Deep learning for prediction of colorectal cancer outcome: a discovery and validation study
Skrede, Ole-Johan, De Raedt, Sepp, Kleppe, Andreas, Hveem, Tarjei S, Liestøl, Knut, Maddison, John, Askautrud, Hanne A, Pradhan, Manohar, Nesheim, John Arne, Albregtsen, Fritz, Farstad, Inger Nina, Domingo, Enric, Church, David N, Nesbakken, Arild, Shepherd, Neil A, Tomlinson, Ian, Kerr, Rachel, Novelli, Marco, Kerr, David J, Danielsen, Håvard E
Published in The Lancet (British edition) (01.02.2020)
Published in The Lancet (British edition) (01.02.2020)
Get full text
Journal Article
A panoply of errors: polymerase proofreading domain mutations in cancer
Rayner, Emily, van Gool, Inge C., Palles, Claire, Kearsey, Stephen E., Bosse, Tjalling, Tomlinson, Ian, Church, David N.
Published in Nature reviews. Cancer (01.02.2016)
Published in Nature reviews. Cancer (01.02.2016)
Get full text
Journal Article
Interpretation of somatic POLE mutations in endometrial carcinoma
León‐Castillo, Alicia, Britton, Heidi, McConechy, Melissa K, McAlpine, Jessica N, Nout, Remi, Kommoss, Stefan, Brucker, Sara Y, Carlson, Joseph W, Epstein, Elisabeth, Rau, Tilman T, Bosse, Tjalling, Church, David N, Gilks, C Blake
Published in The Journal of pathology (01.03.2020)
Published in The Journal of pathology (01.03.2020)
Get full text
Journal Article
Evaluation of PIK3CA Mutation As a Predictor of Benefit From Nonsteroidal Anti-Inflammatory Drug Therapy in Colorectal Cancer
DOMINGO, Enric, CHURCH, David N, SIEBER, Oliver, RAMAMOORTHY, Rajarajan, YANAGISAWA, Yoko, JOHNSTONE, Elaine, DAVIDSON, Brian, KERR, David J, TOMLINSON, Ian P. M, MIDGLEY, Rachel
Published in Journal of clinical oncology (01.12.2013)
Published in Journal of clinical oncology (01.12.2013)
Get full text
Journal Article
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer
van Gool, Inge C, Eggink, Florine A, Freeman-Mills, Luke, Stelloo, Ellen, Marchi, Emanuele, de Bruyn, Marco, Palles, Claire, Nout, Remi A, de Kroon, Cor D, Osse, Elisabeth M, Klenerman, Paul, Creutzberg, Carien L, Tomlinson, Ian Pm, Smit, Vincent Thbm, Nijman, Hans W, Bosse, Tjalling, Church, David N
Published in Clinical cancer research (15.07.2015)
Published in Clinical cancer research (15.07.2015)
Get full text
Journal Article
Prognostic significance of POLE proofreading mutations in endometrial cancer
Church, David N, Stelloo, Ellen, Nout, Remi A, Valtcheva, Nadejda, Depreeuw, Jeroen, ter Haar, Natalja, Noske, Aurelia, Amant, Frederic, Tomlinson, Ian P M, Wild, Peter J, Lambrechts, Diether, Jürgenliemk-Schulz, Ina M, Jobsen, Jan J, Smit, Vincent T H B M, Creutzberg, Carien L, Bosse, Tjalling
Published in JNCI : Journal of the National Cancer Institute (01.01.2015)
Published in JNCI : Journal of the National Cancer Institute (01.01.2015)
Get full text
Journal Article
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
Horeweg, Nanda, Workel, Hagma H., Loiero, Dominik, Church, David N., Vermij, Lisa, Léon-Castillo, Alicia, Krog, Ricki T., de Boer, Stephanie M., Nout, Remi A., Powell, Melanie E., Mileshkin, Linda R., MacKay, Helen, Leary, Alexandra, Singh, Naveena, Jürgenliemk-Schulz, Ina M., Smit, Vincent T. H. B. M., Creutzberg, Carien L., Koelzer, Viktor H., Nijman, Hans W., Bosse, Tjalling, de Bruyn, Marco
Published in Nature communications (16.03.2022)
Published in Nature communications (16.03.2022)
Get full text
Journal Article
CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer
Komdeur, Fenne L., Prins, Thalina M., van de Wall, Stephanie, Plat, Annechien, Wisman, G. Bea A., Hollema, Harry, Daemen, Toos, Church, David N., de Bruyn, Marco, Nijman, Hans W.
Published in Oncoimmunology (02.09.2017)
Published in Oncoimmunology (02.09.2017)
Get full text
Journal Article
Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition
Eggink, Florine A., Van Gool, Inge C., Leary, Alexandra, Pollock, Pamela M., Crosbie, Emma J., Mileshkin, Linda, Jordanova, Ekaterina S., Adam, Julien, Freeman-Mills, Luke, Church, David N., Creutzberg, Carien L., De Bruyn, Marco, Nijman, Hans W., Bosse, Tjalling
Published in Oncoimmunology (01.02.2017)
Published in Oncoimmunology (01.02.2017)
Get full text
Journal Article
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response
Temko, Daniel, Van Gool, Inge C, Rayner, Emily, Glaire, Mark, Makino, Seiko, Brown, Matthew, Chegwidden, Laura, Palles, Claire, Depreeuw, Jeroen, Beggs, Andrew, Stathopoulou, Chaido, Mason, John, Baker, Ann‐Marie, Williams, Marc, Cerundolo, Vincenzo, Rei, Margarida, Taylor, Jenny C, Schuh, Anna, Ahmed, Ahmed, Amant, Frédéric, Lambrechts, Diether, Smit, Vincent THBM, Bosse, Tjalling, Graham, Trevor A, Church, David N, Tomlinson, Ian
Published in The Journal of pathology (01.07.2018)
Published in The Journal of pathology (01.07.2018)
Get full text
Journal Article
Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study
Domingo, Enric, Freeman-Mills, Luke, Rayner, Emily, Glaire, Mark, Briggs, Sarah, Vermeulen, Louis, Fessler, Evelyn, Medema, Jan Paul, Boot, Arnoud, Morreau, Hans, van Wezel, Tom, Liefers, Gerrit-Jan, Lothe, Ragnhild A, Danielsen, Stine A, Sveen, Anita, Nesbakken, Arild, Zlobec, Inti, Lugli, Alessandro, Koelzer, Viktor H, Berger, Martin D, Castellví-Bel, Sergi, Muñoz, Jenifer, de Bruyn, Marco, Nijman, Hans W, Novelli, Marco, Lawson, Kay, Oukrif, Dahmane, Frangou, Eleni, Dutton, Peter, Tejpar, Sabine, Delorenzi, Mauro, Kerr, Rachel, Kerr, David, Tomlinson, Ian, Church, David N
Published in The lancet. Gastroenterology & hepatology (01.11.2016)
Published in The lancet. Gastroenterology & hepatology (01.11.2016)
Get more information
Journal Article
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis
Brown, Matthew, Leon, Alicia, Kedzierska, Katarzyna, Moore, Charlotte, Belnoue-Davis, Hayley L, Flach, Susanne, Lydon, John P, DeMayo, Francesco J, Lewis, Annabelle, Bosse, Tjalling, Tomlinson, Ian, Church, David N
Published in EMBO molecular medicine (11.10.2023)
Published in EMBO molecular medicine (11.10.2023)
Get full text
Journal Article
Refining prognosis and identifying targetable pathways for high-risk endometrial cancer; a TransPORTEC initiative
Stelloo, Ellen, Bosse, Tjalling, Nout, Remi A, MacKay, Helen J, Church, David N, Nijman, Hans W, Leary, Alexandra, Edmondson, Richard J, Powell, Melanie E, Crosbie, Emma J, Kitchener, Henry C, Mileshkin, Linda, Pollock, Pamela M, Smit, Vincent T, Creutzberg, Carien L
Published in Modern pathology (01.06.2015)
Published in Modern pathology (01.06.2015)
Get full text
Journal Article
Patterns of cytotoxic T-cell densities in immunogenic endometrial cancers reveal a potential mechanism for differences in immunotherapy efficacy
Ryan, Neil, Glaire, Mark, Walker, Thomas, ter Haar, Natalja, Ijsselsteijn, Marieke, Bolton, James, de Miranda, Noel, Evans, Gareth, Church, David N, Bosse, Tjalling, Crosbie, Emma
Published in BMJ Oncology (21.05.2024)
Published in BMJ Oncology (21.05.2024)
Get full text
Journal Article
Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer
Nowak, Marta, Jabbar, Faiz, Rodewald, Ann-Katrin, Gneo, Luciana, Tomasevic, Tijana, Harkin, Andrea, Iveson, Tim, Saunders, Mark, Kerr, Rachel, Oein, Karin, Maka, Noori, Hay, Jennifer, Edwards, Joanne, Tomlinson, Ian, Sansom, Owen, Kelly, Caroline, Pezzella, Francesco, Kerr, David, Easton, Alistair, Domingo, Enric, Glimelius, Bengt, Gogenur, Ismail, Jaeger, Emma, Morgan, Hannah, Orange, Clare, Palles, Claire, Roxburgh, Campbell, Koelzer, Viktor H., Church, David N.
Published in Cell reports. Medicine (17.09.2024)
Published in Cell reports. Medicine (17.09.2024)
Get full text
Journal Article
Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer
Roseweir, Antonia K, Park, James H, Hoorn, Sanne ten, Powell, Arfon GMT, Aherne, Susan, Roxburgh, Campbell SD, McMillan, Donald C, Horgan, Paul G, Ryan, Elizabeth, Sheahan, Kieran, Vermeulen, Louis, Paul, James, Harkin, Andrea, Graham, Janet, Sansom, Owen, Church, David N, Tomlinson, Ian, Saunders, Mark, Iveson, Tim J, Edwards, Joanne
Published in The journal of pathology. Clinical research (01.10.2020)
Published in The journal of pathology. Clinical research (01.10.2020)
Get full text
Journal Article
Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets
Frei, Anja L, McGuigan, Anthony, Sinha, Ritik Rak, Glaire, Mark A, Jabbar, Faiz, Gneo, Luciana, Tomasevic, Tijana, Harkin, Andrea, Iveson, Tim J, Saunders, Mark, Oein, Karin, Maka, Noori, Pezella, Francesco, Campo, Leticia, Hay, Jennifer, Edwards, Joanne, Sansom, Owen J, Kelly, Caroline, Tomlinson, Ian, Kildal, Wanja, Kerr, Rachel S, Kerr, David J, Danielsen, Håvard E, Domingo, Enric, Church, David N, Koelzer, Viktor H
Published in The journal of pathology. Clinical research (01.11.2023)
Published in The journal of pathology. Clinical research (01.11.2023)
Get full text
Journal Article