Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ
Casimiro-Garcia, Agustin, Filzen, Gary F, Flynn, Declan, Bigge, Christopher F, Chen, Jing, Davis, Jo Ann, Dudley, Danette A, Edmunds, Jeremy J, Esmaeil, Nadia, Geyer, Andrew, Heemstra, Ronald J, Jalaie, Mehran, Ohren, Jeffrey F, Ostroski, Robert, Ellis, Teresa, Schaum, Robert P, Stoner, Chad
Published in Journal of medicinal chemistry (23.06.2011)
Published in Journal of medicinal chemistry (23.06.2011)
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Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ
Casimiro-Garcia, Agustin, Heemstra, Ronald J., Bigge, Christopher F., Chen, Jing, Ciske, Fred A., Davis, Jo Ann, Ellis, Teresa, Esmaeil, Nadia, Flynn, Declan, Han, Seungil, Jalaie, Mehran, Ohren, Jeffrey F., Powell, Noel A.
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists
Casimiro-Garcia, Agustin, Bigge, Christopher F., Davis, Jo Ann, Padalino, Teresa, Pulaski, James, Ohren, Jeffrey F., McConnell, Patrick, Kane, Christopher D., Royer, Lori J., Stevens, Kimberly A., Auerbach, Bruce, Collard, Wendy, McGregor, Christine, Song, Kun
Published in Bioorganic & medicinal chemistry (15.10.2009)
Published in Bioorganic & medicinal chemistry (15.10.2009)
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Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies
Casimiro-Garcia, Agustin, Bigge, Christopher F., Davis, Jo Ann, Padalino, Teresa, Pulaski, James, Ohren, Jeffrey F., McConnell, Patrick, Kane, Christopher D., Royer, Lori J., Stevens, Kimberly A., Auerbach, Bruce J., Collard, Wendy T., McGregor, Christine, Fakhoury, Stephen A., Schaum, Robert P., Zhou, Hairong
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
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The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor
Kohrt, Jeffrey T., Bigge, Christopher F., Bryant, John W., Casimiro-Garcia, Agustin, Chi, Liguo, Cody, Wayne L., Dahring, Tawny, Dudley, Danette A., Filipski, Kevin J., Haarer, Staci, Heemstra, Ron, Janiczek, Nancy, Narasimhan, Lakshmi, McClanahan, Thomas, Peterson, J. Thomas, Sahasrabudhe, Vaisheli, Schaum, Robert, Van Huis, Chad A., Welch, Kathleen M., Zhang, Erli, Leadley, Robert J., Edmunds, Jeremy J.
Published in Chemical biology & drug design (01.08.2007)
Published in Chemical biology & drug design (01.08.2007)
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Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action
Van Huis, Chad A., Casimiro-Garcia, Agustin, Bigge, Christopher F., Cody, Wayne L., Dudley, Danette A., Filipski, Kevin J., Heemstra, Ronald J., Kohrt, Jeffrey T., Leadley, Robert J., Narasimhan, Lakshmi S., McClanahan, Thomas, Mochalkin, Igor, Pamment, Michael, Thomas Peterson, J., Sahasrabudhe, Vaishali, Schaum, Robert P., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry (15.03.2009)
Published in Bioorganic & medicinal chemistry (15.03.2009)
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The discovery of glycine and related amino acid-based factor Xa inhibitors
Kohrt, Jeffrey T., Filipski, Kevin J., Cody, Wayne L., Bigge, Christopher F., La, Frances, Welch, Kathleen, Dahring, Tawny, Bryant, John W., Leonard, Daniele, Bolton, Gary, Narasimhan, Lakshmi, Zhang, Erli, Peterson, J. Thomas, Haarer, Staci, Sahasrabudhe, Vaishali, Janiczek, Nancy, Desiraju, Shrilakshmi, Hena, Mostofa, Fiakpui, Charles, Saraswat, Neerja, Sharma, Raman, Sun, Shaoyi, Maiti, Samarendra N., Leadley, Robert, Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry (01.07.2006)
Published in Bioorganic & medicinal chemistry (01.07.2006)
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Structure-based Drug Design of Pyrrolidine-1, 2-dicarboxamides as a Novel Series of Orally Bioavailable Factor Xa Inhibitors
Van Huis, Chad A., Bigge, Christopher F., Casimiro-Garcia, Agustin, Cody, Wayne L., Dudley, Danette A., Filipski, Kevin J., Heemstra, Ronald J., Kohrt, Jeffrey T., Narasimhan, Lakshmi S., Schaum, Robert P., Zhang, Erli, Bryant, John W., Haarer, Staci, Janiczek, Nancy, Leadley Jr, Robert J., McClanahan, Thomas, Thomas Peterson, J., Welch, Kathleen M., Edmunds, Jeremy J.
Published in Chemical biology & drug design (01.06.2007)
Published in Chemical biology & drug design (01.06.2007)
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Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex
Bigge, Christopher F, Malone, Thomas C, Hays, Sheryl J, Johnson, Graham, Novak, Perry M, Lescosky, Leonard J, Retz, Daniel M, Ortwine, Daniel F, Probert, Albert W
Published in Journal of medicinal chemistry (01.07.1993)
Published in Journal of medicinal chemistry (01.07.1993)
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Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor
Hays, Sheryl J, Novak, Perry M, Ortwine, Daniel F, Bigge, Christopher F, Colbry, Norman L, Johnson, Graham, Lescosky, Leonard J, Malone, Thomas C, Michael, Andre
Published in Journal of medicinal chemistry (01.03.1993)
Published in Journal of medicinal chemistry (01.03.1993)
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4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: A Novel, Potent, and Selective NR1/2B NMDA Receptor Antagonist
Zhou, Zhang-Lin, Cai, Sui Xiong, Whittemore, Edward R, Konkoy, Christopher S, Espitia, Stephen A, Tran, Minhtam, Rock, David M, Coughenour, Linda L, Hawkinson, Jon E, Boxer, Peter A, Bigge, Christopher F, Wise, Lawrence D, Weber, Eckard, Woodward, Richard M, Keana, John F. W
Published in Journal of medicinal chemistry (29.07.1999)
Published in Journal of medicinal chemistry (29.07.1999)
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Improved Intestinal Transport of PD 158473, an N-methyl-d-Aspartate (NMDA) Antagonist, by Involvement of Multiple Transporters
Oh, Doo-Man, Han, Hyo-Kyung, Williamson, Rufus M., Bigge, Christopher F., Amidon, Gordon L., Stewart, Barbra H., Surendran, Narayanan
Published in Journal of pharmaceutical sciences (01.12.2002)
Published in Journal of pharmaceutical sciences (01.12.2002)
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Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione and related quinoxalinediones: characterization of .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity
Bigge, Christopher F, Malone, Thomas C, Boxer, Peter A, Nelson, Carrie B, Ortwine, Daniel F, Schelkun, Robert, Retz, Daniel M, Lescosky, Leonard J, Borosky, Susan A
Published in Journal of medicinal chemistry (01.09.1995)
Published in Journal of medicinal chemistry (01.09.1995)
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Evidence for overlapping substrate specificity between large neutral amino acid (LNAA) and dipeptide (hPEPT1) transporters for PD 158473, an NMDA antagonist
SURENDRAN, N, COVITZ, K.-M. Y, HAN, H.-K, SADEE, W, OH, D.-M, AMIDON, G. L, WILLIAMSON, R. M, BIGGE, C. F, STEWART, B. H
Published in Pharmaceutical research (01.03.1999)
Published in Pharmaceutical research (01.03.1999)
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Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists
Ortwine, Daniel F, Malone, Thomas C, Bigge, Christopher F, Drummond, James T, Humblet, Christine, Johnson, Graham, Pinter, Garry W
Published in Journal of medicinal chemistry (01.04.1992)
Published in Journal of medicinal chemistry (01.04.1992)
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Journal Article
Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists: Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines
Wright, Jon L, Gregory, Tracy F, Bigge, Christopher F, Boxer, Peter A, Serpa, Kevin, Meltzer, Leonard T, Wise, Lawrence D, Cai, Sui Xiong, Hawkinson, Jon E, Konkoy, Christopher S, Whittemore, Edward R, Woodward, Richard M, Zhou, Zhang-Lin
Published in Journal of medicinal chemistry (01.07.1999)
Published in Journal of medicinal chemistry (01.07.1999)
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Photoisomerization Mechanism of the Rhodopsin Chromophore: Picosecond Photolysis of Pigment Containing 11-Cis-Locked Eight-Membered Ring Retinal
Mizukami, Taku, Kandori, Hideki, Shichida, Yoshinori, Chen, Arh-Hwang, Derguini, Fadila, Caldwell, Charles G., Bigge, Christopher F., Nakanishi, Koji, Yoshizawa, Toru
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.1993)
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.1993)
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Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced .alpha.-amino acids as competitive N-methyl-D-aspartic acid antagonists
Bigge, Christopher F, Johnson, Graham, Ortwine, Daniel F, Drummond, James T, Retz, Daniel M, Brahce, Laura J, Coughenour, Linda L, Marcoux, Frank W, Probert, Albert W
Published in Journal of medicinal chemistry (01.04.1992)
Published in Journal of medicinal chemistry (01.04.1992)
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