Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, Colin, Tullet, Jennifer M.A, Wieser, Daniela, Irvine, Elaine, Lingard, Steven J, Choudhury, Agharul I, Claret, Marc, Al-Qassab, Hind, Carmignac, Danielle, Ramadani, Faruk, Woods, Angela, Robinson, Iain C.A, Schuster, Eugene, Batterham, Rachel L, Kozma, Sara C, Thomas, George, Carling, David, Okkenhaug, Klaus, Thornton, Janet M, Partridge, Linda, Gems, David, Withers, Dominic J
Published in Science (American Association for the Advancement of Science) (02.10.2009)
Published in Science (American Association for the Advancement of Science) (02.10.2009)
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Extrahypothalamic GABAergic nociceptin-expressing neurons regulate AgRP neuron activity to control feeding behavior
Smith, Mark A, Choudhury, Agharul I, Glegola, Justyna A, Viskaitis, Paulius, Irvine, Elaine E, de Campos Silva, Pedro Caldas Custodio, Khadayate, Sanjay, Zeilhofer, Hanns Ulrich, Withers, Dominic J
Published in The Journal of clinical investigation (01.01.2020)
Published in The Journal of clinical investigation (01.01.2020)
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Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States
Viskaitis, Paulius, Irvine, Elaine E., Smith, Mark A., Choudhury, Agharul I., Alvarez-Curto, Elisa, Glegola, Justyna A., Hardy, Darran G., Pedroni, Silvia M.A., Paiva Pessoa, Maria R., Fernando, Anushka B.P., Katsouri, Loukia, Sardini, Alessandro, Ungless, Mark A., Milligan, Graeme, Withers, Dominic J.
Published in Cell reports (Cambridge) (19.12.2017)
Published in Cell reports (Cambridge) (19.12.2017)
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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
Costello, Derek A, Claret, Marc, Al-Qassab, Hind, Plattner, Florian, Irvine, Elaine E, Choudhury, Agharul I, Giese, K Peter, Withers, Dominic J, Pedarzani, Paola
Published in PloS one (27.02.2012)
Published in PloS one (27.02.2012)
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Ribosomal S6K1 in POMC and AgRP neurons regulates glucose homeostasis but not feeding behavior in mice
Smith, Mark A., Katsouri, Loukia, Irvine, Elaine E., Hankir, Mohammed K., Pedroni, Silvia MA, Voshol, Peter J., Gordon, Matthew W., Choudhury, Agharul I., Woods, Angela, Vidal-Puig, Antonio, Carling, David, Withers, Dominic J.
Published in Cell reports (Cambridge) (21.04.2015)
Published in Cell reports (Cambridge) (21.04.2015)
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Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice
Millership, Steven J., Tunster, Simon J., Van de Pette, Mathew, Choudhury, Agharul I., Irvine, Elaine E., Christian, Mark, Fisher, Amanda G., John, Rosalind M., Scott, James, Withers, Dominic J.
Published in Molecular metabolism (Germany) (01.12.2018)
Published in Molecular metabolism (Germany) (01.12.2018)
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Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons
Smith, Mark A., Katsouri, Loukia, Virtue, Samuel, Choudhury, Agharul I., Vidal-Puig, Antonio, Ashford, Michael L.J., Withers, Dominic J.
Published in Cell reports (Cambridge) (09.10.2018)
Published in Cell reports (Cambridge) (09.10.2018)
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Journal Article
Insulin Receptor Substrate 2 Is a Negative Regulator of Memory Formation
Irvine, Elaine E, Drinkwater, Laura, Radwanska, Kasia, Al-Qassab, Hind, Smith, Mark A, O'Brien, Melissa, Kielar, Catherine, Choudhury, Agharul I, Krauss, Stefan, Cooper, Jonathan D, Withers, Dominic J, Giese, Karl Peter
Published in Learning & memory (Cold Spring Harbor, N.Y.) (01.06.2011)
Published in Learning & memory (Cold Spring Harbor, N.Y.) (01.06.2011)
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Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance
Chandarana, Keval, Gelegen, Cigdem, Irvine, Elaine E, Choudhury, Agharul I, Amouyal, Chloé, Andreelli, Fabrizio, Withers, Dominic J, Batterham, Rachel L
Published in Molecular metabolism (Germany) (01.08.2013)
Published in Molecular metabolism (Germany) (01.08.2013)
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Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity
Rached, Marie-Therese, Millership, Steven J., Pedroni, Silvia M.A., Choudhury, Agharul I., Costa, Ana S.H., Hardy, Darran G., Glegola, Justyna A., Irvine, Elaine E., Selman, Colin, Woodberry, Megan C., Yadav, Vijay K., Khadayate, Sanjay, Vidal-Puig, Antonio, Virtue, Samuel, Frezza, Christian, Withers, Dominic J.
Published in Molecular metabolism (Germany) (01.02.2019)
Published in Molecular metabolism (Germany) (01.02.2019)
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Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice
Scott, William R, Gelegen, Cigdem, Chandarana, Keval, Karra, Efthimia, Yousseif, Ahmed, Amouyal, Chloé, Choudhury, Agharul I, Andreelli, Fabrizio, Withers, Dominic J, Batterham, Rachel L
Published in PloS one (20.03.2013)
Published in PloS one (20.03.2013)
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A link between FTO, ghrelin, and impaired brain food-cue responsivity
Karra, Efthimia, O'Daly, Owen G, Choudhury, Agharul I, Yousseif, Ahmed, Millership, Steven, Neary, Marianne T, Scott, William R, Chandarana, Keval, Manning, Sean, Hess, Martin E, Iwakura, Hiroshi, Akamizu, Takashi, Millet, Queensta, Gelegen, Cigdem, Drew, Megan E, Rahman, Sofia, Emmanuel, Julian J, Williams, Steven C R, Rüther, Ulrich U, Brüning, Jens C, Withers, Dominic J, Zelaya, Fernando O, Batterham, Rachel L
Published in The Journal of clinical investigation (01.08.2013)
Published in The Journal of clinical investigation (01.08.2013)
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Role of Central Nervous System and Ovarian Insulin Receptor Substrate 2 Signaling in Female Reproductive Function in the Mouse
Neganova, Irina, Al-Qassab, Hind, Heffron, Helen, Selman, Colin, Choudhury, Agharul I, Lingard, Steven J, Diakonov, Ivan, Patterson, Michael, Ghatei, Mohammad, Bloom, Stephen R, Franks, Stephen, Huhtaniemi, Ilpo, Hardy, Kate, Withers, Dominic J
Published in Biology of reproduction (01.06.2007)
Published in Biology of reproduction (01.06.2007)
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Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
Selman, Colin, Lingard, Steven, Choudhury, Agharul I, Batterham, Rachel L, Claret, Marc, Clements, Melanie, Ramadani, Faruk, Okkenhaug, Klaus, Schuster, Eugene, Blanc, Eric, Piper, Matthew D, Al-Qassab, Hind, Speakman, John R, Carmignac, Danielle, Robinson, Iain C A, Thornton, Janet M, Gems, David, Partridge, Linda, Withers, Dominic J
Published in The FASEB journal (01.03.2008)
Published in The FASEB journal (01.03.2008)
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Diet and Gastrointestinal Bypass―Induced Weight Loss: The Roles of Ghrelin and Peptide YY
CHANDARANA, Keval, GELEGEN, Cigdem, KARRA, Efthimia, CHOUDHURY, Agharul I, DREW, Megan E, FAUVEAU, Veronique, VIOLLET, Benoit, ANDREELLI, Fabrizio, WITHERS, Dominic J, BATTERHAM, Rachel L
Published in Diabetes (New York, N.Y.) (01.03.2011)
Published in Diabetes (New York, N.Y.) (01.03.2011)
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Neuronatin regulates pancreatic β cell insulin content and secretion
Millership, Steven J, Da Silva Xavier, Gabriela, Choudhury, Agharul I, Bertazzo, Sergio, Chabosseau, Pauline, Pedroni, Silvia Ma, Irvine, Elaine E, Montoya, Alex, Faull, Peter, Taylor, William R, Kerr-Conte, Julie, Pattou, Francois, Ferrer, Jorge, Christian, Mark, John, Rosalind M, Latreille, Mathieu, Liu, Ming, Rutter, Guy A, Scott, James, Withers, Dominic J
Published in The Journal of clinical investigation (01.08.2018)
Published in The Journal of clinical investigation (01.08.2018)
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Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
Killick, Richard, Scales, Georgie, Leroy, Karelle, Causevic, Mirsada, Hooper, Claudie, Irvine, Elaine E., Choudhury, Agharul I, Drinkwater, Laura, Kerr, Fiona, Al-Qassab, Hind, Stephenson, John, Yilmaz, Zehra, Giese, K. Peter, Brion, Jean-Pierre, Withers, Dominic J., Lovestone, Simon
Published in Biochemical and biophysical research communications (14.08.2009)
Published in Biochemical and biophysical research communications (14.08.2009)
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Journal Article
Role of Central Nervous System and Ovarian Insulin Receptor Substrate 2 Signaling in Female Reproductive Function in the Mouse1
Neganova, Irina, Al-Qassab, Hind, Heffron, Helen, Selman, Colin, Choudhury, Agharul I, Lingard, Steven J, Diakonov, Ivan, Patterson, Michael, Ghatei, Mohammad, Bloom, Stephen R, Franks, Stephen, Huhtaniemi, Ilpo, Hardy, Kate, Withers, Dominic J
Published in Biology of reproduction (01.06.2007)
Published in Biology of reproduction (01.06.2007)
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Journal Article
The role of insulin receptor substrate 2 in hypothalamic and beta cell function
Choudhury, Agharul I, Heffron, Helen, Smith, Mark A, Al-Qassab, Hind, Xu, Allison W, Selman, Colin, Simmgen, Marcus, Clements, Melanie, Claret, Marc, Maccoll, Gavin, Bedford, David C, Hisadome, Kazunari, Diakonov, Ivan, Moosajee, Vazira, Bell, Jimmy D, Speakman, John R, Batterham, Rachel L, Barsh, Gregory S, Ashford, Michael L J, Withers, Dominic J
Published in The Journal of clinical investigation (01.04.2005)
Published in The Journal of clinical investigation (01.04.2005)
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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
Claret, Marc, Smith, Mark A, Batterham, Rachel L, Selman, Colin, Choudhury, Agharul I, Fryer, Lee G D, Clements, Melanie, Al-Qassab, Hind, Heffron, Helen, Xu, Allison W, Speakman, John R, Barsh, Gregory S, Viollet, Benoit, Vaulont, Sophie, Ashford, Michael L J, Carling, David, Withers, Dominic J
Published in The Journal of clinical investigation (01.08.2007)
Published in The Journal of clinical investigation (01.08.2007)
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