LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
Li, Pingping, Oh, Da Young, Bandyopadhyay, Gautam, Lagakos, William S, Talukdar, Saswata, Osborn, Olivia, Johnson, Andrew, Chung, Heekyung, Mayoral, Rafael, Maris, Michael, Ofrecio, Jachelle M, Taguchi, Sayaka, Lu, Min, Olefsky, Jerrold M
Published in Nature medicine (01.03.2015)
Published in Nature medicine (01.03.2015)
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Journal Article
The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models
Tam, Betty Y., Chiu, Kevin, Chung, Heekyung, Bossard, Carine, Nguyen, John Duc, Creger, Emily, Eastman, Brian W., Mak, Chi Ching, Ibanez, Maureen, Ghias, Abdullah, Cahiwat, Joseph, Do, Long, Cho, Shawn, Nguyen, Jackie, Deshmukh, Vishal, Stewart, Josh, Chen, Chiao-Wen, Barroga, Charlene, Dellamary, Luis, KC, Sunil K., Phalen, Timothy J., Hood, John, Cha, Steven, Yazici, Yusuf
Published in Cancer letters (31.03.2020)
Published in Cancer letters (31.03.2020)
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Journal Article
Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice
Morinaga, Hidetaka, Mayoral, Rafael, Heinrichsdorff, Jan, Osborn, Olivia, Franck, Niclas, Hah, Nasun, Walenta, Evelyn, Bandyopadhyay, Gautam, Pessentheiner, Ariane R, Chi, Tyler J, Chung, Heekyung, Bogner-Strauss, Juliane G, Evans, Ronald M, Olefsky, Jerrold M, Oh, Da Young
Published in Diabetes (New York, N.Y.) (01.04.2015)
Published in Diabetes (New York, N.Y.) (01.04.2015)
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Journal Article
Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function
Riopel, Matthew, Seo, Jong Bae, Bandyopadhyay, Gautam K, Li, Pingping, Wollam, Joshua, Chung, Heekyung, Jung, Seung-Ryoung, Murphy, Anne, Wilson, Maria, de Jong, Ron, Patel, Sanjay, Balakrishna, Deepika, Bilakovics, James, Fanjul, Andrea, Plonowski, Artur, Koh, Duk-Su, Larson, Christopher J, Olefsky, Jerrold M, Lee, Yun Sok
Published in The Journal of clinical investigation (01.04.2018)
Published in The Journal of clinical investigation (01.04.2018)
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Journal Article
Adipocyte SIRT1 knockout promotes PPAR γ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
Mayoral, Rafael, Osborn, Olivia, McNelis, Joanne, Johnson, Andrew M, Oh, Da Young, Izquierdo, Cristina Llorente, Chung, Heekyung, Li, Pingping, Traves, Paqui G, Bandyopadhyay, Gautam, Pessentheiner, Ariane R, Ofrecio, Jachelle M, Cook, Joshua R, Qiang, Li, Accili, Domenico, Olefsky, Jerrold M
Published in Molecular metabolism (Germany) (01.05.2015)
Published in Molecular metabolism (Germany) (01.05.2015)
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Journal Article
Isolation and characterization of phosphate solubilizing bacteria from the rhizosphere of crop plants of Korea
Chung, Heekyung, Park, Myoungsu, Madhaiyan, Munusamy, Seshadri, Sundaram, Song, Jaekyeong, Cho, Hyunsuk, Sa, Tongmin
Published in Soil biology & biochemistry (01.10.2005)
Published in Soil biology & biochemistry (01.10.2005)
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Journal Article
Both microsatellite length and sequence context determine frameshift mutation rates in defective DNA mismatch repair
Chung, Heekyung, Lopez, Claudia G., Holmstrom, Joy, Young, Dennis J., Lai, Jenny F., Ream-Robinson, Deena, Carethers, John M.
Published in Human molecular genetics (01.07.2010)
Published in Human molecular genetics (01.07.2010)
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Journal Article
Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair
Chung, Heekyung, Young, Dennis J, Lopez, Claudia G, Le, Thuy-Anh T, Lee, Jeffrey K, Ream-Robinson, Deena, Huang, Sherry C, Carethers, John M
Published in PloS one (21.10.2008)
Published in PloS one (21.10.2008)
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Journal Article
Vitamin E Supplementation Does Not Alter Azoxymethane-Induced Colonic Aberrant Crypt Foci Formation in Young or Old Mice
Chung, Heekyung, Wu, Dayong, Han, Sung Nim, Gay, Raina, Goldin, Barry, Bronson, Roderick E., Mason, Joel B., Smith, Donald E., Meydani, Simin Nikbin
Published in The Journal of nutrition (01.02.2003)
Published in The Journal of nutrition (01.02.2003)
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Journal Article
Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity
Chung, Heekyung, Chou, Winjet, Sears, Dorothy D, Patterson, Ruth E, Webster, Nicholas, Ellies, Lesley G
Published in Metabolism, clinical and experimental (01.12.2016)
Published in Metabolism, clinical and experimental (01.12.2016)
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Journal Article
Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity
Lee, Yun Sok, Kim, Jung-Whan, Osborne, Olivia, Oh, Da Young, Sasik, Roman, Schenk, Simon, Chen, Ai, Chung, Heekyung, Murphy, Anne, Watkins, Steven M, Quehenberger, Oswald, Johnson, Randall S, Olefsky, Jerrold M
Published in Cell (05.06.2014)
Published in Cell (05.06.2014)
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Journal Article
A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice
Oh, Da Young, Walenta, Evelyn, Akiyama, Taro E, Lagakos, William S, Lackey, Denise, Pessentheiner, Ariane R, Sasik, Roman, Hah, Nasun, Chi, Tyler J, Cox, Jason M, Powels, Mary Ann, Di Salvo, Jerry, Sinz, Christopher, Watkins, Steven M, Armando, Aaron M, Chung, Heekyung, Evans, Ronald M, Quehenberger, Oswald, McNelis, Joanne, Bogner-Strauss, Juliane G, Olefsky, Jerrold M
Published in Nature medicine (01.08.2014)
Published in Nature medicine (01.08.2014)
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Journal Article
Abstract 3521: Transcriptome analysis of TCGA prostate cancer samples identifies an association of poorer survival and aggressive disease biology with CDC-like kinase (CLK) expression and spliceosome regulation
Cho, Shawn, Choudhury, Atish D., Fleener, Catherine, Do, Long, Bossard, Carine, Chung, Heekyung, Phalen, Timothy J., Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 6401: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt and cyclin D-CDK4/6-RB pathway inhibition in hormone-receptor-positive (HR+) breast cancer models
Chung, Heekyung, Sitts, Lauren, Wu, Chu-Chiao, Eastman, Brian, Mak, Chi Ching, KC, Sunil, Stewart, Josh, Bossard, Carine, Phalen, Timothy J., Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract A09: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong inhibition of the Wnt signaling pathway and antitumor effects in diverse ovarian cancer models
Chung, Heekyung, Sitts, Lauren, Creger, Emily, Liao, Erica, Eastman, Brian, Mak, Chi-Ching, Sunil, K.C., Tam, Betty, Bucci, Gail, Stewart, Josh, Bossard, Carine, Phalen, Timothy, Cha, Steven
Published in Clinical cancer research (01.07.2020)
Published in Clinical cancer research (01.07.2020)
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Journal Article
Abstract P3-13-01: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong inhibition of the Wnt signaling pathway and antitumor effects as monotherapy and in combination with chemotherapy in triple-negative breast cancer (TNBC) models
Chung, Heekyung, Sitts, Lauren, Creger, Emily, Nguyen, John Duc, Eastman, Brian, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bossard, Carine, Phalen, Timothy, Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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Journal Article
SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Acute Myeloid Leukemia Models
Chung, Heekyung, Creger, Emily, Sitts, Lauren, Chiu, Kevin, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bucci, Gail, Stewart, Josh, Phalen, Timothy, Cha, Steven
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Mantle Cell Lymphoma Models
Chung, Heekyung, Creger, Emily, Sitts, Lauren, Chiu, Kevin, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bucci, Gail, Stewart, Josh, Phalen, Timothy, Cha, Steven
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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