Search Results - "CHRISTOPHER F. BIGGE" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ

Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ

by Casimiro-Garcia, Agustin, Filzen, Gary F, Flynn, Declan, Bigge, Christopher F, Chen, Jing, Davis, Jo Ann, Dudley, Danette A, Edmunds, Jeremy J, Esmaeil, Nadia, Geyer, Andrew, Heemstra, Ronald J, Jalaie, Mehran, Ohren, Jeffrey F, Ostroski, Robert, Ellis, Teresa, Schaum, Robert P, Stoner, Chad
Published in Journal of medicinal chemistry (23.06.2011)

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Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

by Casimiro-Garcia, Agustin, Heemstra, Ronald J., Bigge, Christopher F., Chen, Jing, Ciske, Fred A., Davis, Jo Ann, Ellis, Teresa, Esmaeil, Nadia, Flynn, Declan, Han, Seungil, Jalaie, Mehran, Ohren, Jeffrey F., Powell, Noel A.
Published in Bioorganic & medicinal chemistry letters (01.02.2013)

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Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists

Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists

by Casimiro-Garcia, Agustin, Bigge, Christopher F., Davis, Jo Ann, Padalino, Teresa, Pulaski, James, Ohren, Jeffrey F., McConnell, Patrick, Kane, Christopher D., Royer, Lori J., Stevens, Kimberly A., Auerbach, Bruce, Collard, Wendy, McGregor, Christine, Song, Kun
Published in Bioorganic & medicinal chemistry (15.10.2009)

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Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies

by Casimiro-Garcia, Agustin, Bigge, Christopher F., Davis, Jo Ann, Padalino, Teresa, Pulaski, James, Ohren, Jeffrey F., McConnell, Patrick, Kane, Christopher D., Royer, Lori J., Stevens, Kimberly A., Auerbach, Bruce J., Collard, Wendy T., McGregor, Christine, Fakhoury, Stephen A., Schaum, Robert P., Zhou, Hairong
Published in Bioorganic & medicinal chemistry (01.05.2008)

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The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

by Kohrt, Jeffrey T., Bigge, Christopher F., Bryant, John W., Casimiro-Garcia, Agustin, Chi, Liguo, Cody, Wayne L., Dahring, Tawny, Dudley, Danette A., Filipski, Kevin J., Haarer, Staci, Heemstra, Ron, Janiczek, Nancy, Narasimhan, Lakshmi, McClanahan, Thomas, Peterson, J. Thomas, Sahasrabudhe, Vaisheli, Schaum, Robert, Van Huis, Chad A., Welch, Kathleen M., Zhang, Erli, Leadley, Robert J., Edmunds, Jeremy J.
Published in Chemical biology & drug design (01.08.2007)

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Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action

Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action

by Van Huis, Chad A., Casimiro-Garcia, Agustin, Bigge, Christopher F., Cody, Wayne L., Dudley, Danette A., Filipski, Kevin J., Heemstra, Ronald J., Kohrt, Jeffrey T., Leadley, Robert J., Narasimhan, Lakshmi S., McClanahan, Thomas, Mochalkin, Igor, Pamment, Michael, Thomas Peterson, J., Sahasrabudhe, Vaishali, Schaum, Robert P., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry (15.03.2009)

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Ionotropic glutamate receptors

Ionotropic glutamate receptors

by Bigge, Christopher F
Published in Current opinion in chemical biology (01.08.1999)

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The discovery of glycine and related amino acid-based factor Xa inhibitors

The discovery of glycine and related amino acid-based factor Xa inhibitors

by Kohrt, Jeffrey T., Filipski, Kevin J., Cody, Wayne L., Bigge, Christopher F., La, Frances, Welch, Kathleen, Dahring, Tawny, Bryant, John W., Leonard, Daniele, Bolton, Gary, Narasimhan, Lakshmi, Zhang, Erli, Peterson, J. Thomas, Haarer, Staci, Sahasrabudhe, Vaishali, Janiczek, Nancy, Desiraju, Shrilakshmi, Hena, Mostofa, Fiakpui, Charles, Saraswat, Neerja, Sharma, Raman, Sun, Shaoyi, Maiti, Samarendra N., Leadley, Robert, Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry (01.07.2006)

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Structure-based Drug Design of Pyrrolidine-1, 2-dicarboxamides as a Novel Series of Orally Bioavailable Factor Xa Inhibitors

Structure-based Drug Design of Pyrrolidine-1, 2-dicarboxamides as a Novel Series of Orally Bioavailable Factor Xa Inhibitors

by Van Huis, Chad A., Bigge, Christopher F., Casimiro-Garcia, Agustin, Cody, Wayne L., Dudley, Danette A., Filipski, Kevin J., Heemstra, Ronald J., Kohrt, Jeffrey T., Narasimhan, Lakshmi S., Schaum, Robert P., Zhang, Erli, Bryant, John W., Haarer, Staci, Janiczek, Nancy, Leadley Jr, Robert J., McClanahan, Thomas, Thomas Peterson, J., Welch, Kathleen M., Edmunds, Jeremy J.
Published in Chemical biology & drug design (01.06.2007)

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Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex

Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex

by Bigge, Christopher F, Malone, Thomas C, Hays, Sheryl J, Johnson, Graham, Novak, Perry M, Lescosky, Leonard J, Retz, Daniel M, Ortwine, Daniel F, Probert, Albert W
Published in Journal of medicinal chemistry (01.07.1993)

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Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor

Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor

by Hays, Sheryl J, Novak, Perry M, Ortwine, Daniel F, Bigge, Christopher F, Colbry, Norman L, Johnson, Graham, Lescosky, Leonard J, Malone, Thomas C, Michael, Andre
Published in Journal of medicinal chemistry (01.03.1993)

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NEW PREPARATIONS OF THE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, 4-(3-PHOSPHONOPROPYL)-2-PIPERAZINECARBOXYLIC ACID (CPP)

NEW PREPARATIONS OF THE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, 4-(3-PHOSPHONOPROPYL)-2-PIPERAZINECARBOXYLIC ACID (CPP)

by BIGGE, CF, HAYS, SJ, NOVAK, PM, DRUMMOND, JT, JOHNSON, G, BOBOVSKI, TP
Published in Tetrahedron letters (01.01.1989)

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4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: A Novel, Potent, and Selective NR1/2B NMDA Receptor Antagonist

4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: A Novel, Potent, and Selective NR1/2B NMDA Receptor Antagonist

by Zhou, Zhang-Lin, Cai, Sui Xiong, Whittemore, Edward R, Konkoy, Christopher S, Espitia, Stephen A, Tran, Minhtam, Rock, David M, Coughenour, Linda L, Hawkinson, Jon E, Boxer, Peter A, Bigge, Christopher F, Wise, Lawrence D, Weber, Eckard, Woodward, Richard M, Keana, John F. W
Published in Journal of medicinal chemistry (29.07.1999)

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Improved Intestinal Transport of PD 158473, an N-methyl-d-Aspartate (NMDA) Antagonist, by Involvement of Multiple Transporters

Improved Intestinal Transport of PD 158473, an N-methyl-d-Aspartate (NMDA) Antagonist, by Involvement of Multiple Transporters

by Oh, Doo-Man, Han, Hyo-Kyung, Williamson, Rufus M., Bigge, Christopher F., Amidon, Gordon L., Stewart, Barbra H., Surendran, Narayanan
Published in Journal of pharmaceutical sciences (01.12.2002)

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Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione and related quinoxalinediones: characterization of .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity

Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione and related quinoxalinediones: characterization of .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity

by Bigge, Christopher F, Malone, Thomas C, Boxer, Peter A, Nelson, Carrie B, Ortwine, Daniel F, Schelkun, Robert, Retz, Daniel M, Lescosky, Leonard J, Borosky, Susan A
Published in Journal of medicinal chemistry (01.09.1995)

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Evidence for overlapping substrate specificity between large neutral amino acid (LNAA) and dipeptide (hPEPT1) transporters for PD 158473, an NMDA antagonist

Evidence for overlapping substrate specificity between large neutral amino acid (LNAA) and dipeptide (hPEPT1) transporters for PD 158473, an NMDA antagonist

by SURENDRAN, N, COVITZ, K.-M. Y, HAN, H.-K, SADEE, W, OH, D.-M, AMIDON, G. L, WILLIAMSON, R. M, BIGGE, C. F, STEWART, B. H
Published in Pharmaceutical research (01.03.1999)

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Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists

Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists

by Ortwine, Daniel F, Malone, Thomas C, Bigge, Christopher F, Drummond, James T, Humblet, Christine, Johnson, Graham, Pinter, Garry W
Published in Journal of medicinal chemistry (01.04.1992)

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Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists: Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines

Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists: Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines

by Wright, Jon L, Gregory, Tracy F, Bigge, Christopher F, Boxer, Peter A, Serpa, Kevin, Meltzer, Leonard T, Wise, Lawrence D, Cai, Sui Xiong, Hawkinson, Jon E, Konkoy, Christopher S, Whittemore, Edward R, Woodward, Richard M, Zhou, Zhang-Lin
Published in Journal of medicinal chemistry (01.07.1999)

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Photoisomerization Mechanism of the Rhodopsin Chromophore: Picosecond Photolysis of Pigment Containing 11-Cis-Locked Eight-Membered Ring Retinal

Photoisomerization Mechanism of the Rhodopsin Chromophore: Picosecond Photolysis of Pigment Containing 11-Cis-Locked Eight-Membered Ring Retinal

by Mizukami, Taku, Kandori, Hideki, Shichida, Yoshinori, Chen, Arh-Hwang, Derguini, Fadila, Caldwell, Charles G., Bigge, Christopher F., Nakanishi, Koji, Yoshizawa, Toru
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.1993)

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Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced .alpha.-amino acids as competitive N-methyl-D-aspartic acid antagonists

Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced .alpha.-amino acids as competitive N-methyl-D-aspartic acid antagonists

by Bigge, Christopher F, Johnson, Graham, Ortwine, Daniel F, Drummond, James T, Retz, Daniel M, Brahce, Laura J, Coughenour, Linda L, Marcoux, Frank W, Probert, Albert W
Published in Journal of medicinal chemistry (01.04.1992)

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