The tertiary structure and domain organization of coagulation factor VIII
Shen, Betty W., Spiegel, Paul Clint, Chang, Chong-Hwan, Huh, Jae-Wook, Lee, Jung-Sik, Kim, Jeanman, Kim, Young-Ho, Stoddard, Barry L.
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Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
Gentles, Robert G., Ding, Min, Bender, John A., Bergstrom, Carl P., Grant-Young, Katharine, Hewawasam, Piyasena, Hudyma, Thomas, Martin, Scott, Nickel, Andrew, Regueiro-Ren, Alicia, Tu, Yong, Yang, Zhong, Yeung, Kap-Sun, Zheng, Xiaofan, Chao, Sam, Sun, Jung-Hui, Beno, Brett R., Camac, Daniel M., Chang, Chong-Hwan, Gao, Mian, Morin, Paul E., Sheriff, Steven, Tredup, Jeff, Wan, John, Witmer, Mark R., Xie, Dianlin, Hanumegowda, Umesh, Knipe, Jay, Mosure, Kathy, Santone, Kenneth S., Parker, Dawn D., Zhuo, Xiaoliang, Lemm, Julie, Liu, Mengping, Pelosi, Lenore, Rigat, Karen, Voss, Stacey, Wang, Yi, Wang, Ying-Kai, Colonno, Richard J., Gao, Min, Roberts, Susan B., Gao, Qi, Ng, Alicia, Meanwell, Nicholas A, Kadow, John F.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus
Zheng, Xiaofan, Hudyma, Thomas W., Martin, Scott W., Bergstrom, Carl, Ding, Min, He, Feng, Romine, Jeffrey, Poss, Michael A., Kadow, John F., Chang, Chong-Hwan, Wan, John, Witmer, Mark R., Morin, Paul, Camac, Daniel M., Sheriff, Steven, Beno, Brett R., Rigat, Karen L., Wang, Ying-Kai, Fridell, Robert, Lemm, Julie, Qiu, Dike, Liu, Mengping, Voss, Stacey, Pelosi, Lenore, Roberts, Susan B., Gao, Min, Knipe, Jay, Gentles, Robert G.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3
Yue, Eddy W, Higley, C. Anne, DiMeo, Susan V, Carini, David J, Nugiel, David A, Benware, Carrie, Benfield, Pamela A, Burton, Catherine R, Cox, Sarah, Grafstrom, Robert H, Sharp, Diane M, Sisk, Lisa M, Boylan, John F, Muckelbauer, Jodi K, Smallwood, Angela M, Chen, Haiying, Chang, Chong-Hwan, Seitz, Steven P, Trainor, George L
Published in Journal of medicinal chemistry (21.11.2002)
Published in Journal of medicinal chemistry (21.11.2002)
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Comparison of reaction centers from Rhodobacter sphaeroides and Rhodopseudomonas viridis: overall architecture and protein-pigment interactions
El-Kabbani, Ossama, Chang, Chong Hwan, Tiede, David, Norris, James, Schiffer, Marianne
Published in Biochemistry (Easton) (01.06.1991)
Published in Biochemistry (Easton) (01.06.1991)
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Biarylpyrazolyl Oxadiazole as Potent, Selective, Orally Bioavailable Cannabinoid-1 Receptor Antagonists for the Treatment of Obesity
Lee, Suk Ho, Seo, Hee Jeong, Lee, Sung-Han, Jung, Myung Eun, Park, Ji-Hyun, Park, Hyun-Ju, Yoo, Jakyung, Yun, Hoseop, Na, Jooran, Kang, Suk Youn, Song, Kwang-Seop, Kim, Min-ah, Chang, Chong-Hwan, Kim, Jeongmin, Lee, Jinhwa
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
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Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies
Jadhav, Prabhakar K, Woerner, Francis J, Lam, Patrick Y. S, Hodge, C. Nicholas, Eyermann, Charles J, Man, Hon-Wah, Daneker, Wayne F, Bacheler, Lee T, Rayner, Marlene M, Meek, James L, Erickson-Viitanen, Susan, Jackson, David A, Calabrese, Joseph C, Schadt, Margaret, Chang, Chong-Hwan
Published in Journal of medicinal chemistry (23.04.1998)
Published in Journal of medicinal chemistry (23.04.1998)
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Molecular Recognition of Cyclic Urea HIV-1 Protease Inhibitors
Ala, Paul J., DeLoskey, Richard J., Huston, Edward E., Jadhav, Prabhakar K., Lam, Patrick Y.S., Eyermann, Charles J., Hodge, C. Nicholas, Schadt, Margaret C., Lewandowski, Frank A., Weber, Patricia C., McCabe, Denise D., Duke, Jodie L., Chang, Chong-Hwan
Published in The Journal of biological chemistry (15.05.1998)
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Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases
Markwalder, Jay A, Arnone, Marc R, Benfield, Pamela A, Boisclair, Michael, Burton, Catherine R, Chang, Chong-Hwan, Cox, Sarah S, Czerniak, Philip M, Dean, Charity L, Doleniak, Deborah, Grafstrom, Robert, Harrison, Barbara A, Kaltenbach, Robert F, Nugiel, David A, Rossi, Karen A, Sherk, Susan R, Sisk, Lisa M, Stouten, Pieter, Trainor, George L, Worland, Peter, Seitz, Steven P
Published in Journal of medicinal chemistry (18.11.2004)
Published in Journal of medicinal chemistry (18.11.2004)
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Mapping Hydration Water Molecules in the HIV-1 Protease/DMP323 Complex in Solution by NMR Spectroscopy
Wang, Yun-Xing, Freedberg, Darón I, Grzesiek, Stephan, Torchia, Dennis A, Wingfield, Paul T, Kaufman, Joshua D, Stahl, Stephen J, Chang, Chong-Hwan, Hodge, C. Nicholas
Published in Biochemistry (Easton) (01.10.1996)
Published in Biochemistry (Easton) (01.10.1996)
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SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
Qiao, Jennifer X., Chang, Chong-Hwan, Cheney, Daniel L., Morin, Paul E., Wang, Gren Z., King, Sarah R., Wang, Tammy C., Rendina, Alan R., Luettgen, Joseph M., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Structure–activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties
Corte, James R., Fang, Tianan, Pinto, Donald J.P., Han, Wei, Hu, Zilun, Jiang, Xiang-Jun, Li, Yun-Long, Gauuan, Jolicia F., Hadden, Mark, Orton, Darren, Rendina, Alan R., Luettgen, Joseph M., Wong, Pancras C., He, Kan, Morin, Paul E., Chang, Chong-Hwan, Cheney, Daniel L., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
Published in Bioorganic & medicinal chemistry letters (01.05.2008)
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Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors
Patrick Y. S. Lam, Jahdav, Prabhakar K., Eyermann, Charles J., Hodge, C. Nicholas, Ru, Yu, Bacheler, Lee T., Meek, James L., Otto, Michael J., Rayner, Marlene M., Wong, Y. Nancy, Chang, Chong-Hwan, Weber, Patricia C., Jackson, David A., Sharpe, Thomas R., Erickson-Viitanen, Susan
Published in Science (American Association for the Advancement of Science) (21.01.1994)
Published in Science (American Association for the Advancement of Science) (21.01.1994)
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Quinazolines as cyclin dependent kinase inhibitors
Sielecki, Thais M., Johnson, Tricia L., Liu, Jie, Muckelbauer, Jodi K., Grafstrom, Robert H., Cox, Sarah, Boylan, John, Burton, Catherine R., Chen, Haiying, Smallwood, Angela, Chang, Chong-Hwan, Boisclair, Michael, Benfield, Pamela A., Trainor, George L., Seitz, Steven P.
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
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Cyclic HIV Protease Inhibitors: Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas
Lam, Patrick Y. S, Ru, Yu, Jadhav, Prabhakar K, Aldrich, Paul E, DeLucca, George V, Eyermann, Charles J, Chang, Chong-Hwan, Emmett, George, Holler, Edward R, Daneker, Wayne F, Li, Liangzhu, Confalone, Pat N, McHugh, Robert J, Han, Qi, Li, Renhua, Markwalder, Jay A, Seitz, Steven P, Sharpe, Thomas R, Bacheler, Lee T, Rayner, Marlene M, Klabe, Ronald M, Shum, Linyee, Winslow, Dean L, Kornhauser, David M, Jackson, David A, Erickson-Viitanen, Susan, Hodge, C. Nicholas
Published in Journal of medicinal chemistry (30.08.1996)
Published in Journal of medicinal chemistry (30.08.1996)
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Methylsulfonylpyrazolyl oxadiazoles and thiadiazoles as potent, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity
Seo, Hee Jeong, Kim, Min Ju, Song, Kwang-Seop, Lee, Sung-Han, Jung, Myung Eun, Kim, Mi-Soon, Park, Hyun-Ju, Yoo, Jakyung, Chang, Chong-Hwan, Kim, Jeongmin, Lee, Jinhwa
Published in Future medicinal chemistry (01.08.2009)
Published in Future medicinal chemistry (01.08.2009)
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