Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
Chen, Jun, Joshi, Shailen K., DiDomenico, Stanley, Perner, Richard J., Mikusa, Joe P., Gauvin, Donna M., Segreti, Jason A., Han, Ping, Zhang, Xu-Feng, Niforatos, Wende, Bianchi, Bruce R., Baker, Scott J., Zhong, Chengmin, Simler, Gricelda H., McDonald, Heath A., Schmidt, Robert G., McGaraughty, Steve P., Chu, Katharine L., Faltynek, Connie R., Kort, Michael E., Reilly, Regina M., Kym, Philip R.
Published in Pain (Amsterdam) (01.05.2011)
Published in Pain (Amsterdam) (01.05.2011)
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Journal Article
TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats
McGaraughty, Steve, Chu, Katharine L, Perner, Richard J, DiDomenico, Stan, Kort, Michael E, Kym, Philip R
Published in Molecular pain (05.03.2010)
Published in Molecular pain (05.03.2010)
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Journal Article
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial
Rowbotham, Michael C., Nothaft, Wolfram, Duan, W. Rachel, Wang, Yi, Faltynek, Connie, McGaraughty, Steve, Chu, Katharine L., Svensson, Peter
Published in Pain (Amsterdam) (01.05.2011)
Published in Pain (Amsterdam) (01.05.2011)
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Journal Article
Characterization and comparison of rat monosodium iodoacetate and medial meniscal tear models of osteoarthritic pain
Brederson, Jill‐Desiree, Chu, Katharine L., Xu, Jun, Nikkel, Arthur L., Markosyan, Stella, Jarvis, Michael F., Edelmayer, Rebecca, Bitner, Robert S., McGaraughty, Steve
Published in Journal of orthopaedic research (01.08.2018)
Published in Journal of orthopaedic research (01.08.2018)
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Journal Article
A Selective Nav1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats
McGaraughty, Steve, Chu, Katharine L, Scanio, Marc J C, Kort, Michael E, Faltynek, Connie R, Jarvis, Michael F
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
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Journal Article
(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo
Surowy, Carol S, Neelands, Torben R, Bianchi, Bruce R, McGaraughty, Steve, El Kouhen, Rachid, Han, Ping, Chu, Katharine L, McDonald, Heath A, Vos, Melissa, Niforatos, Wende, Bayburt, Erol K, Gomtsyan, Arthur, Lee, Chih-Hung, Honore, Prisca, Sullivan, James P, Jarvis, Michael F, Faltynek, Connie R
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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Journal Article
TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation
Brederson, Jill-Desiree, Chu, Katharine L., Reilly, Regina M., Brown, Brian S., Kym, Philip R., Jarvis, Michael F., McGaraughty, Steve
Published in Synapse (New York, N.Y.) (01.03.2012)
Published in Synapse (New York, N.Y.) (01.03.2012)
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Journal Article
Characterization of Fasudil in Preclinical Models of Pain
Boyce-Rustay, Janel M, Simler, Gricelda H, McGaraughty, Steve, Chu, Katharine L, Wensink, Erica J, Vasudevan, Anil, Honore, Prisca
Published in The journal of pain (01.10.2010)
Published in The journal of pain (01.10.2010)
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Journal Article
Efficacy and safety results of depatuxizumab mafodotin (ABT‐414) in patients with advanced solid tumors likely to overexpress epidermal growth factor receptor
Goss, Glenwood D., Vokes, Everett E., Gordon, Michael S., Gandhi, Leena, Papadopoulos, Kyriakos P., Rasco, Drew W., Fischer, JuDee S., Chu, Katharine L., Ames, William W., Mittapalli, Rajendar K., Lee, Ho‐Jin, Zeng, Jiewei, Roberts‐Rapp, Lisa A., Loberg, Lise I., Ansell, Peter J., Reilly, Edward B., Ocampo, Christopher J., Holen, Kyle D., Tolcher, Anthony W.
Published in Cancer (15.05.2018)
Published in Cancer (15.05.2018)
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Journal Article
Effects of A‐317491, a novel and selective P2X 3 /P2X 2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration
McGaraughty, Steve, Wismer, Carol T, Zhu, Chang Z, Mikusa, Joseph, Honore, Prisca, Chu, Katharine L, Lee, Chih‐Hung, Faltynek, Connie R, Jarvis, Michael F
Published in British journal of pharmacology (02.02.2009)
Published in British journal of pharmacology (02.02.2009)
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Journal Article
A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats
Jarvis, Michael F., Scott, Victoria E., McGaraughty, Steve, Chu, Katharine L., Xu, Jun, Niforatos, Wende, Milicic, Ivan, Joshi, Shailen, Zhang, Qingwei, Xia, Zhiren
Published in Biochemical pharmacology (15.06.2014)
Published in Biochemical pharmacology (15.06.2014)
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Journal Article
TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats
McGaraughty, Steve, Chu, Katharine L, Xu, Jun, Leys, Laura, Radek, Richard J, Dart, Michael J, Gomtsyan, Arthur, Schmidt, Robert G, Kym, Philip R, Brederson, Jill-Desiree
Published in Journal of neurophysiology (01.08.2017)
Published in Journal of neurophysiology (01.08.2017)
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Journal Article
Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats
Xu, Jun, Chu, Katharine L., Brederson, Jill-Desiree, Jarvis, Michael F., McGaraughty, Steve
Published in Journal of neuroscience research (01.08.2012)
Published in Journal of neuroscience research (01.08.2012)
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Journal Article
Disturbances in slow-wave sleep are induced by models of bilateral inflammation, neuropathic, and postoperative pain, but not osteoarthritic pain in rats
Leys, Laura J., Chu, Katharine L., Xu, Jun, Pai, Madhavi, Yang, He S., Robb, Holly M., Jarvis, Michael F., Radek, Richard J., McGaraughty, Steve
Published in Pain (Amsterdam) (01.07.2013)
Published in Pain (Amsterdam) (01.07.2013)
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Journal Article
A mixed Ca2+ channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain
Xu, Jun, Chu, Katharine L, Zhu, Chang Z, Niforatos, Wende, Swensen, Andrew, Searle, Xenia, Lee, Lance, Jarvis, Michael F, McGaraughty, Steve
Published in Journal of neurophysiology (01.01.2014)
Published in Journal of neurophysiology (01.01.2014)
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Journal Article
Contributions of Central and Peripheral TRPV1 Receptors to Mechanically Evoked and Spontaneous Firing of Spinal Neurons in Inflamed Rats
McGaraughty, Steve, Chu, Katharine L, Brown, Brian S, Zhu, Chang Z, Zhong, Chengmin, Joshi, Shailen K, Honore, Prisca, Faltynek, Connie R, Jarvis, Michael F
Published in Journal of neurophysiology (01.12.2008)
Published in Journal of neurophysiology (01.12.2008)
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Journal Article
Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models
Zhu, Chang Z, Vortherms, Timothy A, Zhang, Min, Xu, Jun, Swensen, Andrew M, Niforatos, Wende, Neelands, Torben, Milicic, Ivan, Lewis, La Geisha, Zhong, Chengmin, Gauvin, Donna, Mikusa, Joseph, Zhan, Cenchen, Pai, Madhavi, Roderwald, Victoria, Chu, Katharine L, Cole, Emily E, Bespalov, Anton, Searle, Xenia B, McGaraughty, Steve, Bitner, Robert S, Jarvis, Michael F, Bannon, Anthony W, Joshi, Shailen K, Scott, Victoria E, Lee, Chih-Hung
Published in The journal of pain (01.04.2014)
Published in The journal of pain (01.04.2014)
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