Eftilagimod alpha, a soluble lymphocyte activation gene-3 (LAG-3) protein plus pembrolizumab in patients with metastatic melanoma
Atkinson, Victoria, Khattak, Adnan, Haydon, Andrew, Eastgate, Melissa, Roy, Amitesh, Prithviraj, Prashanth, Mueller, Christian, Brignone, Chrystelle, Triebel, Frederic
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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A Phase I Pharmacokinetic and Biological Correlative Study of IMP321, a Novel MHC Class II Agonist, in Patients with Advanced Renal Cell Carcinoma
BRIGNONE, Chrystelle, ESCUDIER, Bernard, GRYGAR, Caroline, MARCU, Manon, TRIEBEL, Frédéric
Published in Clinical cancer research (01.10.2009)
Published in Clinical cancer research (01.10.2009)
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First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity
Brignone, Chrystelle, Gutierrez, Maya, Mefti, Fawzia, Brain, Etienne, Jarcau, Rosana, Cvitkovic, Frédérique, Bousetta, Nabil, Medioni, Jacques, Gligorov, Joseph, Grygar, Caroline, Marcu, Manon, Triebel, Frédéric
Published in Journal of translational medicine (23.07.2010)
Published in Journal of translational medicine (23.07.2010)
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MHC class II engagement by its ligand LAG-3 (CD223) contributes to melanoma resistance to apoptosis
Hemon, Patrice, Jean-Louis, Francette, Ramgolam, Kiran, Brignone, Chrystelle, Viguier, Manuelle, Bachelez, Hervé, Triebel, Frédéric, Charron, Dominique, Aoudjit, Fawzi, Al-Daccak, Reem, Michel, Laurence
Published in The Journal of immunology (1950) (01.05.2011)
Published in The Journal of immunology (1950) (01.05.2011)
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Immunophenotyping of Peripheral Blood Mononuclear Cells in Septic Shock Patients With High-Dimensional Flow Cytometry Analysis Reveals Two Subgroups With Differential Responses to Immunostimulant Drugs
Wang, Ya, Gloss, Brian, Tang, Benjamin, Dervish, Suat, Santner-Nanan, Brigitte, Whitehead, Christina, Masters, Kristy, Skarratt, Kristen, Teoh, Sally, Schibeci, Stephen, Fewings, Nicole, Brignone, Chrystelle, Triebel, Frederic, Booth, David, McLean, Anthony, Nalos, Marek
Published in Frontiers in immunology (22.03.2021)
Published in Frontiers in immunology (22.03.2021)
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Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300
Grossman, Steven R., Deato, Maria E., Brignone, Chrystelle, Chan, Ho Man, Kung, Andrew L., Tagami, Hideaki, Nakatani, Yoshihiro, Livingston, David M.
Published in Science (American Association for the Advancement of Science) (11.04.2003)
Published in Science (American Association for the Advancement of Science) (11.04.2003)
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595 Biomarker results from the 1st line non-small cell lung cancer cohort of TACTI-002: pharmacodynamic effects of combining eftilagimod alpha (soluble LAG-3) and pembrolizumab
Forster, Martin, Felip, Enriqueta, Majem, Margarita, Doger, Bernard, Clay, Tim, Carcereny, Enric, Bondarenko, Igor, Peguero, Julio, Dols, Manuel Cobo, Ursol, Grygorii, Kalinka, Ewa, Ledo, Gema Garcia, Martinez, Laia Vilà, Krebs, Matthew, Iams, Wade T, Mueller, Christian, Brignone, Chrystelle, Triebel, Frederic
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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948 Final results from AIPAC: A phase IIb comparing eftilagimod alpha (a soluble LAG-3 protein) vs. placebo in combination with weekly paclitaxel in HR+ HER2- MBC
Wildiers, Hans, Dirix, Luc, Armstrong, Anne, Cuypere, Eveline De, Dalenc, Florence, Chan, Steven, Marme, Frederik, Schröder, Carolina Pia, Huober, Jens, Vuylsteke, Peter, Jacquin, Jean-Philippe, Brain, Etienne, Kümmel, Sherko, Pápai, Zsuzsanna, Mueller, Christian, Brignone, Chrystelle, Triebel, Frederic
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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790 A phase II study (TACTI-002) of eftilagimod alpha (a soluble LAG-3 protein) with pembrolizumab in PD-L1 unselected patients with metastatic non-small cell lung(NSCLC) or head and neck carcinoma(HNSCC)
Krebs, Matthew, Majem, Margarita, Felip, Enriqueta, Forster, Martin, Doger, Bernard, Clay, Tim, Carcereny, Enric, Peguero, Julio, Horn, Leora, Bajaj, Pawan, Roxburgh, Patricia, Brignone, Chrystelle, Mueller, Christian, Triebel, Frederic
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway
BRIGNONE, Chrystelle, BRADLEY, Kathleen E, KISSELEV, Alexei F, GROSSMAN, Steven R
Published in Oncogene (20.05.2004)
Published in Oncogene (20.05.2004)
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Recruitment of the Actin-binding Protein HIP-55 to the Immunological Synapse Regulates T Cell Receptor Signaling and Endocytosis
Le Bras, Séverine, Foucault, Isabelle, Foussat, Arnaud, Brignone, Chrystelle, Acuto, Oreste, Deckert, Marcel
Published in The Journal of biological chemistry (09.04.2004)
Published in The Journal of biological chemistry (09.04.2004)
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A LAG-3-Specific Agonist Antibody for the Treatment of T Cell-Induced Autoimmune Diseases
Angin, Mathieu, Brignone, Chrystelle, Triebel, Frédéric
Published in The Journal of immunology (1950) (15.02.2020)
Published in The Journal of immunology (1950) (15.02.2020)
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Journal Article
Eftilagimod Alpha (Soluble LAG3 Protein) Combined with Pembrolizumab as Second-Line Therapy for Patients with Metastatic Head and Neck Squamous Cell Carcinoma
Forster, Martin, Brana, Irene, Pousa, Antonio L, Doger, Bernard, Roxburgh, Patricia, Bajaj, Pawan, Peguero, Julio, Krebs, Matthew, Carcereny, Enric, Patel, Grisma, Mueller, Christian, Brignone, Chrystelle, Triebel, Frederic
Published in Clinical cancer research (03.09.2024)
Published in Clinical cancer research (03.09.2024)
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Journal Article
Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR+ Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase IIb Trial
Wildiers, Hans, Armstrong, Anne, Cuypere, Eveline, Dalenc, Florence, Dirix, Luc, Chan, Steve, Marme, Frederik, Schröder, Carolina P, Huober, Jens, Duhoux, Francois P, Vuylsteke, Peter, Jager, Agnes, Brain, Etienne, Kuemmel, Sherko, Pápai, Zsuzsanna, Menke-van der Houven van Oordt, Catharina Willemien, Perjesi, Luca, Mueller, Christian, Brignone, Chrystelle, Triebel, Frederic
Published in Clinical cancer research (01.02.2024)
Published in Clinical cancer research (01.02.2024)
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Abstract PD14-08: Primary efficacy results from AIPAC: A double-blinded, placebo controlled, randomized multinational phase IIb trial comparing weekly paclitaxel plus eftilagimod alpha (soluble LAG-3 protein) vs. weekly paclitaxel plus placebo in HR-positive metastatic breast cancer patients
Wildiers, Hans, Armstrong, Anne, Cuypere, Eveline, Dalenc, Florence, Dirix, Luc, Chan, Steve, Marme, Frederik, Schröder, Carolina Pia, Huober, Jens, Wagemans, Jill, Vuylsteke, Peter, Jacquin, Jean-Philippe, Brain, Etienne, Kümmel, Sherko, Pápai, Zsuzsanna, Perjesi, Luca, Mueller, Christian, Brignone, Chrystelle, Triebel, Frederic
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Journal Article
ANTIBODY MOLECULES TO LAG-3 AND USES THEREOF
GERHARD JOHANN FREY, CHRYSTELLE BRIGNONE, JENNIFER MARIE MATARAZA, WALTER A BLATTLER, CHANG HWAI WEN, CATHERINE ANNE SABATOS-PEYTON, FREDERIC TRIEBEL
Year of Publication 10.05.2024
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Year of Publication 10.05.2024
Patent
Combination of paclitaxel and a LAG-3 fusion protein (eftilagimod alpha), as a first-line chemoimmunotherapy in patients with metastatic breast carcinoma (MBC): Final results from the run-in phase of a placebo-controlled randomized phase II
Duhoux, Francois P., Jager, Agnes, Dirix, Luc Yves, Huizing, Manon Thirza, Jerusalem, Guy Heinrich Maria, Vuylsteke, Peter, De Cuypere, Eveline, Breiner, Doris, Mueller, Christian, Brignone, Chrystelle, Triebel, Frederic
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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