Identification of benzofuran central cores for the inhibition of leukotriene A4 hydrolase
Eccles, Wendy, Blevitt, Jonathan M., Booker, Jamila N., Chrovian, Christa C., Crawford, Shelby, de Leon, Aimee Rose, Deng, Xiaohu, Fourie, Anne M., Grice, Cheryl A., Herman, Krystal, Karlsson, Lars, Kearney, Aaron M., Lee-Dutra, Alice, Liang, Jimmy, Luna, Rosa, Pippel, Dan, Rao, Navin, Riley, Jason P., Santillán, Alejandro, Savall, Brad, Tanis, Virginia M., Xue, Xiaohua, Young, Arlene L.
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Journal Article
A Dipolar Cycloaddition Reaction To Access 6‑Methyl-4,5,6,7-tetrahydro‑1H‑[1,2,3]triazolo[4,5‑c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate
Chrovian, Christa C, Soyode-Johnson, Akinola, Peterson, Alexander A, Gelin, Christine F, Deng, Xiaohu, Dvorak, Curt A, Carruthers, Nicholas I, Lord, Brian, Fraser, Ian, Aluisio, Leah, Coe, Kevin J, Scott, Brian, Koudriakova, Tatiana, Schoetens, Freddy, Sepassi, Kia, Gallacher, David J, Bhattacharya, Anindya, Letavic, Michael A
Published in Journal of medicinal chemistry (11.01.2018)
Published in Journal of medicinal chemistry (11.01.2018)
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Journal Article
Discovery of a Series of Substituted 1H‑((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators
Gelin, Christine F., Stenne, Brice, Coate, Heather, Hiscox, Afton, Soyode-Johnson, Akinola, Wall, Jessica L., Lord, Brian, Schoellerman, Jeffrey, Coe, Kevin J., Wang, Kai, Alcázar, Jesus, Chrovian, Christa C., Dvorak, Curt A., Carruthers, Nicholas I., Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A.
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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Journal Article
Discovery of a Series of Substituted 1 H -((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators
Gelin, Christine F, Stenne, Brice, Coate, Heather, Hiscox, Afton, Soyode-Johnson, Akinola, Wall, Jessica L, Lord, Brian, Schoellerman, Jeffrey, Coe, Kevin J, Wang, Kai, Alcázar, Jesus, Chrovian, Christa C, Dvorak, Curt A, Carruthers, Nicholas I, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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Journal Article
Design, Synthesis, and Preclinical Evaluation of 3‑Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5‑b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders
Chrovian, Christa C, Soyode-Johnson, Akinola, Stenne, Brice, Pippel, Daniel J, Schoellerman, Jeffrey, Lord, Brian, Needham, Alexandra S, Xia, Chungfang, Coe, Kevin J, Sepassi, Kia, Schoetens, Freddy, Scott, Brian, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists
Rudolph, Dale A., Alcazar, Jesus, Ameriks, Michael K., Anton, Ana Belen, Ao, Hong, Bonaventure, Pascal, Carruthers, Nicholas I., Chrovian, Christa C., De Angelis, Meri, Lord, Brian, Rech, Jason C., Wang, Qi, Bhattacharya, Anindya, Andres, Jose Ignacio, Letavic, Michael A.
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Journal Article
1 H -Pyrrolo[3,2- b ]pyridine GluN2B-Selective Negative Allosteric Modulators
Chrovian, Christa C, Soyode-Johnson, Akinola, Wall, Jessica L, Rech, Jason C, Schoellerman, Jeff, Lord, Brian, Coe, Kevin J, Carruthers, Nicholas I, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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Journal Article
1H‑Pyrrolo[3,2‑b]pyridine GluN2B-Selective Negative Allosteric Modulators
Chrovian, Christa C, Soyode-Johnson, Akinola, Wall, Jessica L, Rech, Jason C, Schoellerman, Jeff, Lord, Brian, Coe, Kevin J, Carruthers, Nicholas I, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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Journal Article
P2X7 Antagonists as Potential Therapeutic Agents for the Treatment of CNS Disorders
Chrovian, Christa C., Rech, Jason C., Bhattacharya, Anindya, Letavic, Michael A.
Published in Progress in Medicinal Chemistry (2014)
Published in Progress in Medicinal Chemistry (2014)
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Book Chapter
Journal Article
Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3‑a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain
Chrovian, Christa C, Soyode-Johnson, Akinola, Ao, Hong, Bacani, Genesis M, Carruthers, Nicholas I, Lord, Brian, Nguyen, Leslie, Rech, Jason C, Wang, Qi, Bhattacharya, Anindya, Letavic, Michael A
Published in ACS chemical neuroscience (20.04.2016)
Published in ACS chemical neuroscience (20.04.2016)
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Journal Article
Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase
Eccles, Wendy, Blevitt, Jonathan M., Booker, Jamila N., Chrovian, Christa C., Crawford, Shelby, de Leon, Aimee Rose, Deng, Xiaohu, Fourie, Anne M., Grice, Cheryl A., Herman, Krystal, Karlsson, Lars, Kearney, Aaron M., Lee-Dutra, Alice, Liang, Jimmy, Luna, Rosa, Pippel, Dan, Rao, Navin, Riley, Jason P., Santillan, Alejandro, Savall, Brad, Tanis, Virginia M., Xue, Xiaohua, Young, Arlene L.
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Journal Article
Azabenzthiazole inhibitors of leukotriene A4 hydrolase
Tanis, Virginia M., Bacani, Genesis M., Blevitt, Jonathan M., Chrovian, Christa C., Crawford, Shelby, De Leon, Aimee, Fourie, Anne M., Gomez, Laurent, Grice, Cheryl A., Herman, Krystal, Kearney, Aaron M., Landry-Bayle, Adrienne M., Lee-Dutra, Alice, Nelson, Jay, Riley, Jason P., Santillán, Alejandro, Wiener, John J.M., Xue, Xiaohua, Young, Arlene L.
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
AKINOLA SOYODE-JOHNSON, JASON C RECH, MICHAEL A LETAVIC, CHRISTA C CHROVIAN, JESSICA L WALL
Year of Publication 23.12.2021
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Year of Publication 23.12.2021
Patent
A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1 H -[1,2,3]triazolo[4,5- c ]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate
Chrovian, Christa C., Soyode-Johnson, Akinola, Peterson, Alexander A., Gelin, Christine F., Deng, Xiaohu, Dvorak, Curt A., Carruthers, Nicholas I., Lord, Brian, Fraser, Ian, Aluisio, Leah, Coe, Kevin J., Scott, Brian, Koudriakova, Tatiana, Schoetens, Freddy, Sepassi, Kia, Gallacher, David J., Bhattacharya, Anindya, Letavic, Michael A.
Published in Journal of medicinal chemistry (11.01.2018)
Published in Journal of medicinal chemistry (11.01.2018)
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Journal Article
Azabenzthiazole inhibitors of leukotriene A(4) hydrolase
Tanis, Virginia M., Bacani, Genesis M., Blevitt, Jonathan M., Chrovian, Christa C., Crawford, Shelby, De Leon, Aimee, Fourie, Anne M., Gomez, Laurent, Grice, Cheryl A., Herman, Krystal, Kearney, Aaron M., Landry-Bayle, Adrienne M., Lee-Dutra, Alice, Nelson, Jay, Riley, Jason P., Santillan, Alejandro, Wiener, John J. M., Xue, Xiaohua, Young, Arlene L.
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
RECH, JASON C, WALL, JESSICA L, LETAVIC, MICHAEL A, CHROVIAN, CHRISTA C, SOYODE-JOHNSON, AKINOLA
Year of Publication 03.10.2023
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Year of Publication 03.10.2023
Patent
P2X7 MODULATING N-ACYL-TRIAZOLOPYRAZINES
RECH, JASON C, ANDRES GIL, JOSE IGNACIO, LETAVIC, MICHAEL A, RUDOLPH, DALE A, SOYODE-JOHNSON, AKINOLA, CHROVIAN, CHRISTA C
Year of Publication 03.10.2023
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Year of Publication 03.10.2023
Patent