Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
Padyana, Anil K., Gross, Stefan, Jin, Lei, Cianchetta, Giovanni, Narayanaswamy, Rohini, Wang, Feng, Wang, Rui, Fang, Cheng, Lv, Xiaobing, Biller, Scott A., Dang, Lenny, Mahoney, Christopher E., Nagaraja, Nelamangala, Pirman, David, Sui, Zhihua, Popovici-Muller, Janeta, Smolen, Gromoslaw A.
Published in Nature communications (09.01.2019)
Published in Nature communications (09.01.2019)
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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
Yen, Katharine, Travins, Jeremy, Wang, Fang, David, Muriel D, Artin, Erin, Straley, Kimberly, Padyana, Anil, Gross, Stefan, DeLaBarre, Byron, Tobin, Erica, Chen, Yue, Nagaraja, Raj, Choe, Sung, Jin, Lei, Konteatis, Zenon, Cianchetta, Giovanni, Saunders, Jeffrey O, Salituro, Francesco G, Quivoron, Cyril, Opolon, Paule, Bawa, Olivia, Saada, Véronique, Paci, Angelo, Broutin, Sophie, Bernard, Olivier A, de Botton, Stéphane, Marteyn, Benoît S, Pilichowska, Monika, Xu, YingXia, Fang, Cheng, Jiang, Fan, Wei, Wentao, Jin, Shengfang, Silverman, Lee, Liu, Wei, Yang, Hua, Dang, Lenny, Dorsch, Marion, Penard-Lacronique, Virginie, Biller, Scott A, Su, Shin-San Michael
Published in Cancer discovery (01.05.2017)
Published in Cancer discovery (01.05.2017)
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Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Popovici-Muller, Janeta, Lemieux, René M, Artin, Erin, Saunders, Jeffrey O, Salituro, Francesco G, Travins, Jeremy, Cianchetta, Giovanni, Cai, Zhenwei, Zhou, Ding, Cui, Dawei, Chen, Ping, Straley, Kimberly, Tobin, Erica, Wang, Fang, David, Muriel D, Penard-Lacronique, Virginie, Quivoron, Cyril, Saada, Véronique, de Botton, Stéphane, Gross, Stefan, Dang, Lenny, Yang, Hua, Utley, Luke, Chen, Yue, Kim, Hyeryun, Jin, Shengfang, Gu, Zhiwei, Yao, Gui, Luo, Zhiyong, Lv, Xiaobing, Fang, Cheng, Yan, Liping, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shin-San M, Yen, Katharine
Published in ACS medicinal chemistry letters (12.04.2018)
Published in ACS medicinal chemistry letters (12.04.2018)
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A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
Mahoney, Christopher E., Pirman, David, Chubukov, Victor, Sleger, Taryn, Hayes, Sebastian, Fan, Zi Peng, Allen, Eric L., Chen, Ying, Huang, Lingling, Liu, Meina, Zhang, Yingjia, McDonald, Gabrielle, Narayanaswamy, Rohini, Choe, Sung, Chen, Yue, Gross, Stefan, Cianchetta, Giovanni, Padyana, Anil K., Murray, Stuart, Liu, Wei, Marks, Kevin M., Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Nagaraja, Nelamangala, Biller, Scott A., Roddy, Thomas, Popovici-Muller, Janeta, Smolen, Gromoslaw A.
Published in Nature communications (09.01.2019)
Published in Nature communications (09.01.2019)
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Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH
Allen, Eric L., Ulanet, Danielle B., Pirman, David, Mahoney, Christopher E., Coco, John, Si, Yaguang, Chen, Ying, Huang, Lingling, Ren, Jinmin, Choe, Sung, Clasquin, Michelle F., Artin, Erin, Fan, Zi Peng, Cianchetta, Giovanni, Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Smolen, Gromoslaw A.
Published in Cell reports (Cambridge) (11.10.2016)
Published in Cell reports (Cambridge) (11.10.2016)
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Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88
Dzierba, Carolyn D., Bi, Yingzhi, Dasgupta, Bireshwar, Hartz, Richard A., Ahuja, Vijay, Cianchetta, Giovanni, Kumi, Godwin, Dong, Li, Aleem, Saadat, Fink, Cynthia, Garcia, Yudith, Green, Michael, Han, Jianxin, Kwon, Soojin, Qiao, Ying, Wang, Jiancheng, Zhang, Yulian, Liu, Ying, Zipp, Greg, Liang, Zhi, Burford, Neil, Ferrante, Meredith, Bertekap, Robert, Lewis, Martin, Cacace, Angela, Grace, James, Wilson, Alan, Nouraldeen, Amr, Westphal, Ryan, Kimball, David, Carson, Kenneth, Bronson, Joanne J., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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Virtual Screening for Novel Openers of Pancreatic KATP Channels
Carosati, Emanuele, Mannhold, Raimund, Wahl, Philip, Hansen, John Bondo, Fremming, Tinna, Zamora, Ismael, Cianchetta, Giovanni, Baroni, Massimo
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy
Kung, Charles, Hixon, Jeff, Choe, Sung, Marks, Kevin, Gross, Stefan, Murphy, Erin, DeLaBarre, Byron, Cianchetta, Giovanni, Sethumadhavan, Shalini, Wang, Xiling, Yan, Shunqi, Gao, Yi, Fang, Cheng, Wei, Wentao, Jiang, Fan, Wang, Shaohui, Qian, Kevin, Saunders, Jeff, Driggers, Ed, Woo, Hin Koon, Kunii, Kaiko, Murray, Stuart, Yang, Hua, Yen, Katharine, Liu, Wei, Cantley, Lewis C., Vander Heiden, Matthew G., Su, Shinsan M., Jin, Shengfang, Salituro, Francesco G., Dang, Lenny
Published in Chemistry & biology (21.09.2012)
Published in Chemistry & biology (21.09.2012)
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AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency
Kung, Charles, Hixon, Jeff, Kosinski, Penelope A., Cianchetta, Giovanni, Histen, Gavin, Chen, Yue, Hill, Collin, Gross, Stefan, Si, Yaguang, Johnson, Kendall, DeLaBarre, Byron, Luo, Zhiyong, Gu, Zhiwei, Yao, Gui, Tang, Huachun, Fang, Cheng, Xu, Yingxia, Lv, Xiaobing, Biller, Scott, Su, Shin-San Michael, Yang, Hua, Popovici-Muller, Janeta, Salituro, Francesco, Silverman, Lee, Dang, Lenny
Published in Blood (14.09.2017)
Published in Blood (14.09.2017)
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Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas
Remacha, Laura, Pirman, David, Mahoney, Christopher E., Coloma, Javier, Calsina, Bruna, Currás-Freixes, Maria, Letón, Rocío, Torres-Pérez, Rafael, Richter, Susan, Pita, Guillermo, Herráez, Belén, Cianchetta, Giovanni, Honrado, Emiliano, Maestre, Lorena, Urioste, Miguel, Aller, Javier, García-Uriarte, Óscar, Gálvez, María Ángeles, Luque, Raúl M., Lahera, Marcos, Moreno-Rengel, Cristina, Eisenhofer, Graeme, Montero-Conde, Cristina, Rodríguez-Antona, Cristina, Llorca, Óscar, Smolen, Gromoslaw A., Robledo, Mercedes, Cascón, Alberto
Published in American journal of human genetics (04.04.2019)
Published in American journal of human genetics (04.04.2019)
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Journal Article
Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas
Remacha, Laura, Pirman, David, Mahoney, Christopher E., Coloma, Javier, Calsina, Bruna, Currás-Freixes, Maria, Letón, Rocío, Torres-Pérez, Rafael, Richter, Susan, Pita, Guillermo, Herráez, Belén, Cianchetta, Giovanni, Honrado, Emiliano, Maestre, Lorena, Urioste, Miguel, Aller, Javier, García-Uriarte, Óscar, Gálvez, María Ángeles, Luque, Raúl M., Lahera, Marcos, Moreno-Rengel, Cristina, Eisenhofer, Graeme, Montero-Conde, Cristina, Rodríguez-Antona, Cristina, Llorca, Óscar, Smolen, Gromoslaw A., Robledo, Mercedes, Cascón, Alberto
Published in American journal of human genetics (02.05.2019)
Published in American journal of human genetics (02.05.2019)
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PYRUVATE KINASE ACTIVATORS FOR USE IN TREATING BLOOD DISORDERS
CIANCHETTA GIOVANNI, CAI ZHENWEI, SUI ZHIHUA, CUI DAWEI, JI JINGJING, LIU TAO, PADYANA ANIL KUMAR
Year of Publication 31.08.2023
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Year of Publication 31.08.2023
Patent
Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation
Goodwin, Nicole C, Cianchetta, Giovanni, Burgoon, Hugh A, Healy, Jason, Mabon, Ross, Strobel, Eric D, Allen, Jason, Wang, Shuli, Hamman, Brian D, Rawlins, David B
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Abstract 3504: A chemical biology screen identifies a unique vulnerability of neuroendocrine cancer cells to SQLE inhibition
Mahoney, Christopher, Pirman, David, Chubukov, Victor, Sleger, Taryn, Padyana, Anil, Gross, Stefan, Hayes, Sebastian, Fan, Zi Peng, McDonald, Gabrielle, Chen, Yu, Murtie, Joshua, Cianchetta, Giovanni, Nagaraja, Raj, Narayanaswamy, Rohini, Choe, Sung, Murray, Stuart, Jin, Shengfang, Biller, Scott, Roddy, Thomas, Smolen, Gromoslaw A.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Virtual Screening for Novel Openers of Pancreatic K ATP Channels
Carosati, Emanuele, Mannhold, Raimund, Wahl, Philip, Hansen, John Bondo, Fremming, Tinna, Zamora, Ismael, Cianchetta, Giovanni, Baroni, Massimo
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis
Cianchetta, Giovanni, Stouch, Terry, Yu, Wangsheng, Shi, Zhi-Cai, Tari, Leslie W, Swanson, Ronald V, Hunter, Michael J, Hoffman, Isaac D, Liu, Qingyun
Published in Current chemical genomics (14.04.2010)
Published in Current chemical genomics (14.04.2010)
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피루브산 키나아제 조절제 및 이의 용도
CIANCHETTA GIOVANNI, CAI ZHENWEI, SUI ZHIHUA, CUI DAWEI, JI JINGJING, LIU TAO, KUNG CHARLES, PADYANA ANIL KUMAR
Year of Publication 19.05.2020
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Year of Publication 19.05.2020
Patent
혈액 장애의 치료에 사용하기 위한 피루브산 키나아제 활성화제
CIANCHETTA GIOVANNI, CAI ZHENWEI, SUI ZHIHUA, CUI DAWEI, JI JINGJING, LIU TAO, PADYANA ANIL KUMAR
Year of Publication 19.05.2020
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Year of Publication 19.05.2020
Patent
A Pharmacophore Hypothesis for P-Glycoprotein Substrate Recognition Using GRIND-Based 3D-QSAR
Cianchetta, Giovanni, Singleton, Robert W, Zhang, Meng, Wildgoose, Marianne, Giesing, Dennis, Fravolini, Arnaldo, Cruciani, Gabriele, Vaz, Roy J
Published in Journal of medicinal chemistry (21.04.2005)
Published in Journal of medicinal chemistry (21.04.2005)
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Predictive models for hERG potassium channel blockers
Cianchetta, Giovanni, Li, Yi, Kang, Jiesheng, Rampe, David, Fravolini, Arnaldo, Cruciani, Gabriele, Vaz, Roy J.
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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