapil, Ciaramella, Giuseppe, Simon-Loriere, Etienne, Sakuntabhai, Anavaj
Published in Frontiers in immunology (21.06.2019)
Published in Frontiers in immunology (21.06.2019)
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Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry
WESTBY, Mike, SMITH-BURCHNELL, Caroline, MORI, Julie, LEWIS, Marilyn, MOSLEY, Nichael, STOCKDALE, Mark, DORR, Patrick, CIARAMELLA, Giuseppe, PERROS, Manos
Published in Journal of Virology (01.03.2007)
Published in Journal of Virology (01.03.2007)
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Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells
Lindgren, Gustaf, Ols, Sebastian, Liang, Frank, Thompson, Elizabeth A, Lin, Ang, Hellgren, Fredrika, Bahl, Kapil, John, Shinu, Yuzhakov, Olga, Hassett, Kimberly J, Brito, Luis A, Salter, Hugh, Ciaramella, Giuseppe, Loré, Karin
Published in Frontiers in immunology (13.11.2017)
Published in Frontiers in immunology (13.11.2017)
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A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
Kose, Nurgun, Fox, Julie M, Sapparapu, Gopal, Bombardi, Robin, Tennekoon, Rashika N, de Silva, A Dharshan, Elbashir, Sayda M, Theisen, Matthew A, Humphris-Narayanan, Elisabeth, Ciaramella, Giuseppe, Himansu, Sunny, Diamond, Michael S, Crowe, Jr, James E
Published in Science immunology (17.05.2019)
Published in Science immunology (17.05.2019)
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Rhesus Macaque Myeloid-Derived Suppressor Cells Demonstrate T Cell Inhibitory Functions and Are Transiently Increased after Vaccination
Lin, Ang, Liang, Frank, Thompson, Elizabeth A, Vono, Maria, Ols, Sebastian, Lindgren, Gustaf, Hassett, Kimberly, Salter, Hugh, Ciaramella, Giuseppe, Loré, Karin
Published in The Journal of immunology (1950) (01.01.2018)
Published in The Journal of immunology (1950) (01.01.2018)
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HIV capsid is a tractable target for small molecule therapeutic intervention
Blair, Wade S, Pickford, Chris, Irving, Stephen L, Brown, David G, Anderson, Marie, Bazin, Richard, Cao, Joan, Ciaramella, Giuseppe, Isaacson, Jason, Jackson, Lynn, Hunt, Rachael, Kjerrstrom, Anne, Nieman, James A, Patick, Amy K, Perros, Manos, Scott, Andrew D, Whitby, Kevin, Wu, Hua, Butler, Scott L
Published in PLoS pathogens (09.12.2010)
Published in PLoS pathogens (09.12.2010)
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Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo
Smekalova, Elena M., Martinez, Maria G., Combe, Emmanuel, Kumar, Anuj, Dejene, Selam, Leboeuf, Dominique, Chen, Chao-Ying, Dorkin, J. Robert, Shuang, Lan Shuan, Kieft, Sarah, Young, Lauren, Barrera, Luis Alberto, Packer, Michael S., Ciaramella, Giuseppe, Testoni, Barbara, Gregoire, Francine, Zoulim, Fabien
Published in Molecular therapy. Nucleic acids (12.03.2024)
Published in Molecular therapy. Nucleic acids (12.03.2024)
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Uptake, Efficacy, and Systemic Distribution of Naked, Inhaled Short Interfering RNA (siRNA) and Locked Nucleic Acid (LNA) Antisense
Moschos, Sterghios A, Frick, Manfred, Taylor, Bruce, Turnpenny, Paul, Graves, Helen, Spink, Karen G, Brady, Kevin, Lamb, David, Collins, David, Rockel, Thomas D, Weber, Markus, Lazari, Ovadia, Perez-Tosar, Luis, Fancy, Sally A, Lapthorn, Chris, Green, Martin X, Evans, Steve, Selby, Matthew, Jones, Gareth, Jones, Lyn, Kearney, Sarah, Mechiche, Houria, Gikunju, Diana, Subramanian, Romesh, Uhlmann, Eugen, Jurk, Marion, Vollmer, Jörg, Ciaramella, Giuseppe, Yeadon, Michael
Published in Molecular therapy (01.12.2011)
Published in Molecular therapy (01.12.2011)
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Corrigendum: Induction of Robust B Cell Responses After Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells
Lindgren, Gustaf, Ols, Sebastian, Liang, Frank, Thompson, Elizabeth A, Lin, Ang, Hellgren, Fredrika, Bahl, Kapil, John, Shinu, Yuzhakov, Olga, Hassett, Kimberly J, Brito, Luis A, Salter, Hugh, Ciaramella, Giuseppe, Loré, Karin
Published in Frontiers in immunology (2019)
Published in Frontiers in immunology (2019)
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111 Highly efficient multiplexed base editing enables development of universal CD7-targeting CAR-T Cells to treat T-ALL
Gehrke, Jason, Edwards, Aaron, Murray, Ryan, Messana, Angelica, Coholan, Lindsey, Poulin, Henry, Le, Melissa, Ladd, Alden, Naniong, Mark, Musenge, Faith, Camblin, Adam, Poh, Yeh-Chuin, Smith, Sarah, Ciaramella, Giuseppe
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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