Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy
Chuang, Chihyuan, Collibee, Scott, Ashcraft, Luke, Wang, Wenyue, Vander Wal, Mark, Wang, Xiaolin, Hwee, Darren T, Wu, Yangsong, Wang, Jingying, Chin, Eva R, Cremin, Peadar, Zamora, Jeanelle, Hartman, James, Schaletzky, Julia, Wehri, Eddie, Robertson, Laura A, Malik, Fady I, Morgan, Bradley P
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Journal Article
Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin
Metcalf, Brian, Chuang, Chihyuan, Dufu, Kobina, Patel, Mira P, Silva-Garcia, Abel, Johnson, Carl, Lu, Qing, Partridge, James R, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C, Jacobson, Matthew P, Hua, Lan, Xu, Qing, Gwaltney, Stephen L, Yee, Calvin, Harris, Jason, Morgan, Bradley P, James, Joyce, Xu, Donghong, Hutchaleelaha, Athiwat, Paulvannan, Kumar, Oksenberg, Donna, Li, Zhe
Published in ACS medicinal chemistry letters (09.03.2017)
Published in ACS medicinal chemistry letters (09.03.2017)
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Journal Article
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease
Oksenberg, Donna, Dufu, Kobina, Patel, Mira P., Chuang, Chihyuan, Li, Zhe, Xu, Qing, Silva‐Garcia, Abel, Zhou, Chengjing, Hutchaleelaha, Athiwat, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Sinha, Uma, Metcalf, Brian W., Archer, David R.
Published in British journal of haematology (01.10.2016)
Published in British journal of haematology (01.10.2016)
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Journal Article
SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR USING THE SAME IN INCREASING TISSUE OXYGENATION
CHUANG CHIHYUAN, JEFFREY WARRINGTON, MATTHEW P JACOBSON, BRIAN METCALF
Year of Publication 10.04.2024
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Year of Publication 10.04.2024
Patent
Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats
Collibee, Scott E., Romero, Antonio, Muci, Alexander R., Hwee, Darren T., Chuang, Chihyuan, Hartman, James J., Motani, Alykhan S., Ashcraft, Luke, DeRosier, Andre, Grillo, Mark, Lu, Qing, Malik, Fady I., Morgan, Bradley P.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility
Romero, Antonio, Ashcraft, Luke, Chandra, Aroop, DiMassa, Vincent, Cremin, Peadar, Collibee, Scott E., Chuang, Chihyuan, Hartman, James, Hwee, Darren T., St. Jean, David, Malinowski, Justin, DeBenedetto, Mikkel, Moebius, David, Payette, Joshua, Vargas, Richard, Yeoman, John, Motani, Alykhan, Reagan, Jeffrey, Malik, Fady I., Morgan, Bradley P.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function
Collibee, Scott E, Bergnes, Gustave, Chuang, Chihyuan, Ashcraft, Luke, Gardina, Jeffrey, Garard, Marc, Jamison, Chris R, Lu, Kevin, Lu, Pu-Ping, Muci, Alexander, Romero, Antonio, Valkevich, Ellen, Wang, Wenyue, Warrington, Jeffrey, Yao, Bing, Durham, Nickie, Hartman, James, Marquez, Anna, Hinken, Aaron, Schaletzky, Julia, Xu, Donghong, Hwee, Darren T, Morgans, David, Malik, Fady I, Morgan, Bradley P
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
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Journal Article
Preclinical characterization of CK-4021586, a new class of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy
Sankar Sarkar, Saswata, Hartman, James J., Hwee, Darren T., Chuang, Chihyuan, Cremin, Peadar, deRosier, Andre, Edell, Samantha, Madhvani, Roshni, Wu, Yangsong, Yco, Lisette, Zamora, Jeanelle, Murphy, Anne, Morgan, Bradley P., Malik, Fady I.
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Journal Article
CARDIAC SARCOMERE INHIBITORS
CHUANG CHIHYUAN, LUKE W ASHCRAFT, MARK VANDERWAL, BRADLEY P MORGAN, KEVIN LAU
Year of Publication 16.04.2024
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Year of Publication 16.04.2024
Patent
CD38 조절제 및 이의 사용 방법
IWAN BARTLOMIEJ PRZEMYSLAW, ASHCRAFT LUKE W, CHUANG CHIHYUAN, MORGAN BRADLEY P, GARCIA ALFREDO, MERMIN MOLLY EICHEL
Year of Publication 12.04.2024
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Year of Publication 12.04.2024
Patent
심장 근절 억제제
ASHCRAFT LUKE W, MORGAN BRADLEY P, CHUANG CHIHYUAN, GARCIA ALFREDO, HO JUSTIN
Year of Publication 05.02.2024
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Year of Publication 05.02.2024
Patent
DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS
CHUANG CHIHYUAN, LUKE W ASHCRAFT, MARK VANDERWAL, WANG WENYUE, BRADLEY P MORGAN
Year of Publication 29.11.2023
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Year of Publication 29.11.2023
Patent
Characterization of the Cardiac Myosin Inhibitor CK-3773274: a Potential Therapeutic Approach for Hypertrophic Cardiomyopathy
Hartman, James J., Hwee, Darren T., Wang, Jingying, Wu, Yangsong, Schaletzky, Julia, Paliwal, Preeti, Lee, Ken, Taheri, Khanha D., Wehri, Eddie, Ewing, Todd J., Michel, Joseph P., Chuang, Chihyuan, Chin, Eva R., Morgan, Bradley P., Malik, Fady I.
Published in Biophysical journal (07.02.2020)
Published in Biophysical journal (07.02.2020)
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Journal Article
SUBSTITUTED BENZALDEHYDE COMPOUND AND METHOD FOR THEIR USE IN INCREASING TISSUE OXYGENATION
CHUANG CHIHYUAN, JEFFREY WARRINGTON, MATTHEW P JACOBSON, BRIAN METCALF
Year of Publication 26.07.2021
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Year of Publication 26.07.2021
Patent
Abstract 332: Pharmacologic Characterization of the Cardiac Myosin Inhibitor, CK-3773274: A Potential Therapeutic Approach for Hypertrophic Cardiomyopathy
Hwee, Darren T, Hartman, James J, Wang, Jingying, Wu, Yangsong, Schaletzky, Julia, Paliwal, Preeti, Lee, Ken, Taheri, Khanha D, Wehri, Eddie, Chuang, Chihyuan, Morgan, Bradley P, Malik, Fady I, Chin, Eva R
Published in Circulation research (02.08.2019)
Published in Circulation research (02.08.2019)
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Journal Article
SUBSTITUTED BENZALDEHYDE COMPOUND AND APPLICATION METHOD THEREOF IN INCREASE OF TISSUE OXYGENATION
CHUANG CHIHYUAN, JEFFREY WARRINGTON, MATTHEW P JACOBSON, BRIAN METCALF
Year of Publication 14.05.2020
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Year of Publication 14.05.2020
Patent
Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy
Hartman, James J, Hwee, Darren T, Robert-Paganin, Julien, Chuang, Chihyuan, Chin, Eva R, Edell, Samantha, Lee, Ken H, Madhvani, Roshni, Paliwal, Preeti, Pernier, Julien, Sarkar, Saswata Sankar, Schaletzky, Julia, Schauer, Kristine, Taheri, Khanha D, Wang, Jingying, Wehri, Eddie, Wu, Yangsong, Houdusse, Anne, Morgan, Bradley P, Malik, Fady I
Published in Nature cardiovascular research (01.08.2024)
Published in Nature cardiovascular research (01.08.2024)
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Journal Article
심장 근절 억제제
LAU KEVIN, VANDERWAL MARK, ASHCRAFT LUKE W, CHUANG CHIHYUAN, MORGAN BRADLEY P
Year of Publication 09.06.2021
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Year of Publication 09.06.2021
Patent