Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer
Kapoor, Avnish, Yao, Wantong, Ying, Haoqiang, Hua, Sujun, Liewen, Alison, Wang, Qiuyun, Zhong, Yi, Wu, Chang-Jiun, Sadanandam, Anguraj, Hu, Baoli, Chang, Qing, Chu, Gerald C., Al-Khalil, Ramsey, Jiang, Shan, Xia, Hongai, Fletcher-Sananikone, Eliot, Lim, Carol, Horwitz, Gillian I., Viale, Andrea, Pettazzoni, Piergiorgio, Sanchez, Nora, Wang, Huamin, Protopopov, Alexei, Zhang, Jianhua, Heffernan, Timothy, Johnson, Randy L., Chin, Lynda, Wang, Y. Alan, Draetta, Giulio, DePinho, Ronald A.
Published in Cell (03.07.2014)
Published in Cell (03.07.2014)
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Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
Biancur, Douglas E., Paulo, Joao A., Małachowska, Beata, Quiles Del Rey, Maria, Sousa, Cristovão M., Wang, Xiaoxu, Sohn, Albert S. W., Chu, Gerald C., Gygi, Steven P., Harper, J. Wade, Fendler, Wojciech, Mancias, Joseph D., Kimmelman, Alec C.
Published in Nature communications (03.07.2017)
Published in Nature communications (03.07.2017)
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Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Ying, Haoqiang, Kimmelman, Alec C., Lyssiotis, Costas A., Hua, Sujun, Chu, Gerald C., Fletcher-Sananikone, Eliot, Locasale, Jason W., Son, Jaekyoung, Zhang, Hailei, Coloff, Jonathan L., Yan, Haiyan, Wang, Wei, Chen, Shujuan, Viale, Andrea, Zheng, Hongwu, Paik, Ji-hye, Lim, Carol, Guimaraes, Alexander R., Martin, Eric S., Chang, Jeffery, Hezel, Aram F., Perry, Samuel R., Hu, Jian, Gan, Boyi, Xiao, Yonghong, Asara, John M., Weissleder, Ralph, Wang, Y. Alan, Chin, Lynda, Cantley, Lewis C., DePinho, Ronald A.
Published in Cell (27.04.2012)
Published in Cell (27.04.2012)
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Oncogenic Kras drives invasion and maintains metastases in colorectal cancer
Boutin, Adam T, Liao, Wen-Ting, Wang, Melody, Hwang, Soyoon Sarah, Karpinets, Tatiana V, Cheung, Hannah, Chu, Gerald C, Jiang, Shan, Hu, Jian, Chang, Kyle, Vilar, Eduardo, Song, Xingzhi, Zhang, Jianhua, Kopetz, Scott, Futreal, Andrew, Wang, Y Alan, Kwong, Lawrence N, DePinho, Ronald A
Published in Genes & development (15.02.2017)
Published in Genes & development (15.02.2017)
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Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases
Ding, Zhihu, Wu, Chang-Jiun, Jaskelioff, Mariela, Ivanova, Elena, Kost-Alimova, Maria, Protopopov, Alexei, Chu, Gerald C., Wang, Guocan, Lu, Xin, Labrot, Emma S., Hu, Jian, Wang, Wei, Xiao, Yonghong, Zhang, Hailei, Zhang, Jianhua, Zhang, Jingfang, Gan, Boyi, Perry, Samuel R., Jiang, Shan, Li, Liren, Horner, James W., Wang, Y. Alan, Chin, Lynda, DePinho, Ronald A.
Published in Cell (02.03.2012)
Published in Cell (02.03.2012)
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Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee
ITTMANN, Michael, JIAOTI HUANG, LODA, Massimo, THOMAS, George, BOROWSKY, Alexander, CARDIFF, Robert D, RADAELLI, Enrico, MARTIN, Philip, SIGNORETTI, Sabina, SULLIVAN, Ruth, SIMONS, Brian W, WARD, Jerrold M, ROBINSON, Brian D, CHU, Gerald C
Published in Cancer research (Chicago, Ill.) (01.05.2013)
Published in Cancer research (Chicago, Ill.) (01.05.2013)
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GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
Nolan-Stevaux, Olivier, Lau, Janet, Truitt, Morgan L, Chu, Gerald C, Hebrok, Matthias, Fernández-Zapico, Martin E, Hanahan, Douglas
Published in Genes & development (01.01.2009)
Published in Genes & development (01.01.2009)
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p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
DePinho, Ronald A, Zheng, Hongwu, Ying, Haoqiang, Yan, Haiyan, Kimmelman, Alec C, Hiller, David J, Chen, An-Jou, Perry, Samuel R, Tonon, Giovanni, Chu, Gerald C, Ding, Zhihu, Stommel, Jayne M, Dunn, Katherine L, Wiedemeyer, Ruprecht, You, Mingjian J, Brennan, Cameron, Wang, Y. Alan, Ligon, Keith L, Wong, Wing H, Chin, Lynda
Published in Nature (23.10.2008)
Published in Nature (23.10.2008)
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Stromal biology of pancreatic cancer
Chu, Gerald C., Kimmelman, Alec C., Hezel, Aram F., DePinho, Ronald A.
Published in Journal of cellular biochemistry (01.07.2007)
Published in Journal of cellular biochemistry (01.07.2007)
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Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
Bardeesy, Nabeel, Cheng, Kuang-Hung, Berger, Justin H, Chu, Gerald C, Pahler, Jessica, Olson, Peter, Hezel, Aram F, Horner, James, Lauwers, Gregory Y, Hanahan, Douglas, DePinho, Ronald A
Published in Genes & development (15.11.2006)
Published in Genes & development (15.11.2006)
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Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
Friedlander, Sharon Y. Gidekel, Chu, Gerald C., Snyder, Eric L., Girnius, Nomeda, Dibelius, Gregory, Crowley, Denise, Vasile, Eliza, DePinho, Ronald A., Jacks, Tyler
Published in Cancer cell (06.11.2009)
Published in Cancer cell (06.11.2009)
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Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes
Scott, Kenneth L., Nogueira, Cristina, Heffernan, Timothy P., van Doorn, Remco, Dhakal, Sabin, Hanna, Jason A., Min, Chengyin, Jaskelioff, Mariela, Xiao, Yonghong, Wu, Chang-Jiun, Cameron, Lisa A., Perry, Samuel R., Zeid, Rhamy, Feinberg, Tamar, Kim, Minjung, Vande Woude, George, Granter, Scott R., Bosenberg, Marcus, Chu, Gerald C., DePinho, Ronald A., Rimm, David L., Chin, Lynda
Published in Cancer cell (12.07.2011)
Published in Cancer cell (12.07.2011)
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Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma
Olson, Peter, Chu, Gerald C, Perry, Samuel R, Nolan-Stevaux, Olivier, Hanahan, Douglas
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2011)
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Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation
David, Gregory, Grandinetti, Kathryn B, Finnerty, Patricia M, Simpson, Natalie, Chu, Gerald C, DePinho, Ronald A
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2008)
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Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression
Wang, Yufang, Velho, Sérgia, Vakiani, Efsevia, Peng, Shouyong, Bass, Adam J, Chu, Gerald C, Gierut, Jessica, Bugni, James M, Der, Channing J, Philips, Mark, Solit, David B, Haigis, Kevin M
Published in Cancer discovery (01.03.2013)
Published in Cancer discovery (01.03.2013)
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Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer
Kimmelman, Alec C, Hezel, Aram F, Aguirre, Andrew J, Zheng, Hongwu, Paik, Ji-hye, Ying, Haoqiang, Chu, Gerald C, Zhang, Jean X, Sahin, Ergun, Yeo, Giminna, Ponugoti, Aditya, Nabioullin, Roustem, Deroo, Scott, Yang, Shenghong, Wang, Xiaoxu, McGrath, John P, Protopopova, Marina, Ivanova, Elena, Zhang, Jianhua, Feng, Bin, Tsao, Ming S, Redston, Mark, Protopopov, Alexei, Xiao, Yonghong, Futreal, P. Andrew, Hahn, William C, Klimstra, David S, Chin, Lynda, DePinho, Ronald A
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.2008)
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Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
Wiedemeyer, Ruprecht, Brennan, Cameron, Heffernan, Timothy P., Xiao, Yonghong, Mahoney, John, Protopopov, Alexei, Zheng, Hongwu, Bignell, Graham, Furnari, Frank, Cavenee, Webster K., Hahn, William C., Ichimura, Koichi, Collins, V. Peter, Chu, Gerald C., Stratton, Michael R., Ligon, Keith L., Futreal, P. Andrew, Chin, Lynda
Published in Cancer cell (01.04.2008)
Published in Cancer cell (01.04.2008)
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Ott1 (Rbm15) Is Essential for Placental Vascular Branching Morphogenesis and Embryonic Development of the Heart and Spleen
Raffel, Glen D., Chu, Gerald C., Jesneck, Jonathan L., Cullen, Dana E., Bronson, Roderick T., Bernard, Olivier A., Gilliland, D. Gary
Published in Molecular and Cellular Biology (01.01.2009)
Published in Molecular and Cellular Biology (01.01.2009)
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Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations
Yang, Annan, Rajeshkumar, N V, Wang, Xiaoxu, Yabuuchi, Shinichi, Alexander, Brian M, Chu, Gerald C, Von Hoff, Daniel D, Maitra, Anirban, Kimmelman, Alec C
Published in Cancer discovery (01.08.2014)
Published in Cancer discovery (01.08.2014)
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Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
Kwong, Lawrence N, Costello, James C, Liu, Huiyun, Jiang, Shan, Helms, Timothy L, Langsdorf, Aliete E, Jakubosky, David, Genovese, Giannicola, Muller, Florian L, Jeong, Joseph H, Bender, Ryan P, Chu, Gerald C, Flaherty, Keith T, Wargo, Jennifer A, Collins, James J, Chin, Lynda
Published in Nature medicine (01.10.2012)
Published in Nature medicine (01.10.2012)
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