A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release
Chu, Zhi-Liang, Carroll, Chris, Alfonso, Jean, Gutierrez, Veronica, He, Hongmei, Lucman, Annette, Pedraza, Melinda, Mondala, Helen, Gao, Hui, Bagnol, Didier, Chen, Ruoping, Jones, Robert M, Behan, Dominic P, Leonard, James
Published in Endocrinology (Philadelphia) (01.05.2008)
Published in Endocrinology (Philadelphia) (01.05.2008)
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Journal Article
Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119
Semple, Graeme, Fioravanti, Beatriz, Pereira, Guillherme, Calderon, Imelda, Uy, Jane, Choi, Karoline, Xiong, Yifeng, Ren, Albert, Morgan, Michael, Dave, Vibha, Thomsen, William, Unett, David J, Xing, Charles, Bossie, Stuart, Carroll, Chris, Chu, Zhi-Liang, Grottick, Andrew J, Hauser, Erin K, Leonard, James, Jones, Robert M
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
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Journal Article
Suppression of Tumor Necrosis Factor-Induced Cell Death by Inhibitor of Apoptosis c-IAP2 is under NF-κ B Control
Chu, Zhi-Liang, McKinsey, Timothy A., Liu, Lily, Gentry, Jennifer J., Malim, Michael H., Ballard, Dean W.
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.1997)
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Journal Article
A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis
Chu, Zhi-Liang, Pio, Frederick, Xie, Zhihua, Welsh, Kate, Krajewska, Maryla, Krajewski, Stan, Godzik, Adam, Reed, John C.
Published in The Journal of biological chemistry (23.03.2001)
Published in The Journal of biological chemistry (23.03.2001)
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Journal Article
A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release
Chu, Zhi-Liang, Jones, Robert M, He, Hongmei, Carroll, Chris, Gutierrez, Veronica, Lucman, Annette, Moloney, Molly, Gao, Hui, Mondala, Helen, Bagnol, Didier, Unett, David, Liang, Yin, Demarest, Keith, Semple, Graeme, Behan, Dominic P, Leonard, James
Published in Endocrinology (Philadelphia) (01.06.2007)
Published in Endocrinology (Philadelphia) (01.06.2007)
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Journal Article
N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119
Chu, Zhi-Liang, Carroll, Chris, Chen, Ruoping, Alfonso, Jean, Gutierrez, Veronica, He, Hongmei, Lucman, Annette, Xing, Charles, Sebring, Kristen, Zhou, Jinyao, Wagner, Brandee, Unett, David, Jones, Robert M, Behan, Dominic P, Leonard, James
Published in Molecular endocrinology (Baltimore, Md.) (01.01.2010)
Published in Molecular endocrinology (Baltimore, Md.) (01.01.2010)
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Journal Article
A Copper-Catalyzed Domino Route toward Purine-Fused Tricyclic Derivatives
Xie, Ming-Sheng, Chu, Zhi-Liang, Niu, Hong-Ying, Qu, Gui-Rong, Guo, Hai-Ming
Published in Journal of organic chemistry (07.02.2014)
Published in Journal of organic chemistry (07.02.2014)
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Journal Article
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control
Semple, Graeme, Ren, Albert, Fioravanti, Beatriz, Pereira, Guillherme, Calderon, Imelda, Choi, Karoline, Xiong, Yifeng, Shin, Young-Jun, Gharbaoui, Tawfik, Sage, Carleton R., Morgan, Michael, Xing, Charles, Chu, Zhi-Liang, Leonard, James N., Grottick, Andrew J., Al-Shamma, Hussein, Liang, Yin, Demarest, Keith T., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Journal Article
Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile
Semple, Graeme, Lehmann, Juerg, Wong, Amy, Ren, Albert, Bruce, Marc, Shin, Young-Jun, Sage, Carleton R., Morgan, Michael, Chen, Wei-Chao, Sebring, Kristen, Chu, Zhi-Liang, Leonard, James N., Al-Shamma, Hussein, Grottick, Andrew J., Du, Fuyong, Liang, Yin, Demarest, Keith, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series
Han, Sangdon, Narayanan, Sanju, Kim, Sun Hee, Calderon, Imelda, Zhu, Xiuwen, Kawasaki, Andrew, Yue, Dawei, Lehmann, Juerg, Wong, Amy, Buzard, Daniel J., Semple, Graeme, Carroll, Chris, Chu, Zhi-Liang, Al-Sharmma, Hussein, Shu, Hsin-Hui, Tung, Shiu-Feng, Unett, David J., Behan, Dominic P., Yoon, Woo Hyun, Morgan, Michael, Usmani, Khawja A., Chen, Chuan, Sadeque, Abu, Leonard, James N., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.08.2015)
Published in Bioorganic & medicinal chemistry letters (01.08.2015)
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Journal Article
Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists
Buzard, Daniel J., Kim, Sun Hee, Lehmann, Juerg, Han, Sangdon, Calderon, Imelda, Wong, Amy, Kawasaki, Andrew, Narayanan, Sanju, Bhat, Rohit, Gharbaoui, Tawfik, Lopez, Luis, Yue, Dawei, Whelan, Kevin, Al-Shamma, Hussien, Unett, David J., Shu, Hsin-Hui, Tung, Shiu-Feng, Chang, Steve, Chuang, Ching-Fen, Morgan, Michael, Sadeque, Abu, Chu, Zhi-Liang, Leonard, James N., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
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Journal Article
IKKγ Mediates the Interaction of Cellular IκB Kinases with the Tax Transforming Protein of Human T Cell Leukemia Virus Type 1
Chu, Zhi-Liang, Shin, Young-Ah, Yang, Jin-Ming, DiDonato, Joseph A., Ballard, Dean W.
Published in The Journal of biological chemistry (28.05.1999)
Published in The Journal of biological chemistry (28.05.1999)
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Journal Article
Transcription factor NF-κB regulates inducible CD83 gene expression in activated T lymphocytes
McKinsey, Timothy A., Chu, Zhi-Liang, Tedder, Thomas F., Ballard, Dean W.
Published in Molecular immunology (01.09.2000)
Published in Molecular immunology (01.09.2000)
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Journal Article
Abstract LB166: Discovery of CT3021, a novel potent adenosine A2a/A2b/A1 receptor triple antagonist
Han, Sandong, Kim, Nam Hee, He, Hongmei, Chu, Zhi Liang
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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