Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Soethoudt, Marjolein, Grether, Uwe, Fingerle, Jürgen, Grim, Travis W., Fezza, Filomena, de Petrocellis, Luciano, Ullmer, Christoph, Rothenhäusler, Benno, Perret, Camille, van Gils, Noortje, Finlay, David, MacDonald, Christa, Chicca, Andrea, Gens, Marianela Dalghi, Stuart, Jordyn, de Vries, Henk, Mastrangelo, Nicolina, Xia, Lizi, Alachouzos, Georgios, Baggelaar, Marc P., Martella, Andrea, Mock, Elliot D., Deng, Hui, Heitman, Laura H., Connor, Mark, Di Marzo, Vincenzo, Gertsch, Jürg, Lichtman, Aron H., Maccarrone, Mauro, Pacher, Pal, Glass, Michelle, van der Stelt, Mario
Published in Nature communications (03.01.2017)
Published in Nature communications (03.01.2017)
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Journal Article
Real-time measurements of vascular permeability in the mouse eye using vitreous fluorophotometry
Colé, Nadine, Thoele, Janina, Ullmer, Christoph, Foxton, Richard H
Published in Scientific reports (07.06.2023)
Published in Scientific reports (07.06.2023)
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Journal Article
The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
Keitel, Verena, Ullmer, Christoph, Häussinger, Dieter
Published in Biological chemistry (01.07.2010)
Published in Biological chemistry (01.07.2010)
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Journal Article
Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells
Ho, Leona T Y, Skiba, Nikolai, Ullmer, Christoph, Rao, Ponugoti Vasantha
Published in Investigative ophthalmology & visual science (01.04.2018)
Published in Investigative ophthalmology & visual science (01.04.2018)
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Journal Article
TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function
Merlen, Grégory, Kahale, Nicolas, Ursic-Bedoya, Jose, Bidault-Jourdainne, Valeska, Simerabet, Hayat, Doignon, Isabelle, Tanfin, Zahra, Garcin, Isabelle, Péan, Noémie, Gautherot, Julien, Davit-Spraul, Anne, Guettier, Catherine, Humbert, Lydie, Rainteau, Dominique, Ebnet, Klaus, Ullmer, Christoph, Cassio, Doris, Tordjmann, Thierry
Published in Gut (01.01.2020)
Published in Gut (01.01.2020)
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Journal Article
Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity
Ho, Leona T.Y., Osterwald, Anja, Ruf, Iris, Hunziker, Daniel, Mattei, Patrizio, Challa, Pratap, Vann, Robin, Ullmer, Christoph, Rao, Ponugoti Vasanth
Published in Biochimica et biophysica acta. Molecular basis of disease (01.01.2020)
Published in Biochimica et biophysica acta. Molecular basis of disease (01.01.2020)
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Journal Article
Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis
Ninou, Ioanna, Kaffe, Eleanna, Müller, Stefan, Budd, David C., Stevenson, Christopher S., Ullmer, Christoph, Aidinis, Vassilis
Published in Pulmonary pharmacology & therapeutics (01.10.2018)
Published in Pulmonary pharmacology & therapeutics (01.10.2018)
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Journal Article
Lysophosphatidic Acid Is a Proinflammatory Stimulus of Renal Tubular Epithelial Cells
Magkrioti, Christiana, Antonopoulou, Georgia, Fanidis, Dionysios, Pliaka, Vaia, Sakellaropoulos, Theodore, Alexopoulos, Leonidas G., Ullmer, Christoph, Aidinis, Vassilis
Published in International journal of molecular sciences (05.07.2022)
Published in International journal of molecular sciences (05.07.2022)
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Journal Article
Enterohepatic Takeda G-Protein Coupled Receptor 5 Agonism in Metabolic Dysfunction-Associated Fatty Liver Disease and Related Glucose Dysmetabolism
Gillard, Justine, Picalausa, Corinne, Ullmer, Christoph, Adorini, Luciano, Staels, Bart, Tailleux, Anne, Leclercq, Isabelle A.
Published in Nutrients (29.06.2022)
Published in Nutrients (29.06.2022)
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Journal Article
Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration
Storti, Federica, Klee, Katrin, Todorova, Vyara, Steiner, Regula, Othman, Alaa, van der Velde-Visser, Saskia, Samardzija, Marijana, Meneau, Isabelle, Barben, Maya, Karademir, Duygu, Pauzuolyte, Valda, Boye, Sanford L, Blaser, Frank, Ullmer, Christoph, Dunaief, Joshua L, Hornemann, Thorsten, Rohrer, Lucia, den Hollander, Anneke, von Eckardstein, Arnold, Fingerle, Jürgen, Maugeais, Cyrille, Grimm, Christian
Published in eLife (13.03.2019)
Published in eLife (13.03.2019)
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Journal Article
Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis
Porter, Richard Frederick, Szczesniak, Anna-Maria, Toguri, James Thomas, Gebremeskel, Simon, Johnston, Brent, Lehmann, Christian, Fingerle, Jürgen, Rothenhäusler, Benno, Perret, Camille, Rogers-Evans, Mark, Kimbara, Atsushi, Nettekoven, Matthias, Guba, Wolfgang, Grether, Uwe, Ullmer, Christoph, Kelly, Melanie E M
Published in Molecules (Basel, Switzerland) (13.09.2019)
Published in Molecules (Basel, Switzerland) (13.09.2019)
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Journal Article
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
Grether, Uwe, Foxton, Richard H, Gruener, Sabine, Korn, Claudia, Kimbara, Atsushi, Osterwald, Anja, Zirwes, Elisabeth, Uhles, Sabine, Thoele, Janina, Colé, Nadine, Rogers-Evans, Mark, Röver, Stephan, Nettekoven, Matthias, Martin, Rainer E, Adam, Jean-Michel, Fingerle, Jürgen, Bissantz, Caterina, Guba, Wolfgang, Alker, André, Szczesniak, Anna M, Porter, Ross F, Toguri, Tom J, Revelant, Franco, Poirier, Agnès, Perret, Camille, Winther, Lotte, Caruso, Antonello, Fezza, Filomena, Maccarrone, Mauro, Kelly, Melanie E M, Fauser, Sascha, Ullmer, Christoph
Published in Frontiers in pharmacology (12.07.2024)
Published in Frontiers in pharmacology (12.07.2024)
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Journal Article
Incretin-like effects of small molecule trace amine-associated receptor 1 agonists
Raab, Susanne, Wang, Haiyan, Uhles, Sabine, Cole, Nadine, Alvarez-Sanchez, Ruben, Künnecke, Basil, Ullmer, Christoph, Matile, Hugues, Bedoucha, Marc, Norcross, Roger D, Ottaway-Parker, Nickki, Perez-Tilve, Diego, Conde Knape, Karin, Tschöp, Matthias H, Hoener, Marius C, Sewing, Sabine
Published in Molecular metabolism (Germany) (01.01.2016)
Published in Molecular metabolism (Germany) (01.01.2016)
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Journal Article
Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [ 11 C]MA2 and [ 18 F]MA3
Ahamed, Muneer, van Veghel, Daisy, Ullmer, Christoph, Van Laere, Koen, Verbruggen, Alfons, Bormans, Guy M
Published in Frontiers in neuroscience (22.09.2016)
Published in Frontiers in neuroscience (22.09.2016)
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Journal Article
TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload
Bidault-Jourdainne, Valeska, Merlen, Grégory, Glénisson, Mathilde, Doignon, Isabelle, Garcin, Isabelle, Péan, Noémie, Boisgard, Raphael, Ursic-Bedoya, José, Serino, Matteo, Ullmer, Christoph, Humbert, Lydie, Abdelrafee, Ahmed, Golse, Nicolas, Vibert, Eric, Duclos-Vallée, Jean-Charles, Rainteau, Dominique, Tordjmann, Thierry
Published in JHEP reports (01.04.2021)
Published in JHEP reports (01.04.2021)
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Journal Article
Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor
Hunziker, Daniel, Reinehr, Sabrina, Palmhof, Marina, Wagner, Natalie, Biniasch, Thomas, Stute, Gesa, Mattei, Patrizio, Schmitz, Petra, DiGiorgio, Patrick, Hert, Jérôme, Rudolph, Markus G, Benz, Joerg, Stihle, Martine, Gsell, Bernard, Müller, Stephan, Gasser, Rodolfo, Schonhoven, Nina, Ullmer, Christoph, Joachim, Stephanie C
Published in Frontiers in pharmacology (18.01.2022)
Published in Frontiers in pharmacology (18.01.2022)
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Journal Article
6‑Alkoxy-5-aryl-3-pyridinecarboxamides, a New Series of Bioavailable Cannabinoid Receptor Type 1 (CB1) Antagonists Including Peripherally Selective Compounds
Röver, Stephan, Andjelkovic, Mirjana, Bénardeau, Agnès, Chaput, Evelyne, Guba, Wolfgang, Hebeisen, Paul, Mohr, Susanne, Nettekoven, Matthias, Obst, Ulrike, Richter, Wolfgang F, Ullmer, Christoph, Waldmeier, Pius, Wright, Matthew B
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Journal Article
Galantamine Is an Allosterically Potentiating Ligand of Neuronal Nicotinic but Not of Muscarinic Acetylcholine Receptors
Samochocki, Marek, Höffle, Anja, Fehrenbacher, Andreas, Jostock, Ruth, Ludwig, Jürgen, Christner, Claudia, Radina, Martin, Zerlin, Marion, Ullmer, Christoph, Pereira, Edna F R, Lübbert, Hermann, Albuquerque, Edson X, Maelicke, Alfred
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
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Journal Article