Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
Basi, Guriqbal S, Hemphill, Susanna, Brigham, Elizabeth F, Liao, Anna, Aubele, Danielle L, Baker, Jeanne, Barbour, Robin, Bova, Michael, Chen, Xiao-Hua, Dappen, Michael S, Eichenbaum, Tovah, Goldbach, Erich, Hawkinson, Jon, Lawler-Herbold, Rose, Hu, Kang, Hui, Terence, Jagodzinski, Jacek J, Keim, Pamela S, Kholodenko, Dora, Latimer, Lee H, Lee, Mike, Marugg, Jennifer, Mattson, Matthew N, McCauley, Scott, Miller, James L, Motter, Ruth, Mutter, Linda, Neitzel, Martin L, Ni, Huifang, Nguyen, Lan, Quinn, Kevin, Ruslim, Lany, Semko, Christopher M, Shapiro, Paul, Smith, Jenifer, Soriano, Ferdie, Szoke, Balazs, Tanaka, Kevin, Tang, Pearl, Tucker, John A, Ye, Xiacong Michael, Yu, Mei, Wu, Jing, Xu, Ying-Zi, Garofalo, Albert W, Sauer, John Michael, Konradi, Andrei W, Ness, Daniel, Shopp, George, Pleiss, Michael A, Freedman, Stephen B, Schenk, Dale
Published in Alzheimer's research & therapy (29.12.2010)
Published in Alzheimer's research & therapy (29.12.2010)
Get full text
Journal Article
Arylsulfonamide pyrimidines as VLA-4 antagonists
Xu, Ying-zi, Konradi, Andrei W., Bard, Frederique, Dappen, Michael, Dofiles, Lilibeth, Dreyer, Mark, Gallager, Ian, Garrido, Caroline, Krimm, Mike, Liao, Zhenmei, Messersmith, Elizabeth, Mutter, Linda, Pleiss, Michael A., Samant, Bhushan, Semko, Christopher M., Smith, Jennifer, Stappenbeck, Frank, Stupi, Brian, Vandervert, Chris, Welch, Brent, Wipke, Brian, Yednock, Ted
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Get full text
Journal Article
Synthesis of Novel Tetrahydro-1H-pyrazolo[4,3-c]pyridines via Intramolecular Nitrilimine Cycloaddition
Garofalo, Albert William, Jagodzinski, Jacek Jerzy, Konradi, Andrei William, Ng, Raymond Anthony, Semko, Christopher Michael, Sham, Hing Leung, Sun, Minghua, Ye, Xiaocong Michael
Published in Chemical & pharmaceutical bulletin (2012)
Published in Chemical & pharmaceutical bulletin (2012)
Get full text
Journal Article
PEG conjugates of potent α4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration
Smith, Jenifer L., Rossiter, Kassandra I., Semko, Christopher M., Xu, Ying-Zi, Quincy, David A., Jagodzinski, Jacek, Dappen, Michael S., Konradi, Andrei W., Vandevert, Christopher, Garrido, Caroline, Mao, Wenxian, San Pablo, F. Bong, Wipke, Brian, Dofiles, Lilibeth, Wadsworth, Angie, Peterson, Eric, Lorenzana, Carlos, Simmonds, Stellanie, Messersmith, Elizabeth K., Bard, Frederique, Pleiss, Michael A., Yednock, Ted A.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Get full text
Journal Article
Orally available and efficacious α4β1/α4β7 integrin inhibitors
Xu, Ying-zi, Smith, Jenifer L., Semko, Christopher M., Rossiter, Kassandra I., Fukuda, Juri Y., Dappen, Michael S., Quincy, David A., Konradi, Andrei W., Mao, Wenxian, Welch, Brent, Dreyer, Mark L., Samant, Bhushan, Zhang, Hongbin, Lugar, Judevin, Liao, Zhenmei, Henschel, Carrol, Petersen, Eric, Vandevert, Christopher, Shoemaker, Mark, Wehner, Nancy, Mutter, Linda, Shopp, George, Krimm, Michael, Chen, Linda, Wipke, Brian, Dofiles, Lilibeth, Gallager, Ian, Sauer, John-Michael, Messersmith, Elizabeth K., Pleiss, Michael A., Bard, Frederique, Yednock, Ted A.
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Get full text
Journal Article
Discovery of sulfonamide–pyrazole γ-secretase inhibitors
Mattson, Matthew N., Neitzel, Martin L., Quincy, David A., Semko, Christopher M., Garofalo, Albert W., Keim, Pamela S., Konradi, Andrei W., Pleiss, Michael A., Sham, Hing L., Brigham, Elizabeth F., Goldbach, Erich G., Zhang, Hongbin, Sauer, John-Michael, Basi, Guriqbal S.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Get full text
Journal Article
Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model
Semko, Christopher M., Chen, Linda, Dressen, Darren B., Dreyer, Mark L., Dunn, Whitney, Farouz, Francine S., Freedman, Stephen B., Holsztynska, Elizabeth J., Jefferies, Michael, Konradi, Andrei W., Liao, Anna, Lugar, Judevin, Mutter, Linda, Pleiss, Michael A., Quinn, Kevin P., Thompson, Thomas, Thorsett, Eugene D., Vandevert, Christopher, Xu, Ying-Zi, Yednock, Ted A.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Get full text
Journal Article
Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists
Huryn, Donna M, Ashwell, Susan, Baudy, Reinhardt, Dressen, Darren B, Gallaway, William, Grant, Francine S, Konradi, Andrei, Ley, Robert W, Petusky, Susan, Pleiss, Michael A, Sarantakis, Dimitri, Semko, Christopher M, Sherman, Mary M, Tio, Cesar, Zhang, Lu
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
Get full text
Journal Article
RAPAMYCIN ANALOGS AS MTOR INHIBITORS
ARUN P THOTTUMKARA, NIDHI TIBREWAL, MICAH JAMES EVANS GLIEDT, WANG GANG, CHRISTOPHER SEMKO, JULIE CHU-LI LEE, GERT KISS, JENNIFER PITZEN, JAMES BRADLEY AGGEN, ADRIAN LIAM GILL, G LESLIE BURNETT, WALTER WON
Year of Publication 26.07.2023
Get full text
Year of Publication 26.07.2023
Patent
Orally available and efficacious alpha 4 beta 1/alpha 4 beta 7 integrin inhibitors
Xu, Ying-zi, Smith, Jenifer L., Semko, Christopher M., Rossiter, Kassandra I., Fukuda, Juri Y., Dappen, Michael S., Quincy, David A., Konradi, Andrei W., Mao, Wenxian, Welch, Brent, Dreyer, Mark L., Samant, Bhushan, Zhang, Hongbin, Lugar, Judevin, Liao, Zhenmei, Henschel, Carrol, Petersen, Eric, Vandevert, Christopher, Shoemaker, Mark, Wehner, Nancy, Mutter, Linda, Shopp, George, Krimm, Michael, Chen, Linda, Wipke, Brian, Dofiles, Lilibeth, Gallager, Ian, Sauer, John-Michael, Messersmith, Elizabeth K., Pleiss, Michael A., Bard, Frederique, Yednock, Ted A.
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Get full text
Journal Article
Orally available and efficacious I-4I21/I-4I27 integrin inhibitors
Xu, Ying-zi, Smith, Jenifer, Semko, Christopher, Rossiter, Kassandra, Fukuda, Juri, Dappen, Michael, Quincy, David, Konradi, Andrei, Mao, Wenxian, Welch, Brent, Dreyer, Mark, Samant, Bhushan, Zhang, Hongbin, Lugar, Judevin, Liao, Zhenmei, Henschel, Carrol, Petersen, Eric, Vandevert, Christopher, Shoemaker, Mark, Wehner, Nancy, Mutter, Linda, Shopp, George, Krimm, Michael, Chen, Linda, Wipke, Brian, Dofiles, Lilibeth, Gallager, Ian, Sauer, John-Michael, Messersmith, Elizabeth, Pleiss, Michael, Bard, Frederique, Yednock, Ted
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Published in Bioorganic & medicinal chemistry letters (01.08.2013)
Get full text
Journal Article
PEG conjugates of potent I-4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration
Smith, Jenifer, Rossiter, Kassandra, Semko, Christopher, Xu, Ying-Zi, Quincy, David, Jagodzinski, Jacek, Dappen, Michael, Konradi, Andrei, Vandevert, Christopher, Garrido, Caroline, Mao, Wenxian, Pablo, F, Wipke, Brian, Dofiles, Lilibeth, Wadsworth, Angie, Peterson, Eric, Lorenzana, Carlos, Simmonds, Stellanie, Messersmith, Elizabeth, Bard, Frederique, Pleiss, Michael, Yednock, Ted
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Get full text
Journal Article
PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
KISS, Gert, GILL, Adrian, AAY, Naing, MELLEM, Kevin, SEMKO, Christopher, BUCKL, Andreas, KOLTUN, Elena S
Year of Publication 21.03.2024
Get full text
Year of Publication 21.03.2024
Patent
PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
KISS, Gert, GILL, Adrian, AAY, Naing, MELLEM, Kevin, SEMKO, Christopher, BUCKL, Andreas, KOLTUN, Elena S
Year of Publication 11.10.2023
Get full text
Year of Publication 11.10.2023
Patent
PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
KISS, Gert, GILL, Adrian, AAY, Naing, MELLEM, Kevin, SEMKO, Christopher, BUCKL, Andreas, KOLTUN, Elena S
Year of Publication 23.08.2023
Get full text
Year of Publication 23.08.2023
Patent