Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets
Bi, Junfeng, Chowdhry, Sudhir, Wu, Sihan, Zhang, Wenjing, Masui, Kenta, Mischel, Paul S.
Published in Nature reviews. Cancer (01.01.2020)
Published in Nature reviews. Cancer (01.01.2020)
Get full text
Journal Article
SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
Rada, Patricia, Rojo, Ana I., Chowdhry, Sudhir, McMahon, Michael, Hayes, John D., Cuadrado, Antonio
Published in Molecular and Cellular Biology (01.03.2011)
Published in Molecular and Cellular Biology (01.03.2011)
Get full text
Journal Article
Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway
Hayes, John D, McMahon, Michael, Chowdhry, Sudhir, Dinkova-Kostova, Albena T
Published in Antioxidants & redox signaling (01.12.2010)
Published in Antioxidants & redox signaling (01.12.2010)
Get more information
Journal Article
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
Bi, Junfeng, Ichu, Taka-Aki, Zanca, Ciro, Yang, Huijun, Zhang, Wei, Gu, Yuchao, Chowdhry, Sudhir, Reed, Alex, Ikegami, Shiro, Turner, Kristen M., Zhang, Wenjing, Villa, Genaro R., Wu, Sihan, Quehenberger, Oswald, Yong, William H., Kornblum, Harley I., Rich, Jeremy N., Cloughesy, Timothy F., Cavenee, Webster K., Furnari, Frank B., Cravatt, Benjamin F., Mischel, Paul S.
Published in Cell metabolism (03.09.2019)
Published in Cell metabolism (03.09.2019)
Get full text
Journal Article
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
Chowdhry, Sudhir, Nazmy, Maiiada H., Meakin, Paul J., Dinkova-Kostova, Albena T., Walsh, Shaun V., Tsujita, Tadayuki, Dillon, John F., Ashford, Michael L.J., Hayes, John D.
Published in Free radical biology & medicine (15.01.2010)
Published in Free radical biology & medicine (15.01.2010)
Get full text
Journal Article
Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases
Dayalan Naidu, Sharadha, Sutherland, Calum, Zhang, Ying, Risco, Ana, de la Vega, Laureano, Caunt, Christopher J., Hastie, C. James, Lamont, Douglas J., Torrente, Laura, Chowdhry, Sudhir, Benjamin, Ivor J., Keyse, Stephen M., Cuenda, Ana, Dinkova-Kostova, Albena T.
Published in Molecular and cellular biology (01.09.2016)
Published in Molecular and cellular biology (01.09.2016)
Get full text
Journal Article
Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning
Bell, Karen F, Al-Mubarak, Bashayer, Fowler, Jill H, Baxter, Paul S, Gupta, Kunal, Tsujita, Tadayuki, Chowdhry, Sudhir, Patani, Rickie, Chandran, Siddharthan, Horsburgh, Karen, Hayes, John D, Hardingham, Giles E
Published in Proceedings of the National Academy of Sciences - PNAS (04.01.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (04.01.2011)
Get full text
Journal Article
Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress
Al-Mubarak, Bashayer R., Bell, Karen F.S., Chowdhry, Sudhir, Meakin, Paul J., Baxter, Paul S., McKay, Sean, Dando, Owen, Ashford, Michael L.J., Gazaryan, Irina, Hayes, John D., Hardingham, Giles E.
Published in Redox biology (01.11.2021)
Published in Redox biology (01.11.2021)
Get full text
Journal Article
Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes
Deighton, Ruth F, Márkus, Nóra M, Al-Mubarak, Bashayer, Bell, Karen F S, Papadia, Sofia, Meakin, Paul J, Chowdhry, Sudhir, Hayes, John D, Hardingham, Giles E
Published in Proceedings of the National Academy of Sciences - PNAS (06.05.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (06.05.2014)
Get full text
Journal Article
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling
Chowdhry, Sudhir, Zanca, Ciro, Rajkumar, Utkrisht, Koga, Tomoyuki, Diao, Yarui, Raviram, Ramya, Liu, Feng, Turner, Kristen, Yang, Huijun, Brunk, Elizabeth, Bi, Junfeng, Furnari, Frank, Bafna, Vineet, Ren, Bing, Mischel, Paul S.
Published in Nature (London) (01.05.2019)
Published in Nature (London) (01.05.2019)
Get full text
Journal Article
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
Chowdhry, S, Zhang, Y, McMahon, M, Sutherland, C, Cuadrado, A, Hayes, J D
Published in Oncogene (08.08.2013)
Published in Oncogene (08.08.2013)
Get full text
Journal Article
Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance
Meakin, Paul J., Chowdhry, Sudhir, Sharma, Ritu S., Ashford, Fiona B., Walsh, Shaun V., McCrimmon, Rory J., Dinkova-Kostova, Albena T., Dillon, John F., Hayes, John D., Ashford, Michael L. J.
Published in Molecular and cellular biology (01.09.2014)
Published in Molecular and cellular biology (01.09.2014)
Get full text
Journal Article
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2
Bell, Karen F.S., Al-Mubarak, Bashayer, Martel, Marc-André, McKay, Sean, Wheelan, Nicola, Hasel, Philip, Márkus, Nóra M., Baxter, Paul, Deighton, Ruth F., Serio, Andrea, Bilican, Bilada, Chowdhry, Sudhir, Meakin, Paul J., Ashford, Michael L.J., Wyllie, David J.A., Scannevin, Robert H., Chandran, Siddharthan, Hayes, John D., Hardingham, Giles E.
Published in Nature communications (13.05.2015)
Published in Nature communications (13.05.2015)
Get full text
Journal Article
PL-17 - Redox-dependent and independent regulation of GSH metabolism and GST family of genes
Hayes, John D., Chowdhry, Sudhir, Robertson, Holly, Sutherland, Calum
Published in Free radical biology & medicine (01.07.2016)
Published in Free radical biology & medicine (01.07.2016)
Get full text
Journal Article
Redox-dependent and independent regulation of GSH metabolism and GST family of genes
Hayes, John D., Chowdhry, Sudhir, Robertson, Holly, Sutherland, Calum
Published in Free radical biology & medicine (01.07.2016)
Published in Free radical biology & medicine (01.07.2016)
Get full text
Journal Article
Abstract 3631: Preclinical and clinical pharmacodynamic characterization of BBI-355, a novel, orally bioavailable, and selective CHK1 inhibitor being evaluated in the first-in-human Phase 1/2 POTENTIATE clinical trial of patients with cancer harboring oncogene amplifications
Liao, Debbie, Hansen, Ryan, Chowdhry, Sudhir, Holmes, Evan, Wiese, Julie, Steffy, Auzon, Pferdekamper, AnneMarie, Tse, Edison, Garcia, Salvador, Reynolds, Rebecca, Weymer, Sara, Wagner, Klaus, Hassig, Chris, Kasibhatla, Shailaja
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Get full text
Journal Article
Abstract 1520: Replication stress and the inability to repair damaged DNA, the potential “Achilles' heel” of ecDNA+ tumor cells
Chowdhry, Sudhir, Garcia, Salvador, Nguyen, Nam-Phuong, Celeste, Anthony, Tse, Edison, Milutinovic, Snezana, Wilkinson, Deepti, Hassig, Christian, Kasibhatla, Shailaja
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Get full text
Journal Article
복제 스트레스 경로 제제 조성물 및 암의 치료 방법
CHRISTIANSEN JASON, HANSEN RYAN, HASSIG CHRISTIAN, HORNBY ZACHARY, CHOWDHRY SUDHIR, MILUTINOVIC SNEZANA, WILKINSON DEEPTI, CELESTE ANTHONY, TURNER KRISTEN
Year of Publication 03.07.2023
Get full text
Year of Publication 03.07.2023
Patent
Molecular Characterization of Acquired Resistance to KRASG12C-EGFR Inhibition in Colorectal Cancer
Yaeger, Rona, Mezzadra, Riccardo, Sinopoli, Jenna, Bian, Yu, Marasco, Michelangelo, Kaplun, Esther, Gao, Yijun, Zhao, HuiYong, Paula, Arnaud Da Cruz, Zhu, Yingjie, Perez, Almudena Chaves, Chadalavada, Kalyani, Tse, Edison, Chowdhry, Sudhir, Bowker, Sydney, Chang, Qing, Qeriqi, Besnik, Weigelt, Britta, Nanjangud, Gouri J, Berger, Michael F, Der-Torossian, Hirak, Anderes, Kenna, Socci, Nicholas D, Shia, Jinru, Riely, Gregory J, Murciano-Goroff, Yonina R, Li, Bob T, Christensen, James G, Reis-Filho, Jorge S, Solit, David B, de Stanchina, Elisa, Lowe, Scott W, Rosen, Neal, Misale, Sandra
Published in Cancer discovery (09.01.2023)
Published in Cancer discovery (09.01.2023)
Get full text
Journal Article