Timed action of IL-27 protects from immunopathology while preserving defense in influenza
Liu, Francesca Diane M, Kenngott, Elisabeth E, Schröter, Micha F, Kühl, Anja, Jennrich, Silke, Watzlawick, Ralf, Hoffmann, Ute, Wolff, Thorsten, Norley, Stephen, Scheffold, Alexander, Stumhofer, Jason S, Saris, Christiaan J M, Schwab, Jan M, Hunter, Christopher A, Debes, Gudrun F, Hamann, Alf
Published in PLoS pathogens (01.05.2014)
Published in PLoS pathogens (01.05.2014)
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Journal Article
IL-27 Limits IL-2 Production during Th1 Differentiation
Villarino, Alejandro V, Stumhofer, Jason S, Saris, Christiaan J. M, Kastelein, Robert A, de Sauvage, Frederic J, Hunter, Christopher A
Published in Journal of Immunology (01.01.2006)
Published in Journal of Immunology (01.01.2006)
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Journal Article
Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice
Hirase, Tetsuaki, Hara, Hiromitsu, Miyazaki, Yoshiyuki, Ide, Noriko, Nishimoto-Hazuku, Ai, Fujimoto, Hirokazu, Saris, Christiaan J M, Yoshida, Hiroki, Node, Koichi
Published in American journal of physiology. Heart and circulatory physiology (01.08.2013)
Published in American journal of physiology. Heart and circulatory physiology (01.08.2013)
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Journal Article
The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity
Artis, David, Villarino, Alejandro, Silverman, Michael, He, Weimian, Thornton, Elizabeth M, Mu, Sharon, Summer, Shamin, Covey, Todd M, Huang, Elaine, Yoshida, Hiroki, Koretzky, Gary, Goldschmidt, Michael, Wu, Gary D, de Sauvage, Fred, Miller, Hugh R. P, Saris, Christiaan J. M, Scott, Phillip, Hunter, Christopher A
Published in The Journal of immunology (1950) (01.11.2004)
Published in The Journal of immunology (1950) (01.11.2004)
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Journal Article
Positive and Negative Regulation of the IL-27 Receptor during Lymphoid Cell Activation
Villarino, Alejandro V, Larkin, Joseph, III, Saris, Christiaan J. M, Caton, Andrew J, Lucas, Sophie, Wong, Terence, de Sauvage, Frederic J, Hunter, Christopher A
Published in The Journal of immunology (1950) (15.06.2005)
Published in The Journal of immunology (1950) (15.06.2005)
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Journal Article
IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD
Villarino, Alejandro V., Artis, David, Bezbradica, Jelena S., Miller, Omer, Saris, Christiaan J. M., Joyce, Sebastian, Hunter, Christopher A.
Published in International immunology (01.06.2008)
Published in International immunology (01.06.2008)
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Journal Article
Discovery of Pyridazinopyridinones as Potent and Selective p38 Mitogen-Activated Protein Kinase Inhibitors
Wu, Bin, Wang, Hui-Ling, Pettus, Liping, Wurz, Ryan P, Doherty, Elizabeth M, Henkle, Bradley, McBride, Helen J, Saris, Christiaan J. M, Wong, Lu Min, Plant, Matthew H, Sherman, Lisa, Lee, Matthew R, Hsieh, Faye, Tasker, Andrew S
Published in Journal of medicinal chemistry (09.09.2010)
Published in Journal of medicinal chemistry (09.09.2010)
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Journal Article
A role for IL-27p28 as an antagonist of gp130-mediated signaling
Hunter, Christopher A, Stumhofer, Jason S, Tait, Elia D, III, William J Quinn, Hosken, Nancy, Spudy, Björn, Goenka, Radhika, Fielding, Ceri A, O'Hara, Aisling C, Chen, Yi, Jones, Michael L, Saris, Christiaan J M, Rose-John, Stefan, Cua, Daniel J, Jones, Simon A, Elloso, Merle M, Grötzinger, Joachim, Cancro, Michael P, Levin, Steven D
Published in Nature immunology (01.12.2010)
Published in Nature immunology (01.12.2010)
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Journal Article
Interleukin-27 Receptor Limits Atherosclerosis in Ldlr−/− Mice
Koltsova, Ekaterina K, Kim, Gisen, Lloyd, Kathleen M, Saris, Christiaan J.M, von Vietinghoff, Sibylle, Kronenberg, Mitchell, Ley, Klaus
Published in Circulation research (26.10.2012)
Published in Circulation research (26.10.2012)
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Journal Article
Identification of triazolopyridazinones as potent p38α inhibitors
Herberich, Brad, Jackson, Claire, Wurz, Ryan P., Pettus, Liping H., Sherman, Lisa, Liu, Qiurong, Henkle, Bradley, Saris, Christiaan J.M., Wong, Lu Min, Chmait, Samer, Lee, Matthew R., Mohr, Christopher, Hsieh, Faye, Tasker, Andrew S.
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
IL-27 Regulates Homeostasis of the Intestinal CD4+ Effector T Cell Pool and Limits Intestinal Inflammation in a Murine Model of Colitis
Troy, Amy E, Zaph, Colby, Du, Yurong, Taylor, Betsy C, Guild, Katherine J, Hunter, Christopher A, Saris, Christiaan J. M, Artis, David
Published in The Journal of immunology (1950) (01.08.2009)
Published in The Journal of immunology (1950) (01.08.2009)
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Journal Article
Independent and interdependent immunoregulatory effects of IL-27, IFN-β, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis
Fitzgerald, Denise C, Fonseca-Kelly, Zoë, Cullimore, Melissa L, Safabakhsh, Pegah, Saris, Christiaan J M, Zhang, Guang-Xian, Rostami, Abdolmohamad
Published in The Journal of immunology (1950) (01.04.2013)
Published in The Journal of immunology (1950) (01.04.2013)
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Journal Article
IL-27 Inhibits Hyperglycemia and Pancreatic Islet Inflammation Induced by Streptozotocin in Mice
Fujimoto, Hirokazu, Hirase, Tetsuaki, Miyazaki, Yoshiyuki, Hara, Hiromitsu, Ide-Iwata, Noriko, Nishimoto-Hazuku, Ai, Saris, Christiaan J.M, Yoshida, Hiroki, Node, Koichi
Published in The American journal of pathology (01.11.2011)
Published in The American journal of pathology (01.11.2011)
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Journal Article
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27
Brender, Christine, Tannahill, Gillian M., Jenkins, Brendan J., Fletcher, Joel, Columbus, Ruth, Saris, Christiaan J.M., Ernst, Matthias, Nicola, Nicos A., Hilton, Douglas J., Alexander, Warren S., Starr, Robyn
Published in Blood (01.10.2007)
Published in Blood (01.10.2007)
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Journal Article
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
Hunter, Christopher A, O'Shea, John J, Stumhofer, Jason S, Saris, Christiaan J M, Turka, Laurence A, Harris, Tajie H, Porrett, Paige M, Ernst, Matthias, Laurence, Arian, Silver, Jonathan S
Published in Nature immunology (01.12.2007)
Published in Nature immunology (01.12.2007)
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Journal Article
Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
Fonseca-Kelly, Zoë, Yu, Shuo, Fitzgerald, Denise C, Gran, Bruno, El-Behi, Mohamed, Saris, Christiaan J M, Rostami, Abdolmohamad, Li, Hongmei, Zhang, Guang-Xian, Ciric, Bogoljub
Published in Nature immunology (01.12.2007)
Published in Nature immunology (01.12.2007)
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Journal Article
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
Hunter, Christopher A, Stumhofer, Jason S, Laurence, Arian, Wilson, Emma H, Huang, Elaine, Tato, Cristina M, Johnson, Leanne M, Villarino, Alejandro V, Huang, Qiulong, Yoshimura, Akihiko, Sehy, David, Saris, Christiaan J M, O'Shea, John J, Hennighausen, Lothar, Ernst, Matthias
Published in Nature Immunology (01.09.2006)
Published in Nature Immunology (01.09.2006)
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Journal Article
The WSX-1 pathway restrains intestinal T-cell immunity
McAleer, Jeremy P, Saris, Christiaan J M, Vella, Anthony T
Published in International immunology (01.02.2011)
Published in International immunology (01.02.2011)
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Journal Article
Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase
Wurz, Ryan P., Pettus, Liping H., Xu, Shimin, Henkle, Bradley, Sherman, Lisa, Plant, Matthew, Miner, Kent, McBride, Helen, Wong, Lu Min, Saris, Christiaan J.M., Lee, Matthew R., Chmait, Samer, Mohr, Christopher, Hsieh, Faye, Tasker, Andrew S.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article