Synthesis, radiolabeling and preclinical evaluation of a [11 C]GMOM derivative as PET radiotracer for the ion channel of the N-methyl-D-aspartate receptor
Klein, Pieter J, Schuit, Robert C, Metaxas, Athanasios, Christiaans, Johannes AM, Kooijman, Esther, Lammertsma, Adriaan A, van Berckel, Bart NM, Windhorst, Albert D
Published in Nuclear medicine and biology (01.08.2017)
Published in Nuclear medicine and biology (01.08.2017)
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Preclinical evaluation of [18 F]PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors
Golla, Sandeep S.V, Klein, Pieter J, Bakker, Jaco, Schuit, Robert C, Christiaans, Johannes A.M, van Geest, Leo, Kooijman, Esther J.M, Oropeza-Seguias, Gisela M, Langermans, Jan A.M, Leysen, Josée E, Boellaard, Ronald, Windhorst, Albert D, van Berckel, Bart N.M, Metaxas, Athanasios
Published in Nuclear medicine and biology (01.02.2015)
Published in Nuclear medicine and biology (01.02.2015)
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Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[11 C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors
Christiaans, Johannes A.M, Klein, Pieter J, Metaxas, Athanasios, Kooijman, Esther J.M, Schuit, Robert C, Leysen, Josée E, Lammertsma, Adriaan A, van Berckel, Bart N.M, Windhorst, Albert D
Published in Nuclear medicine and biology (01.09.2014)
Published in Nuclear medicine and biology (01.09.2014)
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Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors
Venäläinen, Jarkko I., Garcia-Horsman, J. Arturo, Forsberg, Markus M., Jalkanen, Aaro, Wallén, Erik A.A., Jarho, Elina M., Christiaans, Johannes A.M., Gynther, Jukka, Männistö, Pekka T.
Published in Biochemical pharmacology (28.02.2006)
Published in Biochemical pharmacology (28.02.2006)
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4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors
WALLEN, Erik A. A, CHRISTIAANS, Johannes A. M, SAARIO, Susanna M, FORSBERG, Markus M, VENÄLÄINEN, Jarkko I, PASO, Hanna M, MÄNNISTÖ, Pekka T, GYNTHER, Jukka
Published in Bioorganic & medicinal chemistry (01.07.2002)
Published in Bioorganic & medicinal chemistry (01.07.2002)
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Synthesis, radiolabeling and evaluation of novel amine guanidine derivatives as potential positron emission tomography tracers for the ion channel of the N-methyl-d-aspartate receptor
Klein, Pieter J., Chomet, Marion, Metaxas, Athanasios, Christiaans, Johannes A.M., Kooijman, Esther, Schuit, Robert C., Lammertsma, Adriaan A., van Berckel, Bart N.M., Windhorst, Albert D.
Published in European journal of medicinal chemistry (08.08.2016)
Published in European journal of medicinal chemistry (08.08.2016)
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Synthesis, structure activity relationship, radiolabeling and preclinical evaluation of high affinity ligands for the ion channel of the N-methyl-d-aspartate receptor as potential imaging probes for positron emission tomography
Klein, Pieter J., Christiaans, Johannes A.M., Metaxas, Athanasios, Schuit, Robert C., Lammertsma, Adriaan A., van Berckel, Bart N.M., Windhorst, Albert D.
Published in Bioorganic & medicinal chemistry (01.03.2015)
Published in Bioorganic & medicinal chemistry (01.03.2015)
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Evaluation of the Novel PET Tracer [11C]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates
van der Aart, Jasper, Yaqub, Maqsood, Kooijman, Esther J. M., Bakker, Jaco, Langermans, Jan A. M., Schuit, Robert C., Hofman, Mark B. M., Christiaans, Johannes A. M., Lammertsma, Adriaan A., Windhorst, Albert D., van Berckel, Bart N. M.
Published in Molecular imaging and biology (01.08.2019)
Published in Molecular imaging and biology (01.08.2019)
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Binding characterization of N‐(2‐chloro‐5‐thiomethylphenyl)‐N′‐(3‐[3H]3methoxy phenyl)‐N′‐methylguanidine ([3H]GMOM), a non‐competitive N‐methyl‐D‐aspartate (NMDA) receptor antagonist
Metaxas, Athanasios, van Berckel, Bart N. M., Klein, Pieter J., Verbeek, Joost, Nash, Emily C., Kooijman, Esther J. M., Renjaän, Véronique A., Golla, Sandeep S. V., Boellaard, Ronald, Christiaans, Johannes A. M., Windhorst, Albert D., Leysen, Josée E.
Published in Pharmacology research & perspectives (01.02.2019)
Published in Pharmacology research & perspectives (01.02.2019)
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A Cyclopent-2-enecarbonyl Group Mimics Proline at the P2 Position of Prolyl Oligopeptidase Inhibitors
Jarho, Elina M, Venäläinen, Jarkko I, Huuskonen, Juhani, Christiaans, Johannes A. M, Garcia-Horsman, J. Arturo, Forsberg, Markus M, Järvinen, Tomi, Gynther, Jukka, Männistö, Pekka T, Wallén, Erik A. A
Published in Journal of medicinal chemistry (04.11.2004)
Published in Journal of medicinal chemistry (04.11.2004)
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2( S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2( S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors
Jarho, Elina M., Venäläinen, Jarkko I., Poutiainen, Sami, Leskinen, Harri, Vepsäläinen, Jouko, Christiaans, Johannes A.M., Forsberg, Markus M., Männistö, Pekka T., Wallén, Erik A.A.
Published in Bioorganic & medicinal chemistry (01.03.2007)
Published in Bioorganic & medicinal chemistry (01.03.2007)
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Dicarboxylic Acid Azacycle l-Prolyl-pyrrolidine Amides as Prolyl Oligopeptidase Inhibitors and Three-Dimensional Quantitative Structure−Activity Relationship of the Enzyme−Inhibitor Interactions
Jarho, Elina M, Wallén, Erik A. A, Christiaans, Johannes A. M, Forsberg, Markus M, Venäläinen, Jarkko I, Männistö, Pekka T, Gynther, Jukka, Poso, Antti
Published in Journal of medicinal chemistry (28.07.2005)
Published in Journal of medicinal chemistry (28.07.2005)
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Addition of tert-butylcuprate to (2 S)- N-acyl-Δ 5-dehydroprolinates as a diastereoselective synthetic procedure for obtaining (2 S,5 S)-5- tert-butylproline
Wallén, Erik A.A., Christiaans, Johannes A.M., Gynther, Jukka, Vepsäläinen, Jouko
Published in Tetrahedron letters (2003)
Published in Tetrahedron letters (2003)
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Journal Article
Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site
Venäläinen, Jarkko I, Juvonen, Risto O, Garcia-Horsman, J Arturo, Wallén, Erik A A, Christiaans, Johannes A M, Jarho, Elina M, Gynther, Jukka, Männistö, Pekka T
Published in Biochemical journal (15.09.2004)
Published in Biochemical journal (15.09.2004)
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An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors
Jarho, Elina M., Venäläinen, Jarkko I., Juntunen, Juha, Yli-Kokko, A. Leena, Vepsäläinen, Jouko, Christiaans, Johannes A.M., Forsberg, Markus M., Järvinen, Tomi, Männistö, Pekka T., Wallén, Erik A.A.
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
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Journal Article
Conformationally rigid N-acyl-5-alkyl- l-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors
Wallén, Erik A.A., Christiaans, Johannes A.M., Saarinen, Taija J., Jarho, Elina M., Forsberg, Markus M., Venäläinen, Jarkko I., Männistö, Pekka T., Gynther, Jukka
Published in Bioorganic & medicinal chemistry (15.08.2003)
Published in Bioorganic & medicinal chemistry (15.08.2003)
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Journal Article
New Prolyl Oligopeptidase Inhibitors Developed from Dicarboxylic Acid Bis(l-prolyl-pyrrolidine) Amides
Wallén, Erik A. A, Christiaans, Johannes A. M, Jarho, Elina M, Forsberg, Markus M, Venäläinen, Jarkko I, Männistö, Pekka T, Gynther, Jukka
Published in Journal of medicinal chemistry (09.10.2003)
Published in Journal of medicinal chemistry (09.10.2003)
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Synthesis and in Vitro Pharmacology of a Series of New Chiral Histamine H3-Receptor Ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl Ether Derivatives
Kovalainen, Jari T, Christiaans, Johannes A. M, Kotisaari, Sanna, Laitinen, Jarmo T, Männistö, Pekka T, Tuomisto, Leena, Gynther, Jukka
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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