CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases
Liang, Jiaxin, Chen, Mengqian, Hughes, Daniel, Chumanevich, Alexander A, Altilia, Serena, Kaza, Vimala, Lim, Chang-Uk, Kiaris, Hippokratis, Mythreye, Karthikeyan, Pena, Maria Marjorette, Broude, Eugenia V, Roninson, Igor B
Published in Cancer research (Chicago, Ill.) (01.12.2018)
Published in Cancer research (Chicago, Ill.) (01.12.2018)
Get full text
Journal Article
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation
Shaked, Helena, Hofseth, Lorne J, Chumanevich, Alena, Chumanevich, Alexander A, Wang, Jin, Wang, Yinsheng, Taniguchi, Koji, Guma, Monica, Shenouda, Steve, Clevers, Hans, Harris, Curtis C, Karin, Michael
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2012)
Get full text
Journal Article
Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor
Chumanevich, Alexander A, Causey, Corey P, Knuckley, Bryan A, Jones, Justin E, Poudyal, Deepak, Chumanevich, Alena P, Davis, Tia, Matesic, Lydia E, Thompson, Paul R, Hofseth, Lorne J
Published in American journal of physiology: Gastrointestinal and liver physiology (01.06.2011)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.06.2011)
Get full text
Journal Article
Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer
Broude, Eugenia V, Győrffy, Balázs, Chumanevich, Alexander A, Chen, Mengqian, McDermott, Martina S J, Shtutman, Michael, Catroppo, James F, Roninson, Igor B
Published in Current cancer drug targets (01.10.2015)
Published in Current cancer drug targets (01.10.2015)
Get more information
Journal Article
Molecules from American Ginseng Suppress Colitis through Nuclear Factor Erythroid-2-Related Factor 2
Chaparala, Anusha, Tashkandi, Hossam, Chumanevich, Alexander A, Witalison, Erin E, Windust, Anthony, Cui, Taixing, Nagarkatti, Mitzi, Nagarkatti, Prakash, Hofseth, Lorne J
Published in Nutrients (21.06.2020)
Published in Nutrients (21.06.2020)
Get full text
Journal Article
The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest
Cui, Xiangli, Witalison, Erin E, Chumanevich, Alena P, Chumanevich, Alexander A, Poudyal, Deepak, Subramanian, Venkataraman, Schetter, Aaron J, Harris, Curtis C, Thompson, Paul R, Hofseth, Lorne J
Published in PloS one (07.01.2013)
Published in PloS one (07.01.2013)
Get full text
Journal Article
The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice
Zhang, Qi, Chumanevich, Alexander A., Nguyen, Ivy, Chumanevich, Anastasiya A., Sartawi, Nora, Hogan, Jake, Khazan, Minou, Harris, Quinn, Massey, Bryson, Chatzistamou, Ioulia, Buckhaults, Phillip J., Banister, Carolyn E., Wirth, Michael, Hebert, James R., Murphy, E. Angela, Hofseth, Lorne J.
Published in Toxicology reports (01.12.2023)
Published in Toxicology reports (01.12.2023)
Get full text
Journal Article
Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds
Chumanevich, Anastasiya A, Chaparala, Anusha, Witalison, Erin E, Tashkandi, Hossam, Hofseth, Anne B, Lane, Corey, Pena, Edsel, Liu, Piaomu, Pittman, Doug L, Nagarkatti, Prakash, Nagarkatti, Mitzi, Hofseth, Lorne J, Chumanevich, Alexander A
Published in Oncotarget (03.01.2017)
Published in Oncotarget (03.01.2017)
Get full text
Journal Article
Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer
McDermott, Martina S.J., Chumanevich, Alexander A., Lim, Chang-uk, Liang, Jiaxin, Chen, Mengqian, Altilia, Serena, Oliver, David, Rae, James M., Shtutman, Michael, Kiaris, Hippokratis, Győrffy, Balázs, Roninson, Igor B., Broude, Eugenia V.
Published in Oncotarget (21.02.2017)
Published in Oncotarget (21.02.2017)
Get full text
Journal Article
Caught in the Act: The 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate
Kovalevsky, Andrey Y, Chumanevich, Alexander A, Liu, Fengling, Louis, John M, Weber, Irene T
Published in Biochemistry (Easton) (25.12.2007)
Published in Biochemistry (Easton) (25.12.2007)
Get full text
Journal Article
Design, Synthesis, Protein−Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance
Ghosh, Arun K, Kulkarni, Sarang, Anderson, David D, Hong, Lin, Baldridge, Abigail, Wang, Yuan-Fang, Chumanevich, Alexander A, Kovalevsky, Andrey Y, Tojo, Yasushi, Amano, Masayuki, Koh, Yasuhiro, Tang, Jordan, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
Get full text
Journal Article
Allura Red AC is a xenobiotic. Is it also a carcinogen?
Hofseth, Lorne J, Hebert, James R, Murphy, E Angela, Trauner, Erica, Vikas, Athul, Harris, Quinn, Chumanevich, Alexander A
Published in Carcinogenesis (New York) (12.08.2024)
Published in Carcinogenesis (New York) (12.08.2024)
Get full text
Journal Article
A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics
Zhang, Li, Cheng, Chen, Li, Jing, Wang, Lili, Chumanevich, Alexander A, Porter, Donald C, Mindich, Aleksei, Gorbunova, Svetlana, Roninson, Igor B, Chen, Mengqian, McInnes, Campbell
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
Get full text
Journal Article
Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer
Serrao, Anne, Jenkins, Laura M., Chumanevich, Alexander A., Horst, Ben, Liang, Jiaxin, Gatza, Michael L., Lee, Nam Y., Roninson, Igor B., Broude, Eugenia V., Mythreye, Karthikeyan
Published in Oncogene (01.08.2018)
Published in Oncogene (01.08.2018)
Get full text
Journal Article
Mediator kinase inhibition reverses castration resistance of advanced prostate cancer
Li, Jing, Hilimire, Thomas A, Yueying, Liu, Wang, Lili, Liang, Jiaxin, Győrffy, Balázs, Sikirzhytski, Vitali, Ji, Hao, Zhang, Li, Cheng, Chen, Ding, Xiaokai, Kerr, Kendall R, Dowling, Charles E, Chumanevich, Alexander A, Mack, Zachary T, Schools, Gary P, Lim, Chang-Uk, Ellis, Leigh, Zi, Xiaolin, Porter, Donald C, Broude, Eugenia V, McInnes, Campbell, Wilding, George, Lilly, Michael B, Roninson, Igor B, Chen, Mengqian
Published in The Journal of clinical investigation (15.05.2024)
Published in The Journal of clinical investigation (15.05.2024)
Get full text
Journal Article
Novel complex MAD phasing and RNase H structural insights using selenium oligonucleotides
Abdur, Rob, Gerlits, Oksana O., Gan, Jianhua, Jiang, Jiansheng, Salon, Jozef, Kovalevsky, Andrey Y., Chumanevich, Alexander A., Weber, Irene T., Huang, Zhen
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2014)
Get full text
Journal Article
Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase
Chumanevich, Alexander A., Poudyal, Deepak, Cui, Xiangli, Davis, Tia, Wood, Patricia A., Smith, Charles D., Hofseth, Lorne J.
Published in Carcinogenesis (New York) (01.10.2010)
Published in Carcinogenesis (New York) (01.10.2010)
Get full text
Journal Article
Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer
McDermott, Martina S J, Chumanevich, Alexander A, Lim, Chang-Uk, Liang, Jiaxin, Chen, Mengqian, Altilia, Serena, Oliver, David, Rae, James M, Shtutman, Michael, Kiaris, Hippokratis, Győrffy, Balázs, Roninson, Igor B, Broude, Eugenia V
Published in Oncotarget (21.02.2017)
Published in Oncotarget (21.02.2017)
Get full text
Journal Article
The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors
Causey, Corey P, Jones, Justin E, Slack, Jessica L, Kamei, Daisuke, Jones, Larry E, Subramanian, Venkataraman, Knuckley, Bryan, Ebrahimi, Pedram, Chumanevich, Alexander A, Luo, Yuan, Hashimoto, Hiroshi, Sato, Mamoru, Hofseth, Lorne J, Thompson, Paul R
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
Get full text
Journal Article
Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice
Chaparala, Anusha, Poudyal, Deepak, Tashkandi, Hossam, Witalison, Erin E, Chumanevich, Alexander A, Hofseth, Jenna L, Nguyen, Ivy, Hardy, Olivia, Pittman, Douglas L, Wyatt, Michael D, Windust, Anthony, Murphy, Elizabeth A, Nagarkatti, Mitzi, Nagarkatti, Prakash, Hofseth, Lorne J
Published in Oncotarget (02.06.2020)
Published in Oncotarget (02.06.2020)
Get full text
Journal Article